GSBS Dissertations and Theses

 

Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Publications from 2017

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A Two-Pronged Approach to Preeclampsia: Understanding Gene Expression and Targeting sFlt1 using RNAi, Ami Ashar-Patel

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Investigating Structural and Functional Defects in ALS-causing Profilin 1 Variants, Sivakumar Boopathy

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Axon Death Pathways Converge on Axed to Promote Axon Disassembly, Thomas C. Burdett

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mRNA Decay Pathways Use Translation Fidelity and Competing Decapping Complexes for Substrate Selection, Alper Celik

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Therapeutic Antibody Against Neisseria gonorrhoeae Lipooligosaccharide, a Phase-variable Virulence Factor, Srinjoy Chakraborti

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Platelet Transcriptome Heterogeneity: A Role for RNA Uptake in Vascular Health and Disease, Lauren R. Clancy

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Identification and Characterization of Rab39a and Its Role in Crosspresentation, Freidrich M. Cruz

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Regulation of Pluripotency and Differentiation by Chromatin Remodeling Factors, Ly-Sha Ee

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The Role of Skeletal Survey in Identifying Non-Accidental Trauma in Pediatric Trauma Patients, Jonathan Green

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Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1, Nils Henninger

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Three-dimensional Folding of Eukaryotic Genomes, Tsung-Han S. Hsieh

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Exploring New Therapeutic Strategies for Osteoarthritis: From Genetic Manipulation of Skeletal Tissues to Chemically-modified Synthetic Hydrogels, Henry Huang

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A Synthetic Genetic System to Investigate Brain Connectivity and Genetically Manipulate Interacting Cells, Ting-Hao Huang

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Behavioral and Functional Analysis of a Calcium Channelopathy in Caenorhaditis elegans, Yung-Chi Huang

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Single-Molecule Studies of Replication Kinetics in Response to DNA Damage, Divya Ramalingam Iyer

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Role of Tim3 in Mediating T Cell Exhaustion During Chronic Mycobacterium Tuberculosis Infection, Miye K. Jacques

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Regulation of Alloreactive CD8 T Cell Responses by Costimulation and Inflammation, Sonal Jangalwe

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Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation, Hatem E. Kamber Kaya

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Genomic and Transcriptomic Investigation of Endemic Burkitt Lymphoma and Epstein Barr Virus, Yasin Kaymaz

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Generation of Pharyngeal Foregut Endoderm from Pluripotent Stem Cells, Nicola A. Kearns

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Neuronal circuitry controlling circadian photoreception in Drosophila, Pallavi Lamba

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Complement-Related Regulates Autophagy in Neighboring Cells, Lin Lin

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Impact of Intra-Articular Injection Use on Patient-Reported Outcomes Among Patients with Knee Osteoarthritis, Shao-Hsien Liu

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Investigating the Role of PIR1 and CD200R1 in the Innate Immune Response to Viral Pathogens, Christopher R. MacKay

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CAF-1 p150 and Ki-67 Regulate Nuclear Structure Throughout the Human Cell Cycle, Timothy D. Matheson

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Regulation of the FGF/ERK Signaling Pathway: Roles in Zebrafish Gametogenesis and Embryogenesis, Jennifer M. Maurer

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Regulation of Local Translation, Synaptic Plasticity, and Cognitive Function by CNOT7, Rhonda L. McFleder

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Characterization of Severe Malaria in Liberian Children 5 Years Old and Younger, Patricia A. McQuilkin

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A Mechanistic Investigation of Insulin Receptor Substrate 2 Function in Breast Cancer Progression, Jose R. Mercado-Matos

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Recent Trends in Sepsis Mortality, Associations between Initial Source of Sepsis and Hospital Mortality, and Predictors of Sepsis Readmission in Sepsis Survivors, Christine Motzkus

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Role of Energy Metabolism in the Thermogenic Gene Program, Minwoo Nam

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Patient and Social Determinants of Health Trajectories Following Coronary Events, Lisa Nobel

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Alterations in mRNA 3′UTR Isoform Abundance Accompany Gene Expression Changes in Huntington's Disease, Lindsay S. Romo

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Pathways Involved in Recognition and Induction of Trained Innate Immunity by Plasmodium falciparum, Jacob E. Schrum

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Ki-67 Regulates Cell Cycle Progression and Heterochromatin Organization, Xiaoming Sun

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Intergenerational Effects of Nicotine in an Animal Model of Paternal Nicotine Exposure, Markus Parzival Vallaster

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Novel Mechanisms Regulating Dopamine Transporter Endocytic Trafficking: Ack1-Controlled Endocytosis And Retromer-Mediated Recycling, Sijia Wu

