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Publications from 2013
Cardiac remodeling in obesity, Gerard P. Aurigemma, Giovanni de Simone, and Timothy P. Fitzgibbons
CD40 Deficiency in Mice Exacerbates Obesity-induced Adipose Tissue Inflammation, Hepatic Steatosis and Insulin Resistance, Chang-An Guo, Sophia Kogan, Shinya U. Amano, Mengxi Wang, Sezin Dagdeviren, Randall H. Friedline, Myriam Aouadi, Jason K. Kim, and Michael P. Czech
Comparative effectiveness of a rapid point-of-care test for detection of Chlamydia trachomatis among women in a clinical setting, Wei Huang, Charlotte A. Gaydos, Mathilda R. Barnes, Mary Jett-Goheen, and Diane R. Blake
The role of MyD88 signaling in heterosubtypic influenza A virus infections, Rachel F. Madera and Daniel H. Libraty
Transposition-driven genomic heterogeneity in the Drosophila brain, Paola N. Perrat, Shamik DasGupta, Jie Wang, William E. Theurkauf, Zhiping Weng, Michael Rosbash, and Scott Waddell
Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo, Teresa Repasy, Jinhee Lee, Simeone Marino, Nuria Martinez, Denise E. Kirschner, Gregory M. Hendricks, Stephen P. Baker MScPH, Andrew A. Wilson, Darrell N. Kotton, and Hardy Kornfeld
Inflammasomes and host defenses against bacterial infections, Gregory I. Vladimer, Robyn Lynn Marty-Roix, Shubhendu Ghosh, Dan Weng, and Egil Lien
Publications from 2012
Wld(S) Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca(2+) Buffering., Michelle A. Avery, Timothy M. Rooney, Jignesh D. Pandya, Thomas M. Wishart, Thomas H. Gillingwater, James W. Geddes, Patrick G. Sullivan, and Marc R. Freeman
The Secreted Immunoglobulin Domain Proteins ZIG-5 and ZIG-8 Cooperate with L1CAM/SAX-7 to Maintain Nervous System Integrity, Claire Y. Benard, Cassandra Blanchette, Janine Recio, and Oliver Hobert
Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome, Caroline M. Connor, Aslihan Dincer, Juerg R. Straubhaar, Janina R. Galler, Isaac B. Houston, and Schahram Akbarian
Recent Progress in Polymorphism-Based Population Genetic Inference, Jessica L. Crisci, Yu-Ping Poh, Angela M. Bean, Alfred Simkin, and Jeffrey D. Jensen
Type 1 ryanodine receptor knock-in mutation causing central core disease of skeletal muscle also displays a neuronal phenotype, Valerie De Crescenzo, Kevin E. Fogarty, Jason J. Lefkowitz, Karl D. Bellve, Elena Zvaritch, David H. MacLennan, and John V. Walsh Jr.
POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster, Brian M. Farley and Sean P. Ryder
The Acid-Sensitive, Anesthetic-Activated Potassium Leak Channel, KCNK3, Is Regulated By 14-3-3beta-Dependent, PKC-Mediated Endocytic Trafficking, Luke Gabriel, Anatoli Lvov, Demetra Orthodoxou, Ann R. Rittenhouse, William R. Kobertz, and Haley E. Melikian
Using Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis, Hugh S. Gannon and Stephen N. Jones
Integrin beta4 regulates SPARC protein to promote invasion, Kristin D. Gerson, Jeffrey R. Shearstone, V.S.R. Krishna Maddula, Bruce E. Seligmann, and Arthur M. Mercurio
An optimized two-finger archive for ZFN-mediated gene targeting, Ankit Gupta, Amy L. Rayla, Abirami Lakshmanan, Scot A. Wolfe, Ryan G. Christensen, and Gary D. Stormo
Risk-assessment models for predicting venous thromboembolism among hospitalized non-surgical patients: a systematic review, Wei Huang, Frederick A. Anderson Jr., Frederick A. Spencer, Alexander S. Gallus, and Robert J. Goldberg
Cell and gene therapy for genetic diseases: inherited disorders affecting the lung and those mimicking sudden infant death syndrome, Allison M. Keeler and Terence R. Flotte
Inhibitory control of synaptic and behavioral plasticity by octopaminergic signaling, Alex C. Koon and Vivian Budnik
Intrinsic organization of the anesthetized brain, Zhifeng Liang, Jean A. King, and Nanyin Zhang
Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury, Mary A. Logan, Rachel Hackett, Johnna E. Doherty, Amy E. Sheehan, Sean D. Speese, and Marc R. Freeman
Allele- and tir-independent functions of intimin in diverse animal infection models, Emily M. Mallick, Michael J. Brady, Steven A. Luperchio, Vijay K. Vanguri, Loranne Magoun, Hui Liu, Barbara J. Sheppard, Jean Mukherjee, Arthur Donohue-Rolfe, Saul Tzipori, John M. Leong, and David B. Schauer
A novel murine infection model for Shiga toxin-producing Escherichia coli, Emily M. Mallick, Megan E. McBee, Vijay K. Vanguri, Angela R. Melton-Celsa, Katherine Schlieper, Brad J. Karalius, Alison D. O’Brien, Joan R. Butterton, John M. Leong, and David B. Schauer
Gender-Specific Reduction of Estrogen-Sensitive Small RNA, miR-30b, in Subjects With Schizophrenia, Nikolaos Mellios, Marzena Galdzicka, Edward Ginns, Stephen P. Baker, Evgeny I. Rogaev, Jun Xu, and Schahram Akbarian
Slow-cycling therapy-resistant cancer cells, Nathan F. Moore, JeanMarie Houghton, and Stephen Lyle
Structural insights into neuronal K+ channel-calmodulin complexes, Karen Mruk, Shivender Shandilya, Robert O. Blaustein, Celia A. Schiffer, and William R. Kobertz
Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles, Christian Mueller, Qiushi Tang, Alisha Gruntman, Keith S. Blomenkamp, Jeffrey H. Teckman, Lina Song, Phillip D. Zamore, and Terence R. Flotte
Rabenosyn-5 Defines the Fate of the Transferrin Receptor Following Clathrin-mediated Endocytosis, Deanna M. Navaroli, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera
Translational control of mitochondrial energy production mediates neuron morphogenesis, Aparna Oruganty-Das, Teclise Ng, Tsuyoshi Udagawa, Eyleen L. K. Goh, and Joel D. Richter
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway, Jeannette M. Osterloh, Jing Yang, Timothy M. Rooney, A. Nicole Fox, Robert Adalbert, Eric H. Powell, Amy E. Sheehan, Michelle A. Avery, Rachel Hackett, Mary A. Logan, Jennifer M. MacDonald, Jennifer S. Ziegenfuss, Stefan Milde, Ying-Ju Hou, Carl Nathan, Aihao Ding, Robert H. Brown Jr., Laura Comforti, Michael Coleman, Marc Tessier-Lavigne, Stephan Zuchner, and Marc R. Freeman
The neuroethology of C. elegans escape, Jennifer K. Pirri and Mark J. Alkema
Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2β, Sohan Punia, Kyle K. Rumery, Elizabeth A. Yu, Christopher M. Lambert, Abner L. Notkins, and David R. Weaver
Immune responses in cystic fibrosis: are they intrinsically defective?, Dmitry Ratner and Christian Mueller
Here Today, Gone Tomorrow…and Back Again? A Review of Herbal Marijuana Alternatives (K2, Spice), Synthetic Cathinones (Bath Salts), Kratom, Salvia divinorum, Methoxetamine, and Piperazines, Christopher D. Rosenbaum, Stephanie P. Carreiro, and Kavita M. Babu
PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors, Joan Sanchez-Gurmaches, Chien-Min Hung, Cynthia A. Sparks, Yuefeng Tang, Huawei Li, and David A. Guertin
CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2, Roy J. Soberman, Christopher R. MacKay, Christine A. Vaine, Glennice Bowen Ryan, Anna M. Cerny, Mikayla R. Thompson, Boris Nikolic, Valeria Primo, Peter Christmas, Paul Sheiffele, Lisa Aronov, David M. Knipe, and Evelyn A. Kurt-Jones
Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling, Sean D. Speese, James A. Ashley, Vahbiz Jokhi, John J. Nunnari, Romina Barria, Yihang Li, Bulent Ataman, Alex C. Koon, Young-Tae Chang, Qian Li, Melissa J. Moore, and Vivian Budnik
Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A, Yoshiko Usami, Sergei Popov, Eric R. Weiss, Christie Vriesema-Magnuson, Arianna Calistri, and Heinrich G. Gottlinger
