GSBS Student Publications

 

Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed more than 1000 research articles to the field of biomedical sciences. The GSBS Student Publications collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts. To view this collection broken out by academic program, visit GSBS Student Publications by Academic Program.

Attention GSBS students: Click on Submit Research in the left sidebar to submit your publications. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2016

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Memory-Relevant Mushroom Body Output Synapses Are Cholinergic, Oliver Barnstedt, David Owald, Johannes Felsenberg, Ruth Brain, John-Paul Moszynski, Clifford B. Talbot, Paola N. Perrat, and Scott Waddell

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Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines, Johannes Boltze, Daniel-Christoph Wagner, Nils Henninger, Nikolaus Plesnila, and Cenk Ayata

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Drosophila Vision Depends on Carcinine Uptake by an Organic Cation Transporter, Ratna Chaturvedi, Zhuo Luan, Peiyi Guo, and Hong-Sheng Li

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Microglia: Architects of the Developing Nervous System, Jeffrey L. Frost and Dorothy P. Schafer

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Expansion of the Knockdown Resistance Frequency Map for Human Head Lice (Phthiraptera: Pediculidae) in the United States Using Quantitative Sequencing, Kyle J. Gellatly, Sarah Krim, Daniel J. Palenchar, Katie Shepherd, Kyong Sup Yoon, Christopher J. Rhodes, Si Hyeock Lee, and J. Marshall Clark

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Racial/Ethnic Disparities in Meeting 5-2-1-0 Recommendations among Children and Adolescents in the United States, Christina Haughton, Monica L. Wang, and Stephenie C. Lemon

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Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species, Jiang He, Ruobo Zhou, Zhuhao Wu, Monica A. Carrasco, Peri T. Kurshan, Jonathan E. Farley, David J. Simon, Guiping Wang, Boran Han, Junjie Hao, Evan Heller, Marc R. Freeman, Kang Shen, Tom Maniatis, Marc Tessier-Lavigne, and Xiaowei Zhuang

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Impact of Leukoaraiosis Burden on Hemispheric Lateralization of the National Institutes of Health Stroke Scale Deficit in Acute Ischemic Stroke, Johanna Helenius, Richard P. Goddeau, Majaz Moonis, and Nils Henninger

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Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1, Nils Henninger, James P. Bouley, Elif M. Sikoglu, Jiyan An, Constance M. Moore, Jean A. King, Robert Bowser, Marc R. Freeman, and Robert H. Brown Jr.

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Extending the Time Window for Endovascular and Pharmacological Reperfusion, Nils Henninger and Marc Fisher

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Redefining the Translational Status of 80S Monosomes, Erin E. Heyer and Melissa J. Moore

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Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes, Henry Huang, Eric S. Veien, Hong Zhang, David C. Ayers, and Jie Song

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Monitoring cell-cell contacts in vivo in transgenic animals, Ting-Hao Huang, Tarciso Velho, and Carlos Lois

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Improving Pregnancy Outcomes through Maternity Care Coordination: A Systematic Review, Aimee R. Kroll-Desrosiers, Sybil L. Crawford, Tiffany A. Moore Simas, Amy K. Rosen, and Kristin M. Mattocks

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Using Drosophila models of Huntington's disease as a translatable tool, Elizabeth A. Lewis and Gaynor A. Smith

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Implementation and reporting of causal mediation analysis in 2015: a systematic review in epidemiological studies, Shao-Hsien Liu, Christine M. Ulbricht, Stavroula A. Chrysanthopoulou, and Kate L. Lapane

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Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding, Yihang Li, Linda Hassinger, Travis Thomson, Baojin Ding, James A. Ashley, William Hassinger, and Vivian Budnik

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ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience, Francesco Massari, Nils Henninger, Juan Diego Lozano, Anand Patel, Anna L. Kuhn, Mary Howk, Mary Perras, Christopher Brooks, Matthew J. Gounis, Peter Kan, Ajay K. Wakhloo, and Ajit S. Puri

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PULSE-SMART: Pulse-Based Arrhythmia Discrimination Using a Novel Smartphone Application, David D. McManus, Jo Woon Chong, Apurv Soni, Jane S. Saczynski, Nada Esa, Craig Napolitano, Chad E. Darling, Edward W. Boyer, Rochelle Rosen, Kevin C. Floyd, and Ki H. Chon

