The Program in Neuroscience is an academic program of the Graduate School of Biomedical Sciences (GSBS) at the University of Massachusetts Medical School. Neuroscience investigators focus on: the neural, molecular, and genetic mechanisms that underlie nervous system development, learning and memory, addiction, glial responses to neuronal injury, and circadian rhythmicity; mechanisms of synaptic neurotransmitter release, analysis of how neurotransmitter receptors and membrane channels operate, and how drugs act on these processes to modify cellular function and behavior; magnetic resonance imaging technology to study and map changes in the brain associated with physiological stimuli as well as drugs of abuse; and disorders of the central nervous system, with special emphasis on neurodegenerative disorders, autism spectrum disorders, mental retardation and other developmental disabilities. This collection showcases publications and presentations authored by students in this program.

Attention GSBS Neuroscience students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2008

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Drosophila memory: will Orb(2) predict the future, Michael Jonathan Krashes and Scott Waddell

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Rapid consolidation to a radish and protein synthesis-dependent long-term memory after single-session appetitive olfactory conditioning in Drosophila, Michael Jonathan Krashes and Scott Waddell

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Clonal analysis of Drosophila antennal lobe neurons: diverse neuronal architectures in the lateral neuroblast lineage, Sen-Lin Lai, Takeshi Awasaki, Kei Ito, and Tzumin Lee

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L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity, Liwang Liu, John F. Heneghan, Gregory J. Michael, Lee F. Stanish, Michaela Egertova, and Ann R. Rittenhouse

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Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol, Gilles E. Martin, Linzy M. Hendrickson, Krista L. Penta, Ryan M. Friesen, Andrzej Z. Pietrzykowski, Andrew R. Tapper, and Steven N. Treistman

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A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex, Nikolaos Mellios, Hsien-Sung Huang, Anastasia P. Grigorenko, Evgeny I. Rogaev, and Schahram Akbarian

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Mutation of a TADR protein leads to rhodopsin and Gq-dependent retinal degeneration in Drosophila, Lina Ni, Peiyi Guo, Keith Reddig, Mirna Mitra, and Hong-Sheng Li

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Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol, Andrzej Z. Pietrzykowski, Ryan M. Friesen, Gilles E. Martin, Sylvie I. Puig, Cheryl L. Nowak, Patricia M. Wynne, Hava T. Siegelmann, and Steven N. Treistman

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Modulation of voltage-gated calcium channel activity by free arachidonic acid, Mandy L. Roberts-Crowley and Ann R. Rittenhouse

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Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors, Frederick Albert Schroeder, Krista L. Penta, Anouch Matevossian, Sara R. Jones, Christine L. Konradi, Andrew R. Tapper, and Schahram Akbarian

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Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam, Jacob S. Yang, Jia-Min Bai, and Tzumin Lee

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Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation, Haisun Zhu, Ivo Sauman, Quan Yuan, Amy L. Casselman, Myai Emery-Le, Patrick Emery, and Steven M. Reppert

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Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling, Jennifer S. Ziegenfuss, Romi Biswas, Michelle A. Avery, Kyoungja Hong, Amy E. Sheehan, Yee-Guide Yeung, E. Richard Stanley, and Marc R. Freeman

Publications from 2007

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Interactions between circadian neurons control temperature synchronization of Drosophila behavior, Ania Busza, Alejandro D. Murad, and Patrick Emery

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Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits, Marian DiFiglia, Miguel Sena-Esteves, Kathryn O. Chase, Ellen Sapp, Edith L. Pfister, Meghan B. Sass, Jennifer Yoder, P. Reeves, Rajendra K. Pandey, Kallanthottathil G. Rajeev, Muthiah Manoharan, Dinah W. Y. Sah, Phillip D. Zamore, and Neil Aronin

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Beta-subunits are important modulators of the acute response to alcohol in human BK channels, Paula Leslie Feinberg-Zadek and Steven N. Treistman

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Transcriptional repression by a conserved intronic sequence in the nicotinic receptor alpha3 subunit gene, Yuly F. Fuentes Medel and Paul D. Gardner

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Postsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin, David Gorczyca, James A. Ashley, Sean Speese, Norberto G. Gherbesi, Ulrich Thomas, Eckart Gundelfinger, L. Sian Gramates, and Vivian Budnik

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GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia, Hsien-Sung Huang and Schahram Akbarian

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Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters, Hsien-Sung Huang, Anouch Matevossian, Catheryne Whittle, Se Young Kim, Armin Schumacher, Stephen P. Baker, and Schahram Akbarian

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PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila, Rachna Kaushik, Pipat Nawathean, Ania Busza, Alejandro D. Murad, Patrick Emery, and Michael Rosbash

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Drosophila olfactory memory: single genes to complex neural circuits, Alex Carl Keene and Scott Waddell

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Sequential use of mushroom body neuron subsets during drosophila odor memory processing, Michael Jonathan Krashes, Alex Carl Keene, Benjamin M. Leung, J. Douglas Armstrong, and Scott Waddell

