GSBS Dissertations and Theses

 

Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

Attention GSBS students: Click on Submit Thesis/Dissertation in the left sidebar to submit your final, approved thesis/dissertation. You’ll need to log in or create a free account. Questions? Contact Lisa Palmer.

Follow


Dissertations and Theses from 2016

PDF

Evaluating Acceptability, Feasibility and Efficacy of a Diabetes Care Support Program Facilitated by Cellular-Enabled Glucose Meters: A Dissertation, Daniel J. Amante

PDF

Single Molecule Visualization of the DEAH-Box ARPase Prp22 Interacting with the Spliceosome: A Dissertation, Eric G. Anderson

PDF

Barriers and Facilitators to Deaf Trauma Survivors’ Help-Seeking Behavior: Lessons for Behavioral Clinical Trials Research: A Master’s Thesis, Melissa L. Anderson

PDF

Characterization of Higher-order Chromatin Structure in Bone Differentiation and Breast Cancer: A Dissertation, Ahmet Rasim Barutcu

PDF

Cytosolic and Endosomal DNA-Sensing Pathways Differentially Regulate Inflammatory Arthritis, Autoantibody Production, and Bone Remodeling: A Dissertation, Rebecca A. Baum

PDF

The Role of Late Antigen in CD4 Memory T Cell Formation during Influena [i.e. Influenza] Infection: A Dissertation, Bianca L. Bautista

PDF

Molecular Mechanisms of Assembly and Long-term Maintenance of Neuronal Architecture: A Dissertation, Cassandra R. Blanchette

PDF

Tissue Compartmentalization and Tropism of HIV-1: A Dissertation, Robin L. Brese

PDF

Memory CD8+ T Cell Function during Mycobacterium Tuberculosis Infection: A Dissertation, Stephen M. Carpenter

PDF

The Role of MDM2 Phosphorylation in P53 Responses to DNA Damage and Tumor Suppression: A Dissertation, Michael I. Carr

PDF

A Novel SMC-Like Protein Modulates C. Elegans Condensin Functions: A Dissertation, Lucy F. Chao

PDF

Developing an Adeno-Associated Viral Vector (AAV) Toolbox for CNS Gene Therapy: A Dissertation, Sourav Roy Choudhury

PDF

FC Receptor-Mediated Activities of Env-Specific Monoclonal Antibodies Generated from Human Volunteers Receiving a DNA Prime-Protein Boost HIV Vaccine: A Dissertation, Matthew R. Costa

PDF

Requirement and Function of Hippo Pathway Signaling in the Mammalian Gastrointestinal Tract: A Dissertation, Jennifer L. Cotton

PDF

Characterizing the Disorder in Tristetraprolin and its Contribution to Post-Transcriptional Gene Regulation: A Dissertation, Laura M. Deveau

PDF

A Role for the Lipid Droplet Protein HIG2 in Promoting Lipid Deposition in Liver and Adipose Tissue: A Dissertation, Marina T. DiStefano

PDF

Frailty and Outcomes in Liver Transplantation: A Dissertation, Natasha H. Dolgin

PDF

Levels of YCG1 Limit Condensin Function during the Cell Cycle: A Dissertation, Tyler W. Doughty

PDF

The Impact of mTORC2 Signaling on the Initiation and Progression of KRAS-Driven Pancreatic Neoplasias: A Dissertation, David R. Driscoll

PDF

Structural Mechanisms of the Sliding Clamp and Sliding Clamp Loader: Insights into Disease and Function: A Dissertation, Caroline M. Duffy

PDF

Investigation of RNA Binding Protein Pumilio as a Genetic Modifier of Mutant CHMP2B in Frontotemporal Dementia (FTD): A Masters Thesis, Xing Du

PDF

Viruses Implicated in the Initiation of Type 1 Diabetes Affect β Cell Function and Antiviral Innate Immune Responses: A Dissertation, Glen R. Gallagher

PDF

Contraceptive Utilization and Downstream Feto-Maternal Outcomes for Women with Substance Use Disorders: A Dissertation, Gillian J. Griffith

PDF

Eosinophils as Drivers of the IL-23/IL-17 Axis: Implications for Acute Aspergillosis and Allergic Asthma: A Dissertation, Evelyn V. Santos Guerra

PDF

A Walk on the Fine Line Between Reward and Risk: AAV-IFNβ Gene Therapy for Glioblastoma: A Dissertation, Dwijit Guhusarkar

PDF

Investigating the Architecture and Vesicle Tethering Function of the Yeast Exocyst Complex: A Dissertation, Margaret R. Heider

