Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Dissertations and Theses from 2011

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The Effect of Glycemic Index and Glycemic Load on Glucose Control, Lipid Profiles and Anthropometrics Among Low-Income Latinos With Type 2 Diabetes: A Dissertation, Lauren A. Gellar

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Blocking the Notch Pathway with Gamma-Secretase Inhibitors Enhances Temozolomide Treatment of Gliomas through Therapy-Induced Senescence: A Dissertation, Candace A. Gilbert

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A Global Analysis of the Adaptations Required for Sterol Catabolism in Mycobacterium Tuberculosis: A Dissertation, Jennifer E. Griffin

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Role of the Yeast Ste20 Protein Kinase Ortholog Map4k4 in Adipose Tissue Function: A Dissertation, Kalyani V. P. Guntur

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Dissecting Signaling Pathways that Regulate Axonal Guidance Effects of Sonic Hedgehog: A Dissertation, Daorong Guo

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M.tb Killing by Macrophage Innate Immune Mechanisms: A Dissertation, Michelle L. Hartman

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Using Light to Observe and Control Cellular Function: Improving Bioluminescence Imaging and Photocontrol of Rho GTPase Activation States: A Dissertation, Katryn R. Harwood

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Neuronal Nicotinic Acetylcholine Receptors: Molecular Targets for Alcoholism and Ethanol Reward: A Dissertation, Linzy M. Hendrickson

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Regulation and Function of Neuronal Nicotinic Acetylcholine Receptors in Lung Cancer: A Dissertation, Ma. Reina D. Improgo

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Molecular and Functional Properties of Transmitted HIV-1 Envelope Variants: A Dissertation, Michael G. Kishko

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Autoregulatory and Paracrine Control of Synaptic and Behavioral Plasticity by Dual Modes of Octopaminergic Signaling: A Dissertation, Alex C. Koon

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Dynamics of Erythropoietic Survival Pathways In Vivo: A Dissertation, Miroslav Koulnis

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Molecular Mechanisms of piRNA Biogenesis and Function in Drosophila: A Dissertation, Chengjian Li

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Neuronal Diversification in the Postembryonic Drosophila Brain: A Dissertation, Suewei Lin

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Early Detection and Treatment of Acute Clinical Decline in Hospitalized Patients: An Observational Study of ICU Transfers and an Assessment of the Effectiveness of a Rapid Response Program: A Dissertation, Tanya Lord

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Critical and Independent Roles of the P/CAF Acetyltransferase in ARF-p53 Signaling: A Dissertation, Ian M. Love

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Cooperating Events in Core Binding Factor Leukemia Development: A Dissertation, Dmitri Madera

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Insulin Receptor Substrate-2 (IRS-2): A Novel Hypoxia-Responsive Gene in Breast Cancer: A Dissertation, Katerina Mardilovich

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Intranasal Colonization by Streptococcus Pneumoniae Induces Immunological Protection from Pulmonary and Systemic Infection: A Dissertation, Nang H. Maung

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Cannabis Use and Bipolar Disorder: Bipolar Disorder Case Identification and Cannabis Use Risk Assessment: A Dissertation, Patrick J. McCabe

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Role of Protein Flexibility in Function, Resistance Pathways and Substrate Recognition Specificity in HIV-1 Protease: A Dissertation, Seema Mittal

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A Tale of Two SNPS: Polymorphism Analysis of Toll-like Receptor (TLR) Adapter Proteins: A Dissertation, Kamalpreet Nagpal

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The Function of Innate γδ T Cell Subsets is Molecularly Programmed in the Thymus in Three Stages: A Dissertation, Kavitha Narayan

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The Importance of the Centrosomal Localization Sequence of Cyclin E for Promoting Centrosome Duplication: A Dissertation, Joshua J. Nordberg

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Telomere Length Dynamics in Human T Cells: A Dissertation, Joel M. O'Bryan

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Conformational Lability in MHC II Proteins: A Dissertation, Corrie A. Painter

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Regulation of Runx Proteins in Human Cancers: A Dissertation, Sandhya Pande

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Digital and Analog STAT5 Signaling in Erythropoiesis: A Dissertation, Ermelinda Porpiglia

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Hsp90-Mediated Maturation of Kinases and Nuclear Steroid Hormone Receptors: A Dissertation, Natalie W. Pursell

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Mechanisms of Substrate Recognition by HCV NS3/4A Protease Provide Insights Into Drug Resistance: A Dissertation, Keith P. Romano

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Roles of Secreted Virulence Factors in Pathogenicity of Haemophilus Influenzae: A Dissertation, Charles V. Rosadini

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Herbal Marijuana Alternatives Investigation: K2 and Spice: A Masters Thesis, Christopher D. Rosenbaum

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Support of Mitochondrial DNA Replication by Human Rad51: A Dissertation, Jay M. Sage

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Structural Studies of the Anti-HIV Human Protein APOBEC3G Catalytic Domain: A Dissertation, Shivender Shandilya

