GSBS Student Publications

Title

Nuclear microenvironments support assembly and organization of the transcriptional regulatory machinery for cell proliferation and differentiation

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center

Date

1-27-2004

Document Type

Article

Medical Subject Headings

Cell Cycle; *Cell Differentiation; *Cell Division; Cell Nucleus; Core Binding Factor Alpha 2 Subunit; DNA-Binding Proteins; *Gene Expression Regulation; Models, Molecular; Nuclear Matrix; Nuclear Proteins; Osteocalcin; Proto-Oncogene Proteins; Signal Transduction; Trans-Activators; Transcription Factors; *Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The temporal and spatial organization of transcriptional regulatory machinery provides microenvironments within the nucleus where threshold concentrations of genes and cognate factors facilitate functional interactions. Conventional biochemical, molecular, and in vivo genetic approaches, together with high throughput genomic and proteomic analysis are rapidly expanding our database of regulatory macromolecules and signaling pathways that are requisite for control of genes that govern proliferation and differentiation. There is accruing insight into the architectural organization of regulatory machinery for gene expression that suggests signatures for biological control. Localized scaffolding of regulatory macromolecules at strategic promoter sites and focal compartmentalization of genes, transcripts, and regulatory factors within intranuclear microenvironments provides an infrastructure for combinatorial control of transcription that is operative within the three dimensional context of nuclear architecture.

Rights and Permissions

Citation: J Cell Biochem. 2004 Feb 1;91(2):287-302. Link to article on publisher's site

DOI of Published Version

10.1002/jcb.10777

Related Resources

Link to Article in PubMed

Journal Title

Journal of cellular biochemistry

PubMed ID

14743389