Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

Read the UMassMedNow feature about the ceremony honoring 44 newly qualified GSBS PhD candidates!

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Dissertations and Theses from 2006

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Dissecting the Mechanism for the Selective Induction of Apoptosis in Transformed Cells by CAV Apoptin: a Dissertation, Destin W. Heilman

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M1 Muscarinic Modulation of N-Type Calcium Channels: A Dissertation, John F. Heneghan

Characterization of Novel Lymphoid-Associated Genes Identified by Gene-Trapping: a Dissertation, Pamela James

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Genetic Dissection of the Neural Circuitry Underlying Memory Stability in Drosophila: A Dissertation, Alex Carl Keene

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PLAGL2 Cooperates in Leukemia Development by Upregulating MPL Expression: A Dissertation, Sean F. Landrette

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Mechanisms of Endocytic Sorting: A Dissertation, Deborah Marie Leonard

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SOX13, A γδ T Cell-Specific Gene, Is a WNT-Signaling Antagonist Regulating T Cell Development: A Dissertation, Heather J. Melichar

Identification of Novel Interacting Proteins of Histone Gene Regulator, HINF-P: a Dissertation, Angela Miele

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Probing Protein Dynamics Through Mutational and Computational Studies of HIV-1 Protease: A Dissertation, Jennifer E. Murzycki

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Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways: A Dissertation, Sarah R. Oikemus

Translational Control of M Phase Progression: a dissertation, Kiran Padmanabhan

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Requirements for Assembly and Release of Newcastle Disease Virus-Like Particles: A Dissertation, Homer Dadios Pantua

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Rb Inactivation Leads to E2F1-mediated DNA Double Strand Break Accumulation: A Dissertation, Mary Theresa Pickering

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Perturbation and Modulation of Microtubule Cytoskeletal Elements in Response to the Potentially Oncogenic Molecules, Survivin and P53, and Cytokinesis: A Dissertation, Jack Rosa

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Analysis of Toll-Like Receptor 4 Signal Transduction and IRF3 Activation in the Innate Immune Response: A Dissertation, Daniel C. Rowe

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Transcriptional Regulation During Adipocyte Differentiation: A Role for SWI/SNF Chromatin Remodeling Enzymes: A Dissertation, Nunciada Salma

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Development of Pharmacological Magnetic Resonance Imaging Methods and their Application to the Investigation of Antipsychotic Drugs: a Dissertation, Karl F. Schmidt

Multimodal MRI, Behavioral Testing, and Histology in a Rat Model of Transient Focal Cerebral Ischemia : A Dissertation, Kenneth M. Sicard

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RNA Silencing Pathways in Schizosaccharomyces pombe and Drosophila melanogaster: A Dissertation, Alla A. Sigova

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Quantitative Analysis of Hedgehog Gradient Formation Using an Inducible Expression System: a Dissertation, Vivian F. Su

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IFN-α/β Induction by dsRNA and Toll-Like Receptors Shortens Allograft Survival Induced by Costimulation Blockade: A Dissertation, Thomas B. Thornley

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Regulation of Contractility by Adenosine A1 and A2A Receptors in the Murine Heart: Role of Protein Phosphatase 2A: A Dissertation, Eugene I. Tikh

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Analysis of the Role of Cytosolic Aminopeptidases in the Generation of MHC-Class I Presented Peptides: a Dissertation, Charles Fenton Towne

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Light Intermediate Chain 1: a Multifunctional Cargo Binder for Cytoplasmic Dynein 1: a Dissertation, Thomas Wadzinski

Dissertations and Theses from 2005

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Analysis of Polarity Signaling in Both Early Embryogenesis and Germline Development in C. Elegans: A Dissertation, Yanxia Bei

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Egr-2 and PD-1 Are Required for Induction and Maintenance of T Cell Anergy: A Dissertation, Kenneth D. Bishop

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Mechanisms of Host-Range Function of Vaccinia Virus K1L Gene: a Dissertation, Ritu Rakshit Bradley

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Regulation and Function of Stress-Activated Protein Kinase Signal Transduction Pathways: A Dissertation, Deborah Marie Brancho

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CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing Signals as Revealed by Gene Expression Analysis: A Dissertation, David Spaulding Brown

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The Identification of Cooperating Mutations in TAL1-Mediated Leukemia in the Mouse: A Dissertation, Jennifer Ann Calvo

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Cross-Reactive CD8 T Cell Responses and Heterologous Immunity During Acute Epstein-Barr Virus Infection: a Dissertation, Shalyn Catherine Clute

Structural Determinants of Phosphoinositide Recognition by Grp1 Family Pleckstrin Homology Domains: a Dissertation, Thomas Charles Cronin

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Cytoplasmic Localization of HIV-1 Vif Is Necessary for Apobec3G Neutralization and Viral Replication: A Dissertation, Melissa Ann Farrow