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Global DNA Demethylation During Erythropoiesis: A Dissertation, Jeffrey R. Shearstone

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Nucleic Acid Sensing by the Immune System: Roles For the Receptor For Advanced Glycation End Products (RAGE) and Intracellular Receptor Proteins: A Dissertation, Cherilyn M. Sirois

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Chromosome-Biased Binding and Function of C. elegans DRM Complex, and Its Role in Germline Sex-Silencing: A Dissertation, Tomoko M. Tabuchi

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Insights Into ER Translocation Channel Gating. Structural Regulation of the Transition Between the Closed and Open Channel Conformations: A Dissertation, Steven F. Trueman

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Two Distinct Modes of Signaling by Vascular Endothelial Growth Factor C Guide Blood and Lymphatic Vessel Patterning in Zebrafish: A Dissertation, Jacques A. Villefranc

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Treating GM1 Gangliosidosis With Ex Vivo Hematopoietic Stem Cell Gene Therapy Without Using Total Body Irradiation: A Masters Thesis, Michael Whalen

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Regulation of Humoral Immunity by Pim Kinases: A Dissertation, Kristen N. Willems

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Dissection of α6β4 Integrin-Dependent Signaling and Breast Carcinoma Invasion: A Dissertation, Xiaoqing Yang

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Investigating Age-Dependent Arthropathy in a Circadian Mutant Mouse Model: A Dissertation, Elizabeth A. Yu

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The Role of PC4 in Oxidative Stress: A Dissertation, Lijian Yu

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Improved Methods of Sepsis Case Identification and the Effects of Treatment with Low Dose Steroids: A Dissertation, Huifang Zhao

Dissertations and Theses from 2010

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A View of the IMD Pathway from the RHIM, Kamna Aggarwal

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C. Elegans Metabolic Gene Regulatory Networks: A Dissertation, H. Efsun Arda

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Axon Death Prevented: Wlds and Other Neuroprotective Molecules: A Dissertation, Michelle A. Avery

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Exploring Molecular Mechanisms of Drug Resistance in HIV-1 Protease through Biochemical and Biophysical Studies: A Dissertation, Rajintha M. Bandaranayake

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Co– and Post–Translational N–Linked Glycosylation of Cardiac Potassium Channel Subunits: A Dissertation, Tuba Bas

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Host Cell Attachment by Lyme Disease and Relapsing Fever Spirochetes: A Dissertation, Vivian M. Benoit

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Development and Evaluation of Disease Activity Measures in Rheumatoid Arthritis Using Multi-Level Mixed Modeling and Other Statistical Methodologies: A Dissertation, Mary Jane Bentley

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Energy Metabolism and the Induction of the Unfolded Protein Response: A Dissertation, Alison M. Burkart

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Post-Transcriptional Control of Human Cellular Senescence: A Dissertation, David M. Burns

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Role of the cJun NH2-Terminal Kinase (JNK) in Cancer: A Dissertation, Cristina Arrigo Cellurale

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Glycosylation, Assembly and Trafficking of Cardiac Potassium Channel Complexes: A Dissertation, Kshama D. Chandrasekhar

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Regulation of Immune Pathogenesis by Antigen-Specific CD8 T Cells Following Sequential Heterologous Infections: A Dissertation, Alex T. Chen

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Generating Nucleosomal Asymmetry in Saccharomyces cerevisiae: A Masters Thesis, Yuanyuan Chen

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The Role of Dynamic Cdk1 Phosphorylation in Chromosome Segregation in Schizosaccharomyces pombe: A Dissertation, Sung Hugh Choi

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Mechanical Flow Restoration in Acute Ischemic Stroke: A Model System of Cerebrovascular Occlusion: A Dissertation, Juyu Chueh

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Development of a Multi-Site Phase II Clinical Trial of Valproic Acid for Retinitis Pigmentosa, Christine Moulton Clemson

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Acute Modulation of Endothelial Cell Glucose Transport: A Dissertation, Anthony J. Cura

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A Novel Motif in HIV-1 Nef that Regulates MIP-1β Chemokine Release in Macrophages: A Dissertation, Lue Dai

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An Integral Role of ARRDC3 in Stem Cell Migration and Breast Cancer Progression: A Dissertation, Kyle M. Draheim

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Novel Complement Blocking Antibodies Against Serogroup B N. meningitidis: A Dissertation, Tathagat Dutta Ray

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CD8+ T Cell Serotype-Cross-Reactivity is a Predominant Feature of Dengue Virus Infections in Humans: A Dissertation, Heather L. Friberg-Robertson

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Endogenous Small RNAs in the Drosophila Soma: A Dissertation, Megha Ghildiyal

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Transcriptional Regulation of VEGFA by Unfolded Protein Response Signaling Pathway, Rajarshi Ghosh

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Cross-Talk Between Factors Involved in mRNA Translation and Decay: A Dissertation, Shubhendu Ghosh

