GSBS Dissertations and Theses

Approval Date

8-18-2014

Document Type

Master's Thesis

Academic Program

Interdisciplinary Graduate Program

Department

Medicine

First Thesis Advisor

Chinmay Trivedi, MD, PhD

Keywords

Coronary Vessels, Histone Deacetylases, Developmental Gene Expression Regulation

Subjects

Theses, UMMS; Coronary Vessels; Histone Deacetylases; Gene Expression Regulation, Developmental

Abstract

Coronary vessel development is a crucial part of heart development requiring the interplay of the epicardial, myocardial and endocardial layers of the heart for proper formation. Coronary vascularization is regulated by a host of transcription factors further regulated by chromatin remodeling enzymes, including Histone Deacetylases (HDACs). To investigate the functions of HDACs in coronary vascular development, we have deleted Hdac3 in endocardial cells using Cre LoxP technology. Endocardial cell-­‐specific deletion of Hdac3 results in aberrant coronary vessel formation and complete postnatal lethality. We have thus shown that Hdac3 is a critical regulator of the coronary vascular development pathway.

DOI

10.13028/M2KW3H

Rights and Permissions

Copyright is held by the author, with all rights reserved.

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