Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

Follow


Dissertations and Theses from 2014

PDF

From Neurodegeneration to Infertility and Back - Exploring Functions of Two Genes: ARMC4 and TARDBP: A Dissertation, Wei Cheng

PDF

Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation, Tingting Huang

Dissertations and Theses from 2013

PDF

Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation, Shinya U. Amano

PDF

Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation, Rahul Bharadwaj

PDF

A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation, Alison R. Bright

PDF

Disparate Activation of the Inflammasome by Chitin and Chitosan: A Dissertation, Chelsea L. Bueter

PDF

Adjuvant-Specific Serum Cytokine Profiles in the Context of a DNA Prime-Protein Boost HIV-1 Vaccine: A Dissertation, Rachel Buglione-Corbett

PDF

Layered Reward Signalling Through Octopamine and Dopamine in Drosophila: A Dissertation, Christopher J. Burke

PDF

A Novel Autophagy Regulatory Mechanism that Functions During Programmed Cell Death: A Dissertation, Tsun-Kai Chang

PDF

Expanding the Known DNA-binding Specificity of Homeodomains for Utility in Customizable Sequence-specific Nucleases: A Dissertation, Stephanie W. Chu

PDF

On Identifying Signatures of Positive Selection in Human Populations: A Dissertation, Jessica L. Crisci

PDF

Nuclear Organization in Breast Cancer: A Dissertation, Jason R. Dobson

PDF

Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation, John W. Evans III

PDF

Genetic Deficiency of CD40 in Mice Exacerbates Metabolic Manifestations of Diet-induced Obesity: A Dissertation, Chang-An Guo

PDF

Understanding Regulation of the Cytoskeleton during Cell Cycle Transitions through Examination of Crosstalk between Homologous Fission Yeast Pathways, Septation Initiation Network and Morphogenesis ORB6 Network: A Dissertation, Sneha Gupta

PDF

Modulating Influenza and Heparin Binding Viruses’ Pathogenesis with Extrinsic Receptor Decoy Liposomes: A Dissertation, Gabriel L. Hendricks

PDF

Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation, Ryan T. Hietpas

PDF

Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation, Brendan J. Hilbert

PDF

Suppressive Oligodeoxynucleotides Inhibit Cytosolic DNA Sensing Pathways: A Dissertation, John J. Kaminski III

PDF

Tissue-dependent T Cell Apoptosis and Transcriptional Regulation of Memory CD8+T Cell Differentiation During Viral Infections: A Dissertation, Varun N. Kapoor

PDF

Modulators of the Acute Inflammatory Response: A Dissertation, Dipti Karmarkar

PDF

The Role of Heterologous Immunity in Viral Co-Infections and Neonatal Immunity: A Dissertation, Laurie L. Kenney

PDF

Role of Inflammation in Diet-Induced Obesity: A Dissertation, Sophia Kogan

PDF

Role of Autophagy in Post-Mitotic Midbody Fate and Function: A Dissertation, Tse-Chun Kuo

PDF

Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation, Alexander N. Lagadinos

PDF

Runx Expression in Normal and Osteoarthritic Cartilage: Possible Functions of Runx Proteins in Chondrocytes: A Dissertation, Kimberly T. LeBlanc

PDF

Understanding Neural Networks in Awake Rat by Resting-State Functional MRI: A Dissertation, Zhifeng Liang

PDF

Transcriptional and Translational Mechanisms Controlling Circadian Rhythms in Drosophila: A Dissertation, Jinli Ling

PDF

The Effects of Family and Social Engagement on the Screen Time of Youth with Developmental Disabilities: A Dissertation, Charmaine B. Lo

PDF

The Role and Regulation of Etv2 in Zebrafish Vascular Development: A Dissertation, John C. Moore

PDF

Elucidating the Molecular Mechanism of CYLD-Mediated Necrosis: A Dissertation, David M. Moquin

PDF

Role of the Cytoplasmic Polyadenylation Element Binding Proteins in Neuron: A Dissertation, Aparna Oruganty

PDF

dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation, Jeannette M. Osterloh

PDF

Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation, Aysegul Ozen

PDF

The Role of Ion Channels in Coordinating Neural Circuit Activity in Caenorhabditis elegans: A Dissertation, Jennifer K. Pirri

PDF

Investigation of Multiple Concerted Mechanisms Underlying Stimulus-induced G1 Arrest in Yeast: A Dissertation, Patricia A. Pope

PDF

The Role of Inducible T Cell Kinase (Itk) in the Development of Innate T Cells and in the Formation of Protective Memory Responses: A Dissertation, Amanda L. Prince