The NLRP12 Inflammasome Recognizes Yersinia pestis, Gregory I. Vladimer, Dan Weng, Sara W. Montminy Paquette, Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam, Marie Hjelmseth Aune, Joseph E. Conlon, Joseph J. Burbage, Megan K. Proulx, Qin Liu, George W. Reed, Joan C. Mecsas, Yoichiro Iwakura, John Bertin, Jon D. Goguen, Katherine A. Fitzgerald, and Egil Lien
Sequence Determinants of GLUT1-mediated Accelerated-exchange Transport: Analysis by Homology-Scanning Mutagenesis, Sabrina S. Vollers and Anthony Carruthers
Plasmacytoid dendritic cell interferon-alpha production to R-848 stimulation is decreased in male infants, Jennifer P. Wang, Lei Zhang, Rachel F. Madera, Marcia Woda, and Daniel H. Libraty
Amatoxin poisoning: case reports and review of current therapies, Jeanine Ward, Kishan Kapadia, David Eric Brush, and Steven D. Salhanick
Transitions, Risks, and Actions in Coronary Events--Center for Outcomes Research and Education (TRACE-CORE): Design and Rationale, Molly E. Waring, Richard H. McManus, Jane S. Saczynski, Milena D. Anatchkova, David D. McManus, Randolph Devereaux, Robert J. Goldberg, Jeroan J. Allison, and Catarina I. Kiefe
Long-term, efficient inhibition of microRNA function in mice using rAAV vectors, Jun Xie, Stefan L. Ameres, Randall H. Friedline, Jui-Hung Hung, Yu Zhang, Qing Xie, Li Zhong, Qin Su, Ran He, Mengxin Li, Huapeng Li, Xin Mu, Hongwei Zhang, Jennifer A. Broderick, Jason K. Kim, Zhiping Weng, Terence R. Flotte, Phillip D. Zamore, and Guangping Gao
Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia, Haojian Zhang, Huawei Li, Ngoc Ho, Dongguang Li, and Shaoguang Li
HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells, Haojian Zhang, Huawei Li, Hualin S. Xi, and Shaoguang Li
The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells, Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia M. Miron, Xueqing Zhang, Michael A. Brehm, Dongguang Li, Michael R. Green, and Shaoguang Li
An evaluation of the diagnostic accuracy of the 1991 American College of Chest Physicians/Society of Critical Care Medicine and the 2001 Society of Critical Care Medicine/European Society of Intensive Care Medicine/American College of Chest Physicians/American Thoracic Society/Surgical Infection Society sepsis definition, Huifang Zhao, Stephen O. Heard, Marie T. Mullen, Sybil L. Crawford, Robert J. Goldberg, Gyorgy Frendl, and Craig M. Lilly
Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy, Jennifer S. Ziegenfuss, Johnna E. Doherty, and Marc R. Freeman
Publications from 2011
Factors associated with Medicaid patients' access to buprenorphine treatment, Jeffrey D. Baxter, Robin E. Clark, Mihail D. Samnaliev, Yat (Gary) Leung, and Lobat Hashemi
Vitamin D intake from foods and supplements and depressive symptoms in a diverse Population of Older Women., Elizabeth Bertone-Johnson, Sally I. Powers, Leslie Spangler, Robert L. Brunner, Yvonne L. Michael, Joseph C. Larson, Amy E. Millen, Maria N. Bueche, Elena Salmoirago Blotcher, Simin Liu, Sylvia Wassertheil-Smoller, Judith K. Ockene, Ira S. Ockene, and JoAnn E. Manson
Cyclin-specific docking motifs promote phosphorylation of yeast signaling proteins by G1/S Cdk complexes., Samyabrata Bhaduri and Peter M. Pryciak
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing, Jennifer A. Broderick, William E. Salomon, Sean P. Ryder, Neil Aronin, and Phillip D. Zamore
MicroRNA therapeutics, Jennifer A. Broderick and Phillip D. Zamore
Remembering nutrient quality of sugar in Drosophila, Christopher J. Burke and Scott Waddell
Mindfulness training for coping with hot flashes: results of a randomized trial, James Carmody, Sybil L. Crawford, Elena Salmoirago Blotcher, Katherine Leung, Linda C. Churchill, and NIcholas Olendzki
Phosphate and R2D2 Restrict the Substrate Specificity of Dicer-2, an ATP-Driven Ribonuclease, Elif Sarinay Cenik, Ryuya Fukunaga, Gang Lu, Robert Dutcher, Yeming Wang, Traci M. Tanaka Hall, and Phillip D. Zamore
