Regulation of histone gene expression
Graduate School of Biomedical Sciences; University of Massachusetts Medical Center
Medical Subject Headings
Base Sequence; Cell Cycle; DNA; Gene Expression Regulation; Histones; Humans; Molecular Sequence Data; Promoter Regions (Genetics)
Life Sciences | Medicine and Health Sciences
Histone genes are expressed during the S phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell-cycle progression and the onset of differentiation. Much work has been carried out on the H4 gene promoter, which appears to be organized into a series of distinct regulatory elements. The three-dimensional organization of the promoter and, in particular, its spatial relationship with the nuclear matrix scaffold, may be important factors of transcription regulation.
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Citation: Curr Opin Cell Biol. 1992 Apr;4(2):166-73.
Current opinion in cell biology
Stein, Gary S.; Stein, Janet L.; Van Wijnen, Andre J.; and Lian, Jane B., "Regulation of histone gene expression" (1992). GSBS Student Publications. 1178.