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Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission, Jingjun Li, James A. Ashley, Vivian Budnik, and Manzoor A. Bhat

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Role of PIP2 in regulating versus modulating Ca2+ channel activity, Liwang Liu, John F. Heneghan, Tora Mitra Ganguli, Mandy L. Roberts-Crowley, and Ann R. Rittenhouse

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A subset of dorsal neurons modulates circadian behavior and light responses in Drosophila, Alejandro D. Murad, Myai Emery-Le, and Patrick Emery

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The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo, Jamie L. Rickmyre, Shamik DasGupta, Danny Liang-Yee Ooi, Jessica Keel, Ethan Lee, Marc W. Kirschner, Scott Waddell, and Laura A. Lee

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Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse, Frederick Albert Schroeder, Cong L. Lin, Wim E. Crusio, and Schahram Akbarian

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Roles of Drosophila Kruppel-homolog 1 in neuronal morphogenesis, Lei Shi, Suewei Lin, Yelena Grinberg, Yannick Beck, Christina M. Grozinger, Gene E. Robinson, and Tzumin Lee

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Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization, Lei Shi, Hung-Hsiang Yu, Jacob S. Yang, and Tzumin Lee

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DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons, Kimberly D. Siegmund, Caroline M. Connor, Mihaela Campan, Tiffany I. Long, Daniel J. Weisenberger, Detlev Biniszkiewicz, Rudolf Jaenisch, Peter W. Laird, and Schahram Akbarian

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Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization, Peter Soba, Sijun Zhu, Kazuo Emoto, Susan Younger, Shun-Jen Yang, Hung-Hsiang Yu, Tzumin Lee, Lily Yeh Jan, and Yuh-Nung Jan

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Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks, Quan Yuan, Danielle Metterville, Adriana D. Briscoe, and Steven M. Reppert

Publications from 2006

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Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders, Schahram Akbarian and Hsien-Sung Huang

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The molecular pathology of Rett syndrome: synopsis and update, Schahram Akbarian, Yan Jiang, and Genevieve A. Laforet

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Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP, Bulent Ataman, James A. Ashley, David Gorczyca, Michael Gorczyca, Dennis Mathew, Carolin Wichmann, Stephan J. Sigrist, and Vivian Budnik

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Scaffolding proteins at the Drosophila neuromuscular junction, Bulent Ataman, Vivian Budnik, and Ulrich Thomas

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Cell-type-specific and developmental regulation of heterogeneous nuclear ribonucleoprotein K mRNA in the rat nervous system, Adam R. Blanchette, Yuly F. Fuentes Medel, and Paul D. Gardner

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Functional magnetic resonance imaging in conscious animals: a new tool in behavioural neuroscience research, Craig F. Ferris, Marcelo Febo, Feng Luo, Karl F. Schmidt, Mathew E. Brevard, Josie A. Harder, Praveen P. Kulkarni, Tara L. Messenger, and Jean A. King

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Glial cell biology in Drosophila and vertebrates, Marc R. Freeman and Johnna E. Doherty

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The fly CAMTA transcription factor potentiates deactivation of rhodopsin, a G protein-coupled light receptor, Junhai Han, Ping Gong, Keith Reddig, Mirna Mitra, Peiyi Guo, and Hong-Sheng Li

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Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging, Nils Henninger, Kenneth M. Sicard, Karl F. Schmidt, Juergen F. Bardutzky, and Marc Fisher

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Chromatin immunoprecipitation in postmortem brain, Hsien-Sung Huang, Anouch Matevossian, Yan Jiang, and Schahram Akbarian

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Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidation, Alex Carl Keene, Michael Jonathan Krashes, Benjamin M. Leung, Jessica A. Bernard, and Scott Waddell

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Genetic mosaic with dual binary transcriptional systems in Drosophila, Sen-Lin Lai and Tzumin Lee

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The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons, Jennifer MacDonald, Margaret Beach, Ermelinda Porpiglia, Amy E. Sheehan, Ryan J. Watts, and Marc R. Freeman

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Ectopic CRYPTOCHROME renders TIM light sensitive in the Drosophila ovary, Brandy L. Rush, Alejandro D. Murad, Patrick Emery, and Jadwiga M. Giebultowicz

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Hemodynamic and metabolic changes induced by cocaine in anesthetized rat observed with multimodal functional MRI, Karl F. Schmidt, Marcelo Febo, Qiang Shen, Feng Luo, Kenneth M. Sicard, Craig F. Ferris, Elliot A. Stein, and Timothy Q. Duong

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p38 mitogen-activated protein kinase: a novel modulator of hyperpolarization-activated cyclic nucleotide-gated channels and neuronal excitability, Patricia M. Wynne

Publications from 2005

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Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint, James A. Ashley, Mary Packard, Bulent Ataman, and Vivian Budnik

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Distinct structural features of phospholipids differentially determine ethanol sensitivity and basal function of BK channels, John J. Crowley, Steven N. Treistman, and Alejandro M. Dopico

