Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Dissertations and Theses from 2004

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Regulation and Function of Runx2 During Chondrogenic and Osteogenic Differentiation: a Dissertation, Christopher J. Lengner

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The role of Janus Kinase 3 in CD4+ T Cell Homeostasis and Function: A Dissertation, Shane Renee Mayack

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Changes in Polymer, Scaffold, and IGF-I Delivery Methods Directly Affect Cartilage Tissue Development: A Dissertation, Nichole Renee Mercier

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Structural Basis for Rab5 Activation and Effector Specificity in Endosome Tethering: A Dissertation, Eric Lee Merithew

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Mechanisms of TAL1 Induced Leukemia in Mice: A Dissertation, Jennifer Elinor O'Neil

Convergent Biochemical and Biomechanical Pathways in Tissue Remodeling: The Role of α₂β₁ Integrin and MMP Activity: A Dissertation, Jonathan Adam Phillips

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Macrophages Directly Prime Naïve CD8+ T Cells: a Dissertation, Lu-Ann M. Pozzi

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EBV-Specific CD4+ T Cell Responses in Acute Infectious Mononucleosis: a Dissertation, Melissa Lynn Precopio

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Pathways Linking Deregulated Proliferation to Apoptosis: a Dissertation, Harry A. Rogoff

Signaling Events Leading to CPEB-Mediated Translation: a Dissertation, Madathia Sarkissian

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Functional and Structural Analysis of the Yeast SWI/SNF Complex: a Dissertation, Corey Lewis Smith

Mdm2 and Mdm4 Functions in Growth Control: a Dissertation, Heather Anne Steinman

Crystallographic Studies of Rrythrocruorin from Lumbricus Terrestris: a Dissertation, Kristen Strand-Tibbitts

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Functional MRI of Rat and Monkey Models of Absence Epilepsy: A Dissertation, Jeffrey R. Tenney

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Channel Specific Calcium Dynamics in PC12 Cells: A Dissertation, Keith Tully

Human PC4 Prevents Mutagenesis and Killing by Oxidative DNA Damage: a Dissertation, Jen-Yeu Wang

Organ-Dependent and Epitope-Dependent Repertoire Usage and Apoptosis of Antigen-Specific T Cells in Viral Infections: a Dissertation, Xiaoting Z. Wang

Analysis of Mitochondrial Remodeling in Adipocytes during Adipogenesis and Obesity Development: a Dissertation, Leanne Wilson-Fritch

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Chlamydomonas Reinhardtii ODA5 Encodes an Axonemal Protein Required for Assembly of the Outer Dynein Arm and an Associated Flagellar Adenylate Kinase: A Dissertation, Maureen Wirschell

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Association of Pericentrin with the γ Tubulin Ring Complex: a Dissertation, Wendy Cherie Zimmerman

Dissertations and Theses from 2003

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Actin Pedestal Formation on Mammalian Cells by Enteropathogenic Escherichia coli: A Dissertation, Kenneth Geno Campellone

DC3, a Calcium-Binding Protein Important for Assembly of the Chlamydomonas Outer Dynein Arm: a Dissertation, Diane M. Casey

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HIV-1 Gene Expression: Transcriptional Regulation and RNA Interference Studies: a Dissertation, Ya-Lin Chiu

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Essential Roles of the Meis Family Proteins During Segmentation of the Zebrafish Hindbrain : a Dissertation, Seong-Kyu Choe

Novel, Functional Interactions Between TrkA Kinase and p75 Neurotrophin Receptor in Neuroblastoma Cells: A Dissertation, Peter J. Condon

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Cholesterol and Phospholipid Modulation of BK[subscript Ca] Channel Activity and Ethanol Sensitivity: a dissertation, John J. Crowley

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Chondrocyte Adhesion to RGD-bonded Alginate: Effect on Mechanotransduction and Matrix Metabolism: a Dissertation, Nicholas G. Genes

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The Role of the SWI/SNF Component INI1 in Mammalian Development and Tumorigenesis: a Dissertation, Cynthia J. Guidi

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Intranuclear Trafficking of RUNX/AML/CBFA/PEBP2 Transcription Factors in Living Cells: A Dissertation, Kimberly Stacy Harrington

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The Molecular Mechanisms of T Cell Clonal Anergy: A Dissertation, John E. Harris

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Role of c-Jun NH-terminal Kinase in Bcr/Abl Induced Cell Transformation: a dissertation, Patricia M. Hess

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Mechanistic Analysis of Chromatin Remodeling Enzymes: a Dissertation, Mariela Jaskelioff

Design and Performance of a Localized Fiber Optic, Near-Infrared Spectroscopic Prototype Device for the Detection of the Metabolic Status of "Vulnerable Plaque": in-vitro Investigation of Human Carotid Plaque: a Dissertation, Tania N. Khan

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Involvement of CDP/Cux in the Regulation of Histone H4 Gene Expression, Proliferation and Differentiation: a Dissertation, Mai X. Luong

