Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

Read the UMassMedNow feature about the ceremony honoring 44 newly qualified GSBS PhD candidates!

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Dissertations and Theses from 2009

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Recombinational Repair of a Chromosomal DNA Double Strand Break: A Dissertation, Manisha Sinha

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Functional Elements of EspFu, an Enterohemorrhagic E. coli Effector that Stimulates Actin Assembly: A Dissertation, Brian M. Skehan

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Modeling Co-Occurring Depression and Anxiety in Patients with an Acute Coronary Syndrome: A Dissertation, Mayra Tisminetzky

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Checkpoint Regulation of Replication Forks in Response to DNA Damage: A Dissertation, Nicholas Adrian Willis

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Regulation of BACH1/FANCJ Function in DNA Damage Repair: A Dissertation, Jenny X. Xie

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Long-Range Side Chain-Main Chain Hydrogen Bonds: A Molecular Signature of the TIM Barrel Architecture: A Dissertation, Xiaoyan Yang

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The Circadian Clock in Monarch Butterfly: A Tale of Two CRYs: A Dissertation, Quan Yuan

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Study of the Function and Dynamics of Myosin II and Actin in Cytokinesis: A Dissertation, Mian Zhou

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Identification of the Function of the Vpx Protein of Primate Lentiviruses: A Dissertation, Xiaonan Zhu

Dissertations and Theses from 2008

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Newcastle Disease Virus Virulence: Mechanism of the Interferon Antagonistic Activity of the V Protein and Characterization of a Putative Virulence-Specific Antibody to the Attachment Protein: a dissertation, Judith G. Alamares

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The Molecular Mechanisms of Activity-Dependent Wingless (Wg)/Wnt Signaling at a Drosophila Glutamatergic Synapse: a Dissertation, Bulent Ataman

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Attrition of CD8 T Cells during the Early Stages of Viral Infections: a Dissertation, Kapil Bahl

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Cross-Reactive Memory CD4+ and CD8+ T Cells Alter the Immune Response to Heterologous Secondary Dengue Virus Infections in Mice: A Dissertation, Coreen Michele Beaumier

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Magnetic Resonance Imaging of the Rat Retina: a Dissertation, Govind Bhagavatheeshwaran

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Toll-Like Receptors: Target of Hepatitis C Virus: A Dissertation, Serena Soyoung Yunmee Chang

Molecular Mechanism of RNA-Mediated Gene Silencing in Human Cells: A Dissertation, Chia-Ying Chu

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Functional Analysis of Ing1 and Ing4 in Cell Growth and Tumorigenesis: a Dissertation, Andrew H. Coles

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Analysis of Protein Arginine Methyltransferase Function during Myogenic Gene Transcription: A Dissertation, Caroline S. Dacwag

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Bone Health and Coronary Heart Disease in Postmenopausal Women with Breast Cancer Treated with Tamoxifen: A Dissertation, Hongliu Ding

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Dissecting Small RNA Loading Pathway in Drosophila melanogaster: A Dissertation, Tingting Du

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Checkpoint Regulation of S-Phase Transcription: A Dissertation, Chaitali Dutta

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Regulation of the NF-кB Precursor relish by the Drosophila I-кB Kinase Complex: A Dissertation, Deniz Erturk Hasdemir

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The Role of TEC Family Kinases in Innate T Cell Development and Function: a Dissertation, Martin Felices

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Roles for Histones H4 Serine 1 Phosphorylation in DNA Double Strand Break Repair and Chromatin Compaction: A Dissertation, Melissa Anne Foley

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Development of a Substrate with Photo-Modulatable Rigidity for Probing Spatial and Temporal Responses of Cells to Mechanical Signals: A Dissertation, Margo Tilley Frey

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VPS45p as a Model System for Elucidation of SEC1/MUNC18 Protein Function: A Dissertation, Melonnie Lynn Marie Furgason

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Structural and Functional Studies of the KCNQ1-KCNE K+ Channel Complex: A Dissertation, Steven D. Gage

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Adipocyte Insulin-Mediated Glucose Transport: The Role of Myosin 1c, and a Method for in vivo Investigation: A Dissertation, G. Nana Hagan

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Regulation of Reactive Nitrogen Species (RNS) Metabolism and Resistance Mechanisms in Haemophilus influenzae: A Dissertation, Jane Colleen Harrington

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Small RNA Sorting in Drosophila Produces Chemically Distinct Functional RNA-Protein Complexes: A Dissertation, Michael D. Horwich

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Epigenetic Determinants of Altered Gene Expression in Schizophrenia: a Dissertation, Hsien-Sung Huang

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Role of Disulfide Bond Rearrangement in Newcastle Disease Virus Entry: A Dissertation, Surbhi Jain

