Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Dissertations and Theses from 2010

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Mitochondrial Dysfunction and AKT Isoform-Specific Regulation in 3T3-L1 Adipocytes: A Dissertation, Xiarong Shi

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Pathogenesis of the Helicobacter Induced Mucosal Disease: A Dissertation, Calin Stoicov

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Endocytosis, Phagocytosis, and Innate Immune Responses: A Dissertation, Christine A. St. Pierre

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A Tale of Two ARFs: Tumor Suppressor and Anti-viral Functions of p14ARF: A Dissertation, Michael W. Straza

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Antibody Responses Elicited by DNA Prime-Protein Boost HIV Vaccines: A Dissertation, Michael Vaine

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Roles of Cellular RNA-Dependent RNA Polymerases in Endogenous Small RNA Pathways in Caenorhabditis elegans: A Dissertation, Jessica J. Vasale

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Magnetic Resonance Imaging of Neural and Pulmonary Vascular Function: A Dissertation, Ronn P. Walvick

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Factors Associated with Subjective Improvement Following Midurethral Sling Procedures for Stress Urinary Incontinence: A Masters Thesis, Emily Elise Weber Lebrun

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The Role of Rip2 Protein in the Nod Mediated Innate Immune Response: A Dissertation, Yibin Yang

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Identification and Characterization of SNAPIN as a Novel Antagonist of HIV-1 Egress: A Dissertation, Patrick Younan

Dissertations and Theses from 2009

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Endoderm Patterning in Zebrafish: Pancreas Development: A Dissertation, Kristen M. Alexa

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Elucidation of the Role of the Exocyst Subunit Sec6p in Exocytosis: A Dissertation, Daniel Niron Brewer

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Injection Treatment for Lower Back Pain in Older Adults with Lumbar Spinal Stenosis: A Dissertation, Virginia G. Briggs

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Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation, Yufeng Cai

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Functional Analysis of Yeast Pheromone Receptors in ER Exit, Ligand-Induced Endocytosis and Oligomerization: A Dissertation, Chien-I Chang

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Regulation of the Cdc14-like Phosphatase CLP1 in Schizosaccharomyces pombe and Identification of SID2 Kinase Substrates: A Dissertation, Chun-Ti Chen

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Defining the Importance of Fatty Acid Metabolism in Maintaining Adipocyte Function: A Dissertation, Jennifer L. Christianson

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Role of Supervillin, a Membrane Raft Protein, in Cytoskeletal Organization and Invadopodia Function, Jessica Lynn Crowley

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Mechanisms of NOTCH1 Mediated Leukemogenesis: A Dissertation, Kathleen J. Cullion

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Neural Circuit Analyses of the Olfactory System in Drosophila: Input to Output: A Dissertation, Shamik DasGupta

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Role of WFS1 in Regulating Endoplasmic Reticulum Stress Signaling: A Dissertation, Sonya G. Fonseca

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Pathophysiology of Respiratory Failure Following Acute Organophosphate Poisoning : A Dissertation, Romolo Joseph Gaspari

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A Multiparameter Network Reveals Extensive Divergence Between C. elegans bHLH Transcription Factors: A Dissertation, Christian A. Grove

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Regulation of Cancer Cell Survival Mediated by Endogenous Tumor Suppression: A Dissertation, Minakshi Guha

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Multifaceted Regulation of Peripheral T Cell Tolerance and Autoimmunity by FOXP3+ T Regulatory Cells: A Dissertation, Nitya Jain

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Chromatin Remodeling in Transgenic Mouse Brain: Implications for the Neurobiology of Depression: A Dissertation, Yan Jiang

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Characterization of the Nef-TCR Zeta Interaction and Its Role in Modulation of Src Family Kinase Activity: A Dissertation, Walter Minsub Kim

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Co-evolution of HIV-1 Protease and its Substrates: A Dissertation, Madhavi Kolli

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The Role of Macropinocytosis in Sonic Hedgehog-Induced Axon Growth and Guidance: A Dissertation, Adrianne L. Kolpak

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Regulation of DNA Replication Origins in Fission Yeast: A Dissertation, Naveen Kommajosyula

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Defining the Role of CtBP2 in p53-Independent Tumor Suppressor Function of ARF: A Dissertation, Ramesh C. Kovi

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Systems Level Processing of Memory in the Fly Brain: A Dissertation, Michael Jonathan Krashes

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Prediction, Prevention and Treatment of Virally Induced Type 1 Diabetes: A Dissertation, Annie J. Kruger

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Sensitization of CD8 T Cells During Acute Viral Infections Impacts Bystander and Latecomer CD8 T Cell Responses : A Dissertation, Heather D. Marshall

