GSBS Student Publications


Functional significance of conserved amino acid residues

UMMS Affiliation

Graduate School of Biomedical Sciences; Graduate School of Biomedical Sciences; Department of Molecular Genetics and Microbiology



Document Type


Medical Subject Headings

Amino Acid Sequence; Amino Acids; Bacteriophages; Molecular Sequence Data; Muramidase


Life Sciences | Medicine and Health Sciences


A systemic study of single amino acid substitutions in bacteriophage T4 lysozyme permitted a test of the concept that conserved amino acid residues are more functionally important than nonconserved residues. Substitutions of amino acid residues that are conserved among five bacteriophage-encoded lysozymes were found to lead more frequently to loss of function than substitutions of nonconserved residues. Of 163 residues tested, only 74 (45%) are sensitive to at least one substitution; however, all 14 residues that are fully conserved are sensitive to substitutions.

Rights and Permissions

Citation: Proteins. 1992 May;13(1):38-40. Link to article on publisher's site

Related Resources

Link to article in PubMed

Journal Title


PubMed ID