GSBS Student Publications

Title

Regulation of postreceptor signaling in the pheromone response pathway of Saccharomyces cerevisiae

GSBS Program

Biochemistry & Molecular Pharmacology

UMMS Affiliation

Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology

Date

9-1-1989

Document Type

Article

Medical Subject Headings

Adaptation, Physiological; Cell Division; Peptides; Pheromones; Receptors, Cell Surface; Receptors, Mating Factor; *Receptors, Peptide; Saccharomyces cerevisiae; *Signal Transduction; *Transcription Factors

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

alpha-Factor pheromone inhibits division of yeast a cells. After prolonged exposure to alpha-factor, the cells adapt to the stimulus and resume cell division. The sst2 mutation is known to inhibit adaptation. This report examines adaptation in scg1 (also designated gpa1) and STE4Hpl (Hpl indicates haploid lethal) mutants that exhibit constitutive activation of the pheromone response pathway. Recovery of the STE4Hpl mutant was blocked by the sst2-1 mutation, whereas recovery of the scg1-7 mutant was not completely blocked by sst2-1. These results indicate that both SST2-dependent and -independent mechanisms regulate postreceptor events in the pheromone response pathway. Down regulation of receptors in response to alpha-factor was independent of the signal that was generated in the scg1 mutant.

Rights and Permissions

Citation: Mol Cell Biol. 1989 Sep;9(9):3720-6.

Related Resources

Link to article in PubMed

Journal Title

Molecular and cellular biology

PubMed ID

2550799