Title

Interrelationships of transcriptional machinery with nuclear architecture

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center

Date

1-29-2000

Document Type

Article

Medical Subject Headings

Animals; Cell Nucleus; Chromatin; *Gene Expression Regulation; Humans; Nuclear Matrix; *Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

There is increasing evidence for functional linkages between nuclear architecture and the regulation of gene expression. The nuclear matrix provides a paradigm for involvement of nuclear morphology in assembly of the biochemical machinery for physiological control of transcription. Mechanisms are being experimentally defined that direct regulatory factors to subnuclear sites that support gene expression. Consequently, we are gaining insight into the rules that govern transcriptional control within the three-dimensional context of nuclear organization.

Rights and Permissions

Citation: Crit Rev Eukaryot Gene Expr. 1999;9(3-4):183-90.

Related Resources

Link to Article in PubMed