Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

Read the UMassMedNow feature about the ceremony honoring 44 newly qualified GSBS PhD candidates!

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Dissertations and Theses from 2010

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Development and Evaluation of Disease Activity Measures in Rheumatoid Arthritis Using Multi-Level Mixed Modeling and Other Statistical Methodologies: A Dissertation, Mary Jane Bentley

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Energy Metabolism and the Induction of the Unfolded Protein Response: A Dissertation, Alison M. Burkart

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Post-Transcriptional Control of Human Cellular Senescence: A Dissertation, David M. Burns

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Role of the cJun NH2-Terminal Kinase (JNK) in Cancer: A Dissertation, Cristina Arrigo Cellurale

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Glycosylation, Assembly and Trafficking of Cardiac Potassium Channel Complexes: A Dissertation, Kshama D. Chandrasekhar

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Regulation of Immune Pathogenesis by Antigen-Specific CD8 T Cells Following Sequential Heterologous Infections: A Dissertation, Alex T. Chen

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Generating Nucleosomal Asymmetry in Saccharomyces cerevisiae: A Masters Thesis, Yuanyuan Chen

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The Role of Dynamic Cdk1 Phosphorylation in Chromosome Segregation in Schizosaccharomyces pombe: A Dissertation, Sung Hugh Choi

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Mechanical Flow Restoration in Acute Ischemic Stroke: A Model System of Cerebrovascular Occlusion: A Dissertation, Juyu Chueh

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Development of a Multi-Site Phase II Clinical Trial of Valproic Acid for Retinitis Pigmentosa, Christine Moulton Clemson

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Acute Modulation of Endothelial Cell Glucose Transport: A Dissertation, Anthony J. Cura

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A Novel Motif in HIV-1 Nef that Regulates MIP-1β Chemokine Release in Macrophages: A Dissertation, Lue Dai

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An Integral Role of ARRDC3 in Stem Cell Migration and Breast Cancer Progression: A Dissertation, Kyle M. Draheim

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Novel Complement Blocking Antibodies Against Serogroup B N. meningitidis: A Dissertation, Tathagat Dutta Ray

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CD8+ T Cell Serotype-Cross-Reactivity is a Predominant Feature of Dengue Virus Infections in Humans: A Dissertation, Heather L. Friberg-Robertson

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Endogenous Small RNAs in the Drosophila Soma: A Dissertation, Megha Ghildiyal

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Transcriptional Regulation of VEGFA by Unfolded Protein Response Signaling Pathway, Rajarshi Ghosh

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Cross-Talk Between Factors Involved in mRNA Translation and Decay: A Dissertation, Shubhendu Ghosh

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A Glia-Mediated Feedback Mechanism for the Termination of Drosophila Visual Response: A Dissertation, Peiyi Guo

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Role of the Monocyte/Macrophage Cell Lineage in Obesity-Related Insulin Resistance, Olga T. Hardy

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Maternally Derived Anti-Dengue Antibodies and Risk of DHF in Infants: A Case-Control Study, Steven Hatch

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Role of CPEB in Senescence and Inflammation: A Dissertation, Maria Ivshina

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Dissecting the Role of Innate Pattern Recognition Receptors and Interferon Regulatory Factor-5 in the Immune Response to Human Metapneumovirus and other Pathogens: A Dissertation, Zhaozhao Jiang

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Sequence Determinants of the Folding Free-Energy Landscape of beta alpha-Repeat Proteins: A Dissertation, Sagar V. Kathuria

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The Coupling Between Folding, Zinc Binding, and Disulfide Bond Status of Human Cu, Zn Superoxide Dismutase: A Dissertation, Can Kayatekin

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Drosophila piRNA Function in Genome Maintenance, Telomere Protection and Genome Evolution: A Dissertation, Jaspreet S. Khurana

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Role of Internal Calcium Stores in Exocytosis and Neurotransmission: A Dissertation, Jason J. Lefkowitz

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Behavioral Health Disorders and the Quality of Diabetes Care: A Dissertation, Yat (Gary) Hung Leung

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Regulation of WRN Function by Acetylation and SIRT1-Mediated Deacetylation in Response to DNA Damage: A Dissertation, Kai Li

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Clinical Course of Bipolar Disorder During the Menopausal Transition: Comparison with Reproductive Age and Post Menopausal Women: A Master's Thesis, Wendy K. Marsh

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T Cells Aid in Limiting Pathogen Burden and in Enhancing B1 and B2 Cell Antibody Responses to Membrane Glycolipid and the Surface Lipoprotein Decorin-Binding Protein A during Borrelia burgdorferi Infection: A Dissertation, Robyn Lynn Marty-Roix

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Clinically Relevant Doses of Chemotherapy Drugs Selectively and Reversibly Block Glioblastoma Neurosphere Proliferation in vitro: A Dissertation, Alicia M. Mihaliak

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Converging Pathways in the Regulation of Longevity and Metabolism in Caenorhabditis Elegans: A Dissertation, Sri Devi Narasimhan

