Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Dissertations and Theses from 2013

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HIV-1 and the Nucleolus: A Role for Nucleophosmin/NPM1 in Viral Replication: A Dissertation, Tracy E. Schmidt

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Investigating Cancer Molecular Genetics using Genome-wide RNA Interference Screens: A Dissertation, Ryan W. Serra

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Application of a Naïve Bayes Classifier to Assign Polyadenylation Sites from 3' End Deep Sequencing Data: A Dissertation, Sarah E. Sheppard

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A Role for Neuronal Nicotinic Acetylcholine Receptors in Dopamine-Mediated Behaviors and the Hypnotic Response to Anesthetics: A Dissertation, Lindsey G. Soll

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The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation, Jessica M. Tesell

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Inflammasomes and the Innate Immune Response Against Yersinia Pestis: A Dissertation, Gregory I. Vladimer

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Identification and Analysis of the Domain Required for Trans-Acceleration Kinetics in the Human Glucose Transporter GLUT1: A Dissertation, Sabrina S. Vollers

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Role of Map4k4 in Skeletal Muscle Differentiation: A Dissertation, Mengxi Wang

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RNA Interference by the Numbers: Explaining Biology Through Enzymology: A Dissertation, Liang Meng Wee

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hox Gene Regulation and Function During Zebrafish Embryogenesis: A Dissertation, Steven E. Weicksel

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Morphogenetic Requirements for Embryo Patterning and the Generation of Stem Cell-derived Mice: A Dissertation, Yeonsoo Yoon

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A Novel Role of UAP56 in piRNA Mediated Transposon Silencing: A Dissertation, Fan Zhang

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piRNA Biogenesis and Transposon Silencing in Drosophila: A Dissertation, Zhao Zhang

Dissertations and Theses from 2012

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Mechanisms of KRAS-Mediated Pancreatic Tumor Formation and Progression: A Dissertation, Victoria A. Appleman

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Hepatitis C Virus Non-Structural Protein 3/4A: A Tale of Two Domains: A Dissertation, Cihan Aydin

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The Subtype Specific and Cross-Reactive T Cell Responses to Influenza Viruses in Humans: A Dissertation, Jenny Aurielle B. Babon

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Gene Expression and Profiling of Human Islet Cell Subtypes: A Master’s Thesis, David M. Blodgett

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Understanding Small RNA Formation in Drosophila Melanogaster: A Dissertation, Elif Sarinay Cenik

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Localization of Insulin Receptor Substrate-2 in Breast Cancer: A Dissertation, Jennifer L. Clark

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Transcriptional Regulation of the Interleukin-8 Promoter by Multiple Dengue Viral Proteins: A Dissertation, Jacob M. Collins

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Psychosocial and Behavioral Determinants of Medication Nonadherence Among African Americans with Hypertension: A Dissertation, Yendelela L. Cuffee

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Runx1 C-terminal Domains During Hematopoietic Development and Leukemogenesis: A Dissertation, Christopher R. Dowdy

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On the Source of Peptides for Major Histocompatibility Class I Antigen Presentation: A Dissertation, Diego José Farfán Arribas

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Sequence and Target Specificity of the C. elegans Cell Fate Specification Factor POS-1: A Dissertation, Brian M. Farley

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Role of Perivascular and Visceral Adipose Tissues in Murine Models of Obesity and Atherosclerosis: A Dissertation, Timothy P. Fitzgibbons

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Building the Cell's Antenna: Protein Targeting to the Ciliary Membrane: A Dissertation, John A. Follit

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Role of Glia in Sculpting Synaptic Connections at the Drosophila Neuromuscular Junction: A Dissertation, Yuly F. Fuentes Medel

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Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation, Hugh S. Gannon

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Analysis of Integrin α6β4 Function in Breast Carcinoma: A Dissertation, Kristin D. Gerson

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Getting a Tight Grip on DNA: Optimizing Zinc Fingers for Efficient ZFN-Mediated Gene Editing: A Dissertation, Ankit Gupta

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Characterization of Drug Resistance in Mycobacterium Tuberculosis via Saturating Mutagenesis of Drug Targets: A Master’s Thesis, Michelle J. Harris

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Serotonin-Expressing Cells in the Corpus of the Stomach Originate from Bone Marrow: A Master’s Thesis, Brian T. Johnston

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Gene Therapy for Very Long Chain Acyl-coA Dehydrogenase Deficiency Using Adeno-Associated Virus Vectors: A Dissertation, Allison M. Keeler

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Glial Control of Synapse Assembly at the Drosophila Neuromuscular Junction: A Dissertation, Kimberly S. Kerr

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The Role of Adaptor Protein Complex-3 Delta-Mediated HIV-1 Gag Trafficking in HIV-1 Replication: A Dissertation, Adonia Lee Kim