Argonaute proteins, Elif Sarinay Cenik and Phillip D. Zamore
Use of instrumental variable in prescription drug research with observational data: a systematic review, Yong Chen and Becky A. Briesacher
A modified bacterial one-hybrid system yields improved quantitative models of transcription factor specificity, Ryan G. Christensen, Ankit Gupta, Zheng Zuo, Lawrence A. Schriefer, Scot A. Wolfe, and Gary D. Stormo
White matter neuron alterations in schizophrenia and related disorders, Caroline M. Connor, Benjamin C. Crawford, and Schahram Akbarian
On Characterizing Adaptive Events Unique to Modern Humans, Jessica L. Crisci, Alex Wong, Jeffrey M. Good, and Jeffrey D. Jensen
Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds, Tera M. Filion, Artem Kutikov, and Jie Song
Scalable Functional Bone Substitutes: Strategic Integration of Key Structural Elements of Bone in Synthetic Biomaterials, Tera M. Filion and Jie Song
Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation, Timothy P. Fitzgibbons, Sophia Kogan, Myriam Aouadi, Gregory M. Hendricks, Juerg R. Straubhaar, and Michael P. Czech
Human cryptochrome exhibits light-dependent magnetosensitivity, Lauren E. Foley, Robert J. Gegear, and Steven M. Reppert
High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism, Jennifer E. Griffin, Jeffrey D. Gawronski, Michael A. Dejesus, Thomas R. Ioerger, Brian J. Akerley, and Christopher M. Sassetti
Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases, Ankit Gupta, Xiangdong Meng, Lihua Julie Zhu, Nathan D. Lawson, and Scot A. Wolfe
Culturally appropriate storytelling to improve blood pressure: a randomized trial, Thomas K. Houston, Jeroan J. Allison, Marc Sussman, Wendy Horn, Cheryl L. Holt, John Trobaugh, Maribel Salas, Maria Pisu, Yendelela L. Cuffee, Damien Larkin, Sharina D. Person, Bruce A. Barton, Catarina I. Kiefe, and Sandral Hullett
Cost-effectiveness Analysis of Chlamydia trachomatis Screening Via Internet-based Self-collected Swabs Compared With Clinic-based Sample Collection, Wei Huang, Charlotte A. Gaydos, Mathilda R. Barnes, Mary Jett-Goheen, and Diane R. Blake
Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma, Ma. Reina D. Improgo, Christopher W. Johnson, Andrew R. Tapper, and Paul D. Gardner
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer, Ma. Reina D. Improgo, Andrew R. Tapper, and Paul D. Gardner
Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice, Yan Jiang, Anouch Matevossian, Yin Guo, and Schahram Akbarian
FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans, Irene Kalchhauser, Brian M. Farley, Sandra Pauli, Sean P. Ryder, and Rafal Ciosk
Structural insights into early folding events using continuous-flow time-resolved SAXS, Sagar V. Kathuria, Liang Guo, Rita Graceffa, Raul Barrea, R. Paul Nobrega, C. Robert Matthews, Tom Irving, and Osman Bilsel
Genotypic and functional properties of early infant HIV-1 envelopes, Michael G. Kishko, Mohan Somasundaran, Frank E. Brewster, John L. Sullivan, Paul R. Clapham, and Katherine Luzuriaga
Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling, Alex C. Koon, James A. Ashley, Romina Barria, Shamik DasGupta, Ruth Brain, Scott Waddell, Mark J. Alkema, and Vivian Budnik
Drosophila appetitive olfactory conditioning, Michael Jonathan Krashes and Scott Waddell
Drosophila aversive olfactory conditioning, Michael Jonathan Krashes and Scott Waddell
The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells, Sean F. Landrette, Dmitri Madera, Feng He, and Lucio H. Castilla
Behavioral Health Disorders and Adherence to Measures of Diabetes Care Quality, Yat (Gary) Hung Leung, Jianying Zhang, Wen-Chieh Lin, and Robin E. Clark
Behavioral Disorders and Diabetes-Related Outcomes Among Massachusetts Medicare and Medicaid Beneficiaries, Yat (Gary) Leung, Jianying Zhang, Wen-Chieh Lin, and Robin E. Clark
