The Program in Immunology & Microbiology (formerly the Program in Immunology & Virology) is an academic program of the Graduate School of Biomedical Sciences (GSBS) at the University of Massachusetts Medical School. The program features cutting-edge research in: viral and bacterial immunology and pathogenesis; molecular virology; diabetes and transplantation immunology; molecular and cellular immunology; vaccine development; host response against bacterial and viral pathogens; innate immune mechanisms; and, systems biology of host-pathogen interactions. This collection showcases publications authored by students in this program.

Attention GSBS Immunology & Virology students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2013

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The role of MyD88 signaling in heterosubtypic influenza A virus infections, Rachel F. Madera and Daniel H. Libraty

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Acetylation of conserved lysines in bovine papillomavirus E2 by p300, Edward J. Quinlan, Sara P. Culleton, Shwu-Yuan Wu, Cheng-Ming Chiagn, and Elliot J. Androphy

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Epigenetic Modifications Induced by Blimp-1 Regulate CD8(+) T Cell Memory Progression during Acute Virus Infection, Hyun Mu Shin, Varun N. Kapoor, Tianxia Guan, Susan M. Kaech, Raymond M. Welsh, and Leslie J. Berg

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The Tec kinase ITK regulates thymic expansion, emigration, and maturation of gammadelta NKT cells, Catherine C. Yin, Ok Hyun Cho, Katelyn E. Sylvia, Kavitha Narayan, Amanda L. Prince, John W. Evans, Joonsoo Kang, and Leslie J. Berg

Publications from 2012

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Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways, Miroslav Koulnis, Ermelinda Porpiglia, P. Alberto Porpiglia, Ying Liu, Kelly N. Hallstrom, Daniel Hidalgo, and Merav Socolovsky

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TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation, Ribhu Nayar, Megan E. Enos, Amanda L. Prince, HyunMu Shin, Saskia Hemmers, Jian-kang Jiang, Ulf Klein, Craig J. Thomas, and Leslie J. Berg

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CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2, Roy J. Soberman, Christopher R. MacKay, Christine A. Vaine, Glennice Bowen Ryan, Anna M. Cerny, Mikayla R. Thompson, Boris Nikolic, Valeria Primo, Peter Christmas, Paul Sheiffele, Lisa Aronov, David M. Knipe, and Evelyn A. Kurt-Jones

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Plasmacytoid dendritic cell interferon-alpha production to R-848 stimulation is decreased in male infants, Jennifer P. Wang, Lei Zhang, Rachel F. Madera, Marcia Woda, and Daniel H. Libraty

Publications from 2011

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An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus, Xiaofei E., Mary Theresa Pickering, Michelle E. Debatis, Jonathan Patrick Castillo, Alexander Lagadinos, Shixia Wang, Shan Lu, and Timothy F. Kowalik

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Genotypic and functional properties of early infant HIV-1 envelopes, Michael G. Kishko, Mohan Somasundaran, Frank E. Brewster, John L. Sullivan, Paul R. Clapham, and Katherine Luzuriaga

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The combination of early and rapid type I IFN, IL-1alpha, and IL-1beta production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses, Rachel F. Madera, Jennifer P. Wang, and Daniel H. Libraty

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A conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection, Thomas A. Musich, Paul J. Peters, Maria J. Duenas-Decamp, Maria Paz Gonzalez-Perez, James E. Robinson, Susan Zolla-Pazner, Jonathan K. Ball, Katherine Luzuriaga, and Paul R. Clapham

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The PYHIN protein family as mediators of host defenses, Stefan A. Schattgen and Katherine A. Fitzgerald

Publications from 2010

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Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes, Shalyn Catherine Clute, Yuri N. Naumov, Levi B. Watkin, Nuray Aslan, John L. Sullivan, David A. Thorley-Lawson, Katherine Luzuriaga, Raymond M. Welsh, Roberto Puzone, Franco Celada, and Liisa K. Selin

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CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections, Markus Cornberg, Shalyn Catherine Clute, Levi B. Watkin, Frances M. Saccoccio, Sung-Kwon Kim, Yuri N. Naumov, Michael A. Brehm, Nuray Aslan, Raymond M. Welsh, and Liisa K. Selin

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IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions, Heather D. Marshall, Amanda L. Prince, Leslie J. Berg, and Raymond M. Welsh

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Modulation of Exaggerated-IgE Allergic Responses by Gene Transfer-mediated Antagonism of IL-13 and IL-17e., Christian Mueller, Allison M. Keeler, Sofia Braag, Timothy Menz, Qiushi Tang, and Terence R. Flotte

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A Key Commitment Step in Erythropoiesis Is Synchronized with the Cell Cycle Clock through Mutual Inhibition between PU.1 and S-Phase Progression, Ramona Pop, Jeffrey R. Shearstone, Qichang Shen, Ying Liu, Kelly N. Hallstrom, Miroslav Koulnis, Joost Gribnau, and Merav Socolovsky

Publications from 2009

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Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo, Martin Felices, Catherine C. Yin, Yoko Kosaka, Joonsoo Kang, and Leslie J. Berg

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TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade, David M. Miller, Thomas B. Thornley, Todd Pearson, Annie J. Kruger, Masahiro Yamazaki, Leonard D. Shultz, Raymond M. Welsh, Michael A. Brehm, Aldo A. Rossini, and Dale L. Greiner

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The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development, Amanda L. Prince, Catherine C. Yin, Megan E. Enos, Martin Felices, and Leslie J. Berg