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A Novel Communication Mechanism Between the Presynapse and Postsynapse Through Exosomes: A Dissertation, Ceren Korkut

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Protein Ligand Interactions Probed by NMR: A Dissertation, Jennifer M. Laine

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Catalytic Mechanisms in Sec7 and Vps9 Domain Exchange Factors for Arf and Rab GTPases: A Dissertation, Meng-Tse Lee

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Studies on the Regulation of Cytoplasmic Polyadenylation Element-Binding Protein: A Dissertation, Chien-Ling Lin

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Genetic Approaches to Study Transcriptional Activation and Tumor Suppression: A Dissertation, Ling Lin

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Dissecting Somatic Cell Reprogramming by MicroRNAs and Small Molecules: A Dissertation, Zhonghan Li

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Targeting the Histone Acetyl-Transferase, RTT109, for Novel Anti-Fungal Drug Development: A Dissertation, Jessica Lopes da Rosa-Spiegler

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A Role for c-Jun Kinase (JNK) Signaling in Glial Engulfment of Degenerating Axons: A Dissertation, Jennifer M. MacDonald

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RNA-Sensing Pattern Recognition Receptors and Their Effects on T-Cell Immune Responses: A Dissertation, Rachel F. Madera

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Distinct Gene Circuits Control the Differentiation of Innate Versus Adaptive IL-17 Producing T Cells: A Dissertation, Nidhi Malhotra

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A New Murine Model For Enterohemorrhagic Escherichia coli Infection Reveals That Actin Pedestal Formation Facilitates Mucosal Colonization and Lethal Disease: A Dissertation, Emily M. Mallick

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Inflammation Inhibits Osteoblast-Mediated Bone Formation in Rheumatoid Arthritis and Regulates the Wnt and BMP Signaling Pathways: A Dissertation, Melissa M. Matzelle

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Incidence, prognosis, and factors associated with cardiac arrest in patients hospitalized with acute coronary syndromes (the GRACE Registry): A master's thesis, David D. McManus

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Characterization of New Factors in the 18S Nonfunctional Ribosomal RNA Decay Pathway in S. cerevisiae: A Dissertation, Christopher N. Merrikh

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Slow-Cycling Cancer Cells: A Dissertation, Nathan F. Moore

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Small Molecule Investigation of KCNQ Potassium Channels: A Dissertation, Karen Mruk

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Lack of CFTR in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyper-Inflammatory Adaptive Immune Responses: A Master's Thesis, Christian Mueller

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HIV-1 R5 Tropism: Determinants, Macrophages, and Dendritic Cells: A Dissertation, Thomas A. Musich

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Molecular Mechanisms of Endocytosis: Trafficking and Functional Requirements for the Transferrin Receptor, Small Interfering RNAs and Dopamine Transporter: A Dissertation, Deanna M. Navaroli

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TXNIP is a Mediator of ER Stress-Induced β-Cell Inflammation and Apoptosis: A Dissertation, Christine M. Oslowski

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Contribution of WFS1 to Pancreatic Beta Cell Survival and Adaptive Alterations in WFS1 Deficiency: A Dissertation, Bryan M. O'Sullivan-Murphy

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Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation, Paola N. Perrat

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Maintaining the Balance: Coordinating Excitation and Inhibition in a Simple Motor Circuit: A Dissertation, Hilary A. Petrash

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Therapeutic Silencing of Mutant Huntingtin by Targeting Single Nucleotide Polymorphisms: A Dissertation, Edith L. Pfister

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A Population-Based Epidemiological Description of Socio-Demographic Characteristics and Predictors of Severity Among Hospitalized 2009 H1N1 Influenza Cases in Massachusetts: A Dissertation, Hilary Placzek

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Control of Bovine Papillomavirus E2 Function By Acetylation and the Novel E2 Interacting Protein RINT1: A Dissertation, Edward J. Quinlan

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Antagonistic Pleiotropy: The Role of Smurf2 in Cancer and Aging: A Dissertation, Charusheila Ramkumar

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Innate Signaling Pathways in the Maintenance of Serological Memory: A Dissertation, Forum M. Raval

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Studies on Cellular Host Factors Involved in the HIV-1 Life Cycle: A Dissertation, Anna Kristina Serquiña

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Molecular Studies of T Cell Recognition and Cross-Reactivity: A Dissertation, Zu T. Shen

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Mechanical Activation of Valvular Interstitial Cell Phenotype: A Dissertation, Angela M. Throm Quinlan

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An Extra-Embryonic Wnt Signaling Event Controls Gastrulation in Mice: A Dissertation, Giovane G. Tortelote

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Origin of White and Brown Adipose Cells From Vascular Endothelium: A Dissertation, Khanh-Van T. Tran