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Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice, So Yun Min, Jamie Kady, Minwoo Nam, Raziel Rojas-Rodriguez, Aaron Berkenwald, Jong Hun Kim, Hye Lim Noh, Jason K. Kim, Marcus P. Cooper, Timothy P. Fitzgibbons, Michael A. Brehm, and Silvia Corvera

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Emerging Technologies in the Analysis of C. elegans Nicotinic Acetylcholine Receptors, Alison Philbrook and Michael M. Francis

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Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse, Cassandra A. Slater, Asti Jackson, Pretal P. Muldoon, Anton Dawson, Megan O'Brien, Lindsey G. Soll, Rehab Abdullah, F. Ivy Carroll, Andrew R. Tapper, Michael F. Miles, Matthew L. Banks, Jill C. Bettinger, and Imad M. Damaj

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The presence of physician champions improved Kangaroo mother care in rural western India, Apurv Soni, Amee Amin, Dipen V. Patel, Nisha Fahey, Nikhil Shah, Ajay G. Phatak, Jeroan J. Allison, and Somashekhar M. Nimbalkar

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Association of common mental disorder symptoms with health and healthcare factors among women in rural western India: results of a cross-sectional survey, Apurv Soni, Nisha Fahey, Nancy Byatt, Anusha Prabhakaran, Tiffany A. Moore Simas, Jagdish Vankar, Ajay Phatak, Eileen O'Keefe, Jeroan J. Allison, and Somashekhar Nimbalkar

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Pan-neuronal imaging in roaming Caenorhabditis elegans, Vivek Venkatachalam, Ni Ji, Xian Wang, Christopher M. Clark, James Kameron Mitchell, Mason Klein, Christopher J. Tabone, Jeremy Florman, Hongfei Ji, Joel Greenwood, Andrew D. Chisholm, Jagan Srinivasan, Mark J. Alkema, Mei Zhen, and Aravinthan D.T. Samuel

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Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications, Xiang Wu, Yuanwei Zhang, Kendra Takle, Osman Bilsel, Zhan Jun Li, Hyungseok Lee, Carlos Lois, Yang Xiang, and Gang Han

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miR-124 Regulates the Phase of Drosophila Circadian Locomotor Behavior, Yong Zhang, Pallavi Lamba, Peiyi Guo, and Patrick Emery

Publications from 2015

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Making the White Matter Matters: Progress in Understanding Canavan's Disease and Therapeutic Interventions Through Eight Decades, Seemin Seher Ahmed and Guangping Gao

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Access to care and use of the Internet to search for health information: results from the US National Health Interview Survey, Daniel J. Amante, Timothy P. Hogan, Sherry L. Pagoto, Thomas M. English, and Kate L. Lapane

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A systematic survey of an intragenic epistatic landscape, Claudia Bank, Ryan T. Hietpas, Jeffrey D. Jensen, and Daniel N. Bolon

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Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants, Ankita Bansal, Lihua Julie Zhu, Kelvin Yen, and Heidi A. Tissenbaum

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SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases, Gwendolyn M. Bennett and Craig L. Peterson

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Glypican Is a Modulator of Netrin-Mediated Axon Guidance, Cassandra Blanchette, Paola N. Perrat, Andrea Thackeray, and Claire Y. Benard

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Regulatory T cells resist virus infection-induced apoptosis, Jenny Wun-Yue Che, Anke R.M. Kraft, Liisa K. Selin, and Raymond M. Welsh

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An enhanced gene targeting toolkit for Drosophila: Golic+, Hui-Min Chen, Ya-ling Huang, Barret D. Pfeiffer, Xiaohao Yao, and Tzumin Lee

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Tailor: a computational framework for detecting non-templated tailing of small silencing RNAs, Min-Te Chou, Bo W. Han, Chiung-Po Hsiao, Phillip D. Zamore, Zhiping Weng, and Jui-Hung Hung

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Improving patient notification of solid abdominal viscera incidental findings with a standardized protocol, Courtney E. Collins, Nicole Cherng, Theodore P. McDade, Babak Movahedi, Timothy A. Emhoff, Giles F. Whalen, Jennifer LaFemina, and Jon D. Dorfman