Mechanisms of Host Cell Attachment by the Lyme Disease Spirochete: A Dissertation, Joshua Richard Fischer

Biophysical Analysis of the Human Erythrocyte Glucose Transporter: a Dissertation, Christopher A. Graybill

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A Biochemical Dissection of the RNA Interference Pathway in Drosophila melanogaster: A Dissertation, Benjamin Haley

NMR Characterization of Pathological Disease States: Monitoring Response to Single-Dose Radiotherapy in a RIF-1 Tumor Model and the Role of Spreading Depression in the Evolution of Ischemic Stroke: a Dissertation, Erica C. Henning

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The Role of Tec Kinases in CD4+ T Cell Activation: A Dissertation, Cheng-Rui Michael Li

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The Role of Itk in T Cell Development: A Dissertation, Julie Ann Lucas

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Chemokine Induction by Dengue Virus Infection: Mechanisms and the Role of Viral Proteins: a Dissertation, Carey L. Medin

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Characterization of the Interaction Between the Attachment and Fusion Glycoproteins Required for Paramyxovirus Fusion: a Dissertation, Vanessa R. Melanson

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Regulation of Life Span by DAF-16/Forkhead Transcription Factor in Caenorhabditis elegans: A Dissertation, Seung Wook Oh

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Characterization of JNK Binding Proteins: A Dissertation, Jeffrey Scott Rogers

The Function of Myosin IX: the Ninth Class of Myosin Superfamily: a Dissertation, Nobutaka Saeki

The Human Rev Interacting Protein (hRIP) is Required for Rev Function and HIV-1 Replication: a Dissertation, Nuria Sánchez-Velar

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Biochemical Mechanism of RNA Interference in Higher Organisms: A Dissertation, Dianne S. Schwarz

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Functions of the Cdc14-Family Phosphatase Clp1p in the Cell Cycle Regulation of Schizosaccharomyces pombe: A Dissertation, Susanne Trautmann

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The Epigenetic Silencing of PMP24 During the Progression of Prostate Cancer from an Androgen-Dependent to Androgen-Independent State in the LNCAP Cell Model: a Dissertation, Mengchu Wu

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Regulation of Cell Growth and Differentiation within the Context of Nuclear Architecture by the Runx2 Transcription Factor: a Dissertation, Daniel W. Young

Dissertations and Theses from 2004

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The Role of ITK and RLK in CD8+ T Cell Development and Function: a Dissertation, Luana O. Atherly

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The Roles of DNA Mismatch Repair and Recombination in Drug Resistance: A Dissertation, Melissa A. Calmann

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The Structural Basis for the Phosphorylation-Induced Activation of Smad Proteins: a Dissertation, Benoy M. Chacko

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Prevention of Oxidative Damage by Yeast and Human OXR1: A Dissertation, Nathan Andrew Elliott

Alcohol Modulation of Human BK Channels Evidence for β-Subunit Dependent Plasticity in Functional Ethanol Tolerance: A Dissertation, Paula Leslie Feinberg-Zadek

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Homologous Recombinational DNA Repair: from Prokaryotes to Eukaryotes: a Dissertation, Anthony L. Forget

Wnt8 Is a Novel Target of the Dorsal/Twist/Snail Network and an Inhibitor of Dorsal in the Gastrulating Drosophila Embryo: A Dissertation, Atish Ganguly

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Novel Insights into Schwann Cell Dynamics in Peripheral Nervous System Myelination: a dissertation, Cheryl Lynn Gatto

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The Role of γс Cytokines in T Cell Development, T Cell Homeostasis and CD8+ T Cell Function: A Dissertation, Sara Gozalo

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Midbody Anchoring of SNARE and Exocyst Complexes by Centriolin is Required for Completion of Cytokinesis: A Dissertation, Adam Scott Gromley

Analysis of FYVE Domain-Containing Proteins in Signaling and Endocytosis: a dissertation, Susan J. Hayes

Role of the Sid2-Mob1 Kinase Complex in Controlling the Onset of Cytokinesis in the Fission Yeast Schizosaccharomyces Pombe: a Dissertation, Ming-Chin Hou

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Centrosomes in Cytokinesis, Cell Cycle Progression and Ciliogenesis: a Dissertation, Agata Jurczyk

Role of Virus-Specific CD8+ T Cells in the Severity of Hantavirus Pulmonary Syndrome: A Dissertation, Elizabeth D. Kilpatrick

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Upregulation of Heme Pathway Enzyme ALA Synthase-1 by Glutethimide and 4,6-Dioxoheptanoic Acid and Downregulation by Glucose and Heme: A Dissertation, Sridevi Kolluri

Expression of rag2 and V(D)J Recombinase Activity are Reduced in Aged Mice as a Result of Changes in the Bone Marrow Microenvironment: a Dissertation, Joseph E. Labrie

Role of the JNK Signal Transduction Pathway in Cell Survival: a Dissertation, Jennifer A. Lamb

