GSBS Student Publications

Title

Transcriptional control of cell cycle progression: the histone gene is a paradigm for the G1/S phase and proliferation/differentiation transitions

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology

Date

1-1-1996

Document Type

Article

Medical Subject Headings

Cell Cycle; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; DNA; G1 Phase; Histones; Humans; Promoter Regions (Genetics); S Phase; Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The histone gene is a paradigm for transcriptional control at the G1/S phase transition point in the cell cycle. The histone gene promoter provides a blueprint for integration of regulatory signals which mediate responsiveness to factors controlling competency for cell cycle progression at the initiation of DNA replication. The downregulation of proliferation at the onset of differentiation is accompanied by and functionally linked to modifications in protein-DNA and protein-protein interactions at histone gene promoter regulatory elements. Chromatin structure, nucleosome organization and gene-nuclear matrix interactions facilitate crosstalk between regulatory sequences and targeting of transcription factors to cognate binding domains.

Rights and Permissions

Citation: Cell Biol Int. 1996 Jan;20(1):41-9. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal Title

Cell biology international

PubMed ID

8936406