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Age and Sex Differences in Duration of Pre-Hospital Delay, Hospital Treatment Practices, and Short-Term Outcomes in Patients Hospitalized with an Acute Coronary Syndrome/Acute Myocardial Infarction: A Dissertation, Hoa L. Nguyen

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Structural and Functional Studies of Proteins Involved in Antigen Processing: A Dissertation, Tina T. Nguyen

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Maintenance of Visual Sensitivity in the Drosophila Eye: A Dissertation, Lina Ni

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Regulation of Cellular and HIV-1 Gene Expression by Positive Transcription Elongation Factor B: A Dissertation, Siobhan O'Brien

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RNA Recognition by the Caenorhabditis elegans Embryonic Determinants MEX-5 and MEX-3: A Dissertation, John M. Pagano Jr.

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Novel Therapeutic Targets for Ph+ Chromosome Leukemia and Its Leukemia Stem Cells: A Dissertation, Cong Peng

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Description, Classification, and Prediction of Dengue Illnesses in a Thai Pediatric Cohort: A Dissertation, James A. Potts

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Regulation of Early T Cell Activation by TNF Superfamily Members TNF and FASL: A Dissertation, Bhavana Priyadharshini

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Beyond Toll-Like Receptor 9: Interactions Between Plasmacytoid Dendritic Cells and Aspergillus Fumigatus: A Dissertation, Zaida G. Ramirez-Ortiz

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The C Terminus of Activation Induced Cytidine Deaminase (AID) Recruits Proteins Important for Class Switch Recombination to the IG Locus: A Dissertation, Sanjay Ranjit

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Role and Regulation of Fat Specific Protein (FSP27) in Lipolysis in 3T3-L1 Adipocytes: A Dissertation, Srijana Ranjit

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Elucidation of the Multi-Faceted Roles of the SIN (Septation Initiation Network); Understanding How the SIN Promotes Cytokinesis and Inhibits Interphase Growth in the Fission Yeast Schizosaccharomyces pombe: A Dissertation, Samriddha Ray

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A Mindfulness-Based Intervention for Treatment of Anxiety in ICD Patients: Feasibility and Baseline Findings: A Dissertation, Elena Salmoirago Blotcher

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Elucidating the Transcriptional Network Underlying Expression of a Neuronal Nicotinic Receptor Gene: A Dissertation, Michael D. Scofield

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Immunity, Pathogenesis, and Prevention of Poxvirus Infections: A Dissertation, Mina O. Seedhom

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MRI Contrast Agent Studies of Compartmental Differentiation, Dose-Dependence, and Tumor Characterization in the Brain: A Dissertation, Mohammed S. Shazeeb

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Defining the Roles of p300/CBP (CREB Binding Protein) and S5a in p53 Polyubiquitination, Degradation and DNA Damage Responses: A Dissertation, Dingding Shi

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Molecular Mechanisms of Neurite Complexity in the Drosophila Brain: A Dissertation, Lei Shi

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Mitochondrial Dysfunction and AKT Isoform-Specific Regulation in 3T3-L1 Adipocytes: A Dissertation, Xiarong Shi

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Pathogenesis of the Helicobacter Induced Mucosal Disease: A Dissertation, Calin Stoicov

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Endocytosis, Phagocytosis, and Innate Immune Responses: A Dissertation, Christine A. St. Pierre

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A Tale of Two ARFs: Tumor Suppressor and Anti-viral Functions of p14ARF: A Dissertation, Michael W. Straza

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Antibody Responses Elicited by DNA Prime-Protein Boost HIV Vaccines: A Dissertation, Michael Vaine

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Roles of Cellular RNA-Dependent RNA Polymerases in Endogenous Small RNA Pathways in Caenorhabditis elegans: A Dissertation, Jessica J. Vasale

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Magnetic Resonance Imaging of Neural and Pulmonary Vascular Function: A Dissertation, Ronn P. Walvick

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Factors Associated with Subjective Improvement Following Midurethral Sling Procedures for Stress Urinary Incontinence: A Masters Thesis, Emily Elise Weber Lebrun

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The Role of Rip2 Protein in the Nod Mediated Innate Immune Response: A Dissertation, Yibin Yang

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Identification and Characterization of SNAPIN as a Novel Antagonist of HIV-1 Egress: A Dissertation, Patrick Younan

Dissertations and Theses from 2009

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Endoderm Patterning in Zebrafish: Pancreas Development: A Dissertation, Kristen M. Alexa

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Elucidation of the Role of the Exocyst Subunit Sec6p in Exocytosis: A Dissertation, Daniel Niron Brewer

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Injection Treatment for Lower Back Pain in Older Adults with Lumbar Spinal Stenosis: A Dissertation, Virginia G. Briggs

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Energetic and Dynamic Analysis of Inhibitor Binding to Drug-Resistant HIV-1 Proteases: A Dissertation, Yufeng Cai

