Title

Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center

Date

5-7-2003

Document Type

Article

Medical Subject Headings

Animals; Bone Development; Chromatin; Core Binding Factor Alpha 3 Subunit; Core Binding Factor alpha Subunits; DNA-Binding Proteins; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Promoter Regions (Genetics); Transcription Factors; Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

RUNX (AML/CBFA/PEBP2) transcription factors serve as paradigms for obligatory relationships between nuclear structure and physiological control of phenotypic gene expression. The RUNX proteins contribute to tissue restricted transcription by sequence-specific binding to promoter elements of target genes and serving as scaffolds for the assembly of coregulatory complexes that mediate biochemical and architectural control of activity. We will present an overview of approaches we are pursuing to address: (1) the involvement of RUNX proteins in governing competency for protein/DNA and protein/protein interactions at promoter regulatory sequences; (2) the recruitment of RUNX factors to subnuclear sites where the machinery for expression or repression of target genes is organized; and (3) the trafficking and integration of regulatory signals that control RUNX-mediated transcription.

Rights and Permissions

Citation: Blood Cells Mol Dis. 2003 Mar-Apr;30(2):170-6.

Related Resources

Link to Article in PubMed

PubMed ID

12732180