Transcriptional control of cell cycle progression: the histone gene is a paradigm for the G1/S phase and proliferation/differentiation transitions
Document Type
Journal ArticlePublication Date
1996-01-01Keywords
Cell Cycle; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; DNA; G1 Phase; Histones; Humans; Promoter Regions (Genetics); S Phase; Transcription, GeneticLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
The histone gene is a paradigm for transcriptional control at the G1/S phase transition point in the cell cycle. The histone gene promoter provides a blueprint for integration of regulatory signals which mediate responsiveness to factors controlling competency for cell cycle progression at the initiation of DNA replication. The downregulation of proliferation at the onset of differentiation is accompanied by and functionally linked to modifications in protein-DNA and protein-protein interactions at histone gene promoter regulatory elements. Chromatin structure, nucleosome organization and gene-nuclear matrix interactions facilitate crosstalk between regulatory sequences and targeting of transcription factors to cognate binding domains.Source
Cell Biol Int. 1996 Jan;20(1):41-9. Link to article on publisher's siteDOI
10.1006/cbir.1996.0007Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32619PubMed ID
8936406Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1006/cbir.1996.0007