Nuclear microenvironments support physiological control of gene expression
Graduate School of Biomedical Sciences; Department of Cell Biology and Cancer Center
Medical Subject Headings
*Cell Nucleus; Chromatin; *Gene Expression Regulation; *Nuclear Matrix; Osteocalcin; Regulatory Sequences, Nucleic Acid; Transcription Factors
Life Sciences | Medicine and Health Sciences
There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.
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Citation: Chromosome Res. 2003;11(5):527-36.