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Publications from 2013
Cardiac remodeling in obesity, Gerard P. Aurigemma, Giovanni de Simone, and Timothy P. Fitzgibbons
CD40 Deficiency in Mice Exacerbates Obesity-induced Adipose Tissue Inflammation, Hepatic Steatosis and Insulin Resistance, Chang-An Guo, Sophia Kogan, Shinya U. Amano, Mengxi Wang, Sezin Dagdeviren, Randall H. Friedline, Myriam Aouadi, Jason K. Kim, and Michael P. Czech
Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo, Teresa Repasy, Jinhee Lee, Simeone Marino, Nuria Martinez, Denise E. Kirschner, Gregory M. Hendricks, Stephen P. Baker MScPH, Andrew A. Wilson, Darrell N. Kotton, and Hardy Kornfeld
Inflammasomes and host defenses against bacterial infections, Gregory I. Vladimer, Robyn Lynn Marty-Roix, Shubhendu Ghosh, Dan Weng, and Egil Lien
Publications from 2012
Long-term correction of very long-chain acyl-coA dehydrogenase deficiency in mice using AAV9 gene therapy, Allison M. Keeler, Thomas J. Conlon, Glenn Walter, Huadong Zeng, Scott A. Shaffer, Fu Dungtao, Kirsten E. Erger, Travis L. Cossette, Qiushi Tang, Christian Mueller, and Terence R. Flotte
Cell and gene therapy for genetic diseases: inherited disorders affecting the lung and those mimicking sudden infant death syndrome, Allison M. Keeler and Terence R. Flotte
Rabenosyn-5 Defines the Fate of the Transferrin Receptor Following Clathrin-mediated Endocytosis, Deanna M. Navaroli, Karl D. Bellve, Clive Standley, Lawrence M. Lifshitz, James Cardia, David Lambright, Deborah Leonard, Kevin E. Fogarty, and Silvia Corvera
PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors, Joan Sanchez-Gurmaches, Chien-Min Hung, Cynthia A. Sparks, Yuefeng Tang, Huawei Li, and David A. Guertin
Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A, Yoshiko Usami, Sergei Popov, Eric R. Weiss, Christie Vriesema-Magnuson, Arianna Calistri, and Heinrich G. Gottlinger
The NLRP12 Inflammasome Recognizes Yersinia pestis, Gregory I. Vladimer, Dan Weng, Sara W. Montminy Paquette, Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam, Marie Hjelmseth Aune, Joseph E. Conlon, Joseph J. Burbage, Megan K. Proulx, Qin Liu, George W. Reed, Joan C. Mecsas, Yoichiro Iwakura, John Bertin, Jon D. Goguen, Katherine A. Fitzgerald, and Egil Lien
Publications from 2011
A stele-enriched gene regulatory network in the Arabidopsis root, Siobhan M. Brady, Lifang Zhang, Molly Megraw, Natalia Julia Martinez, Eric Jiang, Charles S. Yi, Weilin Liu, Anna Zeng, Mallorie Taylor-Teeples, Dahae Kim, Sebastian Ahnert, Uwe Ohler, Doreen Ware, Albertha J. M. Walhout, and Philip N. Benfey
Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation, Timothy P. Fitzgibbons, Sophia Kogan, Myriam Aouadi, Gregory M. Hendricks, Juerg R. Straubhaar, and Michael P. Czech
Acquired long QT syndrome from stress cardiomyopathy is associated with ventricular arrhythmias and torsades de pointes, Christopher Madias, Timothy P. Fitzgibbons, Alawi A. Alsheikh-Ali, Joseph L. Bouchard, Benjamin Kalsmith, Ann C. Garlitski, Dennis A. Tighe, N. A. Mark Estes III, Gerard P. Aurigemma, and Mark S. Link
A natural loss-of-function mutation of MyD88 disrupts its ability to form Myddosomes, Kamalpreet Nagpal, Theo S. Plantinga, Cherilyn M. Sirois, Brian G. Monks, Eicke Latz, Mihai G. Netea, and Douglas T. Golenbock
PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism, Sri Devi Narasimhan, Kelvin Yen, Ankita Bansal, Eun-Soo Kwon, Srivatsan Padmanabhan, and Heidi A. Tissenbaum
The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking, Deanna M. Navaroli, Zachary H. Stevens, Zeljko Uzelac, Luke Gabriel, Michael J. King, Lawrence M. Lifshitz, Harald H. Sitte, and Haley E. Melikian
Yeast one-hybrid assays for gene-centered human gene regulatory network mapping, John S. Reece-Hoyes, A. Rasim Barutcu, Rachel Patton McCord, Jun Seop Jeong, Lizhi Jiang, Andrew Macwilliams, Xinping Yang, Kourosh Salehi-Ashtiani, David E. Hill, Seth Blackshaw, Heng Zhu, Job Dekker, and Albertha J. M. Walhout
Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex, Tomoko M. Tabuchi, Bart Deplancke, Naoki Osato, Lihua Julie Zhu, Inmaculada M. Barrasa, Melissa M. Harrison, Robert H. Horvitz, Albertha J. M. Walhout, and Kirsten A. Hagstrom
The role of cellular factors in promoting HIV budding, Eric R. Weiss and Heinrich G. Gottlinger
Publications from 2010
Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network., H. Efsun Arda, Stefan Taubert, Lesley T. MacNeil, Colin C. Conine, Ben Tsuda, Marc Van Gilst, Reynaldo Sequerra, Lynn Doucette-Stamm, Keith R. Yamamoto, and Albertha J. M. Walhout
Gene-centered regulatory networks, H. Efsun Arda and Albertha J. M. Walhout
Alterations in urine, serum and brain metabolomic profiles exhibit sexual dimorphism during malaria disease progression, Angika Basant, Mayuri Rege, Shobhona Sharma, and Haripalsingh M. Sonawat
Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans., Colin C. Conine, Pedro J. Batista, Weifeng Gu, Julie M. Claycomb, Daniel A. Chaves, Masaki Shirayama, and Craig C. Mello
miR-21 and miR-31 Converge on TIAM1 to Regulate Migration and Invasion of Colon Carcinoma Cells, Charisa L. Cottonham, Satoshi Kaneko, and Lan Xu
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, and Eicke Latz
Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling, Pearl Gray, Kathrin S. Michelsen, Cherilyn M. Sirois, Emily Lowe, Kenichi Shimada, Timothy R. Crother, Shuang Chen, Constantinos Brikos, Yonca Bulut, Eicke Latz, David Underhill, and Moshe Arditi
The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer, Ma Reina D. Improgo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner
From smoking to lung cancer: the CHRNA5/A3/B4 connection, Ma. Reina D. Improgo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner
Insertion of tetracysteine motifs into dopamine transporter extracellular domains, Deanna M. Navaroli and Haley E. Melikian
Bi-specific MHC heterodimers for characterization of cross-reactive T cells, Zu T. Shen, Michael A. Brehm, Keith A. Daniels, Alexander B. Sigalov, Liisa K. Selin, Raymond M. Welsh, and Lawrence J. Stern
IFI16 is an innate immune sensor for intracellular DNA, Leonie Unterholzner, Sinead E. Keating, Marcin Baran, Kristy A. Horan, Soren B. Jensen, Shrutie Sharma, Cherilyn M. Sirois, Tengchuan Jin, Eicke Latz, T. Sam Xiao, Katherine A. Fitzgerald, Soren R. Paludan, and Andrew G. Bowie
Rescue of HIV-1 Release by Targeting Widely Divergent NEDD4-Type Ubiquitin Ligases and Isolated Catalytic HECT Domains to Gag, Eric R. Weiss, Elena Popova, Hikaru Yamanaka, Hyung Cheol Kim, Jon M. Huibregtse, and Heinrich G. Göttlinger
Publications from 2009
A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development, Laurence D. Covassin, Arndt F. Siekmann, Michael C. Kacergis, Elizabeth Laver, John C. Moore, Jacques A. Villefranc, Brant M. Weinstein, and Nathan D. Lawson
Prevalence and clinical characteristics of right ventricular dysfunction in transient stress cardiomyopathy, Timothy P. Fitzgibbons, Christopher Madias, Seth Adhar, Joseph L. Bouchard, Jeffrey T. Kuvin, Ayan R. Patel, Natesa G. Pandian, Theo E. Meyer, Gerard P. Aurigemma, and Dennis A. Tighe
Mortality in diastolic heart failure: an update, Timothy P. Fitzgibbons, Theo E. Meyer, and Gerard P. Aurigemma
Publications from 2008
Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi, Daniella C. Bartholomeu, Catherine Ropert, Mariane B. Melo, Peggy Parroche, Caroline F. Junqueira, Santuza M. R. Teixeira, Cherilyn M. Sirois, Pia Kasperkovitz, Cathrine F. Knetter, Egil Lien, Eicke Latz, Douglas T. Golenbock, and Ricardo T. Gazzinelli
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells, Kathryn L. Lipson, Rajarshi Ghosh, and Fumihiko Urano
Long-range chromosomal interactions and gene regulation, Angela Miele and Job Dekker
