GSBS Student Publications

Title

Transcriptional control of osteoblast growth and differentiation

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center

Date

4-1-1996

Document Type

Article

Medical Subject Headings

Animals; Cell Cycle; Cell Differentiation; Cell Division; Histones; Humans; Osteoblasts; Osteocalcin; *Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Osteoblast differentiation is a multistep series of events modulated by an integrated cascade of gene expression that initially supports proliferation and the sequential expression of genes associated with the biosynthesis, organization, and mineralization of the bone extracellular matrix. Transcriptional control defines regulatory events operative both developmentally and for support of bone tissue-specific properties. This review focuses on components of transcriptional regulation that function in growth control during osteoblast proliferation and those that postproliferatively contribute to maturation of the bone phenotype. Emphasis is on transcription of the cell cycle-regulated histone gene and the bone-specific osteocalcin gene as paradigms for genes with promoter elements exhibiting responsiveness to a broad spectrum of physiological regulatory signals. Additionally, the potential contributions provided by the three-dimensional organization of the histone and osteocalcin gene promoters to integration of regulatory activities at multiple, independent, and overlapping regulatory domains are explored.

Rights and Permissions

Citation: Physiol Rev. 1996 Apr;76(2):593-629.

Related Resources

Link to Article in PubMed

Journal Title

Physiological reviews

PubMed ID

8618964