Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Dissertations and Theses from 2014

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Analyses of All Possible Point Mutations within a Protein Reveals Relationships between Function and Experimental Fitness: A Dissertation, Benjamin P. Roscoe

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Putting the Pieces Together: Exons and piRNAs: A Dissertation, Christian K. Roy

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FUS/TLS in Stress Response - Implications for Amyotrophic Lateral Sclerosis: A Dissertation, Reddy Ranjith Kumar Sama

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Evolutionary Approaches to the Study of Small Noncoding Regulatory RNA Pathways: A Dissertation, Alfred T. Simkin

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Role of Hdac3 in Murine Coronary Vessel Development: A Master's Thesis, Kevin M. Smee

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The Three-Dimensional Structure of the Cystic Fibrosis Locus: A Dissertation, Emily M. Smith

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Comparative Effectiveness of Lithium and Valproate for Suicide Prevention and Associations With Nonsuicide Mortality: A Dissertation, Eric G. Smith

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Characterization of Innate Immune Pathways in DNA Vaccine-Induced, Antigen-Specific Immune Responses: A Dissertation, John J. Suschak III

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Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation, Eric C. Swanson

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Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation, Ozge E. Tasdemir-Yilmaz

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Dissecting the Role of Cytosolic Nucleic Acid Sensors in the Type I Interferon Response to Herpes Simplex Virus-1 and other Ligands: A Dissertation, Mikayla R. Thompson

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CD8+ T Cell and NK Responses to a Novel Dengue Epitope: A Possible Role for KIR3DL1 in Dengue Pathogenesis: A Dissertation, Elizabeth Townsley

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Developing Three New Pathophysiologically Based Measures of Nicotine Dependence: A Dissertation, W. W. Sanouri A. Ursprung

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The Cellular Consequences of FUS/TLS Depletion: A Loss of Function Model for Amyotrophic Lateral Sclerosis: A Dissertation, Catherine L. Ward

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Approaches and Considerations Towards a Safe and Effective Adeno-Associated Virus Mediated Therapeutic Intervention for GM1-Gangliosidosis: A Dissertation, Cara M. Weismann

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Caspase-8 and RIP Kinases Regulate Bacteria-Induced Innate Immune Responses and Cell Death: A Dissertation, Dan Weng

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Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation, Liting Xue

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Molecular Landscape of Induced Reprogramming: A Dissertation, Chao-Shun Yang

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Studies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation, Liusong Yin

Dissertations and Theses from 2013

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Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation, Shinya U. Amano

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Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation, Rahul Bharadwaj

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A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation, Alison R. Bright

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Disparate Activation of the Inflammasome by Chitin and Chitosan: A Dissertation, Chelsea L. Bueter

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Adjuvant-Specific Serum Cytokine Profiles in the Context of a DNA Prime-Protein Boost HIV-1 Vaccine: A Dissertation, Rachel Buglione-Corbett

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Layered Reward Signalling Through Octopamine and Dopamine in Drosophila: A Dissertation, Christopher J. Burke

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A Novel Autophagy Regulatory Mechanism that Functions During Programmed Cell Death: A Dissertation, Tsun-Kai Chang

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The Study of Two Strategies for Decreasing Mutant Huntingtin: Degradation by Puromycin Sensitive AminoPeptidase and RNA Interference: A Dissertation, Joanna Chaurette

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Expanding the Known DNA-binding Specificity of Homeodomains for Utility in Customizable Sequence-specific Nucleases: A Dissertation, Stephanie W. Chu

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On Identifying Signatures of Positive Selection in Human Populations: A Dissertation, Jessica L. Crisci

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Nuclear Organization in Breast Cancer: A Dissertation, Jason R. Dobson

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Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation, John W. Evans III

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Dynamic Regulation at the Neuronal Plasma Membrane: Novel Endocytic Mechanisms Control Anesthetic-Activated Potassium Channels and Amphetamine-Sensitive Dopamine Transporters: A Dissertation, Luke R. Gabriel

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Genetic Deficiency of CD40 in Mice Exacerbates Metabolic Manifestations of Diet-induced Obesity: A Dissertation, Chang-An Guo