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MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis, Timea Csak, Shashi Bala, Dora Lippai, Karen Kodys, Donna Catalano, Arvin Iracheta-Vellve, and Gyongyi Szabo

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The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis, Marina T. DiStefano, Laura V. Danai, Rachel J. Roth Flach, Anil K. Chawla, David J. Pedersen, Adilson L. Guilherme, and Michael P. Czech

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Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture, Marta Esteves da Silva, Max Adrian, Philipp Schatzle, Joanna Lipka, Takuya Watanabe, Sukhee Cho, Kensuke Futai, Corette J. Wierenga, Lukas C. Kapitein, and Casper C. Hoogenraad

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Letting Go of JuNK by Disassembly of Adhesive Complexes, Jonathan E. Farley and Marc R. Freeman

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Viral infection of engrafted human islets leads to diabetes, Glen R. Gallagher, Michael A. Brehm, Robert W. Finberg, Bruce A. Barton, Leonard D. Shultz, Dale L. Greiner, Rita Bortell, and Jennifer P. Wang

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Measurement properties of the Western Ontario and McMaster Universities Osteoarthritis Index: a systematic review, Barbara L. Gandek

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The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion, Shangbang Gao, Lin Xie, Taizo Kawano, Michelle D. Po, Sihui Guan, Mei Zhen, Jennifer K. Pirri, and Mark J. Alkema

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Vaccination and heterologous immunity: educating the immune system, Anna Gil, Laurie L. Kenney, Rabinarayan Mishra, Levi B. Watkin, Nuray Aslan, and Liisa K. Selin

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Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2, Ananya R. Guntur, Pengyu Gu, Kendra Takle, Jingyi Chen, Yang Xiang, and Chung-Hui Yang

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Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production, Bo W. Han, Wei Wang, Chengjian Li, Zhiping Weng, and Phillip D. Zamore

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Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke, Johanna Helenius and Nils Henninger

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Response to Letter Regarding Article, "Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke", Johanna Helenius and Nils Henninger

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Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein, Siwei He, Alison Philbrook, Rebecca McWhirter, Christopher V. Gabel, Daniel G. Taub, Maximilian H. Carter, Isabella M. Hanna, Michael M. Francis, and David M. Miller 3rd

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An optimized kit-free method for making strand-specific deep sequencing libraries from RNA fragments, Erin E. Heyer, Hakan Ozadam, Emiliano P. Ricci, Can Cenik, and Melissa J. Moore

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Declining Long-term Risk of Adverse Events after First-time Community-presenting Venous Thromboembolism: The Population-based Worcester VTE Study (1999 to 2009), Wei Huang, Robert J. Goldberg, A. T. Cohen, Frederick A. Anderson Jr., Catarina I. Kiefe, Joel M. Gore, and Frederick A. Spencer

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Sweet taste and nutrient value subdivide rewarding dopaminergic neurons in Drosophila, Wolf Huetteroth, Emmanuel Perisse, Suewei Lin, Martin Klappenbach, Christopher J. Burke, and Scott Waddell

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Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila, Seol Hee Im, Kendra Takle, Juyeon Jo, Daniel T. Babcock, Zhiguo Ma, Yang Xiang, and Michael J. Galko

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Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice, Arvin Iracheta-Vellve, Jan Petrasek, Abhishek Satishchandran, Benedek Gyongyosi, Banishree Saha, Karen Kodys, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Templated repair of long bone defects in rats with bioactive spiral-wrapped electrospun amphiphilic polymer/hydroxyapatite scaffolds, Artem B. Kutikov, Jordan D. Skelly, David C. Ayers, and Jie Song

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Histone deacetylase 3 coordinates deacetylase-independent epigenetic silencing of TGFβ1 to orchestrate second heart field development, Sara L. Lewandowski, Harish P. Janardhan, and Chinmay M. Trivedi

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Using Drosophila models of Huntington's disease as a translatable tool, Elizabeth A. Lewis and Gaynor A. Smith

