GSBS Student Publications

Title

Induction of tolerance for islet transplantation for type 1 diabetes

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Medicine, Division of Endocrinology and Metabolism; Department of Medicine, Diabetes Division

Date

7-18-2003

Document Type

Article

Medical Subject Headings

Animals; Antibodies, Monoclonal; Autoimmune Diseases; Blood Transfusion; CD40 Ligand; Diabetes Mellitus, Type 1; Humans; Immunosuppressive Agents; Islets of Langerhans Transplantation; Mice; Recurrence; Transplantation Immunology; Transplantation Tolerance

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Type 1 diabetes is an autoimmune disorder characterized by selective destruction of pancreatic b cells and absolute insulin deficiency. Even when treated well, control is imperfect and complications inevitable. Advances in immunosuppressive drugs and preparation of donor islets have recently made curative islet transplantation a reality for type 1 diabetes. Unfortunately, short-term side effects and long-term health risks of lifelong systemic immunosuppression compromise the otherwise extraordinary benefits that accrue from a successful graft. Our current goal is to obviate the need for immunosuppression and achieve islet graft tolerance. New protocols based on costimulation blockade have brought us close to that goal, inducing states of both peripheral and central transplantation tolerance. These have overcome both allograft rejection and recurrent autoimmunity, but potentially detrimental effects of environmental agents on tolerance are not yet fully understood. Studies of the underlying mechanisms have provided new insights into the nature of both tolerance and autoimmunity.

Rights and Permissions

Citation: Curr Diab Rep. 2003 Aug;3(4):329-35.

Related Resources

Link to Article in PubMed

Journal Title

Current diabetes reports

PubMed ID

12866997