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Primary and Secondary Immune Responses During Sequential West Nile Virus and Japanese Encephalitis Virus Infections: A Dissertation, Derek W. Trobaugh

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MicroRNA Markers of Acetaminophen Toxicity: A Master's Thesis, Jeanine Ward

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The Role of Heterologous Immunity in Mediating Natural Resistance to Infection in Human Subjects: A Dissertation, Levi B. Watkin

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Investigating the Roles of NEDD4.2s and Nef in the Release and Replication of HIV-1: A Dissertation, Eric R. Weiss

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Chromatin Dynamics in Pluripotency and Differentiation: A Dissertation, Ozlem Yildirim

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The Role of ITK in the Development of Gamma Delta NKT Cells: A Dissertation, Catherine C. Yin

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The Molecular Mechanisms for Maintenance of Cancer Stem Cells in Chronic Myeloid Leukemia: A Dissertation, Haojian Zhang

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Eaters of the Dead: How Glial Cells Respond to and Engulf Degenerating Axons in the CNS: A Dissertation, Jennifer S. Ziegenfuss

Dissertations and Theses from 2011

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Use of Multinational Registries to Assess and Compare Outcomes of Patients with an Acute Coronary Syndrome: A Dissertation, Hamza H. Awad

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Investigation of the C-Terminal Helix of HIV-1 Matrix: A Region Essential for Multiple Functions in the Viral Life Cycle: A Dissertation, Laura A. Brandano

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Cooperativity in Mammalian RNA Silencing: A Dissertation, Jennifer A. Broderick

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Intestine Homeostasis and the Role of Tumor Suppressor Gene 101 in Drosophila Melanogaster: A Dissertation, Madhurima Chatterjee

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Asymmetric Inheritance and Post-mitotic Fate of Midbodies: A Dissertation, Chun-Ting Chen

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Nuclear Import of Smad: A Dissertation, Xiaochu Chen

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Critical Molecular Pathways in Cancer Stem Cells of Chronic Myeloid Leukemia: A Dissertation, Yaoyu Chen

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Comparative Effectiveness of Alendronate and Risedronate on the Risk of Non-Vertebral Fractures in Older Women: An Instrumental Variables Approach: A Dissertation, Yong Chen

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Inflammation Alters Histone Methylation in the Central Nervous System: Implications for Neuropsychiatric Disease: A Dissertation, Caroline M. Connor

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The Role of miR-21 and miR-31 in Cellular Responses Mediated by TGF-β: A Dissertation, Charisa L. Cottonham

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Cellular and Molecular Mechanisms Driving Glial Engulfment of Degenerating Axons: A Dissertation, Johnna E. Doherty

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Tyraminergic G Protein-Coupled Receptors Modulate Locomotion and Navigational Behavior In C. Elegans: A Dissertation, Jamie L. Donnelly

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Quantitative Analysis of Novel Chemical and shRNA Based Methods to Increase Survival of Motor Neuron Protein Levels, Matthew C. Evans

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Biomimetic Synthetic Tissue Scaffolds for Bone Regeneration: A Dissertation, Tera M. Filion Potts

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Factors Associated with Ordering and Completion of Laboratory Monitoring Tests for High-Risk Medications in the Ambulatory Setting: A Dissertation, Shira H. Fischer

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Identification of a Command Neuron Directing the Expression of Feeding Behavior in Drosophila melanogaster: A Dissertation, Thomas F. Flood

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The Effect of Glycemic Index and Glycemic Load on Glucose Control, Lipid Profiles and Anthropometrics Among Low-Income Latinos With Type 2 Diabetes: A Dissertation, Lauren A. Gellar

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Blocking the Notch Pathway with Gamma-Secretase Inhibitors Enhances Temozolomide Treatment of Gliomas through Therapy-Induced Senescence: A Dissertation, Candace A. Gilbert

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A Global Analysis of the Adaptations Required for Sterol Catabolism in Mycobacterium Tuberculosis: A Dissertation, Jennifer E. Griffin

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Role of the Yeast Ste20 Protein Kinase Ortholog Map4k4 in Adipose Tissue Function: A Dissertation, Kalyani V. P. Guntur

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Dissecting Signaling Pathways that Regulate Axonal Guidance Effects of Sonic Hedgehog: A Dissertation, Daorong Guo

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M.tb Killing by Macrophage Innate Immune Mechanisms: A Dissertation, Michelle L. Hartman

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Using Light to Observe and Control Cellular Function: Improving Bioluminescence Imaging and Photocontrol of Rho GTPase Activation States: A Dissertation, Katryn R. Harwood

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Neuronal Nicotinic Acetylcholine Receptors: Molecular Targets for Alcoholism and Ethanol Reward: A Dissertation, Linzy M. Hendrickson