The Interdisciplinary Graduate Program (IGP) is an academic program of the Graduate School of Biomedical Sciences (GSBS) at the University of Massachusetts Medical School. The program was established to support interdisciplinary approaches to graduate training in biomedical research. The more than 130 laboratories that participate in the program are directed by a distinguished group of faculty affiliated with basic science and clinical departments at the Medical School. Program investigators employ a wide range of instrumentation and experimental approaches to their research including: classical and molecular genetics; proteomics and genomics; X-ray crystallography and nuclear magnetic resonance; and digital imaging and laser confocal microscopy of single cells and tissues. Specialized core facilities in gene chip analysis, mass spectroscopy, transgenics, DNA sequencing, analytical ultracentrifugation and biomedical imaging enhance the research capabilities of individual labs. Characterized by a streamlined and flexible graduate curriculum that is tailored to the specific needs of individual students, the IGP encourages rapid initiation of full-time thesis research. This collection showcases publications and presentations authored by students in this program.

Attention GSBS Interdisciplinary Graduate Program students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2014

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Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan, Ankita Bansal, Eun-Soo Kwon, Darryl Conte Jr., Haibo Liu, Michael J. Gilchrist, Lesley T. MacNeil, and Heidi A. Tissenbaum

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Arf4 is required for Mammalian development but dispensable for ciliary assembly, John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, and Gregory J. Pazour

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Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease, Chien-Min Hung, Camila Martinez Calejman, Joan Sanchez-Gurmaches, Huawei Li, Clary B. Clish, Simone Hettmer, Amy J. Wagers, and David A. Guertin

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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death, Dan Weng, Robyn Lynn Marty-Roix, Sandhya Ganesan, Megan K. Proulx, Gregory I. Vladimer, William J. Kaiser, Edward S. Mocarski, Kimberly Lea Pouliot, Francis Ka-Ming Chan, Michelle A. Kelliher, Phillip A. Harris, John Bertin, Peter J. Gough, Dmitry M. Shayakhmetov, Jon D. Goguen, Katherine A. Fitzgerald, Neal S. Silverman, and Egil Lien

Publications from 2013

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Cardiac remodeling in obesity, Gerard P. Aurigemma, Giovanni de Simone, and Timothy P. Fitzgibbons

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Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila, Wei Cheng, Y. Tony Ip, and Zuoshang Xu

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Crosstalk between casein kinase II and Ste20-related kinase Nak1, Lubos Cipak, Sneha Gupta, Iva Rajovic, Quan-Wen Jin, Dorothea Anrather, Gustav Ammerer, Dannel McCollum, and Juraj Gregan

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Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans, Colin C. Conine, James J. Moresco, Weifeng Gu, Masaki Shirayama, Darryl Conte Jr., John R. Yates III, and Craig C. Mello

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CD40 Deficiency in Mice Exacerbates Obesity-induced Adipose Tissue Inflammation, Hepatic Steatosis and Insulin Resistance, Chang-An Guo, Sophia Kogan, Shinya U. Amano, Mengxi Wang, Sezin Dagdeviren, Randall H. Friedline, Myriam Aouadi, Jason K. Kim, and Michael P. Czech

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Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways, Sneha Gupta, Sebastian Mana-Capelli, Janel R. McLean, Chun-Ti Chen, Samriddha Ray, Kathleen L. Gould, and Dannel McCollum

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Post-transcriptional mechanisms contribute to Etv2 repression during vascular development, John C. Moore, Sarah Sheppard, Ilya A. Shestopalov, James K. Chen, and Nathan D. Lawson

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Functional overlap among distinct G1/S inhibitory pathways allows robust G1 arrest by yeast mating pheromones, Patricia A. Pope and Peter M. Pryciak

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Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo, Teresa Repasy, Jinhee Lee, Simeone Marino, Nuria Martinez, Denise E. Kirschner, Gregory M. Hendricks, Stephen P. Baker MScPH, Andrew A. Wilson, Darrell N. Kotton, and Hardy Kornfeld