The Role of RIP1 in the TNFR1 Signal Transduction Pathway: a Dissertation, Thomas H. Lee

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Regulation and Function of Runx2 During Chondrogenic and Osteogenic Differentiation: a Dissertation, Christopher J. Lengner

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The role of Janus Kinase 3 in CD4+ T Cell Homeostasis and Function: A Dissertation, Shane Renee Mayack

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Changes in Polymer, Scaffold, and IGF-I Delivery Methods Directly Affect Cartilage Tissue Development: A Dissertation, Nichole Renee Mercier

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Structural Basis for Rab5 Activation and Effector Specificity in Endosome Tethering: A Dissertation, Eric Lee Merithew

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Mechanisms of TAL1 Induced Leukemia in Mice: A Dissertation, Jennifer Elinor O'Neil

Convergent Biochemical and Biomechanical Pathways in Tissue Remodeling: The Role of α₂β₁ Integrin and MMP Activity: A Dissertation, Jonathan Adam Phillips

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Macrophages Directly Prime Naïve CD8+ T Cells: a Dissertation, Lu-Ann M. Pozzi

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EBV-Specific CD4+ T Cell Responses in Acute Infectious Mononucleosis: a Dissertation, Melissa Lynn Precopio

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Pathways Linking Deregulated Proliferation to Apoptosis: a Dissertation, Harry A. Rogoff

Signaling Events Leading to CPEB-Mediated Translation: a Dissertation, Madathia Sarkissian

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Functional and Structural Analysis of the Yeast SWI/SNF Complex: a Dissertation, Corey Lewis Smith

Mdm2 and Mdm4 Functions in Growth Control: a Dissertation, Heather Anne Steinman

Crystallographic Studies of Rrythrocruorin from Lumbricus Terrestris: a Dissertation, Kristen Strand-Tibbitts

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Functional MRI of Rat and Monkey Models of Absence Epilepsy: A Dissertation, Jeffrey R. Tenney

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Channel Specific Calcium Dynamics in PC12 Cells: A Dissertation, Keith Tully

Human PC4 Prevents Mutagenesis and Killing by Oxidative DNA Damage: a Dissertation, Jen-Yeu Wang

Organ-Dependent and Epitope-Dependent Repertoire Usage and Apoptosis of Antigen-Specific T Cells in Viral Infections: a Dissertation, Xiaoting Z. Wang

Analysis of Mitochondrial Remodeling in Adipocytes during Adipogenesis and Obesity Development: a Dissertation, Leanne Wilson-Fritch

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Chlamydomonas Reinhardtii ODA5 Encodes an Axonemal Protein Required for Assembly of the Outer Dynein Arm and an Associated Flagellar Adenylate Kinase: A Dissertation, Maureen Wirschell

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Association of Pericentrin with the γ Tubulin Ring Complex: a Dissertation, Wendy Cherie Zimmerman

Dissertations and Theses from 2003

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Actin Pedestal Formation on Mammalian Cells by Enteropathogenic Escherichia coli: A Dissertation, Kenneth Geno Campellone

DC3, a Calcium-Binding Protein Important for Assembly of the Chlamydomonas Outer Dynein Arm: a Dissertation, Diane M. Casey

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HIV-1 Gene Expression: Transcriptional Regulation and RNA Interference Studies: a Dissertation, Ya-Lin Chiu

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Essential Roles of the Meis Family Proteins During Segmentation of the Zebrafish Hindbrain : a Dissertation, Seong-Kyu Choe

Novel, Functional Interactions Between TrkA Kinase and p75 Neurotrophin Receptor in Neuroblastoma Cells: A Dissertation, Peter J. Condon

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Cholesterol and Phospholipid Modulation of BK[subscript Ca] Channel Activity and Ethanol Sensitivity: a dissertation, John J. Crowley

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Chondrocyte Adhesion to RGD-bonded Alginate: Effect on Mechanotransduction and Matrix Metabolism: a Dissertation, Nicholas G. Genes

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The Role of the SWI/SNF Component INI1 in Mammalian Development and Tumorigenesis: a Dissertation, Cynthia J. Guidi

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Intranuclear Trafficking of RUNX/AML/CBFA/PEBP2 Transcription Factors in Living Cells: A Dissertation, Kimberly Stacy Harrington

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The Molecular Mechanisms of T Cell Clonal Anergy: A Dissertation, John E. Harris

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Role of c-Jun NH-terminal Kinase in Bcr/Abl Induced Cell Transformation: a dissertation, Patricia M. Hess

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Mechanistic Analysis of Chromatin Remodeling Enzymes: a Dissertation, Mariela Jaskelioff

Design and Performance of a Localized Fiber Optic, Near-Infrared Spectroscopic Prototype Device for the Detection of the Metabolic Status of "Vulnerable Plaque": in-vitro Investigation of Human Carotid Plaque: a Dissertation, Tania N. Khan