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Delineating the C. elegans MicroRNA Regulatory Network: A Dissertation, Natalia Julia Martinez

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IAP Regulation of Tumor Metastasis: A Dissertation, Swarna Mehrotra

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Functional Interaction of BPV-1 E2 with the Papillomavirus Genome: A Dissertation, Suzanne Marie Melanson

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Differentially Expressed MicroRNAs Act As Inhibitors of BDNF in Prefrontal Cortex - Implications for Schizophrenia: A Dissertation, Nikolaos Mellios

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Analysis of Long-Range Chromosomal Interactions in Saccharomyces cerevisiae: A Dissertation, Adriana Miele

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Functional Analysis of MicroRNA-10b in Breast Carcinoma: A Dissertation, Charlotte M. Harwood Moriarty

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Respiratory Syncytial Virus (RSV) Induces Innate Immunity through Toll-Like Receptors and Acquired Immunity via the RSV G Protein: A Dissertation, Matthew R. Murawski

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Hypoxia Inducible Factors in Alcoholic Liver Disease: A Dissertation, Bharath D. Nath

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An Omega-Based Bacterial One-Hybrid System for the Determination of Transcription Factor Specificity, Marcus Blaine Noyes

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Nuclear Dynamics of a Broken Chromosome: A Dissertation, Pranav O. Oza

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Worming to Complete the Insulin/IGF-1 Signaling Cascade: A Dissertation, Srivatsan Padmanabhan

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Caspase Mediated Cleavage, IAP Binding, Ubiquitination and Kinase Activation : Defining the Molecular Mechanisms Required for Drosophila NF-кB Signaling: A Dissertation, Nicholas Paul Paquette

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Evasion of LPS-TLR4 Signaling as a Virulence Determinate for Yersinia pestis, Sara Montminy Paquette

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The Role of the MRN Complex in the S-Phase DNA Damage Checkpoint: A Dissertation, Mary Elizabeth Porter-Goff

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Cytoskeletal Regulation and Morphogen Signaling During Synaptic Outgrowth at the Drosophila Larval Neuromuscular Junction : A Dissertation, Preethi Ramachandran

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Recombinational Repair of a Chromosomal DNA Double Strand Break: A Dissertation, Manisha Sinha

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Functional Elements of EspFu, an Enterohemorrhagic E. coli Effector that Stimulates Actin Assembly: A Dissertation, Brian M. Skehan

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Modeling Co-Occurring Depression and Anxiety in Patients with an Acute Coronary Syndrome: A Dissertation, Mayra Tisminetzky

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Checkpoint Regulation of Replication Forks in Response to DNA Damage: A Dissertation, Nicholas Adrian Willis

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Regulation of BACH1/FANCJ Function in DNA Damage Repair: A Dissertation, Jenny X. Xie

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Long-Range Side Chain-Main Chain Hydrogen Bonds: A Molecular Signature of the TIM Barrel Architecture: A Dissertation, Xiaoyan Yang

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The Circadian Clock in Monarch Butterfly: A Tale of Two CRYs: A Dissertation, Quan Yuan

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Study of the Function and Dynamics of Myosin II and Actin in Cytokinesis: A Dissertation, Mian Zhou

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Identification of the Function of the Vpx Protein of Primate Lentiviruses: A Dissertation, Xiaonan Zhu

Dissertations and Theses from 2008

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Newcastle Disease Virus Virulence: Mechanism of the Interferon Antagonistic Activity of the V Protein and Characterization of a Putative Virulence-Specific Antibody to the Attachment Protein: a dissertation, Judith G. Alamares

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The Molecular Mechanisms of Activity-Dependent Wingless (Wg)/Wnt Signaling at a Drosophila Glutamatergic Synapse: a Dissertation, Bulent Ataman

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Attrition of CD8 T Cells during the Early Stages of Viral Infections: a Dissertation, Kapil Bahl

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Cross-Reactive Memory CD4+ and CD8+ T Cells Alter the Immune Response to Heterologous Secondary Dengue Virus Infections in Mice: A Dissertation, Coreen Michele Beaumier

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Magnetic Resonance Imaging of the Rat Retina: a Dissertation, Govind Bhagavatheeshwaran

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Toll-Like Receptors: Target of Hepatitis C Virus: A Dissertation, Serena Soyoung Yunmee Chang

Molecular Mechanism of RNA-Mediated Gene Silencing in Human Cells: A Dissertation, Chia-Ying Chu

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Functional Analysis of Ing1 and Ing4 in Cell Growth and Tumorigenesis: a Dissertation, Andrew H. Coles

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Analysis of Protein Arginine Methyltransferase Function during Myogenic Gene Transcription: A Dissertation, Caroline S. Dacwag

