Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Dissertations and Theses from 2008

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The Molecular Mechanisms Underlying the Polarized Distribution of Drosophila Dscam in Neurons: A Dissertation, Shun-Jen Yang

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Myocardial Macrophage Phenotypic Variation and Cytokine-Mediated Induction of HIV-Associated Cardiac Disease: A Dissertation, Jennifer Holmes Yearley

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Innate Immunity in Type 2 Diabetes Pathogenesis: Role of the Lipopolysaccharide Signaling Cascade: A Dissertation, James L. Young

Dissertations and Theses from 2007

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Probing the Structural Topology of HIV-1 Virion Infectivity Factor (VIF): A Dissertation, Jared R. Auclair

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A Genetic Analysis of Genomic Stability in Caenorhabditis Elegans: A Dissertation, Melissa M. Auclair

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Human Erythrocyte Glucose Transporter (GLUT1) Structure, Function, and Regulation: A Dissertation, David M. Blodgett

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Mechanism and Function of Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7: A Dissertation, Michael John Brady

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Molecular and Behavioral Analysis of Drosophila Circadian Photoreception and Circadian Thermoreception: A Dissertation, Ania Busza

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Role of Notch1 in Cardiac Cell Differentiation and Migration: A Dissertation, Dinh Le Mary Chau

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Collagen and Fibrin Bioplymer Microthreads for Bioengineered Ligament Generation: a Dissertation, Kevin Cornwell

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Transcript-Specific Cytoplasmic Degradation of YRA1 Pre-mRNA Mediated by the Yeast EDC3 Protein: A Dissertation, Shuyun Dong

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Folding and Assembly of Multimeric Proteins: Dimeric HIV-1 Protease and a Trimeric Coiled Coil Component of a Complex Hemoglobin Scaffold: A Dissertation, Amanda Ann Fitzgerald

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Cooperative Oncogenesis and Polyploidization in Human Cancers: A Dissertation, Susan Ann Heilman

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The Role of CD40 in Naïve and Memory CD8+ T Cell Responses: a Dissertation, Maria Genevieve H. Hernandez

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Motor Property of Mammalian Myosin 10: A Dissertation, Kazuaki Homma

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Cartilage tissue engineering: uses of injection molding and computer aided design for the fabrication of complex geometries with high dimensional tolerances: a dissertation, Morgan E. Hott

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Identification and Characterization of Components of the Intraflagellar transport (IFT) Machinery: a Dissertation, Yuqing Hou

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Transfer of the Ribosome-Nascent Chain Complex to the Translocon in Cotranslational Translocation: A Thesis, Ying Jiang

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Neural Diversity in the Drosophila Olfactory Circuitry: A Dissertation, Sen-Lin Lai

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Autoimmune Diabetes and Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation, Julie Lambert

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How Does ATP Regulate Erythrocyte Glucose Transport?: a Dissertation, Jeffry M. Leitch

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Characterization of the BACH1 Helicase in the DNA Damage Response Pathway: a Dissertation, Rachel Litman

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Identification and Characterization of Agv1, a Pre-Metazoan Arf GAP: A Dissertation, Kimberly Renee Long

The Role of CHD2 in Mammalian Development and Disease: a Dissertation, Concetta G. A. Marfella

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Understanding Assembly of AGO2 RISC: the RNAi enzyme: a Dissertation, Christian B. Matranga

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Molecular and Neuronal Analysis of Circadian Photoresponses in Drosophila: A Dissertation, Alejandro D. Murad

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Distinct Behaviors of Infected and Bystander Dendritic Cells Following Exposure to Dengue Virus: A Dissertation, Zachary Davis Nightingale

Maintenance of Constitutive and Inactive X Heterochromatin in Cancer and a Link to BRCA1: A Dissertation, Gayle Jeannette Pageau

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Surface of Yersinia pestis: LCRV, F1 Production, Invasion and Oxygen: A Dissertation, Kimberly Lea Pouliot

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Modulation of Cav1.3 L-Type Calcium Channels by Arachidonic Acid and Muscarinic M1 Receptors: A Dissertation, Mandy L. Roberts-Crowley

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Rethinking Mechanisms of Actin Pedestal Formation by Enteropathogenic Escherichia Coli in the Context of Multiple Signaling Cascades: a Dissertation, Pamela Joyce Savage

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A Role for Histone Modification in the Mechanism of Action of Antidepressant and Stimulant Drugs: a Dissertation, Frederick Albert Schroeder

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Interaction of a Mammalian Virus with Host RNA Silencing Pathways: A Dissertation, Bradford Michael Stadler

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Regulation of Cell Polarization and Map Kinase Signaling in the Saccharomyces Cerevisiae Pheromone Response Pathway: a Dissertation, Shelly Catherine Strickfaden