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The Function of the Tyrosine Kinase, Itk, in CD4+ T Cell Differentiation and Death: a Dissertation, Andrew Todd Miller

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Poly(ADP)-Ribose Polymerase Activity in the Eukaryotic Mono-ADP-Ribosyl Transferase, ART2: a Dissertation, Alan R. Morrison

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Mechanics of Fibroblast Migration: a Dissertation, Steven Munevar

Function of Cytoskeletal Proteins in GLUT4 Vesicle Transport in Adipocytes: Dissertation, Jin Gyoon Park

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The Genetic Basis of Resistance to Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation, Todd Pearson

Role of Intimin and Tir in Actin Signalling by Enterohemorrhagic and Enteropathogenic Escherichia coli: A Dissertation, Padhma Radhakrishnan

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Regulation of Zebrafish Hindbrain Development by Fibroblast Growth Factor and Retinoic Acid: A Dissertation, Nicole Marie Roy

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Function of the Zinc-Finger Repressor NLZ in the Developing Zebrafish Hindbrain: a Dissertation, Alexander Peter Runko

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T Cell Immunity and HIV-1 Replication in Vertically-Infected Infants and Children: A Dissertation, Zachary Aaron Scott

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CD40-CD154 Blockade Facilitates Induction of Allogeneic Hematopoietic Chimerism and Transplantation Tolerance: A Dissertation, Edward Seung

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MHC Class I Antigen Presentation is Regulated by the SUMO-Conjugating Enzyme UBC9: a Dissertation, Yuelei Shen

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Peptidyltransfer Reaction Catalyzed by the Ribosome and the Ribozyme: a Dissertation, Lele Sun

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Conserved Nucleosome Remodeling/Histone Deacetylase Complex and Germ/Soma Distinction in C. elegans: A Dissertation, Yingdee Unhavaithaya

Dissertations and Theses from 2002

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A Characterization of Substrates and Factors Involved in Yeast Nonsense-Mediated mRNA Decay: A Dissertation, Jonathan Philip Belk

The Role of Dbp2p in Both Nonsense-Mediated mRNA Decay and rRNA Processing: A Dissertation, Andrew Thomas Bond

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The Role of Human Cytomegalovirus Immediate Early Proteins in Cell Growth Control: A Dissertation, Jonathan Patrick Castillo

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Activation and Role of Memory CD8 T Cells in Heterologous Antiviral Immunity and Immunopathology in the Lung: A Dissertation, Hong Chen

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Viral Abrogation of Stem Cell Transplantation Tolerance Causes Graft Rejection and Host Death by Different Mechanisms: a Dissertation, Forman Daron

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Autoantibodies to Centrosomes are Diagnostic for Human Scleroderma and Can Be Induced by Experimental Mycoplasma Infection in Mice: A Dissertation, Irina Catrinel Gavanescu

Altering the Tropism of Retroviral Vectors For In Vivo Gene Therapy: Pseudotyped Virus Targeting by Ligand-Receptor Interactions: A Dissertation, Timothy J. Gollan

Coordinating Cytokinesis with Mitosis by a Conserved Signal Transduction Network in the Fission Yeast Schizosaccharomyces Pombe: a Dissertation, David A. Guertin

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Mechanisms Contributing to Transcriptional Regulation and Chromatin Remodeling of the Bone Specific Osteocalcin Gene, Soraya Elisa Gutierrez Gallegos

The Apoptotic Activity of c-Jun NH2-Terminal Kinase Signal Transduction: A Dissertation, Kui Lei

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The Human Rad52 Protein: a Correlation of Protein Function with Oligomeric state: a Dissertation, Janice A. Lloyd

Actin Reorganization in Drosophila Syncytial Blastoderm Embryos: a Dissertation, Victoria A. Stevenson,

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Roles of Lissencephaly Gene, LIS1, in Regulating Cytoplasmic Dynein Functions: a Dissertation, Chin-Yin Tai

Dissertations and Theses from 2001

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Snail Protein Family in Drosophila Neurogenesis: a Dissertation, Shovon I. Ashraf

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Modulation of N-type Calcium Channels in Rat Superior Cervical Ganglion Neurons: A Dissertation, Curtis F. Barrett

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Mechanisms of Establishment and Maintenance of RNA Virus Persistence in Primary Lymphocytes: a Dissertation, Mark S. Cabatingan

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Stress Activated Protein Kinase Regulation of Gene Expression in Apoptotic Neurons: A Dissertation, Gerard S. De Zutter

Mitotic Roles for Cytoplasmic Dynein and Implications for Brain Developmental Disease: a Dissertation, Nicole E. Faulkner

Visualization of Single RNA Transcripts in situ, Andrea M. Femino

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The Yeast SWI/SNF Complex Structure and Function: A Dissertation , Joan Frances Flanagan

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Analysis of RNA Interference in C. elegans: A Dissertation, Alla Grishok