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CD4 T Cell-Mediated Lysis and Polyclonal Activation of B Cells During Lymphocytic Choriomeningitis Virus Infection: A Dissertation, Evan Robert Jellison

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Analysis of CPEB Family Protein Member CPEB4 Function in Mammalian Neurons: A Dissertation, Ming-Chung Kan

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A Study of Cell Polarity and Fate Specification in Early C. Elegans Embryos: A Dissertation, Soyoung Kim

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The Humanized Mouse Model: The Study of the Human Alloimmune Response: A Dissertation, Marie A. King

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piRNA Function and Biogenesis in the Drosophila Female Germline: A Dissertation, Carla Andrea Klattenhoff

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Chromatin Remodeling and Transcriptional Memory: A Dissertation, Sharmistha Kundu

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Mitotic Response to DNA Damage in Early Drosophila Embroyos: a Dissertation, Seongae Kwak

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Role of Host Cellular Membrane Raft Domains in the Assembly and Release of Newcastle Disease Virus: A Dissertation, Jason P. Laliberte

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Notch-1 and IGF-1 as Survivin Regulatory Pathways in Cancer: A Dissertation, Connie Wing-Ching Lee

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The Role of Endoplasmic Reticulum Stress Signaling in Pancreatic Beta Cells: a Dissertation, Kathryn L. Lipson

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Molecular Mechanisms of Neuropeptide Secretion from Neurohypophysial Terminals: a Dissertation, James M. McNally

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DNA Damage-Induced Apoptosis in the Presence and Absence of the Tumor Suppressor p53: A Dissertation, Laura Michelle McNamee

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TLR Activation Prevents Hematopoietic Chimerism Induced by Costimulation Blockade: A Dissertation, David M. Miller

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Modulation of Voltage-Gated N-Type Calcium Channels by G Protein-Coupled Receptors Involves Lipids and Proteins: A Dissertation, Tora Mitra Ganguli

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Chemical-Biological Investigation of KCNQ1/KCNE K+ Channel Complexes: A Dissertation, Trevor J. Morin

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Role of TNF in Heterologous Immunity between Lymphocytic Choriomeningitis Virus and Vaccinia Virus: A Dissertation, Siwei Nie

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Role of Endoplasmic Reticulum Stress Response Signaling in T Cells: A Dissertation, Steven C. Pino

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Mutations in the vpu and env Genes of HIV-1 Can Adversely Impact Infectivity: A Dissertation, Kathryn H. Richards

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GLUT1 Structure Function; Context, Ligand Cooperativity, and Mutagenesis Studies: A Dissertation, Trista K. Robichaud

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Effect of KCNE1 and KCNE3 Accessory Subunits on KCNQ1 Potassium Channel Function: A Dissertation, Jessica Marie Rocheleau

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The Role of Janus-Kinase-3 in CD4+ T Cell Proliferation and Differentiation: A Dissertation, Min Shi

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Plasma Membrane Localization of Signaling Proteins in Yeast: a Dissertation, Satoe Takahashi

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Role of MAP4K4 Signaling in Adipocyte and Macrophage Derived Inflammation: A Dissertation, Gregory J. Tesz

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Modulation of Neuropeptide Release via Voltage-Dependent and -Independent Signaling in Isolated Neurohypophysial Terminals: a Dissertation, Cristina M. Velazquez-Marrero

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Molecular Dissection of the Cellular Reponse to Dengue Virus Infection, Rajas V. Warke

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Ethanol Sensitivity and Tolerance of Rat Neuronal BK Channels: A Dissertation, Patricia M. Wynne

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The Molecular Mechanisms Underlying the Polarized Distribution of Drosophila Dscam in Neurons: A Dissertation, Shun-Jen Yang

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Myocardial Macrophage Phenotypic Variation and Cytokine-Mediated Induction of HIV-Associated Cardiac Disease: A Dissertation, Jennifer Holmes Yearley

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Innate Immunity in Type 2 Diabetes Pathogenesis: Role of the Lipopolysaccharide Signaling Cascade: A Dissertation, James L. Young

Dissertations and Theses from 2007

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Probing the Structural Topology of HIV-1 Virion Infectivity Factor (VIF): A Dissertation, Jared R. Auclair

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A Genetic Analysis of Genomic Stability in Caenorhabditis Elegans: A Dissertation, Melissa M. Auclair

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Human Erythrocyte Glucose Transporter (GLUT1) Structure, Function, and Regulation: A Dissertation, David M. Blodgett

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Mechanism and Function of Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7: A Dissertation, Michael John Brady

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Molecular and Behavioral Analysis of Drosophila Circadian Photoreception and Circadian Thermoreception: A Dissertation, Ania Busza