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Understanding Regulation of the Cytoskeleton during Cell Cycle Transitions through Examination of Crosstalk between Homologous Fission Yeast Pathways, Septation Initiation Network and Morphogenesis ORB6 Network: A Dissertation, Sneha Gupta

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Modulating Influenza and Heparin Binding Viruses’ Pathogenesis with Extrinsic Receptor Decoy Liposomes: A Dissertation, Gabriel L. Hendricks

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Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation, Ryan T. Hietpas

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Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation, Brendan J. Hilbert

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Suppressive Oligodeoxynucleotides Inhibit Cytosolic DNA Sensing Pathways: A Dissertation, John J. Kaminski III

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Tissue-dependent T Cell Apoptosis and Transcriptional Regulation of Memory CD8+T Cell Differentiation During Viral Infections: A Dissertation, Varun N. Kapoor

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Modulators of the Acute Inflammatory Response: A Dissertation, Dipti Karmarkar

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The Role of Heterologous Immunity in Viral Co-Infections and Neonatal Immunity: A Dissertation, Laurie L. Kenney

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Role of Inflammation in Diet-Induced Obesity: A Dissertation, Sophia Kogan

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Role of Autophagy in Post-Mitotic Midbody Fate and Function: A Dissertation, Tse-Chun Kuo

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Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation, Alexander N. Lagadinos

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Runx Expression in Normal and Osteoarthritic Cartilage: Possible Functions of Runx Proteins in Chondrocytes: A Dissertation, Kimberly T. LeBlanc

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Understanding Neural Networks in Awake Rat by Resting-State Functional MRI: A Dissertation, Zhifeng Liang

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Transcriptional and Translational Mechanisms Controlling Circadian Rhythms in Drosophila: A Dissertation, Jinli Ling

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The Effects of Family and Social Engagement on the Screen Time of Youth with Developmental Disabilities: A Dissertation, Charmaine B. Lo

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The Role and Regulation of Etv2 in Zebrafish Vascular Development: A Dissertation, John C. Moore

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Elucidating the Molecular Mechanism of CYLD-Mediated Necrosis: A Dissertation, David M. Moquin

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Role of the Cytoplasmic Polyadenylation Element Binding Proteins in Neuron: A Dissertation, Aparna Oruganty

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dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation, Jeannette M. Osterloh

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Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation, Aysegul Ozen

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The Role of Ion Channels in Coordinating Neural Circuit Activity in Caenorhabditis elegans: A Dissertation, Jennifer K. Pirri

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Investigation of Multiple Concerted Mechanisms Underlying Stimulus-induced G1 Arrest in Yeast: A Dissertation, Patricia A. Pope

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The Role of Inducible T Cell Kinase (Itk) in the Development of Innate T Cells and in the Formation of Protective Memory Responses: A Dissertation, Amanda L. Prince

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HIV-1 and the Nucleolus: A Role for Nucleophosmin/NPM1 in Viral Replication: A Dissertation, Tracy E. Schmidt

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Investigating Cancer Molecular Genetics using Genome-wide RNA Interference Screens: A Dissertation, Ryan W. Serra

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Application of a Naïve Bayes Classifier to Assign Polyadenylation Sites from 3' End Deep Sequencing Data: A Dissertation, Sarah E. Sheppard

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A Role for Neuronal Nicotinic Acetylcholine Receptors in Dopamine-Mediated Behaviors and the Hypnotic Response to Anesthetics: A Dissertation, Lindsey G. Soll

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The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation, Jessica M. Tesell

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Inflammasomes and the Innate Immune Response Against Yersinia Pestis: A Dissertation, Gregory I. Vladimer

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Identification and Analysis of the Domain Required for Trans-Acceleration Kinetics in the Human Glucose Transporter GLUT1: A Dissertation, Sabrina S. Vollers

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Role of Map4k4 in Skeletal Muscle Differentiation: A Dissertation, Mengxi Wang

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RNA Interference by the Numbers: Explaining Biology Through Enzymology: A Dissertation, Liang Meng Wee

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hox Gene Regulation and Function During Zebrafish Embryogenesis: A Dissertation, Steven E. Weicksel

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Morphogenetic Requirements for Embryo Patterning and the Generation of Stem Cell-derived Mice: A Dissertation, Yeonsoo Yoon

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A Novel Role of UAP56 in piRNA Mediated Transposon Silencing: A Dissertation, Fan Zhang