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Inflammasomes and host defenses against bacterial infections, Gregory I. Vladimer, Robyn Lynn Marty-Roix, Shubhendu Ghosh, Dan Weng, and Egil Lien

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Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation, Mengxi Wang, Shinya U. Amano, Rachel J. Roth Flach, Anil Chawla, Myriam Aouadi, and Michael P. Czech

Publications from 2012

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Long-term correction of very long-chain acyl-coA dehydrogenase deficiency in mice using AAV9 gene therapy, Allison M. Keeler, Thomas J. Conlon, Glenn Walter, Huadong Zeng, Scott A. Shaffer, Fu Dungtao, Kirsten E. Erger, Travis L. Cossette, Qiushi Tang, Christian Mueller, and Terence R. Flotte

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Cell and gene therapy for genetic diseases: inherited disorders affecting the lung and those mimicking sudden infant death syndrome, Allison M. Keeler and Terence R. Flotte

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Chromatin-mediated Candida albicans virulence, Jessica Lopes da Rosa and Paul D. Kaufman

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Rabenosyn-5 Defines the Fate of the Transferrin Receptor Following Clathrin-mediated Endocytosis, Deanna M. Navaroli, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera

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Translational control of mitochondrial energy production mediates neuron morphogenesis, Aparna Oruganty-Das, Teclise Ng, Tsuyoshi Udagawa, Eyleen L. K. Goh, and Joel D. Richter

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PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors, Joan Sanchez-Gurmaches, Chien-Min Hung, Cynthia A. Sparks, Yuefeng Tang, Huawei Li, and David A. Guertin

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Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A, Yoshiko Usami, Sergei Popov, Eric R. Weiss, Christie Vriesema-Magnuson, Arianna Calistri, and Heinrich G. Gottlinger

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The NLRP12 Inflammasome Recognizes Yersinia pestis, Gregory I. Vladimer, Dan Weng, Sara W. Montminy Paquette, Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam, Marie Hjelmseth Aune, Joseph E. Conlon, Joseph J. Burbage, Megan K. Proulx, Qin Liu, George W. Reed, Joan C. Mecsas, Yoichiro Iwakura, John Bertin, Jon D. Goguen, Katherine A. Fitzgerald, and Egil Lien

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Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties, LiangMeng Wee, Carlos Fabian Flores-Jasso, William E. Salomon, and Phillip D. Zamore

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Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection, Zhao Zhang, William E. Theurkauf, Zhiping Weng, and Phillip D. Zamore

Publications from 2011

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A stele-enriched gene regulatory network in the Arabidopsis root, Siobhan M. Brady, Lifang Zhang, Molly Megraw, Natalia Julia Martinez, Eric Jiang, Charles S. Yi, Weilin Liu, Anna Zeng, Mallorie Taylor-Teeples, Dahae Kim, Sebastian Ahnert, Uwe Ohler, Doreen Ware, Albertha J. M. Walhout, and Philip N. Benfey

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The cilia protein IFT88 is required for spindle orientation in mitosis, Benedicte Delaval, Alison Bright, Nathan D. Lawson, and Stephen J. Doxsey

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Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation, Timothy P. Fitzgibbons, Sophia Kogan, Myriam Aouadi, Gregory M. Hendricks, Juerg R. Straubhaar, and Michael P. Czech

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Crosstalk between NDR kinase pathways coordinates cell cycle dependent actin rearrangements, Sneha Gupta and Dannel McCollum

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Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity, Tse-Chun Kuo, Chun-Ting Chen, Desiree Baron, Tamer T. Onder, Sabine Loewer, Sandra Almeida, Cara M. Weismann, Ping Xu, JeanMarie Houghton, Fen-Biao Gao, George Q. Daley, and Stephen J. Doxsey

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Acquired long QT syndrome from stress cardiomyopathy is associated with ventricular arrhythmias and torsades de pointes, Christopher Madias, Timothy P. Fitzgibbons, Alawi A. Alsheikh-Ali, Joseph L. Bouchard, Benjamin Kalsmith, Ann C. Garlitski, Dennis A. Tighe, N. A. Mark Estes III, Gerard P. Aurigemma, and Mark S. Link