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Role of Notch1 in Cardiac Cell Differentiation and Migration: A Dissertation, Dinh Le Mary Chau

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Collagen and Fibrin Bioplymer Microthreads for Bioengineered Ligament Generation: a Dissertation, Kevin Cornwell

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Transcript-Specific Cytoplasmic Degradation of YRA1 Pre-mRNA Mediated by the Yeast EDC3 Protein: A Dissertation, Shuyun Dong

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Folding and Assembly of Multimeric Proteins: Dimeric HIV-1 Protease and a Trimeric Coiled Coil Component of a Complex Hemoglobin Scaffold: A Dissertation, Amanda Ann Fitzgerald

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Cooperative Oncogenesis and Polyploidization in Human Cancers: A Dissertation, Susan Ann Heilman

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The Role of CD40 in Naïve and Memory CD8+ T Cell Responses: a Dissertation, Maria Genevieve H. Hernandez

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Motor Property of Mammalian Myosin 10: A Dissertation, Kazuaki Homma

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Cartilage tissue engineering: uses of injection molding and computer aided design for the fabrication of complex geometries with high dimensional tolerances: a dissertation, Morgan E. Hott

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Identification and Characterization of Components of the Intraflagellar transport (IFT) Machinery: a Dissertation, Yuqing Hou

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Transfer of the Ribosome-Nascent Chain Complex to the Translocon in Cotranslational Translocation: A Thesis, Ying Jiang

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Neural Diversity in the Drosophila Olfactory Circuitry: A Dissertation, Sen-Lin Lai

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Autoimmune Diabetes and Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation, Julie Lambert

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How Does ATP Regulate Erythrocyte Glucose Transport?: a Dissertation, Jeffry M. Leitch

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Characterization of the BACH1 Helicase in the DNA Damage Response Pathway: a Dissertation, Rachel Litman

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Identification and Characterization of Agv1, a Pre-Metazoan Arf GAP: A Dissertation, Kimberly Renee Long

The Role of CHD2 in Mammalian Development and Disease: a Dissertation, Concetta G. A. Marfella

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Understanding Assembly of AGO2 RISC: the RNAi enzyme: a Dissertation, Christian B. Matranga

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Molecular and Neuronal Analysis of Circadian Photoresponses in Drosophila: A Dissertation, Alejandro D. Murad

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Distinct Behaviors of Infected and Bystander Dendritic Cells Following Exposure to Dengue Virus: A Dissertation, Zachary Davis Nightingale

Maintenance of Constitutive and Inactive X Heterochromatin in Cancer and a Link to BRCA1: A Dissertation, Gayle Jeannette Pageau

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Surface of Yersinia pestis: LCRV, F1 Production, Invasion and Oxygen: A Dissertation, Kimberly Lea Pouliot

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Modulation of Cav1.3 L-Type Calcium Channels by Arachidonic Acid and Muscarinic M1 Receptors: A Dissertation, Mandy L. Roberts-Crowley

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Rethinking Mechanisms of Actin Pedestal Formation by Enteropathogenic Escherichia Coli in the Context of Multiple Signaling Cascades: a Dissertation, Pamela Joyce Savage

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A Role for Histone Modification in the Mechanism of Action of Antidepressant and Stimulant Drugs: a Dissertation, Frederick Albert Schroeder

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Interaction of a Mammalian Virus with Host RNA Silencing Pathways: A Dissertation, Bradford Michael Stadler

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Regulation of Cell Polarization and Map Kinase Signaling in the Saccharomyces Cerevisiae Pheromone Response Pathway: a Dissertation, Shelly Catherine Strickfaden

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Functional and Structural Dissection of the SWI/SNF Chromatin Remodeling Complex: A Dissertation, Xiaofang Yang

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The Argonaute Family of Genes in Caenorhabditis Elegans: a Dissertation, Erbay Yigit

Dissertations and Theses from 2006

The Role of Cell Adhesion, the Cytoskeleton, and Membrane Trafficking: a Dissertation, James A. Ashley

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Serotype Cross-Reactive CD8+ T Cell Response to Heterologous Secondary Dengue Virus Infections in Humans: a Dissertation, Hema Sundara Bashyam

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Human Rad51: Regulation of Cellular Localization and Function in Response to DNA Damage: A Dissertation, Brian Thomas Bennett

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Identification of Novel (RNAi Deficient) Genes in C. elegans: A Dissertation, Chun-Chieh G. Chen

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Posttargeting Events in Cotranslational Translocation Through the Sec61 Complex: a Thesis, Zhiliang Cheng

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Characterization of the Relationship Between Measles Virus Fusion, Receptor Binding, and the Virus-Specific Interaction Between the Hemagglutinin and Fusion Glycoproteins: a Dissertation, Elizabeth Ann Corey