UMass Chan Affiliations
Department of Cell Biology and Cancer CenterGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
1996-04-01Keywords
Animals; Cell Cycle; Cell Differentiation; Cell Division; Histones; Humans; Osteoblasts; Osteocalcin; *Transcription, GeneticLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Osteoblast differentiation is a multistep series of events modulated by an integrated cascade of gene expression that initially supports proliferation and the sequential expression of genes associated with the biosynthesis, organization, and mineralization of the bone extracellular matrix. Transcriptional control defines regulatory events operative both developmentally and for support of bone tissue-specific properties. This review focuses on components of transcriptional regulation that function in growth control during osteoblast proliferation and those that postproliferatively contribute to maturation of the bone phenotype. Emphasis is on transcription of the cell cycle-regulated histone gene and the bone-specific osteocalcin gene as paradigms for genes with promoter elements exhibiting responsiveness to a broad spectrum of physiological regulatory signals. Additionally, the potential contributions provided by the three-dimensional organization of the histone and osteocalcin gene promoters to integration of regulatory activities at multiple, independent, and overlapping regulatory domains are explored.Source
Physiol Rev. 1996 Apr;76(2):593-629.
DOI
10.1152/physrev.1996.76.2.593Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32605PubMed ID
8618964Related Resources
ae974a485f413a2113503eed53cd6c53
10.1152/physrev.1996.76.2.593