Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed more than 400 doctoral dissertations to the field of biomedical sciences. The GSBS Dissertations collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

New! Usage statistics from July 2009 (PDF)

Submissions from 2009

Functional Analysis of Yeast Pheromone Receptors in ER Exit, Ligand-Induced Endocytosis and Oligomerization: A Dissertation, Chien-I Chang

Defining the Importance of Fatty Acid Metabolism in Maintaining Adipocyte Function: A Dissertation, Jennifer L. Christianson

Role of Supervillin, a Membrane Raft Protein, in Cytoskeletal Organization and Invadopodia Function, Jessica Lynn Crowley

Role of WFS1 in Regulating Endoplasmic Reticulum Stress Signaling: A Dissertation, Sonya G. Fonseca

Regulation of Cancer Cell Survival Mediated by Endogenous Tumor Suppression: A Dissertation, Minakshi Guha

Multifaceted Regulation of Peripheral T Cell Tolerance and Autoimmunity by FOXP3+ T Regulatory Cells: A Dissertation, Nitya Jain

Chromatin Remodeling in Transgenic Mouse Brain: Implications for the Neurobiology of Depression: A Dissertation, Yan Jiang

Defining the Role of CtBP2 in p53-Independent Tumor Suppressor Function of ARF: A Dissertation, Ramesh C. Kovi

Systems Level Processing of Memory in the Fly Brain: A Dissertation, Michael Jonathan Krashes

Prediction, Prevention and Treatment of Virally Induced Type 1 Diabetes: A Dissertation, Annie Joseph Kruger

Delineating the C. elegans MicroRNA Regulatory Network: A Dissertation, Natalia Julia Martinez

Functional Interaction of BPV-1 E2 with the Papillomavirus Genome: A Dissertation, Suzanne Marie Melanson

Differentially Expressed MicroRNAs Act As Inhibitors of BDNF in Prefrontal Cortex - Implications for Schizophrenia: A Dissertation, Nikolaos Mellios

Analysis of Long-Range Chromosomal Interactions in Saccharomyces cerevisiae: A Dissertation, Adriana Miele

Functional Analysis of MicroRNA-10b in Breast Carcinoma: A Dissertation, Charlotte M. Harwood Moriarty

Respiratory Syncytial Virus (RSV) Induces Innate Immunity through Toll-Like Receptors and Acquired Immunity via the RSV G Protein: A Dissertation, Matthew R. Murawski

An Omega-Based Bacterial One-Hybrid System for the Determination of Transcription Factor Specificity, Marcus Blaine Noyes

Nuclear Dynamics of a Broken Chromosome: A Dissertation, Pranav O. Oza

Worming to Complete the Insulin/IGF-1 Signaling Cascade: A Dissertation, Srivatsan Padmanabhan

The Role of the MRN Complex in the S-Phase DNA Damage Checkpoint: A Dissertation, Mary Elizabeth Porter-Goff

Recombinational Repair of a Chromosomal DNA Double Strand Break: A Dissertation, Manisha Sinha

Modeling Co-Occurring Depression and Anxiety in Patients with an Acute Coronary Syndrome: A Dissertation, Mayra Tisminetzky

Checkpoint Regulation of Replication Forks in Response to DNA Damage: A Dissertation, Nicholas Adrian Willis

Long-Range Side Chain-Main Chain Hydrogen Bonds: A Molecular Signature of the TIM Barrel Architecture: A Dissertation, Xiaoyan Yang

The Circadian Clock in Monarch Butterfly: A Tale of Two CRYs: A Dissertation, Quan Yuan

Study of the Function and Dynamics of Myosin II and Actin in Cytokinesis: A Dissertation, Mian Zhou

Submissions from 2008

Newcastle Disease Virus Virulence: Mechanism of the Interferon Antagonistic Activity of the V Protein and Characterization of a Putative Virulence-Specific Antibody to the Attachment Protein: a dissertation, Judith G. Alamares

The Molecular Mechanisms of Activity-Dependent Wingless (Wg)/Wnt Signaling at a Drosophila Glutamatergic Synapse: a Dissertation, Bulent Ataman

Attrition of CD8 T Cells during the Early Stages of Viral Infections: a Dissertation, Kapil Bahl

Cross-Reactive Memory CD4+ and CD8+ T Cells Alter the Immune Response to Heterologous Secondary Dengue Virus Infections in Mice: A Dissertation, Coreen Michele Beaumier

Magnetic Resonance Imaging of the Rat Retina: a Dissertation, Govind Bhagavatheeshwaran