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Association of objectively measured physical activity and metabolic syndrome among U.S. adults with osteoarthritis, Shao-Hsien Liu, Molly E. Waring, Charles B. Eaton, and Kate L. Lapane

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A television in the bedroom is associated with higher weekday screen time among youth with attention deficit hyperactivity disorder (ADD/ADHD), Charmaine B. Lo, Molly E. Waring, Sherry L. Pagoto, and Stephenie C. Lemon

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The putative Na(+)/Cl(-)-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis, Zhuo Luan, Caitlin Quigley, and Hong-Sheng Li

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Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons, Wenjie Mao, Takuya Watanabe, Sukhee Cho, Jeffrey L. Frost, Tina Truong, Xiaohu Zhao, and Kensuke Futai

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Traumatic atrial myxoma rupture mimicking post-concussive symptoms, Yunis M. Mayasi, Jennifer Leidy, and Nils Henninger

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Precision cancer mouse models through genome editing with CRISPR-Cas9, Haiwei Mou, Zachary Kennedy, Daniel G. Anderson, Hao Yin, and Wen Xue

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Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion, Stanislav Nagy, Yung-Chi Huang, Mark J. Alkema, and David Biron

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Functional Upregulation of alpha4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward, Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D. Gardner, and Andrew R. Tapper

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Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels, Kelly H. Oh, Linu S. Abraham, Chandler Gegg, Christian Silvestri, Yung-Chi Huang, Mark J. Alkema, Jacob Furst, Daniela Raicu, and Hongkyun Kim

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Clinical impact of leukoaraiosis burden and chronological age on neurological deficit recovery and 90-day outcome after minor ischemic stroke, Sanjeeva R. Onteddu, Richard P. Goddeau, Artin Minaeian, and Nils Henninger

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Prevalence of Pelvic Vein Pathology in Patients with Cryptogenic Stroke and Patent Foramen Ovale Undergoing MRV Pelvis, Marcey Osgood, Elizabeth Budman, Raphael A. Carandang, Richard P. Goddeau, and Nils Henninger

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Nucleus to Synapse Nesprin1 Railroad Tracks Direct Synapse Maturation through RNA Localization, Mary Packard, Vahbiz Jokhi, Baojin Ding, Catalina Ruiz-Canada, James A. Ashley, and Vivian Budnik

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Performance of the Present-on-Admission Indicator for Clostridium difficile Infection, Amy L. Pakyz, Julie A. Patterson, Christine Motzkus-Feagans, Samuel F. Hohmann, Michael B. Edmond, and Kate L. Lapane

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Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Banishree Saha, Abhishek Satishchandran, Karen Kodys, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Pain management in nursing home residents with cancer, Camilla B. Pimentel, Becky A. Briesacher, Jerry H. Gurwitz, Allison B. Rosen, Marc T. Pimentel, and Kate L. Lapane

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Use of atypical antipsychotics in nursing homes and pharmaceutical marketing, Camilla B. Pimentel, Jennifer L. Donovan, Terry S. Field, Jerry H. Gurwitz, Leslie R. Harrold, Abir O. Kanaan, Celeste A. Lemay, Kathleen M. Mazor, Jennifer Tjia, and Becky A. Briesacher

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A Change in the Ion Selectivity of Ligand-Gated Ion Channels Provides a Mechanism to Switch Behavior, Jennifer K. Pirri, Diego Rayes, and Mark J. Alkema

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Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth, Yulian P. Ramirez, Ann C. Mladek, Roger M. Phillips, Mikko Gynther, Jarkko Rautio, Alonzo H. Ross, Richard T. Wheelhouse, and Jann N. Sakaria

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Temporal effect of depressive symptoms on the longitudinal evolution of rheumatoid arthritis disease activity, Alan M. Rathbun, Leslie R. Harrold, and George W. Reed

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Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis, Mayuri Rege, Vidya Subramanian, Chenchen Zhu, Tsung-Han S. Hsieh, Assaf Weiner, Nir Friedman, Sandra Clauder-Munster, Lars M. Steinmetz, Oliver J. Rando, Laurie A. Boyer, and Craig L. Peterson

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Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress, Zhiji Ren and Victor R. Ambros

