GSBS Dissertations and Theses

Approval Date

2-23-2016

Document Type

Doctoral Dissertation

Academic Program

Immunology and Microbiology, MD/PhD

Department

Medicine

First Thesis Advisor

Stuart M. Levitz, MD

Keywords

Aspergillus fumigatus, Asthma, Eosinophils, Interleukin-17, Interleukin-23, Pulmonary Aspergillosis

Subjects

Dissertations, UMMS; Aspergillus fumigatus; Asthma; Eosinophils; Interleukin-17; Interleukin-23; Pulmonary Aspergillosis

Abstract

Aspergillus fumigatus is an opportunistic fungal pathogen that causes lethal invasive pulmonary disease in immunocompromised hosts and allergic asthma in sensitized individuals. This dissertation explores how eosinophils may protect hosts from acute infection while driving asthma pathogenesis by co-producing IL-23 and IL-17 in both contexts. In an acute model of pulmonary aspergillosis, eosinophils were observed to associate with and kill A. fumigatus spores in vivo. In addition, eosinopenia was correlated with higher mortality rates, decreased recruitment of inflammatory monocytes to the lungs, and decreased expansion of lung macrophages. As IL-17 signaling must occur on a local level to elicit its stereotypical response, such as the up-regulation of antimicrobial peptides and specific chemokines from stromal cells, eosinophils were discovered to be a significant source of pulmonary IL-17 as well as one of its upstream inducers, IL-23. In the context of asthma, this discovery opens a new paradigm whereby eosinophils might be driving asthma pathogenesis.

DOI

10.13028/M2XS3K

Rights and Permissions

Copyright is held by the author, with all rights reserved.

 
 

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