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Functional and Structural Dissection of the SWI/SNF Chromatin Remodeling Complex: A Dissertation, Xiaofang Yang

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The Argonaute Family of Genes in Caenorhabditis Elegans: a Dissertation, Erbay Yigit

Dissertations and Theses from 2006

The Role of Cell Adhesion, the Cytoskeleton, and Membrane Trafficking: a Dissertation, James A. Ashley

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Serotype Cross-Reactive CD8+ T Cell Response to Heterologous Secondary Dengue Virus Infections in Humans: a Dissertation, Hema Sundara Bashyam

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Human Rad51: Regulation of Cellular Localization and Function in Response to DNA Damage: A Dissertation, Brian Thomas Bennett

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Identification of Novel (RNAi Deficient) Genes in C. elegans: A Dissertation, Chun-Chieh G. Chen

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Posttargeting Events in Cotranslational Translocation Through the Sec61 Complex: a Thesis, Zhiliang Cheng

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Characterization of the Relationship Between Measles Virus Fusion, Receptor Binding, and the Virus-Specific Interaction Between the Hemagglutinin and Fusion Glycoproteins: a Dissertation, Elizabeth Ann Corey

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Dissecting the Mechanism for the Selective Induction of Apoptosis in Transformed Cells by CAV Apoptin: a Dissertation, Destin W. Heilman

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M1 Muscarinic Modulation of N-Type Calcium Channels: A Dissertation, John F. Heneghan

Characterization of Novel Lymphoid-Associated Genes Identified by Gene-Trapping: a Dissertation, Pamela James

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Genetic Dissection of the Neural Circuitry Underlying Memory Stability in Drosophila: A Dissertation, Alex Carl Keene

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PLAGL2 Cooperates in Leukemia Development by Upregulating MPL Expression: A Dissertation, Sean F. Landrette

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Mechanisms of Endocytic Sorting: A Dissertation, Deborah Marie Leonard

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SOX13, A γδ T Cell-Specific Gene, Is a WNT-Signaling Antagonist Regulating T Cell Development: A Dissertation, Heather J. Melichar

Identification of Novel Interacting Proteins of Histone Gene Regulator, HINF-P: a Dissertation, Angela Miele

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Probing Protein Dynamics Through Mutational and Computational Studies of HIV-1 Protease: A Dissertation, Jennifer E. Murzycki

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Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways: A Dissertation, Sarah R. Oikemus

Translational Control of M Phase Progression: a dissertation, Kiran Padmanabhan

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Requirements for Assembly and Release of Newcastle Disease Virus-Like Particles: A Dissertation, Homer Dadios Pantua

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Rb Inactivation Leads to E2F1-mediated DNA Double Strand Break Accumulation: A Dissertation, Mary Theresa Pickering

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Perturbation and Modulation of Microtubule Cytoskeletal Elements in Response to the Potentially Oncogenic Molecules, Survivin and P53, and Cytokinesis: A Dissertation, Jack Rosa

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Analysis of Toll-Like Receptor 4 Signal Transduction and IRF3 Activation in the Innate Immune Response: A Dissertation, Daniel C. Rowe

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Transcriptional Regulation During Adipocyte Differentiation: A Role for SWI/SNF Chromatin Remodeling Enzymes: A Dissertation, Nunciada Salma

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Development of Pharmacological Magnetic Resonance Imaging Methods and their Application to the Investigation of Antipsychotic Drugs: a Dissertation, Karl F. Schmidt

Multimodal MRI, Behavioral Testing, and Histology in a Rat Model of Transient Focal Cerebral Ischemia : A Dissertation, Kenneth M. Sicard

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RNA Silencing Pathways in Schizosaccharomyces pombe and Drosophila melanogaster: A Dissertation, Alla A. Sigova

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Quantitative Analysis of Hedgehog Gradient Formation Using an Inducible Expression System: a Dissertation, Vivian F. Su

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IFN-α/β Induction by dsRNA and Toll-Like Receptors Shortens Allograft Survival Induced by Costimulation Blockade: A Dissertation, Thomas B. Thornley

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Regulation of Contractility by Adenosine A1 and A2A Receptors in the Murine Heart: Role of Protein Phosphatase 2A: A Dissertation, Eugene I. Tikh

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Analysis of the Role of Cytosolic Aminopeptidases in the Generation of MHC-Class I Presented Peptides: a Dissertation, Charles Fenton Towne

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Light Intermediate Chain 1: a Multifunctional Cargo Binder for Cytoplasmic Dynein 1: a Dissertation, Thomas Wadzinski

Dissertations and Theses from 2005

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Analysis of Polarity Signaling in Both Early Embryogenesis and Germline Development in C. Elegans: A Dissertation, Yanxia Bei