PDF

HIV-1 and the Nucleolus: A Role for Nucleophosmin/NPM1 in Viral Replication: A Dissertation, Tracy E. Schmidt

PDF

Investigating Cancer Molecular Genetics using Genome-wide RNA Interference Screens: A Dissertation, Ryan W. Serra

PDF

Application of a Naïve Bayes Classifier to Assign Polyadenylation Sites from 3' End Deep Sequencing Data: A Dissertation, Sarah E. Sheppard

PDF

The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation, Jessica M. Tesell

PDF

Inflammasomes and the Innate Immune Response Against Yersinia Pestis: A Dissertation, Gregory I. Vladimer

PDF

Identification and Analysis of the Domain Required for Trans-Acceleration Kinetics in the Human Glucose Transporter GLUT1: A Dissertation, Sabrina S. Vollers

PDF

Role of Map4k4 in Skeletal Muscle Differentiation: A Dissertation, Mengxi Wang

PDF

RNA Interference by the Numbers: Explaining Biology Through Enzymology: A Dissertation, Liang Meng Wee

PDF

hox Gene Regulation and Function During Zebrafish Embryogenesis: A Dissertation, Steven E. Weicksel

PDF

Morphogenetic Requirements for Embryo Patterning and the Generation of Stem Cell-derived Mice: A Dissertation, Yeonsoo Yoon

PDF

A Novel Role of UAP56 in piRNA Mediated Transposon Silencing: A Dissertation, Fan Zhang

PDF

piRNA Biogenesis and Transposon Silencing in Drosophila: A Dissertation, Zhao Zhang

Dissertations and Theses from 2012

PDF

Mechanisms of KRAS-Mediated Pancreatic Tumor Formation and Progression: A Dissertation, Victoria A. Appleman

PDF

Hepatitis C Virus Non-Structural Protein 3/4A: A Tale of Two Domains: A Dissertation, Cihan Aydin

PDF

The Subtype Specific and Cross-Reactive T Cell Responses to Influenza Viruses in Humans: A Dissertation, Jenny Aurielle B. Babon

PDF

Gene Expression and Profiling of Human Islet Cell Subtypes: A Master’s Thesis, David M. Blodgett

PDF

Understanding Small RNA Formation in Drosophila Melanogaster: A Dissertation, Elif Sarinay Cenik

PDF

Localization of Insulin Receptor Substrate-2 in Breast Cancer: A Dissertation, Jennifer L. Clark

PDF

Transcriptional Regulation of the Interleukin-8 Promoter by Multiple Dengue Viral Proteins: A Dissertation, Jacob M. Collins

PDF

Psychosocial and Behavioral Determinants of Medication Nonadherence Among African Americans with Hypertension: A Dissertation, Yendelela L. Cuffee

PDF

Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation, Christopher R. Dowdy

PDF

On the Source of Peptides for Major Histocompatibility Class I Antigen Presentation: A Dissertation, Diego José Farfán Arribas

PDF

Sequence and Target Specificity of the C. elegans Cell Fate Specification Factor POS-1: A Dissertation, Brian M. Farley

PDF

Role of Perivascular and Visceral Adipose Tissues in Murine Models of Obesity and Atherosclerosis: A Dissertation, Timothy P. Fitzgibbons

PDF

Building the Cell's Antenna: Protein Targeting to the Ciliary Membrane: A Dissertation, John A. Follit

PDF

Role of Glia in Sculpting Synaptic Connections at the Drosophila Neuromuscular Junction: A Dissertation, Yuly F. Fuentes Medel

PDF

Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation, Hugh S. Gannon

PDF

Analysis of Integrin α6β4 Function in Breast Carcinoma: A Dissertation, Kristin D. Gerson

PDF

Getting a Tight Grip on DNA: Optimizing Zinc Fingers for Efficient ZFN-Mediated Gene Editing: A Dissertation, Ankit Gupta

PDF

Characterization of Drug Resistance in Mycobacterium Tuberculosis via Saturating Mutagenesis of Drug Targets: A Master’s Thesis, Michelle J. Harris

PDF

Serotonin-Expressing Cells in the Corpus of the Stomach Originate from Bone Marrow: A Master’s Thesis, Brian T. Johnston

PDF

Gene Therapy for Very Long Chain Acyl-coA Dehydrogenase Deficiency Using Adeno-Associated Virus Vectors: A Dissertation, Allison M. Keeler

PDF

Glial Control of Synapse Assembly at the Drosophila Neuromuscular Junction: A Dissertation, Kimberly S. Kerr