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The neural consequences of repeated cocaine exposure revealed by functional MRI in awake rats, Marcelo Febo, Annabell C. Segarra, Govind Nair, Karl F. Schmidt, Timothy Q. Duong, and Craig F. Ferris

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Drosophila memory: dopamine signals punishment, Alex Carl Keene and Scott Waddell

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ATP elicits inward currents in isolated vasopressinergic neurohypophysial terminals via P2X2 and P2X3 receptors, Thomas K. Knott, Cristina M. Velazquez-Marrero, and Jose R. Lemos

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Analysis of the prokineticin 2 system in a diurnal rodent, the unstriped Nile grass rat (Arvicanthis niloticus), Christopher M. Lambert, Kazuhiko K. Machida, Laura Smale, Antonio A. Nunez, and David R. Weaver

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Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2, Dennis Mathew, Bulent Ataman, Jinyun Chen, Yali Zhang, Susan Cumberledge, and Vivian Budnik

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Chronic ethanol exposure induces an N-type calcium channel splice variant with altered channel kinetics, Philip M. Newton, Keith Tully, Thomas McMahon, Jacklyn Connolly, Jahan Dadgar, Steven N. Treistman, and Robert O. Messing

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Connecting the navigational clock to sun compass input in monarch butterfly brain, Ivo Sauman, Adriana D. Briscoe, Haisun Zhu, Dingding Shi, Oren Froy, Julia Stalleicken, Quan Yuan, Amy L. Casselman, and Steven M. Reppert

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Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning, Dinghui Yu, Alex Carl Keene, Anjana Srivatsan, Scott Waddell, and Ronald L. Davis

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The two CRYs of the butterfly, Haisun Zhu, Quan Yuan, Adriana D. Briscoe, Oren Froy, Amy L. Casselman, and Steven M. Reppert

Publications from 2004

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Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception, Ania Busza, Myai Emery-Le, Michael Rosbash, and Patrick Emery

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Ca2+ syntillas, miniature Ca2+ release events in terminals of hypothalamic neurons, are increased in frequency by depolarization in the absence of Ca2+ influx, Valerie De Crescenzo, Ronghua ZhuGe, Cristina M. Velazquez-Marrero, Lawrence M. Lifshitz, Edward E. Custer, Jeffrey Carmichael, F. Anthony Lai, Richard A. Tuft, Kevin E. Fogarty, Jose R. Lemos, and John V. Walsh

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Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output, Alex Carl Keene, Markus Stratmann, Andreas Keller, Paola N. Perrat, Leslie B. Vosshall, and Scott Waddell

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Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling, Jianhong Li, Yin Guo, Frederick Albert Schroeder, Rachael M. Youngs, Thomas W. Schmidt, Craig F. Ferris, Christine L. Konradi, and Schahram Akbarian

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Phospholipid metabolism is required for M1 muscarinic inhibition of N-type calcium current in sympathetic neurons, Liwang Liu, Mandy L. Roberts, and Ann R. Rittenhouse

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Imaging oxygen consumption in forepaw somatosensory stimulation in rats under isoflurane anesthesia, Zhaohui M. Liu, Karl F. Schmidt, Kenneth M. Sicard, and Timothy Q. Duong

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Somatic localization of a specific large-conductance calcium-activated potassium channel subtype controls compartmentalized ethanol sensitivity in the nucleus accumbens, Gilles E. Martin, Sylvie I. Puig, Andrzej Z. Pietrzykowski, Paula L. Feinberg-Zadek, Patrick Emery, and Steven N. Treistman

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Syntaxin 1A Drives Fusion of Large Dense-Core Neurosecretory Granules Into a Planar Lipid Bilayer, James M. McNally, Dixon J. Woodbury, and Jose R. Lemos

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New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants, Catalina Ruiz-Canada, James A. Ashley, Stephanie Mockel-Cole, Eric Drier, Jerry Yin, and Vivian Budnik

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fMRI of generalized absence status epilepticus in conscious marmoset monkeys reveals corticothalamic activation, Jeffrey R. Tenney, Paul C. Marshall, Jean A. King, and Craig F. Ferris

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Distinct intracellular calcium profiles following influx through N- versus L-type calcium channels: role of Ca2+-induced Ca2+ release, Keith Tully and Steven N. Treistman

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Bilayer thickness modulates the conductance of the BK channel in model membranes, Chunbo Yuan, Robert J. O'Connell, Paula Leslie Feinberg-Zadek, Linda J. Johnston, and Steven N. Treistman

Publications from 2003

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Cholesterol antagonizes ethanol potentiation of human brain BKCa channels reconstituted into phospholipid bilayers, John J. Crowley, Steven N. Treistman, and Alejandro M. Dopico

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Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis, Hongliu Ding, Dianne S. Schwarz, Alex Carl Keene, El Bachir Affar, Laura Fenton, Xugang Xia, Yang Shi, Phillip D. Zamore, and Zuoshang Xu