GSBS Student Publications


Regulation of histone gene expression

UMMS Affiliation

Graduate School of Biomedical Sciences; University of Massachusetts Medical Center



Document Type


Medical Subject Headings

Base Sequence; Cell Cycle; DNA; Gene Expression Regulation; Histones; Humans; Molecular Sequence Data; Promoter Regions (Genetics)


Life Sciences | Medicine and Health Sciences


Histone genes are expressed during the S phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell-cycle progression and the onset of differentiation. Much work has been carried out on the H4 gene promoter, which appears to be organized into a series of distinct regulatory elements. The three-dimensional organization of the promoter and, in particular, its spatial relationship with the nuclear matrix scaffold, may be important factors of transcription regulation.

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Citation: Curr Opin Cell Biol. 1992 Apr;4(2):166-73.

Related Resources

Link to Article in PubMed

Journal Title

Current opinion in cell biology

PubMed ID