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A Systems Approach to Dissecting Immune Gene Regulatory Networks in the Modulation of Brain Function, Yang Xu

Publications from 2016

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Evaluating Acceptability, Feasibility and Efficacy of a Diabetes Care Support Program Facilitated by Cellular-Enabled Glucose Meters: A Dissertation, Daniel J. Amante

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Single Molecule Visualization of the DEAH-Box ARPase Prp22 Interacting with the Spliceosome: A Dissertation, Eric G. Anderson

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Barriers and Facilitators to Deaf Trauma Survivors’ Help-Seeking Behavior: Lessons for Behavioral Clinical Trials Research: A Master’s Thesis, Melissa L. Anderson

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Temporal Organization of Behavioral States through Local Neuromodulation in C. elegans, Navonil Banerjee

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Characterization of Higher-order Chromatin Structure in Bone Differentiation and Breast Cancer: A Dissertation, Ahmet Rasim Barutcu

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Cytosolic and Endosomal DNA-Sensing Pathways Differentially Regulate Inflammatory Arthritis, Autoantibody Production, and Bone Remodeling: A Dissertation, Rebecca A. Baum

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The Role of Late Antigen in CD4 Memory T Cell Formation during Influena [i.e. Influenza] Infection: A Dissertation, Bianca L. Bautista

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Molecular Mechanisms of Assembly and Long-term Maintenance of Neuronal Architecture: A Dissertation, Cassandra R. Blanchette

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Tissue Compartmentalization and Tropism of HIV-1: A Dissertation, Robin L. Brese

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Memory CD8+ T Cell Function during Mycobacterium Tuberculosis Infection: A Dissertation, Stephen M. Carpenter

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The Role of MDM2 Phosphorylation in P53 Responses to DNA Damage and Tumor Suppression: A Dissertation, Michael I. Carr

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A Novel SMC-Like Protein Modulates C. Elegans Condensin Functions: A Dissertation, Lucy F. Chao

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Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation, Sourav Roy Choudhury

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FC Receptor-Mediated Activities of Env-Specific Monoclonal Antibodies Generated from Human Volunteers Receiving a DNA Prime-Protein Boost HIV Vaccine: A Dissertation, Matthew R. Costa

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Requirement and Function of Hippo Pathway Signaling in the Mammalian Gastrointestinal Tract: A Dissertation, Jennifer L. Cotton

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The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis, Sezin Dagdeviren

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Sex, Drugs, and Rodent Reward: An Exploration of the Sex-Specific Roles of Nicotinic Acetylcholine Receptors in Ethanol Reward, Melissa Guildford Derner

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Characterizing the Disorder in Tristetraprolin and its Contribution to Post-Transcriptional Gene Regulation: A Dissertation, Laura M. Deveau

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A Role for the Lipid Droplet Protein HIG2 in Promoting Lipid Deposition in Liver and Adipose Tissue: A Dissertation, Marina T. DiStefano

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Frailty and Outcomes in Liver Transplantation: A Dissertation, Natasha H. Dolgin

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Levels of YCG1 Limit Condensin Function during the Cell Cycle: A Dissertation, Tyler W. Doughty

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The Impact of mTORC2 Signaling on the Initiation and Progression of KRAS-Driven Pancreatic Neoplasias: A Dissertation, David R. Driscoll

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Structural Mechanisms of the Sliding Clamp and Sliding Clamp Loader: Insights into Disease and Function: A Dissertation, Caroline M. Duffy

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Investigation of RNA Binding Protein Pumilio as a Genetic Modifier of Mutant CHMP2B in Frontotemporal Dementia (FTD): A Masters Thesis, Xing Du

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Histopathological Characterization of the Dystrophic Phenotype and Development of Therapeutic Candidates for a Gene Therapy Pre-Clinical Study in Dysferlin Deficient Mice, Leticia Fridman

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Viruses Implicated in the Initiation of Type 1 Diabetes Affect β Cell Function and Antiviral Innate Immune Responses: A Dissertation, Glen R. Gallagher

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Overcoming Toxicity from Transgene Overexpression Through Vector Design in AAV Gene Therapy for GM2 Gangliosidoses, Diane L. Golebiowski

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Contraceptive Utilization and Downstream Feto-Maternal Outcomes for Women with Substance Use Disorders: A Dissertation, Gillian J. Griffith

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A Translational Pathway for Recombinant Adeno-Associated Virus Human Gene Therapy: From Target Identification and Animal Modeling of the Disease to Non-Human Primate and Human Studies, Alisha Gruntman

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Eosinophils as Drivers of the IL-23/IL-17 Axis: Implications for Acute Aspergillosis and Allergic Asthma: A Dissertation, Evelyn V. Santos Guerra

