GSBS Dissertations and Theses

 

Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

Attention GSBS students: Click on Submit Thesis/Dissertation in the left sidebar to submit your final, approved thesis/dissertation. You’ll need to log in or create a free account. Questions? Contact Lisa Palmer.

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Dissertations and Theses from 2015

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Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation, Timothy M. Rooney

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Identifying, Targeting, and Exploiting a Common Misfolded, Toxic Conformation of SOD1 in ALS: A Dissertation, Melissa S. Rotunno

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Single-Molecule Imaging Reveals that Argonaute Re-Shapes the Properties of its Nucleic Acid Guides: A Dissertation, William E. Salomon

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Sensing of Endogenous Nucleic Acids by the Innate Immune System during Viral Infection: A Dissertation, Stefan A. Schattgen

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Paternal Effects on Metabolism in Mammals: A Dissertation, Jeremy M. Shea

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Hepatitis C Virus: Structural Insights into Protease Inhibitor Efficacy and Drug Resistance: A Dissertation, Djade I. Soumana

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Gene Therapy for Amyotrophic Lateral Sclerosis: An AAV Delivered Artifical MicroRNA Against Human SOD1 Increases Survival and Delays Disease Progression of the SOD1G93A Mouse Model: A Dissertation, Lorelei I. Stoica

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The Shape of Silence: The Solution-State Conformation of Sir Heterochromatin: A Dissertation, Sarah G. Swygert

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A Gene-Centered Method For Mapping 3’UTR-RBP Interactions: A Dissertation, Alex M. Tamburino

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Transcriptional Regulation of the Drosophila Peptidoglycan Sensor PGRP-LC by the Steroid Hormone Ecdysone: A Masters Thesis, Mei Tong

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Role and Regulation of Autophagy During Developmental Cell Death in Drosophila Melanogaster: A Dissertation, Kirsten M. Tracy

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Latent Variable Approaches for Understanding Heterogeneity in Depression: A Dissertation, Christine M. Ulbricht

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The Role of Signal 3 Cytokine Timing in CD8 T Cell Activation: A Dissertation, Stina L. Urban

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Unveiling Molecular Mechanisms of piRNA Pathway from Small Signals in Big Data: A Dissertation, Wei Wang

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Diet-responsive Gene Networks Rewire Metabolism in the Nematode Caenorhabditis elegans to Provide Robustness against Vitamin B12 Deficiency: A Dissertation, Emma Watson

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Causal Inference Methods for Assessing Neurodevelopment in Children Following Prenatal Exposure to Triptan Medications: A Dissertation, Mollie E. Wood

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Functional Characterization of Novel PFN1 Mutations Causative for Familial Amyotrophic Lateral Sclerosis: A Dissertation, Chi-Hong Wu

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Diet Quality and Evening Snacking in Relation to Sleep Duration and Quality among Women with Young Children: A Dissertation, Rui Sherry Xiao

Dissertations and Theses from 2014

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rAAV-Mediated Gene Transfer For Study of Pathological Mechanisms and Therapeutic Intervention in Canavan's Disease: A Dissertation, Seemin Seher Ahmed

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Identification and Characteristics of Factors Regulating Hepatocellular Carcinoma Progression and Metastasis: A Dissertation, Leanne G. Ahronian

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Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation, Belinda Barbagallo

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The Recombination Enhancer Modulates the Conformation of Chr. III in Budding Yeast: A Dissertation, Jon-Matthew Belton

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Chromatin Regulators and DNA Repair: A Dissertation, Gwendolyn M. Bennett

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Regulation of Type II Responses in Lung Fibrosis and Systemic Autoimmunity: A Dissertation, Tia Bumpus Brodeur

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Heterologous Immunity and T Cell Stability During Viral Infections: A Dissertation, Jenny Wun-Yue Che

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From Neurodegeneration to Infertility and Back - Exploring Functions of Two Genes: ARMC4 and TARDBP: A Dissertation, Wei Cheng

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Neural Orchestration of the C. elegans Escape Response: A Dissertation, Christopher M. Clark

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A Feedback Loop Couples Musashi-1 Activity to Omega-9 Fatty Acid Biosynthesis: A Dissertation, Carina C. Clingman

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Long-Term Survival and Prognostic Factors in Patients with Acute Decompensated Heart Failure According to Ejection Fraction Findings: A Population-Based Perspective: A Master Thesis, Andrew H. Coles

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Small RNAs and Argonautes Provide a Paternal Epigenetic Memory of Germline Gene Expression to Promote Thermotolerant Male Fertility: A Dissertation, Colin C. Conine

