Functional interrelationships between nuclear structure and transcriptional control: contributions to regulation of cell cycle- and tissue-specific gene expression
Graduate School of Biomedical Sciences; Department of Cell Biology
Medical Subject Headings
Animals; Cell Cycle; Cell Nucleus; Gene Expression Regulation, Developmental; Humans; *Models, Genetic; Transcription, Genetic
Life Sciences | Medicine and Health Sciences
Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related signals. Chromatin structure, nucleosome organization, and gene-nuclear matrix interactions provide a basis for rendering sequences accessible to transcription factors supporting integration of activities at independent promoter elements of cell cycle- and tissue-specific genes. A model is presented for remodeling of nuclear organization to accommodate developmental transcriptional control.
Rights and Permissions
Citation: J Cell Biochem. 1996 Aug;62(2):198-209. Link to article on publisher's site
Journal of cellular biochemistry
Stein, Gary S.; Stein, Janet L.; Lian, Jane B.; Van Wijnen, Andre J.; and Montecino, Martin A., "Functional interrelationships between nuclear structure and transcriptional control: contributions to regulation of cell cycle- and tissue-specific gene expression" (1996). GSBS Student Publications. 1175.