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Ethanol Tolerance in the Rat Neurohypophysis: a Dissertation, Thomas K. Knott

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Estrogen and Antiestrogen Actions on Human Prostate Cancer: A Dissertation, Kin-Mang Lau

The Role of the Unconventional Myosin Motor Protein, Myosin 5a, in Thyroid Hormone Mediated Actin-Based Vesicle Trafficking: a Dissertaion, Stanley J. Stachelek

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Role of the Intestinal Immune System in the Pathogenesis of Autoimmune Diabetes in the BB Rat Model of Type 1 Diabetes Mellitus, Derrick James Todd

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Long-Lived Memory T Lymphocyte Responses Following Hantavirus Infection: a Dissertation, Heather Lin Van Epps

Members of the Meis/Prep Family Synergize: with Pbx4 and Hoxb1b in Prompting Hindbrain fates in the zebrafish, Nikolaos Vlachakis

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Regulation of Nuclear Hormone Receptors by Corepressors and Coactivators: a Dissertation, Xiaoyang Wu

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Oligomerization and Endocytosis of the α-Factor Receptor: A Dissertation, Ayce Yesilaltay

Dissertations and Theses from 2000

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Conserved Features of Chromatin Remodeling Enzymes: A Dissertation, Laurie A. Boyer

DNA Immunization: Basic Mechanisms of the DNA-Raised Antibody Response Using an Influenza Hemagglutinin-Expressing Plasmid: A Dissertation, Christine Margaret Boyle

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Allosteric Regulation of Recombination Enzymes E. coli RecA and Human Rad51: A Dissertation, Julie Kelley De Zutter

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CIS/SOCS Proteins in Growth Hormone Action: A Dissertation, Ling Du

The Functional Roles of the Human Immunodeficiency Virus Type-1 Matrix Protein during Viral Life Cycle: A Dissertation, Stefan A. Dupont

Characterization of Intrahepatic T-lymphocytes in Patients with Chronic Hepatitis C Virus Infection: a Dissertation, Vicki M. Giuggio

Induction and Maintenance of Transplantation Tolerance by Treatment with a Donor Specific Transfusion and Anti-CD154 mAb: a Dissertation, Neal N. Iwakoshi

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Differential Mechanisms of Nuclear Receptor Regulation by the Coactivator RAC3: A Dissertation, Christopher Leo

Intimin-Tir Interaction in Enterohemorrhagic E. coli: A Dissertation, Hui Liu

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Mutational Analysis of the MutH from Escherichia Coli: a Dissertation, Tamalette Loh

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In Vitro and in vivo Studies of Murine Polytropic Retrovirus Infections: a Dissertation, Scott A. Loiler

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A Study on the Cellular Localization of Factors Involved in Yeast Nonsense-Mediated mRNA Decay and their Mechanisms of Control on Nonsense mRNA Translation: a Dissertation, Alan Baer Maderazo

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Characterization of Immune Responses Following Neonatal DNA Immunization: A Dissertation, Tamera Marie Pertmer

Interaction Between Ribosome-Nascent Chain and sec61 Complexes and Their Role in the Translocation of Proteins Across the Endoplasmic Reticulum Membrane: a Thesis, David Raden

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The Regulation of nNOS During Neuronal Differentiation and the Effect of Nitric Oxide on Hdm2-p53 Binding: a Dissertation, Christopher M. Schonhoff

Regulation of Immunoglobulin Germline ε Transcripts by IL-4, CD40 Ligand and Lipopolysaccharide via Stat6, AP-1 and NF-кB Transcription Factors: A Dissertation, Ching-Hung Shen

Regulation of the Transfer of the Ribosome-Nascent Chain Complex from the Signal Recognition Particle to the Translocation Channel: a Thesis, Weiqun Song

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Sequences Required for Neurotensin Receptor-1 Gene Expression in N1E-115 Neurosblastoma Cells: Critical Importance of a CACCC Element for Activation During DMSO-Induced Neuronal Differentiation: a Dissertation, Daniel Jorge Tavares

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The Role of the Light Intermediate Chains in Cytoplasmic Dynein Function: a Dissertation, Sharon H. Tynan

Human Lymphocyte Engraftment and Function in HU-PBL-SCID Mice: a Dissertation, Eric James Wagar

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The Role of MKK3 in Mediating Signals to the p38 MAP Kinase Pathway: A Dissertation, Mark Allen Wysk

Structural and Mutational Analysis of Rab2A Activation by Mss4: A Dissertation, Zhongyuan Zhu

Dissertations and Theses from 1999

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Structural and Signaling Proteins at the Synapse: Dystroglycan & Insulin Receptor Tyrosine Kinase Substrate p58/53: a Dissertation, Mary-Alice Abbott

Pericentrin and Gamma Tubulin Form a Novel Lattice and a Protein Complex that is an Essential Unit of Centrosome Assembly: a Dissertation, Jason B. Dictenberg