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A natural loss-of-function mutation of MyD88 disrupts its ability to form Myddosomes, Kamalpreet Nagpal, Theo S. Plantinga, Cherilyn M. Sirois, Brian G. Monks, Eicke Latz, Mihai G. Netea, and Douglas T. Golenbock

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PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism, Sri Devi Narasimhan, Kelvin Yen, Ankita Bansal, Eun-Soo Kwon, Srivatsan Padmanabhan, and Heidi A. Tissenbaum

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The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking, Deanna M. Navaroli, Zachary H. Stevens, Zeljko Uzelac, Luke Gabriel, Michael J. King, Lawrence M. Lifshitz, Harald H. Sitte, and Haley E. Melikian

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Yeast one-hybrid assays for gene-centered human gene regulatory network mapping, John S. Reece-Hoyes, A. Rasim Barutcu, Rachel Patton McCord, Jun Seop Jeong, Lizhi Jiang, Andrew Macwilliams, Xinping Yang, Kourosh Salehi-Ashtiani, David E. Hill, Seth Blackshaw, Heng Zhu, Job Dekker, and Albertha J. M. Walhout

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Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex, Tomoko M. Tabuchi, Bart Deplancke, Naoki Osato, Lihua Julie Zhu, Inmaculada M. Barrasa, Melissa M. Harrison, Robert H. Horvitz, Albertha J. M. Walhout, and Kirsten A. Hagstrom

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Glucan particles for selective delivery of siRNA to phagocytic cells in mice, Gregory J. Tesz, Myriam Aouadi, Matthieu Prot, Sarah M. Nicoloro, Emilie Boutet, Shinya U. Amano, Anca Goller, Mengxi Wang, Chang-An Guo, William E. Salomon, Joseph V. Virbasius, Rebecca A. Baum, Mark J. O'Connor, Ernesto Soto, Gary R. Ostroff, and Michael P. Czech

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The role of cellular factors in promoting HIV budding, Eric R. Weiss and Heinrich G. Gottlinger

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Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains, Zhao Zhang, Jia Xu, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Shengmei Ma, Zhiping Weng, William E. Theurkauf, and Phillip D. Zamore

Publications from 2010

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Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network., H. Efsun Arda, Stefan Taubert, Lesley T. MacNeil, Colin C. Conine, Ben Tsuda, Marc Van Gilst, Reynaldo Sequerra, Lynn Doucette-Stamm, Keith R. Yamamoto, and Albertha J. M. Walhout

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Gene-centered regulatory networks, H. Efsun Arda and Albertha J. M. Walhout

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Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression, Angika Basant, Mayuri Rege, Shobhona Sharma, and Haripalsingh M. Sonawat

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Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans., Colin C. Conine, Pedro J. Batista, Weifeng Gu, Julie M. Claycomb, Daniel A. Chaves, Masaki Shirayama, and Craig C. Mello

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miR-21 and miR-31 Converge on TIAM1 to Regulate Migration and Invasion of Colon Carcinoma Cells, Charisa L. Cottonham, Satoshi Kaneko, and Lan Xu

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, and Eicke Latz

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Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling, Pearl Gray, Kathrin S. Michelsen, Cherilyn M. Sirois, Emily Lowe, Kenichi Shimada, Timothy R. Crother, Shuang Chen, Constantinos Brikos, Yonca Bulut, Eicke Latz, David Underhill, and Moshe Arditi

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The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer, Ma Reina D. Improgo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner

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From smoking to lung cancer: the CHRNA5/A3/B4 connection, Ma. Reina D. Improgo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner

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CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion, Ming-Chung Kan, Aparna Oruganty-Das, Amalene Cooper-Morgan, Guang Jin, Sharon A. Swanger, Gary J. Bassell, Harvey M. Florman, Klaus van Leyen, and Joel D. Richter