PDF

The Role of Adaptor Protein Complex-3 Delta-Mediated HIV-1 Gag Trafficking in HIV-1 Replication: A Dissertation, Adonia Lee Kim

PDF

A Novel Communication Mechanism Between the Presynapse and Postsynapse Through Exosomes: A Dissertation, Ceren Korkut

PDF

Protein Ligand Interactions Probed by NMR: A Dissertation, Jennifer M. Laine

PDF

Catalytic Mechanisms in Sec7 and Vps9 Domain Exchange Factors for Arf and Rab GTPases: A Dissertation, Meng-Tse Lee

PDF

Studies on the Regulation of Cytoplasmic Polyadenylation Element-Binding Protein: A Dissertation, Chien-Ling Lin

PDF

Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation, Ling Lin

PDF

Dissecting Somatic Cell Reprogramming by MicroRNAs and Small Molecules: A Dissertation, Zhonghan Li

PDF

Targeting the Histone Acetyl-Transferase, RTT109, for Novel Anti-Fungal Drug Development: A Dissertation, Jessica Lopes da Rosa-Spiegler

PDF

A Role for c-Jun Kinase (JNK) Signaling in Glial Engulfment of Degenerating Axons: A Dissertation, Jennifer M. MacDonald

PDF

RNA-Sensing Pattern Recognition Receptors and Their Effects on T-Cell Immune Responses: A Dissertation, Rachel F. Madera

PDF

Distinct Gene Circuits Control the Differentiation of Innate Versus Adaptive IL-17 Producing T Cells: A Dissertation, Nidhi Malhotra

PDF

A New Murine Model For Enterohemorrhagic Escherichia coli Infection Reveals That Actin Pedestal Formation Facilitates Mucosal Colonization and Lethal Disease: A Dissertation, Emily M. Mallick

PDF

Inflammation Inhibits Osteoblast-Mediated Bone Formation in Rheumatoid Arthritis and Regulates the Wnt and BMP Signaling Pathways: A Dissertation, Melissa M. Matzelle

PDF

Incidence, prognosis, and factors associated with cardiac arrest in patients hospitalized with acute coronary syndromes (the GRACE Registry): A master's thesis, David D. McManus

PDF

Characterization of New Factors in the 18S Nonfunctional Ribosomal RNA Decay Pathway in S. cerevisiae: A Dissertation, Christopher N. Merrikh

PDF

Slow-Cycling Cancer Cells: A Dissertation, Nathan F. Moore

PDF

Small Molecule Investigation of KCNQ Potassium Channels: A Dissertation, Karen Mruk

PDF

Lack of CFTR in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyper-Inflammatory Adaptive Immune Responses: A Master's Thesis, Christian Mueller

PDF

HIV-1 R5 Tropism: Determinants, Macrophages, and Dendritic Cells: A Dissertation, Thomas A. Musich

PDF

Molecular Mechanisms of Endocytosis: Trafficking and Functional Requirements for the Transferrin Receptor, Small Interfering RNAs and Dopamine Transporter: A Dissertation, Deanna M. Navaroli

PDF

TXNIP is a Mediator of ER Stress-Induced β-Cell Inflammation and Apoptosis: A Dissertation, Christine M. Oslowski

PDF

Contribution of WFS1 to Pancreatic Beta Cell Survival and Adaptive Alterations in WFS1 Deficiency: A Dissertation, Bryan M. O'Sullivan-Murphy

PDF

Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation, Paola N. Perrat

PDF

Maintaining the Balance: Coordinating Excitation and Inhibition in a Simple Motor Circuit: A Dissertation, Hilary A. Petrash

PDF

Therapeutic Silencing of Mutant Huntingtin by Targeting Single Nucleotide Polymorphisms: A Dissertation, Edith L. Pfister

PDF

A Population-Based Epidemiological Description of Socio-Demographic Characteristics and Predictors of Severity Among Hospitalized 2009 H1N1 Influenza Cases in Massachusetts: A Dissertation, Hilary Placzek

PDF

Control of Bovine Papillomavirus E2 Function By Acetylation and the Novel E2 Interacting Protein RINT1: A Dissertation, Edward J. Quinlan

PDF

Antagonistic Pleiotropy: The Role of Smurf2 in Cancer and Aging: A Dissertation, Charusheila Ramkumar

PDF

Innate Signaling Pathways in the Maintenance of Serological Memory: A Dissertation, Forum M. Raval

PDF

Studies on Cellular Host Factors Involved in the HIV-1 Life Cycle: A Dissertation, Anna Kristina Serquiña