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piRNA Biogenesis and Transposon Silencing in Drosophila: A Dissertation, Zhao Zhang

Dissertations and Theses from 2012

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Mechanisms of KRAS-Mediated Pancreatic Tumor Formation and Progression: A Dissertation, Victoria A. Appleman

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Hepatitis C Virus Non-Structural Protein 3/4A: A Tale of Two Domains: A Dissertation, Cihan Aydin

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The Subtype Specific and Cross-Reactive T Cell Responses to Influenza Viruses in Humans: A Dissertation, Jenny Aurielle B. Babon

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Gene Expression and Profiling of Human Islet Cell Subtypes: A Master’s Thesis, David M. Blodgett

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Understanding Small RNA Formation in Drosophila Melanogaster: A Dissertation, Elif Sarinay Cenik

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Localization of Insulin Receptor Substrate-2 in Breast Cancer: A Dissertation, Jennifer L. Clark

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Transcriptional Regulation of the Interleukin-8 Promoter by Multiple Dengue Viral Proteins: A Dissertation, Jacob M. Collins

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Psychosocial and Behavioral Determinants of Medication Nonadherence Among African Americans with Hypertension: A Dissertation, Yendelela L. Cuffee

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Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation, Christopher R. Dowdy

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On the Source of Peptides for Major Histocompatibility Class I Antigen Presentation: A Dissertation, Diego José Farfán Arribas

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Sequence and Target Specificity of the C. elegans Cell Fate Specification Factor POS-1: A Dissertation, Brian M. Farley

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Role of Perivascular and Visceral Adipose Tissues in Murine Models of Obesity and Atherosclerosis: A Dissertation, Timothy P. Fitzgibbons

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Building the Cell's Antenna: Protein Targeting to the Ciliary Membrane: A Dissertation, John A. Follit

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Role of Glia in Sculpting Synaptic Connections at the Drosophila Neuromuscular Junction: A Dissertation, Yuly F. Fuentes Medel

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Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation, Hugh S. Gannon

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Analysis of Integrin α6β4 Function in Breast Carcinoma: A Dissertation, Kristin D. Gerson

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Getting a Tight Grip on DNA: Optimizing Zinc Fingers for Efficient ZFN-Mediated Gene Editing: A Dissertation, Ankit Gupta

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Characterization of Drug Resistance in Mycobacterium Tuberculosis via Saturating Mutagenesis of Drug Targets: A Master’s Thesis, Michelle J. Harris

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Serotonin-Expressing Cells in the Corpus of the Stomach Originate from Bone Marrow: A Master’s Thesis, Brian T. Johnston

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Gene Therapy for Very Long Chain Acyl-coA Dehydrogenase Deficiency Using Adeno-Associated Virus Vectors: A Dissertation, Allison M. Keeler

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Glial Control of Synapse Assembly at the Drosophila Neuromuscular Junction: A Dissertation, Kimberly S. Kerr

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The Role of Adaptor Protein Complex-3 Delta-Mediated HIV-1 Gag Trafficking in HIV-1 Replication: A Dissertation, Adonia Lee Kim

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A Novel Communication Mechanism Between the Presynapse and Postsynapse Through Exosomes: A Dissertation, Ceren Korkut

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Protein Ligand Interactions Probed by NMR: A Dissertation, Jennifer M. Laine

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Catalytic Mechanisms in Sec7 and Vps9 Domain Exchange Factors for Arf and Rab GTPases: A Dissertation, Meng-Tse Lee

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Studies on the Regulation of Cytoplasmic Polyadenylation Element-Binding Protein: A Dissertation, Chien-Ling Lin

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Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation, Ling Lin

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Dissecting Somatic Cell Reprogramming by MicroRNAs and Small Molecules: A Dissertation, Zhonghan Li

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Targeting the Histone Acetyl-Transferase, RTT109, for Novel Anti-Fungal Drug Development: A Dissertation, Jessica Lopes da Rosa-Spiegler

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A Role for c-Jun Kinase (JNK) Signaling in Glial Engulfment of Degenerating Axons: A Dissertation, Jennifer M. MacDonald

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RNA-Sensing Pattern Recognition Receptors and Their Effects on T-Cell Immune Responses: A Dissertation, Rachel F. Madera