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Structure and function of nematode RNA-binding proteins, Ebru Kaymak, LiangMeng Wee, and Sean P. Ryder

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Insertion of tetracysteine motifs into dopamine transporter extracellular domains, Deanna M. Navaroli and Haley E. Melikian

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The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe, Samriddha Ray, Kazunori Kume, Sneha Gupta, Wanzhong Ge, Mohan Balasubramanian, Dai Hirata, and Dannel McCollum

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Bi-specific MHC heterodimers for characterization of cross-reactive T cells, Zu T. Shen, Michael A. Brehm, Keith A. Daniels, Alexander B. Sigalov, Liisa K. Selin, Raymond M. Welsh, and Lawrence J. Stern

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IFI16 is an innate immune sensor for intracellular DNA, Leonie Unterholzner, Sinead E. Keating, Marcin Baran, Kristy A. Horan, Soren B. Jensen, Shrutie Sharma, Cherilyn M. Sirois, Tengchuan Jin, Eicke Latz, T. Sam Xiao, Katherine A. Fitzgerald, Soren R. Paludan, and Andrew G. Bowie

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Rescue of HIV-1 Release by Targeting Widely Divergent NEDD4-Type Ubiquitin Ligases and Isolated Catalytic HECT Domains to Gag, Eric R. Weiss, Elena Popova, Hikaru Yamanaka, Hyung Cheol Kim, Jon M. Huibregtse, and Heinrich G. Göttlinger

Publications from 2009

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A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development, Laurence D. Covassin, Arndt F. Siekmann, Michael C. Kacergis, Elizabeth Laver, John C. Moore, Jacques A. Villefranc, Brant M. Weinstein, and Nathan D. Lawson

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Prevalence and clinical characteristics of right ventricular dysfunction in transient stress cardiomyopathy, Timothy P. Fitzgibbons, Christopher Madias, Seth Adhar, Joseph L. Bouchard, Jeffrey T. Kuvin, Ayan R. Patel, Natesa G. Pandian, Theo E. Meyer, Gerard P. Aurigemma, and Dennis A. Tighe

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Mortality in diastolic heart failure: an update, Timothy P. Fitzgibbons, Theo E. Meyer, and Gerard P. Aurigemma

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Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas, Michael J. Parsons, Harshan Pisharath, Shamila Yusuff, John C. Moore, Arndt F. Siekmann, Nathan D. Lawson, and Steven D. Leach

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The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors, John S. Reece-Hoyes, Bart Deplancke, M. Inmaculada Barrasa, Julia Hatzold, Ryan B. Smit, H. Efsun Arda, Patricia A. Pope, Jeb Gaudet, Barbara Conradt, and Albertha J. M. Walhout

Publications from 2008

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Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi, Daniella C. Bartholomeu, Catherine Ropert, Mariane B. Melo, Peggy Parroche, Caroline F. Junqueira, Santuza M. R. Teixeira, Cherilyn M. Sirois, Pia Kasperkovitz, Cathrine F. Knetter, Egil Lien, Eicke Latz, Douglas T. Golenbock, and Ricardo T. Gazzinelli

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The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells, Kathryn L. Lipson, Rajarshi Ghosh, and Fumihiko Urano

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Long-range chromosomal interactions and gene regulation, Angela Miele and Job Dekker

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Preferential utilization of Imp7/8 in nuclear import of Smads, Xiaohao Yao, Xiaochu Chen, Charisa L. Cottonham, and Lan Xu

Publications from 2007

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Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1, Klaus Forstemann, Michael D. Horwich, LiangMeng Wee, Yukihide Tomari, and Phillip D. Zamore

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Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model, Romolo Joseph Gaspari and David Paydarfar

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Ligand-induced conformational changes allosterically activate Toll-like receptor 9, Eicke Latz, Anjali Verma, Alberto Visintin, Mei Gong, Cherilyn M. Sirois, Dionne C. G. Klein, Brian G. Monks, C. James McKnight, Marc S. Lamphier, W. Paul Duprex, Terje Espevik, and Douglas T. Golenbock