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Bone Health and Coronary Heart Disease in Postmenopausal Women with Breast Cancer Treated with Tamoxifen: A Dissertation, Hongliu Ding

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Dissecting Small RNA Loading Pathway in Drosophila melanogaster: A Dissertation, Tingting Du

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Checkpoint Regulation of S-Phase Transcription: A Dissertation, Chaitali Dutta

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Regulation of the NF-кB Precursor relish by the Drosophila I-кB Kinase Complex: A Dissertation, Deniz Erturk Hasdemir

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The Role of TEC Family Kinases in Innate T Cell Development and Function: a Dissertation, Martin Felices

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Roles for Histones H4 Serine 1 Phosphorylation in DNA Double Strand Break Repair and Chromatin Compaction: A Dissertation, Melissa Anne Foley

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Development of a Substrate with Photo-Modulatable Rigidity for Probing Spatial and Temporal Responses of Cells to Mechanical Signals: A Dissertation, Margo Tilley Frey

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VPS45p as a Model System for Elucidation of SEC1/MUNC18 Protein Function: A Dissertation, Melonnie Lynn Marie Furgason

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Structural and Functional Studies of the KCNQ1-KCNE K+ Channel Complex: A Dissertation, Steven D. Gage

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Adipocyte Insulin-Mediated Glucose Transport: The Role of Myosin 1c, and a Method for in vivo Investigation: A Dissertation, G. Nana Hagan

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Regulation of Reactive Nitrogen Species (RNS) Metabolism and Resistance Mechanisms in Haemophilus influenzae: A Dissertation, Jane Colleen Harrington

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Small RNA Sorting in Drosophila Produces Chemically Distinct Functional RNA-Protein Complexes: A Dissertation, Michael D. Horwich

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Epigenetic Determinants of Altered Gene Expression in Schizophrenia: a Dissertation, Hsien-Sung Huang

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Role of Disulfide Bond Rearrangement in Newcastle Disease Virus Entry: A Dissertation, Surbhi Jain

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CD4 T Cell-Mediated Lysis and Polyclonal Activation of B Cells During Lymphocytic Choriomeningitis Virus Infection: A Dissertation, Evan Robert Jellison

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Analysis of CPEB Family Protein Member CPEB4 Function in Mammalian Neurons: A Dissertation, Ming-Chung Kan

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A Study of Cell Polarity and Fate Specification in Early C. Elegans Embryos: A Dissertation, Soyoung Kim

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The Humanized Mouse Model: The Study of the Human Alloimmune Response: A Dissertation, Marie A. King

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piRNA Function and Biogenesis in the Drosophila Female Germline: A Dissertation, Carla Andrea Klattenhoff

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Chromatin Remodeling and Transcriptional Memory: A Dissertation, Sharmistha Kundu

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Mitotic Response to DNA Damage in Early Drosophila Embroyos: a Dissertation, Seongae Kwak

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Role of Host Cellular Membrane Raft Domains in the Assembly and Release of Newcastle Disease Virus: A Dissertation, Jason P. Laliberte

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Notch-1 and IGF-1 as Survivin Regulatory Pathways in Cancer: A Dissertation, Connie Wing-Ching Lee

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The Role of Endoplasmic Reticulum Stress Signaling in Pancreatic Beta Cells: a Dissertation, Kathryn L. Lipson

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Molecular Mechanisms of Neuropeptide Secretion from Neurohypophysial Terminals: a Dissertation, James M. McNally

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DNA Damage-Induced Apoptosis in the Presence and Absence of the Tumor Suppressor p53: A Dissertation, Laura Michelle McNamee

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TLR Activation Prevents Hematopoietic Chimerism Induced by Costimulation Blockade: A Dissertation, David M. Miller

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Modulation of Voltage-Gated N-Type Calcium Channels by G Protein-Coupled Receptors Involves Lipids and Proteins: A Dissertation, Tora Mitra Ganguli

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Chemical-Biological Investigation of KCNQ1/KCNE K+ Channel Complexes: A Dissertation, Trevor J. Morin

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Role of TNF in Heterologous Immunity between Lymphocytic Choriomeningitis Virus and Vaccinia Virus: A Dissertation, Siwei Nie

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Role of Endoplasmic Reticulum Stress Response Signaling in T Cells: A Dissertation, Steven C. Pino

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Mutations in the vpu and env Genes of HIV-1 Can Adversely Impact Infectivity: A Dissertation, Kathryn H. Richards

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GLUT1 Structure Function; Context, Ligand Cooperativity, and Mutagenesis Studies: A Dissertation, Trista K. Robichaud