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A Glia-Mediated Feedback Mechanism for the Termination of Drosophila Visual Response: A Dissertation, Peiyi Guo

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Role of the Monocyte/Macrophage Cell Lineage in Obesity-Related Insulin Resistance, Olga T. Hardy

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Maternally Derived Anti-Dengue Antibodies and Risk of DHF in Infants: A Case-Control Study, Steven Hatch

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Role of CPEB in Senescence and Inflammation: A Dissertation, Maria Ivshina

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Dissecting the Role of Innate Pattern Recognition Receptors and Interferon Regulatory Factor-5 in the Immune Response to Human Metapneumovirus and other Pathogens: A Dissertation, Zhaozhao Jiang

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Sequence Determinants of the Folding Free-Energy Landscape of beta alpha-Repeat Proteins: A Dissertation, Sagar V. Kathuria

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The Coupling Between Folding, Zinc Binding, and Disulfide Bond Status of Human Cu, Zn Superoxide Dismutase: A Dissertation, Can Kayatekin

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Drosophila piRNA Function in Genome Maintenance, Telomere Protection and Genome Evolution: A Dissertation, Jaspreet S. Khurana

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Role of Internal Calcium Stores in Exocytosis and Neurotransmission: A Dissertation, Jason J. Lefkowitz

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Behavioral Health Disorders and the Quality of Diabetes Care: A Dissertation, Yat (Gary) Hung Leung

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Regulation of WRN Function by Acetylation and SIRT1-Mediated Deacetylation in Response to DNA Damage: A Dissertation, Kai Li

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Clinical Course of Bipolar Disorder During the Menopausal Transition: Comparison with Reproductive Age and Post Menopausal Women: A Master's Thesis, Wendy K. Marsh

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T Cells Aid in Limiting Pathogen Burden and in Enhancing B1 and B2 Cell Antibody Responses to Membrane Glycolipid and the Surface Lipoprotein Decorin-Binding Protein A during Borrelia burgdorferi Infection: A Dissertation, Robyn Lynn Marty-Roix

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Clinically Relevant Doses of Chemotherapy Drugs Selectively and Reversibly Block Glioblastoma Neurosphere Proliferation in vitro: A Dissertation, Alicia M. Mihaliak

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Converging Pathways in the Regulation of Longevity and Metabolism in Caenorhabditis Elegans: A Dissertation, Sri Devi Narasimhan

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Age and Sex Differences in Duration of Pre-Hospital Delay, Hospital Treatment Practices, and Short-Term Outcomes in Patients Hospitalized with an Acute Coronary Syndrome/Acute Myocardial Infarction: A Dissertation, Hoa L. Nguyen

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Structural and Functional Studies of Proteins Involved in Antigen Processing: A Dissertation, Tina T. Nguyen

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Maintenance of Visual Sensitivity in the Drosophila Eye: A Dissertation, Lina Ni

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Regulation of Cellular and HIV-1 Gene Expression by Positive Transcription Elongation Factor B: A Dissertation, Siobhan O'Brien

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RNA Recognition by the Caenorhabditis elegans Embryonic Determinants MEX-5 and MEX-3: A Dissertation, John M. Pagano Jr.

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Novel Therapeutic Targets for Ph+ Chromosome Leukemia and Its Leukemia Stem Cells: A Dissertation, Cong Peng

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Description, Classification, and Prediction of Dengue Illnesses in a Thai Pediatric Cohort: A Dissertation, James A. Potts

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Regulation of Early T Cell Activation by TNF Superfamily Members TNF and FASL: A Dissertation, Bhavana Priyadharshini

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Beyond Toll-Like Receptor 9: Interactions Between Plasmacytoid Dendritic Cells and Aspergillus Fumigatus: A Dissertation, Zaida G. Ramirez-Ortiz

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The C Terminus of Activation Induced Cytidine Deaminase (AID) Recruits Proteins Important for Class Switch Recombination to the IG Locus: A Dissertation, Sanjay Ranjit

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Role and Regulation of Fat Specific Protein (FSP27) in Lipolysis in 3T3-L1 Adipocytes: A Dissertation, Srijana Ranjit

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Elucidation of the Multi-Faceted Roles of the SIN (Septation Initiation Network); Understanding How the SIN Promotes Cytokinesis and Inhibits Interphase Growth in the Fission Yeast Schizosaccharomyces pombe: A Dissertation, Samriddha Ray

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A Mindfulness-Based Intervention for Treatment of Anxiety in ICD Patients: Feasibility and Baseline Findings: A Dissertation, Elena Salmoirago Blotcher

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Elucidating the Transcriptional Network Underlying Expression of a Neuronal Nicotinic Receptor Gene: A Dissertation, Michael D. Scofield

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Immunity, Pathogenesis, and Prevention of Poxvirus Infections: A Dissertation, Mina O. Seedhom

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MRI Contrast Agent Studies of Compartmental Differentiation, Dose-Dependence, and Tumor Characterization in the Brain: A Dissertation, Mohammed S. Shazeeb