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p53-independent abrogation of a postmitotic checkpoint contributes to human papillomavirus E6-induced polyploidy, Yingwang Liu, Susan Ann Heilman, Diego Illanes, Greenfield Sluder, and Jason J. Chen

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Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE, Jane Tian, Ana Maria Avalos, Su-Yau Mao, Bo Chen, Kannaki Senthil, Herren Wu, Peggy Parroche, Stacey Drabic, Douglas T. Golenbock, Cherilyn M. Sirois, Jing Hua, Ling Ling An, Laurent Audoly, Greg La Rosa, Angelika Bierhaus, Peter Naworth, Ann Marshak-Rothstein, Mary K. Crow, Katherine A. Fitzgerald, Eicke Latz, Peter A. Kiener, and Anthony J. Coyle

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Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping, Vanessa Vermeirssen, Bart Deplancke, M. Inmaculada Barrasa, John S. Reece-Hoyes, H. Efsun Arda, Christian A. Grove, Natalia Julia Martinez, Reynaldo Sequerra, Lynn Doucette-Stamm, Michael R. Brent, and Albertha J. M. Walhout

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Gateway compatible vectors for analysis of gene function in the zebrafish, Jacques A. Villefranc, Julio D. Amigo, and Nathan D. Lawson

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Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads, Lan Xu, Xiaohao Yao, Xiaochu Chen, Peiyuan Lu, Biliang Zhang, and Y. Tony Ip

Publications from 2006

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Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada, Silvia Corvera, Alison Burkart, Ja-Young Kim, Jennifer L. Christianson, Zhao Wang, and Philipp E. Scherer

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Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish, Laurence D. Covassin, Jacques A. Villefranc, Michael C. Kacergis, Brant M. Weinstein, and Nathan D. Lawson

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Control of cellular senescence by CPEB, Irina Groisman, Maria Ivshina, Veronica Marin, Norman J. Kennedy, Roger J. Davis, and Joel D. Richter

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TLR9 and the recognition of self and non-self nucleic acids, Marc S. Lamphier, Cherilyn M. Sirois, Anjali Verma, Douglas T. Golenbock, and Eicke Latz

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Epigenetic telomere protection by Drosophila DNA damage response pathways, Sarah R. Oikemus, Joana Queiroz-Machado, KuanJu Lai, Nadine Schultz, Claudio E. Sunkel, and Michael H. Brodsky

Publications from 2005

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Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein, Klaus Forstemann, Yukihide Tomari, Tingting Du, Vasily V. Vagin, Ahmet M. Denli, Diana P. Bratu, Carla Andrea Klattenhoff, William E. Theurkauf, and Phillip D. Zamore

Publications from 2004

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Tissue pH determination for the detection of metabolically active, inflamed vulnerable plaques using near-infrared spectroscopy: an in-vitro feasibility study, Tania N. Khan, Babs R. Soller, Morteza Naghavi, and Ward Casscells

Publications from 2003

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Investigation of muscle pH as an indicator of liver pH and injury from hemorrhagic shock, Babs R. Soller, Tania N. Khan, Janice Favreau, Charles Hsi, Juan Carlos Puyana, and Stephen O. Heard

Publications from 2001

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Simultaneous measurement of hepatic tissue pH, venous oxygen saturation and hemoglobin by near infrared spectroscopy, Babs R. Soller, Ndumiso A. Cingo, Juan Carlos Puyana, Tania N. Khan, Charles Hsi, H Kim, Janice Favreau, and Stephen O. Heard

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Application of fiberoptic sensors for the study of hepatic dysoxia in swine hemorrhagic shock, Babs R. Soller, Stephen O. Heard, Ndumiso A. Cingo, Charles Hsi, Janice Favreau, Tania N. Khan, Randy R. Ross, and Juan Carlos Puyana

Publications from 1999

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Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo, Yilei Mao, Pei-Ra Ling, Timothy P. Fitzgibbons, Karen C. McCowen, G. Peter Frick, Bruce R. Bistrian, and Robert J. Smith