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ADHD-200 Patient Characterization and Classification using Resting State Networks: A Dissertation, Suzanne M. Czerniak

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Clinical and Financial Impact of Hospital Readmissions Following Colorectal Resection: Predictors, Outcomes, and Costs: A Thesis, Rachelle N. Damle

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Hypertensive Acute Decompensated Heart Failure Presentations: On the Decline? : A Master's Thesis, Chad E. Darling

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POS-1 Regulation of Endo-mesoderm Identity in C. elegans: A Dissertation, Ahmed M. Elewa

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Impact of COPD on the Mortality and Treatment of Patients Hospitalized with Acute Decompensated Heart Failure (The Worcester Heart Failure Study): A Masters Thesis, Kimberly A. Fisher

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Psychometric Evaluation of Joint-Specific Patient-Reported Outcome Measures Before and After Total Knee Replacement: A Dissertation, Barbara L. Gandek

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Characterization of Anti-Fungal Inflammasome Responses and the Role of Caspase-8 in Innate Immune Signaling: A Dissertation, Sandhya Ganesan

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Investigating Tumor Suppressors in the DNA Damage Response: Caretakers of the Genome and Biomarkers to Predict Therapeutic Response: A Dissertation, Shawna S. Guillemette

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Cognitive Status and Initiation of Lifestyle Changes Following Acute Coronary Heart Syndrome: A Dissertation, Alexandra M. Hajduk

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Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation, Tingting Huang

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A Population-Based Perspective on Clinically Recognized Venous Thromboembolism: Contemporary Trends in Clinical Epidemiology and Risk Assessment of Recurrent Events: A Dissertation, Wei Huang

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Dissecting cis and trans Determinants of Nucleosome Positioning: A Dissertation, Amanda L. Hughes

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Amphiphilic Degradable Polymer/Hydroxyapatite Composites as Smart Bone Tissue Engineering Scaffolds: A Dissertation, Artem B. Kutikov

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EspFU, an Enterohemorrhagic E. Coli Secreted Effector, Hijacks Mammalian Actin Assembly Proteins by Molecular Mimicry and Repetition: A Dissertation, YuShuan (Cindy) Lai

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Mechanistic Analysis of Differential Signal Transduction Mediated by the Insulin Receptor Substrate Proteins IRS-1 and IRS-2: A Dissertation, Justine M. Landis

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Outpatient Emergency Department Utilization: Measurement and Prediction: A Dissertation, Lisa M. Lines

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An Integrated Structural Mechanism for Relief of Autoinhibition and Membrane Targeting in Cytohesin Family Guanine Nucleotide Exchange Factors: A Dissertation, Andrew W. Malaby

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Identification of Molecular Determinants that Shift Co- and Post-Translational N-Glycosylation Kinetics in Type I Transmembrane Peptides: A Dissertation, Heidi L. H. Malaby

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MIRAGE DNA Transposon Silencing by C. elegans Condensin II Subunit HCP-6: A Masters Thesis, Anna Malinkevich

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Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation, Kimberly A. Negrin

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Early Folding Biases in the Folding Free-Energy Surface of βα-Repeat Proteins: A Dissertation, Robert P. Nobrega

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Differences in Access to Care and Healthcare Utilization Among Sexual Minorities: A Master's Thesis, Tan Phu Pham

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GLI-IKBKE Requirement In KRAS-Induced Pancreatic Tumorigenesis: A Dissertation, Mihir S. Rajurkar

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Depression in Rheumatoid Arthritis and an Estimation of the Bi-directional Association of Depression and Disease Burden: A Dissertation, Alan M. Rathbun

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Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation, Teresa S. Repasy

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Analyses of All Possible Point Mutations within a Protein Reveals Relationships between Function and Experimental Fitness: A Dissertation, Benjamin P. Roscoe

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Putting the Pieces Together: Exons and piRNAs: A Dissertation, Christian K. Roy

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FUS/TLS in Stress Response - Implications for Amyotrophic Lateral Sclerosis: A Dissertation, Reddy Ranjith Kumar Sama

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Evolutionary Approaches to the Study of Small Noncoding Regulatory RNA Pathways: A Dissertation, Alfred T. Simkin

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Role of Hdac3 in Murine Coronary Vessel Development: A Master's Thesis, Kevin M. Smee

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The Three-Dimensional Structure of the Cystic Fibrosis Locus: A Dissertation, Emily M. Smith

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Comparative Effectiveness of Lithium and Valproate for Suicide Prevention and Associations With Nonsuicide Mortality: A Dissertation, Eric G. Smith