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Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus, Raziel Rojas-Rodriguez, Tiffany A. Moore Simas, Lawrence M. Lifshitz, Karl D. Bellve, So-Yun Min, Jacqueline Pires, Katherine Leung, Crina Boeras, Aylin Sert, Jacqueline T. Draper, and Silvia Corvera

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Caffeine inhibits glucose transport by binding at the GLUT1 nucleotide-binding site, Jay M. Sage, Anthony J. Cura, Kenneth P. Lloyd, and Anthony Carruthers

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Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides, William E. Salomon, Samson M. Jolly, Melissa J. Moore, Phillip D. Zamore, and Victor Serebrov

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Cognition and mood-related behaviors in l3mbtl1 null mutant mice, Erica Y. Shen, Yan Jiang, Wenjie Mao, Kensuke Futai, Hanno Hock, and Schahram Akbarian

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Unfolding the story of chromatin organization in senescent cells, Eric C. Swanson, Lindsy M. Rapkin, David P. Bazett-Jones, and Jeanne B. Lawrence

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Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis, Gyongyi Szabo and Arvin Iracheta-Vellve

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Calcium and SOL Protease Mediate Temperature Resetting of Circadian Clocks, Ozgur Tataroglu, Xiaohu Zhao, Ania Busza, Jinli Ling, John S. O'Neill, and Patrick Emery

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Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study, Steve M. Taylor, Derrick K. DeConti, Ann M. Moormann, Jeffrey A. Bailey, and Jonathan J. Juliano

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Low Serum Vitamin D Is Independently Associated with Larger Lesion Volumes after Ischemic Stroke, Anya Turetsky, Richard P. Goddeau, and Nils Henninger

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Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice, Aditya Venkatesh, Shan Ma, Yun Z. Le, Michael N. Hall, Markus A. Ruegg, and Claudio Punzo

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Evaluation of smoking-specific and generic quality of life measures in current and former smokers in Germany and the United States, John E. Ware Jr., Barbara L. Gandek, Anuradha Kulasekaran, and Rick Guyer

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High-resolution chromatin dynamics during a yeast stress response, Assaf Weiner, Tsung-Han S. Hsieh, Alon Appleboim, Hsiuyi V. Chen, Ayelet Rahat, Ido Amit, Oliver J. Rando, and Nir Friedman

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Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant, Sijia Wu, Karl D. Bellve, Kevin E. Fogarty, and Haley Melikian

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Tobacco counseling experience prior to starting medical school, tobacco treatment self-efficacy and knowledge among first-year medical students in the United States, Rui Sherry Xiao, Rashelle B. Hayes, Molly E. Waring, Alan C. Geller, Linda C. Churchill, Kolawole S. Okuyemi, Michael Adams, Kathryn N. Huggett, and Judith K. Ockene

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Diet quality and history of gestational diabetes mellitus among childbearing women, United States, 2007-2010, Rui Sherry Xiao, Tiffany A. Moore Simas, Sharina D. Person, Robert J. Goldberg, and Molly E. Waring

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Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal, Rubing Zhao-Shea, Steven Degroot, Liwang Liu, Markus Vallaster, Xueyan Pang, Qin Su, Guangping Gao, Oliver J. Rando, Gilles E. Martin, Olivier George, Paul D. Gardner, and Andrew R. Tapper

Publications from 2014

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Generation of high-titer RCAS virus from DF1 chicken fibroblasts, Leanne G. Ahronian and Brian C. Lewis

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A Systematic Review of Electronic Portal Usage Among Patients with Diabetes, Daniel J. Amante, Timothy P. Hogan, Sherry L. Pagoto, and Thomas M. English

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A bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environments, Claudia Bank, Ryan T. Hietpas, Alex Wong, Daniel N. Bolon, and Jeffrey D. Jensen

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Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan, Ankita Bansal, Eun-Soo Kwon, Darryl Conte Jr., Haibo Liu, Michael J. Gilchrist, Lesley T. MacNeil, and Heidi A. Tissenbaum

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The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter, Rasim Barutcu, Phillip W. Tai, Hai Wu, Jonathan A. R. Gordon, Troy W. Whitfield, Jason Dobson, Anthony N. Imbalzano, Jane B. Lian, Andre J. van Wijnen, Janet L. Stein, and Gary S. Stein