Nuclear structure--skeletal gene expression interrelationships
Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center
Medical Subject Headings
Animals; Bone and Bones; Cell Line, Tumor; Cell Nucleus; Chromatin; Core Binding Factor alpha Subunits; Gene Expression Regulation, Developmental; Humans; NF-kappa B; Nuclear Matrix; Nuclear Pore; Nucleosomes; Osteoblasts; Osteocalcin; Osteosarcoma; Promoter Regions (Genetics); Protein Structure, Tertiary; Receptors, Glucocorticoid; Signal Transduction; Transcription Factors; Transcription, Genetic; Vitamin D; Vitamin D Response Element
Life Sciences | Medicine and Health Sciences
Using the osteocalcin gene as a paradigm for bone tissue-specific transcription, evidence is presented for functional linkage of nuclear architecture with developmental and steroid hormone-responsive control. The involvement of chromatin structure, nucleosome organization and the nuclear matrix is evaluated within the context of integrating regulatory signals that activate and/or suppress transcription of the osteocalcin gene. Mechanisms are evaluated which direct the bone and hematopoietic-specific acute myelogenous leukemia/core binding factor (AML/CBF) transcription factors to nuclear matrix-associated subnuclear domains that are competent to support expression.
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Citation: Front Biosci. 1998 Aug 1;3:d849-64.