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Egr-2 and PD-1 Are Required for Induction and Maintenance of T Cell Anergy: A Dissertation, Kenneth D. Bishop

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Mechanisms of Host-Range Function of Vaccinia Virus K1L Gene: a Dissertation, Ritu Rakshit Bradley

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Regulation and Function of Stress-Activated Protein Kinase Signal Transduction Pathways: A Dissertation, Deborah Marie Brancho

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CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing Signals as Revealed by Gene Expression Analysis: A Dissertation, David Spaulding Brown

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The Identification of Cooperating Mutations in TAL1-Mediated Leukemia in the Mouse: A Dissertation, Jennifer Ann Calvo

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Cross-Reactive CD8 T Cell Responses and Heterologous Immunity During Acute Epstein-Barr Virus Infection: a Dissertation, Shalyn Catherine Clute

Structural Determinants of Phosphoinositide Recognition by Grp1 Family Pleckstrin Homology Domains: a Dissertation, Thomas Charles Cronin

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Cytoplasmic Localization of HIV-1 Vif Is Necessary for Apobec3G Neutralization and Viral Replication: A Dissertation, Melissa Ann Farrow

Mechanisms of Host Cell Attachment by the Lyme Disease Spirochete: A Dissertation, Joshua Richard Fischer

Biophysical Analysis of the Human Erythrocyte Glucose Transporter: a Dissertation, Christopher A. Graybill

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A Biochemical Dissection of the RNA Interference Pathway in Drosophila melanogaster: A Dissertation, Benjamin Haley

NMR Characterization of Pathological Disease States: Monitoring Response to Single-Dose Radiotherapy in a RIF-1 Tumor Model and the Role of Spreading Depression in the Evolution of Ischemic Stroke: a Dissertation, Erica C. Henning

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The Role of Tec Kinases in CD4+ T Cell Activation: A Dissertation, Cheng-Rui Michael Li

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The Role of Itk in T Cell Development: A Dissertation, Julie Ann Lucas

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Chemokine Induction by Dengue Virus Infection: Mechanisms and the Role of Viral Proteins: a Dissertation, Carey L. Medin

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Characterization of the Interaction Between the Attachment and Fusion Glycoproteins Required for Paramyxovirus Fusion: a Dissertation, Vanessa R. Melanson

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Regulation of Life Span by DAF-16/Forkhead Transcription Factor in Caenorhabditis elegans: A Dissertation, Seung Wook Oh

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Characterization of JNK Binding Proteins: A Dissertation, Jeffrey Scott Rogers

The Function of Myosin IX: the Ninth Class of Myosin Superfamily: a Dissertation, Nobutaka Saeki

The Human Rev Interacting Protein (hRIP) is Required for Rev Function and HIV-1 Replication: a Dissertation, Nuria Sánchez-Velar

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Biochemical Mechanism of RNA Interference in Higher Organisms: A Dissertation, Dianne S. Schwarz

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Functions of the Cdc14-Family Phosphatase Clp1p in the Cell Cycle Regulation of Schizosaccharomyces pombe: A Dissertation, Susanne Trautmann

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The Epigenetic Silencing of PMP24 During the Progression of Prostate Cancer from an Androgen-Dependent to Androgen-Independent State in the LNCAP Cell Model: a Dissertation, Mengchu Wu

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Regulation of Cell Growth and Differentiation within the Context of Nuclear Architecture by the Runx2 Transcription Factor: a Dissertation, Daniel W. Young

Dissertations and Theses from 2004

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The Role of ITK and RLK in CD8+ T Cell Development and Function: a Dissertation, Luana O. Atherly

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The Roles of DNA Mismatch Repair and Recombination in Drug Resistance: A Dissertation, Melissa A. Calmann

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The Structural Basis for the Phosphorylation-Induced Activation of Smad Proteins: a Dissertation, Benoy M. Chacko

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Prevention of Oxidative Damage by Yeast and Human OXR1: A Dissertation, Nathan Andrew Elliott

Alcohol Modulation of Human BK Channels Evidence for β-Subunit Dependent Plasticity in Functional Ethanol Tolerance: A Dissertation, Paula Leslie Feinberg-Zadek

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Homologous Recombinational DNA Repair: from Prokaryotes to Eukaryotes: a Dissertation, Anthony L. Forget

Wnt8 Is a Novel Target of the Dorsal/Twist/Snail Network and an Inhibitor of Dorsal in the Gastrulating Drosophila Embryo: A Dissertation, Atish Ganguly

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Novel Insights into Schwann Cell Dynamics in Peripheral Nervous System Myelination: a dissertation, Cheryl Lynn Gatto

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The Role of γс Cytokines in T Cell Development, T Cell Homeostasis and CD8+ T Cell Function: A Dissertation, Sara Gozalo