Publications from 2008

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Hormonal regulation of the humoral innate immune response in Drosophila melanogaster, Thomas Flatt, Andreas Heyland, Florentina Rus, Ermelinda Porpiglia, Chris Sherlock, Rochele Yamamoto, Alina Garbuzov, Subba R. Palli, Marc Tatar, and Neal S. Silverman

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Engineered intermonomeric disulfide bonds in the globular domain of Newcastle disease virus hemagglutinin-neuraminidase protein: implications for the mechanism of fusion promotion, Paul J. Mahon, Anne M. Mirza, Thomas A. Musich, and Ronald M. Iorio

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Immunogenicity and protection efficacy of subunit-based smallpox vaccines using variola major antigens, Pavlo V. Sakhatskyy, Shixia Wang, Chuanyou Zhang, Te-Hui Chou, Michael G. Kishko, and Shan Lu

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Improved induction of antibodies against key neutralizing epitopes by HIV-1 gp120 DNA prime-protein boost vaccination compared to gp120 protein only vaccination, Michael Vaine, Shixia Wang, Emma T. Crooks, Pengfei Jiang, David C. Montefiori, James Binley, and Shan Lu

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Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses, Shenghua Zhou, Annett Halle, Evelyn A. Kurt-Jones, Anna M. Cerny, Ermelinda Porpiglia, Michael Rogers, Douglas Golenbock, and Robert W. Finberg

Publications from 2007

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Negative autoregulation by FAS mediates robust fetal erythropoiesis, Merav Socolovsky, Michael Murrell, Ying Liu, Ramona Pop, Ermelinda Porpiglia, and Andre Levchenko

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Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses, Charles Fenton Towne, Ian A. York, Levi B. Watkin, John S. Lazo, and Kenneth L. Rock

Publications from 2006

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The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons, Jennifer MacDonald, Margaret Beach, Ermelinda Porpiglia, Amy E. Sheehan, Ryan J. Watts, and Marc R. Freeman

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Complex T cell memory repertoires participate in recall responses at extremes of antigenic load, Yuri N. Naumov, Elena N. Naumova, Shalyn Catherine Clute, Levi B. Watkin, Kalyani Kota, Jeffrey P. Gorski, and Liisa K. Selin

Publications from 2005

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Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis, Shalyn Catherine Clute, Levi B. Watkin, Markus Cornberg, Yuri N. Naumov, John L. Sullivan, Katherine Luzuriaga, Raymond M. Welsh, and Liisa K. Selin

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Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion, Carey L. Medin, Katherine A. Fitzgerald, and Alan L. Rothman

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HIV-1-specific CD8+ T cell responses and viral evolution in women and infants, Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga

Publications from 2004

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HCMV infection: modulating the cell cycle and cell death, Jonathan Patrick Castillo and Timothy F. Kowalik

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Endotoxin recognition and signal transduction by the TLR4/MD2-complex, Katherine A. Fitzgerald, Daniel C. Rowe, and Douglas T. Golenbock

Publications from 2003

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway, Katherine A. Fitzgerald, Sarah M. McWhirter, Kerrie L. Faia, Daniel C. Rowe, Eicke Latz, Douglas T. Golenbock, Anthony J. Coyle, Sha-Mei Liao, and Tom Maniatis

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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF, Katherine A. Fitzgerald, Daniel C. Rowe, Betsy J. Barnes, Daniel R. Caffrey, Alberto Visintin, Eicke Latz, Brian G. Monks, Paula M. Pitha, and Douglas T. Golenbock

Publications from 2000

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Basic mechanisms of DNA-raised antibody responses to intramuscular and gene gun immunizations, Christine Margaret Boyle and Harriet L. Robinson

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Attenuation of human immunodeficiency virus type 1 cytopathic effects by replacing a 424-bp region of envelope from a noncytopathic biological clone, Serene Elizabeth Forte, Mohan Somasundaran, and John L. Sullivan

Publications from 1999

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Augmentation of human influenza A virus-specific cytotoxic T lymphocyte memory by influenza vaccine and adjuvanted carriers (ISCOMS), Francis A. Ennis, John Cruz, Julie Marie Jameson, Michael D. Klein, David Burt, and John Thipphawong

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The role of LY49 NK cell subsets in the regulation of murine cytomegalovirus infections, Chin Hun Tay, Lawrence Y. Y. Yu, Vinay Kumar, Llewelyn H. Mason, John R. Ortaldo, and Raymond M. Welsh

Publications from 1998

Control of infections by NK cells, Chin Hun Tay, Eva Szomolanyi-Tsuda, and Raymond M. Welsh

Publications from 1997

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Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells, Chin Hun Tay and Raymond M. Welsh

Publications from 1996

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In vitro characterization of HIV type 1 biological clones from asymptomatic and symptomatic pediatric patients, Serene Elizabeth Forte, John L. Sullivan, and Mohan Somasundaran

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The CD45RB-associated epitope defined by monoclonal antibody CZ-1 is an activation and memory marker for mouse CD4 T cells, Steven Michael Varga and Raymond M. Welsh

Publications from 1995

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NK cell response to viral infections in beta 2-microglobulin-deficient mice, Chin Hun Tay, Raymond M. Welsh, and Randy R. Brutkiewicz

Publications from 1994

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Non-syncytium-inducing HIV type 1 isolated from infected individuals replicates in MT-2 cells, Serene Elizabeth Forte, Kevin S. Byron, John L. Sullivan, and Mohan Somasundaran