Toll-Like Receptors: Target of Hepatitis C Virus: A Dissertation, Serena Soyoung Yunmee Chang

Molecular Mechanism of RNA-Mediated Gene Silencing in Human Cells: A Dissertation, Chia-Ying Chu

Functional Analysis of Ing1 and Ing4 in Cell Growth and Tumorigenesis: a Dissertation, Andrew H. Coles

Analysis of Protein Arginine Methyltransferase Function during Myogenic Gene Transcription: A Dissertation, Caroline S. Dacwag

Bone Health and Coronary Heart Disease in Postmenopausal Women with Breast Cancer Treated with Tamoxifen: A Dissertation, Hongliu Ding

Dissecting Small RNA Loading Pathway in Drosophila melanogaster: A Dissertation, Tingting Du

Checkpoint Regulation of S-Phase Transcription: A Dissertation, Chaitali Dutta

Regulation of the NF-кB Precursor relish by the Drosophila I-кB Kinase Complex: A Dissertation, Deniz Erturk Hasdemir

The Role of TEC Family Kinases in Innate T Cell Development and Function: a Dissertation, Martin Felices

Roles for Histones H4 Serine 1 Phosphorylation in DNA Double Strand Break Repair and Chromatin Compaction: A Dissertation, Melissa Anne Foley

Development of a Substrate with Photo-Modulatable Rigidity for Probing Spatial and Temporal Responses of Cells to Mechanical Signals: A Dissertation, Margo Tilley Frey

VPS45p as a Model System for Elucidation of SEC1/MUNC18 Protein Function: A Dissertation, Melonnie Lynn Marie Furgason

Structural and Functional Studies of the KCNQ1-KCNE K+ Channel Complex: A Dissertation, Steven D. Gage

Adipocyte Insulin-Mediated Glucose Transport: The Role of Myosin 1c, and a Method for in vivo Investigation: A Dissertation, G. Nana Hagan

Regulation of Reactive Nitrogen Species (RNS) Metabolism and Resistance Mechanisms in Haemophilus influenzae: A Dissertation, Jane Colleen Harrington

Small RNA Sorting in Drosophila Produces Chemically Distinct Functional RNA-Protein Complexes: A Dissertation, Michael D. Horwich

Epigenetic Determinants of Altered Gene Expression in Schizophrenia: a Dissertation, Hsien-Sung Huang

Role of Disulfide Bond Rearrangement in Newcastle Disease Virus Entry: A Dissertation, Surbhi Jain

CD4 T Cell-Mediated Lysis and Polyclonal Activation of B Cells During Lymphocytic Choriomeningitis Virus Infection: A Dissertation, Evan Robert Jellison

Analysis of CPEB Family Protein Member CPEB4 Function in Mammalian Neurons: A Dissertation, Ming-Chung Kan

A Study of Cell Polarity and Fate Specification in Early C. Elegans Embryos: A Dissertation, Soyoung Kim

The Humanized Mouse Model: The Study of the Human Alloimmune Response: A Dissertation, Marie A. King

piRNA Function and Biogenesis in the Drosophila Female Germline: A Dissertation, Carla Andrea Klattenhoff

Chromatin Remodeling and Transcriptional Memory: A Dissertation, Sharmistha Kundu

Mitotic Response to DNA Damage in Early Drosophila Embroyos: a Dissertation, Seongae Kwak

Role of Host Cellular Membrane Raft Domains in the Assembly and Release of Newcastle Disease Virus: A Dissertation, Jason P. Laliberte

Notch-1 and IGF-1 as Survivin Regulatory Pathways in Cancer: A Dissertation, Connie Wing-Ching Lee

The Role of Endoplasmic Reticulum Stress Signaling in Pancreatic Beta Cells: a Dissertation, Kathryn L. Lipson

Molecular Mechanisms of Neuropeptide Secretion from Neurohypophysial Terminals: a Dissertation, James M. McNally

DNA Damage-Induced Apoptosis in the Presence and Absence of the Tumor Suppressor p53: A Dissertation, Laura Michelle McNamee

TLR Activation Prevents Hematopoietic Chimerism Induced by Costimulation Blockade: A Dissertation, David M. Miller

Modulation of Voltage-Gated N-Type Calcium Channels by G Protein-Coupled Receptors Involves Lipids and Proteins: A Dissertation, Tora Mitra Ganguli

Chemical-Biological Investigation of KCNQ1/KCNE K+ Channel Complexes: A Dissertation, Trevor J. Morin

Role of TNF in Heterologous Immunity between Lymphocytic Choriomeningitis Virus and Vaccinia Virus: A Dissertation, Siwei Nie