Preferential utilization of Imp7/8 in nuclear import of Smads, Xiaohao Yao, Xiaochu Chen, Charisa L. Cottonham, and Lan Xu
Publications from 2007
Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model, Romolo Joseph Gaspari and David Paydarfar
Ligand-induced conformational changes allosterically activate Toll-like receptor 9, Eicke Latz, Anjali Verma, Alberto Visintin, Mei Gong, Cherilyn M. Sirois, Dionne C. G. Klein, Brian G. Monks, C. James McKnight, Marc S. Lamphier, W. Paul Duprex, Terje Espevik, and Douglas T. Golenbock
p53-independent abrogation of a postmitotic checkpoint contributes to human papillomavirus E6-induced polyploidy, Yingwang Liu, Susan Ann Heilman, Diego Illanes, Greenfield Sluder, and Jason J. Chen
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE, Jane Tian, Ana Maria Avalos, Su-Yau Mao, Bo Chen, Kannaki Senthil, Herren Wu, Peggy Parroche, Stacey Drabic, Douglas T. Golenbock, Cherilyn M. Sirois, Jing Hua, Ling Ling An, Laurent Audoly, Greg La Rosa, Angelika Bierhaus, Peter Naworth, Ann Marshak-Rothstein, Mary K. Crow, Katherine A. Fitzgerald, Eicke Latz, Peter A. Kiener, and Anthony J. Coyle
Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping, Vanessa Vermeirssen, Bart Deplancke, M. Inmaculada Barrasa, John S. Reece-Hoyes, H. Efsun Arda, Christian A. Grove, Natalia Julia Martinez, Reynaldo Sequerra, Lynn Doucette-Stamm, Michael R. Brent, and Albertha J. M. Walhout
Gateway compatible vectors for analysis of gene function in the zebrafish, Jacques A. Villefranc, Julio D. Amigo, and Nathan D. Lawson
Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads, Lan Xu, Xiaohao Yao, Xiaochu Chen, Peiyuan Lu, Biliang Zhang, and Y. Tony Ip
Publications from 2006
Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada, Silvia Corvera, Alison Burkart, Ja-Young Kim, Jennifer L. Christianson, Zhao Wang, and Philipp E. Scherer
Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish, Laurence D. Covassin, Jacques A. Villefranc, Michael C. Kacergis, Brant M. Weinstein, and Nathan D. Lawson
Control of cellular senescence by CPEB, Irina Groisman, Maria Ivshina, Veronica Marin, Norman J. Kennedy, Roger J. Davis, and Joel D. Richter
TLR9 and the recognition of self and non-self nucleic acids, Marc S. Lamphier, Cherilyn M. Sirois, Anjali Verma, Douglas T. Golenbock, and Eicke Latz
Epigenetic telomere protection by Drosophila DNA damage response pathways, Sarah R. Oikemus, Joana Queiroz-Machado, KuanJu Lai, Nadine Schultz, Claudio E. Sunkel, and Michael H. Brodsky
Publications from 2005
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein, Klaus Forstemann, Yukihide Tomari, Tingting Du, Vasily V. Vagin, Ahmet M. Denli, Diana P. Bratu, Carla Andrea Klattenhoff, William E. Theurkauf, and Phillip D. Zamore
Publications from 2004
Tissue pH determination for the detection of metabolically active, inflamed vulnerable plaques using near-infrared spectroscopy: an in-vitro feasibility study, Tania N. Khan, Babs R. Soller, Morteza Naghavi, and Ward Casscells
Publications from 2003
Investigation of muscle pH as an indicator of liver pH and injury from hemorrhagic shock, Babs R. Soller, Tania N. Khan, Janice Favreau, Charles Hsi, Juan Carlos Puyana, and Stephen O. Heard
Publications from 2001
Simultaneous measurement of hepatic tissue pH, venous oxygen saturation and hemoglobin by near infrared spectroscopy, Babs R. Soller, Ndumiso A. Cingo, Juan Carlos Puyana, Tania N. Khan, Charles Hsi, H Kim, Janice Favreau, and Stephen O. Heard
Application of fiberoptic sensors for the study of hepatic dysoxia in swine hemorrhagic shock, Babs R. Soller, Stephen O. Heard, Ndumiso A. Cingo, Charles Hsi, Janice Favreau, Tania N. Khan, Randy R. Ross, and Juan Carlos Puyana
Publications from 1999
Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo, Yilei Mao, Pei-Ra Ling, Timothy P. Fitzgibbons, Karen C. McCowen, G. Peter Frick, Bruce R. Bistrian, and Robert J. Smith