Transcriptional control of osteoblast growth and differentiation
Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center
Medical Subject Headings
Animals; Cell Cycle; Cell Differentiation; Cell Division; Histones; Humans; Osteoblasts; Osteocalcin; *Transcription, Genetic
Life Sciences | Medicine and Health Sciences
Osteoblast differentiation is a multistep series of events modulated by an integrated cascade of gene expression that initially supports proliferation and the sequential expression of genes associated with the biosynthesis, organization, and mineralization of the bone extracellular matrix. Transcriptional control defines regulatory events operative both developmentally and for support of bone tissue-specific properties. This review focuses on components of transcriptional regulation that function in growth control during osteoblast proliferation and those that postproliferatively contribute to maturation of the bone phenotype. Emphasis is on transcription of the cell cycle-regulated histone gene and the bone-specific osteocalcin gene as paradigms for genes with promoter elements exhibiting responsiveness to a broad spectrum of physiological regulatory signals. Additionally, the potential contributions provided by the three-dimensional organization of the histone and osteocalcin gene promoters to integration of regulatory activities at multiple, independent, and overlapping regulatory domains are explored.
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Citation: Physiol Rev. 1996 Apr;76(2):593-629.
Stein, Gary S.; Lian, Jane B.; Stein, Janet L.; Van Wijnen, Andre J.; and Montecino, Martin A., "Transcriptional control of osteoblast growth and differentiation" (1996). GSBS Student Publications. 1168.