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Functional Analysis of Yeast Pheromone Receptors in ER Exit, Ligand-Induced Endocytosis and Oligomerization: A Dissertation, Chien-I Chang

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Regulation of the Cdc14-like Phosphatase CLP1 in Schizosaccharomyces pombe and Identification of SID2 Kinase Substrates: A Dissertation, Chun-Ti Chen

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Defining the Importance of Fatty Acid Metabolism in Maintaining Adipocyte Function: A Dissertation, Jennifer L. Christianson

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Role of Supervillin, a Membrane Raft Protein, in Cytoskeletal Organization and Invadopodia Function, Jessica Lynn Crowley

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Mechanisms of NOTCH1 Mediated Leukemogenesis: A Dissertation, Kathleen J. Cullion

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Neural Circuit Analyses of the Olfactory System in Drosophila: Input to Output: A Dissertation, Shamik DasGupta

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Role of WFS1 in Regulating Endoplasmic Reticulum Stress Signaling: A Dissertation, Sonya G. Fonseca

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Pathophysiology of Respiratory Failure Following Acute Organophosphate Poisoning : A Dissertation, Romolo Joseph Gaspari

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A Multiparameter Network Reveals Extensive Divergence Between C. elegans bHLH Transcription Factors: A Dissertation, Christian A. Grove

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Regulation of Cancer Cell Survival Mediated by Endogenous Tumor Suppression: A Dissertation, Minakshi Guha

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Multifaceted Regulation of Peripheral T Cell Tolerance and Autoimmunity by FOXP3+ T Regulatory Cells: A Dissertation, Nitya Jain

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Chromatin Remodeling in Transgenic Mouse Brain: Implications for the Neurobiology of Depression: A Dissertation, Yan Jiang

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Characterization of the Nef-TCR Zeta Interaction and Its Role in Modulation of Src Family Kinase Activity: A Dissertation, Walter Minsub Kim

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Co-evolution of HIV-1 Protease and its Substrates: A Dissertation, Madhavi Kolli

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The Role of Macropinocytosis in Sonic Hedgehog-Induced Axon Growth and Guidance: A Dissertation, Adrianne L. Kolpak

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Regulation of DNA Replication Origins in Fission Yeast: A Dissertation, Naveen Kommajosyula

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Defining the Role of CtBP2 in p53-Independent Tumor Suppressor Function of ARF: A Dissertation, Ramesh C. Kovi

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Systems Level Processing of Memory in the Fly Brain: A Dissertation, Michael Jonathan Krashes

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Prediction, Prevention and Treatment of Virally Induced Type 1 Diabetes: A Dissertation, Annie J. Kruger

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Sensitization of CD8 T Cells During Acute Viral Infections Impacts Bystander and Latecomer CD8 T Cell Responses : A Dissertation, Heather D. Marshall

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Delineating the C. elegans MicroRNA Regulatory Network: A Dissertation, Natalia Julia Martinez

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IAP Regulation of Tumor Metastasis: A Dissertation, Swarna Mehrotra

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Functional Interaction of BPV-1 E2 with the Papillomavirus Genome: A Dissertation, Suzanne Marie Melanson

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Differentially Expressed MicroRNAs Act As Inhibitors of BDNF in Prefrontal Cortex - Implications for Schizophrenia: A Dissertation, Nikolaos Mellios

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Analysis of Long-Range Chromosomal Interactions in Saccharomyces cerevisiae: A Dissertation, Adriana Miele

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Functional Analysis of MicroRNA-10b in Breast Carcinoma: A Dissertation, Charlotte M. Harwood Moriarty

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Respiratory Syncytial Virus (RSV) Induces Innate Immunity through Toll-Like Receptors and Acquired Immunity via the RSV G Protein: A Dissertation, Matthew R. Murawski

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Hypoxia Inducible Factors in Alcoholic Liver Disease: A Dissertation, Bharath D. Nath

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An Omega-Based Bacterial One-Hybrid System for the Determination of Transcription Factor Specificity, Marcus Blaine Noyes

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Nuclear Dynamics of a Broken Chromosome: A Dissertation, Pranav O. Oza

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Worming to Complete the Insulin/IGF-1 Signaling Cascade: A Dissertation, Srivatsan Padmanabhan

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Caspase Mediated Cleavage, IAP Binding, Ubiquitination and Kinase Activation : Defining the Molecular Mechanisms Required for Drosophila NF-кB Signaling: A Dissertation, Nicholas Paul Paquette

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Evasion of LPS-TLR4 Signaling as a Virulence Determinate for Yersinia pestis, Sara Montminy Paquette

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The Role of the MRN Complex in the S-Phase DNA Damage Checkpoint: A Dissertation, Mary Elizabeth Porter-Goff

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Cytoskeletal Regulation and Morphogen Signaling During Synaptic Outgrowth at the Drosophila Larval Neuromuscular Junction : A Dissertation, Preethi Ramachandran