Uncovering intrinsic connectional architecture of functional networks in awake rat brain, Zhifeng Liang, Jean A. King, and Nanyin Zhang
Hospital Mortality, Length of Stay, and Preventable Complications Among Critically Ill Patients Before and After Tele-ICU Reengineering of Critical Care Processes, Craig M. Lilly, Shawn Cody, Huifang Zhao, Karen Landry, Stephen P. Baker, John McIlwaine, M. Willis Chandler, Richard S. Irwin, Stephen O. Heard, J. Matthias Walz, and Khaldoun Faris
Twelve-month Diagnosed Prevalence of Behavioral Health Disorders among Elderly Medicare and Medicaid Members, Wen-Chieh Lin, Jianying Zhang, Yat (Gary) Hung Leung, and Robin E. Clark
The combination of early and rapid type I IFN, IL-1alpha, and IL-1beta production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses, Rachel F. Madera, Jennifer P. Wang, and Daniel H. Libraty
Acquired long QT syndrome from stress cardiomyopathy is associated with ventricular arrhythmias and torsades de pointes, Christopher Madias, Timothy P. Fitzgibbons, Alawi A. Alsheikh-Ali, Joseph L. Bouchard, Benjamin Kalsmith, Ann C. Garlitski, Dennis A. Tighe, N. A. Mark Estes III, Gerard P. Aurigemma, and Mark S. Link
The C. elegans Touch Response Facilitates Escape From Predacious Fungi, Sean M. Maguire, Christopher M. Clark, Jennifer K. Pirri, John J. Nunnari, and Mark J. Alkema
A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection, Thomas A. Musich, Paul J. Peters, Maria J. Duenas-Decamp, Maria Paz Gonzalez-Perez, James E. Robinson, Susan Zolla-Pazner, Jonathan K. Ball, Katherine Luzuriaga, and Paul R. Clapham
A natural loss-of-function mutation of MyD88 disrupts its ability to form Myddosomes, Kamalpreet Nagpal, Theo S. Plantinga, Cherilyn M. Sirois, Brian G. Monks, Eicke Latz, Mihai G. Netea, and Douglas T. Golenbock
PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism, Sri Devi Narasimhan, Kelvin Yen, Ankita Bansal, Eun-Soo Kwon, Srivatsan Padmanabhan, and Heidi A. Tissenbaum
The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking, Deanna M. Navaroli, Zachary H. Stevens, Zeljko Uzelac, Luke Gabriel, Michael J. King, Lawrence M. Lifshitz, Harald H. Sitte, and Haley E. Melikian
Long-term Trends in Short-term Outcomes in Acute Myocardial Infarction, Hoa L. Nguyen, Jane S. Saczynski, Joel M. Gore, Molly E. Waring, Darleen M. Lessard, Jorge L. Yarzebski, George W. Reed, Frederick A. Spencer, Shu-Xia Li, and Robert J. Goldberg
Xenopus laevis oocytes infected with multi-drug-resistant bacteria: implications for electrical recordings, Denice O'Connell, Karen Mruk, Jessica M. Rocheleau, and William R. Kobertz
Conformational lability in the class II MHC 3-10 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange, Corrie A. Painter, Maria P. Negroni, Kathy A. Kellersberger, Zarixia Zavala-Ruiz, James E. Evans, and Lawrence J. Stern
A Pair of Inhibitory Neurons Are Required to Sustain Labile Memory in the Drosophila Mushroom Body, Jena L. Pitman, Wolf Huetteroth, Christopher J. Burke, Michael Jonathan Krashes, Sen-Lin Lai, Tzumin Lee, and Scott Waddell
Identification of Influenza Cases During the H1N1 Pandemic in Massachusetts Using Population-Based Hospital Discharge Data, Hilary Placzek and Lawrence C. Madoff
Yeast one-hybrid assays for gene-centered human gene regulatory network mapping, John S. Reece-Hoyes, A. Rasim Barutcu, Rachel Patton McCord, Jun Seop Jeong, Lizhi Jiang, Andrew Macwilliams, Xinping Yang, Kourosh Salehi-Ashtiani, David E. Hill, Seth Blackshaw, Heng Zhu, Job Dekker, and Albertha J. M. Walhout
A novel zinc binding system, ZevAB, is critical for survival of nontypeable Haemophilus influenzae in a murine lung infection model, Charles V. Rosadini, Jeffrey D. Gawronski, Daniel Raimunda, José M Argüello, and Brian J. Akerley