Role of Endoplasmic Reticulum Stress Response Signaling in T Cells: A Dissertation, Steven C. Pino

Mutations in the vpu and env Genes of HIV-1 Can Adversely Impact Infectivity: A Dissertation, Kathryn H. Richards

GLUT1 Structure Function; Context, Ligand Cooperativity, and Mutagenesis Studies: A Dissertation, Trista K. Robichaud

Effect of KCNE1 and KCNE3 Accessory Subunits on KCNQ1 Potassium Channel Function: A Dissertation, Jessica Marie Rocheleau

The Role of Janus-Kinase-3 in CD4+ T Cell Proliferation and Differentiation: A Dissertation, Min Shi

Plasma Membrane Localization of Signaling Proteins in Yeast: a Dissertation, Satoe Takahashi

Role of MAP4K4 Signaling in Adipocyte and Macrophage Derived Inflammation: A Dissertation, Gregory J. Tesz

Modulation of Neuropeptide Release via Voltage-Dependent and -Independent Signaling in Isolated Neurohypophysial Terminals: a Dissertation, Cristina M. Velazquez-Marrero

Molecular Dissection of the Cellular Reponse to Dengue Virus Infection, Rajas V. Warke

Ethanol Sensitivity and Tolerance of Rat Neuronal BK Channels: A Dissertation, Patricia M. Wynne

The Molecular Mechanisms Underlying the Polarized Distribution of Drosophila Dscam in Neurons: A Dissertation, Shun-Jen Yang

Myocardial Macrophage Phenotypic Variation and Cytokine-Mediated Induction of HIV-Associated Cardiac Disease: A Dissertation, Jennifer Holmes Yearley

Innate Immunity in Type 2 Diabetes Pathogenesis: Role of the Lipopolysaccharide Signaling Cascade: A Dissertation, James L. Young

Submissions from 2007

Probing the Structural Topology of HIV-1 Virion Infectivity Factor (VIF): A Dissertation, Jared R. Auclair

A Genetic Analysis of Genomic Stability in Caenorhabditis Elegans: A Dissertation, Melissa M. Auclair

Human Erythrocyte Glucose Transporter (GLUT1) Structure, Function, and Regulation: a Dissertation, David M. Blodgett

Mechanism and Function of Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7: A Dissertation, Michael John Brady

Molecular and Behavioral Analysis of Drosophila Circadian Photoreception and Circadian Thermoreception: A Dissertation, Ania Busza

Role of Notch1 in Cardiac Cell Differentiation and Migration: A Dissertation, Dinh Le Mary Chau

Collagen and Fibrin Bioplymer Microthreads for Bioengineered Ligament Generation: a Dissertation, Kevin Cornwell

Transcript-Specific Cytoplasmic Degradation of YRA1 Pre-mRNA Mediated by the Yeast EDC3 Protein: A Dissertation, Shuyun Dong

Folding and Assembly of Multimeric Proteins: Dimeric HIV-1 Protease and a Trimeric Coiled Coil Component of a Complex Hemoglobin Scaffold: A Dissertation, Amanda Ann Fitzgerald

Cooperative Oncogenesis and Polyploidization in Human Cancers: a Dissertation, Susan Ann Heilman

The Role of CD40 in Naïve and Memory CD8+ T Cell Responses: a Dissertation, Maria Genevieve H. Hernandez

Motor Property of Mammalian Myosin 10: A Dissertation, Kazuaki Homma

Cartilage tissue engineering: uses of injection molding and computer aided design for the fabrication of complex geometries with high dimensional tolerances: a dissertation, Morgan E. Hott

Identification and Characterization of Components of the Intraflagellar transport (IFT) Machinery: a Dissertation, Yuqing Hou

Transfer of the Ribosome-Nascent Chain Complex to the Translocon in Cotranslational Translocation: A Thesis, Ying Jiang

Neural Diversity in the Drosophila Olfactory Circuitry: A Dissertation, Sen-Lin Lai

Autoimmune Diabetes and Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation, Julie Lambert

How Does ATP Regulate Erythrocyte Glucose Transport?: a Dissertation, Jeffry M. Leitch

Characterization of the BACH1 Helicase in the DNA Damage Response Pathway: a Dissertation, Rachel Litman

Identification and Characterization of Agv1, a Pre-Metazoan Arf GAP: A Dissertation, Kimberly Renee Long

The Role of CHD2 in Mammalian Development and Disease: a Dissertation, Concetta G. A. Marfella

Understanding Assembly of AGO2 RISC: the RNAi enzyme: a Dissertation, Christian B. Matranga