The good, the bad and the ugly: the practical consequences of centrosome amplification
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Student Authors
Joshua J. NordbergUMass Chan Affiliations
Department of Cell BiologyDocument Type
Journal ArticlePublication Date
2004-03-24Keywords
Animals; Centrosome; Humans; Mitosis; Mitotic Spindle Apparatus; NeoplasmsCell Biology
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Centrosome amplification (the presence of more than two centrosomes at mitosis) is characteristic of many human cancers. Extra centrosomes can cause the assembly of multipolar spindles, which unequally distribute chromosomes to daughter cells; the resulting genetic imbalances may contribute to cellular transformation. However, this raises the question of how a population of cells with centrosome amplification can survive such chaotic mitoses without soon becoming non-viable as a result of chromosome loss. Recent observations indicate that a variety of mechanisms partially mute the practical consequences of centrosome amplification. Consequently, populations of cells propagate with good efficiency, despite centrosome amplification, yet have an elevated mitotic error rate that can fuel the evolution of the transformed state.Source
Curr Opin Cell Biol. 2004 Feb;16(1):49-54. Link to article on publisher's siteDOI
10.1016/j.ceb.2003.11.006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32562PubMed ID
15037304Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.ceb.2003.11.006