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Characterization of Innate Immune Pathways in DNA Vaccine-Induced, Antigen-Specific Immune Responses: A Dissertation, John J. Suschak III

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Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation, Eric C. Swanson

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Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation, Ozge E. Tasdemir-Yilmaz

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Dissecting the Role of Cytosolic Nucleic Acid Sensors in the Type I Interferon Response to Herpes Simplex Virus-1 and other Ligands: A Dissertation, Mikayla R. Thompson

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CD8+ T Cell and NK Responses to a Novel Dengue Epitope: A Possible Role for KIR3DL1 in Dengue Pathogenesis: A Dissertation, Elizabeth Townsley

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Developing Three New Pathophysiologically Based Measures of Nicotine Dependence: A Dissertation, W. W. Sanouri A. Ursprung

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The Cellular Consequences of FUS/TLS Depletion: A Loss of Function Model for Amyotrophic Lateral Sclerosis: A Dissertation, Catherine L. Ward

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Approaches and Considerations Towards a Safe and Effective Adeno-Associated Virus Mediated Therapeutic Intervention for GM1-Gangliosidosis: A Dissertation, Cara M. Weismann

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Caspase-8 and RIP Kinases Regulate Bacteria-Induced Innate Immune Responses and Cell Death: A Dissertation, Dan Weng

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Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation, Liting Xue

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Molecular Landscape of Induced Reprogramming: A Dissertation, Chao-Shun Yang

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Studies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation, Liusong Yin

Dissertations and Theses from 2013

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Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation, Shinya U. Amano

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Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation, Rahul Bharadwaj

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A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation, Alison R. Bright

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Disparate Activation of the Inflammasome by Chitin and Chitosan: A Dissertation, Chelsea L. Bueter

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Adjuvant-Specific Serum Cytokine Profiles in the Context of a DNA Prime-Protein Boost HIV-1 Vaccine: A Dissertation, Rachel Buglione-Corbett

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Layered Reward Signalling Through Octopamine and Dopamine in Drosophila: A Dissertation, Christopher J. Burke

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A Novel Autophagy Regulatory Mechanism that Functions During Programmed Cell Death: A Dissertation, Tsun-Kai Chang

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The Study of Two Strategies for Decreasing Mutant Huntingtin: Degradation by Puromycin Sensitive AminoPeptidase and RNA Interference: A Dissertation, Joanna Chaurette

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Expanding the Known DNA-binding Specificity of Homeodomains for Utility in Customizable Sequence-specific Nucleases: A Dissertation, Stephanie W. Chu

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On Identifying Signatures of Positive Selection in Human Populations: A Dissertation, Jessica L. Crisci

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Nuclear Organization in Breast Cancer: A Dissertation, Jason R. Dobson

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Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation, John W. Evans III

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Dynamic Regulation at the Neuronal Plasma Membrane: Novel Endocytic Mechanisms Control Anesthetic-Activated Potassium Channels and Amphetamine-Sensitive Dopamine Transporters: A Dissertation, Luke R. Gabriel

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Genetic Deficiency of CD40 in Mice Exacerbates Metabolic Manifestations of Diet-induced Obesity: A Dissertation, Chang-An Guo

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Understanding Regulation of the Cytoskeleton during Cell Cycle Transitions through Examination of Crosstalk between Homologous Fission Yeast Pathways, Septation Initiation Network and Morphogenesis ORB6 Network: A Dissertation, Sneha Gupta

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Modulating Influenza and Heparin Binding Viruses’ Pathogenesis with Extrinsic Receptor Decoy Liposomes: A Dissertation, Gabriel L. Hendricks

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Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation, Ryan T. Hietpas

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Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation, Brendan J. Hilbert

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Suppressive Oligodeoxynucleotides Inhibit Cytosolic DNA Sensing Pathways: A Dissertation, John J. Kaminski III

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Tissue-dependent T Cell Apoptosis and Transcriptional Regulation of Memory CD8+T Cell Differentiation During Viral Infections: A Dissertation, Varun N. Kapoor

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Modulators of the Acute Inflammatory Response: A Dissertation, Dipti Karmarkar

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The Role of Heterologous Immunity in Viral Co-Infections and Neonatal Immunity: A Dissertation, Laurie L. Kenney

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Role of Inflammation in Diet-Induced Obesity: A Dissertation, Sophia Kogan

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Role of Autophagy in Post-Mitotic Midbody Fate and Function: A Dissertation, Tse-Chun Kuo

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Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation, Alexander N. Lagadinos

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Runx Expression in Normal and Osteoarthritic Cartilage: Possible Functions of Runx Proteins in Chondrocytes: A Dissertation, Kimberly T. LeBlanc