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A Walk on the Fine Line Between Reward and Risk: AAV-IFNβ Gene Therapy for Glioblastoma: A Dissertation, Dwijit Guhasarkar

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Investigating the Architecture and Vesicle Tethering Function of the Yeast Exocyst Complex: A Dissertation, Margaret R. Heider

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mTORC2 Promotes Lipid Storage and Suppresses Thermogenesis in Brown Adipose Tissue in Part Through AKT-Independent Regulation of FoxO1: A Dissertation, Chien-Min Hung

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Roles of the Mother Centriole Appendage Protein Cenexin in Microtubule Organization during Cell Migration and Cell Division: A Dissertation, Hui-Fang Hung

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Systematic Experimental Determination of Functional Constraints on Proteins and Adaptive Potential of Mutations: A Dissertation, Li Jiang

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Synapse Development: Ribonucleoprotein Transport from the Nucleus to the Synapse: A Dissertation, Vahbiz Jokhi

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Understanding the Sequence-Specificity and RNA Target Recognition Properties of the Oocyte Maturation Factor, OMA-1, in Caenorhabditis elegans: A Dissertation, Ebru Kaymak

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XIST and CoT-1 Repeat RNAs are Integral Components of a Complex Nuclear Scaffold Required to Maintain SAF-A and Modify Chromosome Architecture: A Dissertation, Heather J. Kolpa

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Computational Approaches for the Analysis of Chromosome Conformation Capture Data and Their Application to Study Long-Range Gene Regulation: A Dissertation, Bryan R. Lajoie

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Histone Deacetylase 3 Coordinates Heart Development Through Stage-Specific Roles in Cardiac Progenitor Cells, Sara L. Lewandowski

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Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation, Kuan-Hung Lin

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Mechanisms of Synaptic Development and Premature Aging in Drosophila: A Dissertation, Yihang Li

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The Identification and Targeting of Partially-Folded Conformations on the Folding Free-Energy Landscapes of ALS-Linked Proteins for Therapeutic Intervention: A Dissertation, Brian C. Mackness

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Targeting Drug Resistance in Chronic Myeloid Leukemia: A Dissertation, Leyuan Ma

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The Origin of Human White, Brown, and Brite/Beige Adipocytes, So Yun Min

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Plague and the Defeat of Mammalian Innate Immunity: Systematic Genetic Analysis of Yersinia pestis Virulence Factors: A Dissertation, Samantha G. Palace

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Identification of Novel Pathways that Promote Anoikis through Genome-wide Screens, Victoria E. Pedanou

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Conceptualizing, Understanding, and Assessing Research Literacy in a Diverse Population: A Dissertation, Lauren R. Powell

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Understanding Drug Resistance and Antibody Neutralization Escape in Antivirals: A Dissertation, Kristina L. Prachanronarong

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Predictors of Post-injury Mortality in Elderly Patients with Trauma: A Master's Thesis, Charles M. Psoinos

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The Drosophila Homolog of the Intellectual Disability Gene ACSL4 Acts in Glia to Regulate Morphology and Neuronal Activity: A Dissertation, Caitlin M. Quigley

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The Structural Basis for the Interdependence of Drug Resistance in the HIV-1 Protease, Debra A. Ragland

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Activation and Inhibition of Multiple Inflammasome Pathways by the Yersinia Pestis Type Three Secretion System: A Dissertation, Dmitry Ratner

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Identification and Characterization of MicroRNA Modulators in Caenorhabditis Elegans: A Dissertation, Zhiji Ren

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Identification of Essential Metabolic and Genetic Adaptations to the Quiescent State in Mycobacterium Tuberculosis: A Dissertation, Emily S. C. Rittershaus

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The Mechanistic Role and Therapeutic Potential of microRNA-122 in Alcoholic Liver Disease: A Dissertation, Abhishek Satishchandran

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A Role for TNMD in Adipocyte Differentiation and Adipose Tissue Function: A Dissertation, Ozlem Senol-Cosar

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Functions of Argonaute Proteins in Self Versus Non-Self Recognition in the C. elegans Germline: A Dissertation, Meetu Seth

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Function of the β4 Integrin in Cancer Stem Cells and Tumor Formation in Breast Cancer: A Masters Thesis, Huayan Sun

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The SMURF2-YY1-C-MYC Axis in the Germinal Center Reaction and Diffuse Large B Cell Lymphoma: A Dissertation, Sally E. Trabucco

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Mechanisms Regulating Early Mesendodermal Differentiation of Human Embryonic Stem Cells: A Dissertation, Jennifer J. VanOudenhove

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Activation of mTORC1 Improves Cone Cell Metabolism and Extends Vision in Retinitis Pigmentosa Mice: A Dissertation, Aditya Venkatesh