PDF

mTORC2 Promotes Lipid Storage and Suppresses Thermogenesis in Brown Adipose Tissue in Part Through AKT-Independent Regulation of FoxO1: A Dissertation, Chien-Min Hung

PDF

Roles of the Mother Centriole Appendage Protein Cenexin in Microtubule Organization during Cell Migration and Cell Division: A Dissertation, Hui-Fang Hung

PDF

Systematic Experimental Determination of Functional Constraints on Proteins and Adaptive Potential of Mutations: A Dissertation, Li Jiang

PDF

Synapse Development: Ribonucleoprotein Transport from the Nucleus to the Synapse: A Dissertation, Vahbiz Jokhi

PDF

Understanding the Sequence-Specificity and RNA Target Recognition Properties of the Oocyte Maturation Factor, OMA-1, in Caenorhabditis elegans: A Dissertation, Ebru Kaymak

PDF

XIST and CoT-1 Repeat RNAs are Integral Components of a Complex Nuclear Scaffold Required to Maintain SAF-A and Modify Chromosome Architecture: A Dissertation, Heather J. Kolpa

PDF

Computational Approaches for the Analysis of Chromosome Conformation Capture Data and Their Application to Study Long-Range Gene Regulation: A Dissertation, Bryan R. Lajoie

PDF

Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation, Kuan-Hung Lin

PDF

Mechanisms of Synaptic Development and Premature Aging in Drosophila: A Dissertation, Yihang Li

PDF

The Identification and Targeting of Partially-Folded Conformations on the Folding Free-Energy Landscapes of ALS-Linked Proteins for Therapeutic Intervention: A Dissertation, Brian C. Mackness

PDF

Targeting Drug Resistance in Chronic Myeloid Leukemia: A Dissertation, Leyuan Ma

PDF

Plague and the Defeat of Mammalian Innate Immunity: Systematic Genetic Analysis of Yersinia pestis Virulence Factors: A Dissertation, Samantha G. Palace

PDF

Conceptualizing, Understanding, and Assessing Research Literacy in a Diverse Population: A Dissertation, Lauren R. Powell

PDF

Understanding Drug Resistance and Antibody Neutralization Escape in Antivirals: A Dissertation, Kristina L. Prachanronarong

PDF

Predictors of Post-injury Mortality in Elderly Patients with Trauma: A Master's Thesis, Charles M. Psoinos

PDF

The Drosophila Homolog of the Intellectual Disability Gene ACSL4 Acts in Glia to Regulate Morphology and Neuronal Activity: A Dissertation, Caitlin M. Quigley

PDF

Activation and Inhibition of Multiple Inflammasome Pathways by the Yersinia Pestis Type Three Secretion System: A Dissertation, Dmitry Ratner

PDF

Identification and Characterization of MicroRNA Modulators in Caenorhabditis Elegans: A Dissertation, Zhiji Ren

PDF

The Mechanistic Role and Therapeutic Potential of microRNA-122 in Alcoholic Liver Disease: A Dissertation, Abhishek Satishchandran

PDF

A Role for TNMD in Adipocyte Differentiation and Adipose Tissue Function: A Dissertation, Ozlem Senol-Cosar

PDF

Function of the β4 Integrin in Cancer Stem Cells and Tumor Formation in Breast Cancer: A Masters Thesis, Huayan Sun

PDF

The SMURF2-YY1-C-MYC Axis in the Germinal Center Reaction and Diffuse Large B Cell Lymphoma: A Dissertation, Sally E. Trabucco

PDF

Mechanisms Regulating Early Mesendodermal Differentiation of Human Embryonic Stem Cells: A Dissertation, Jennifer J. VanOudenhove

PDF

Activation of mTORC1 Improves Cone Cell Metabolism and Extends Vision in Retinitis Pigmentosa Mice: A Dissertation, Aditya Venkatesh

PDF

Exploiting DNA Repair and ER Stress Response Pathways to Induce Apoptosis in Glioblastoma Multiforme: A Dissertation, Jessica L. Weatherbee

Dissertations and Theses from 2015

PDF

Regulation of Metabolism by Hepatic OXPHOS: A Dissertation, Thomas E. Akie

PDF

MicroRNAs Protect the Robustness of Distal Tip Cell Migrations from Temperature Changes in Caenorhabditis elegans: A Dissertation, Samantha L. Burke

PDF

Rapid Access to Perinatal Psychiatric Care in Depression (RAPPID): A Master’s Thesis, Nancy Byatt

PDF

Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A Dissertation, Cheng Chang

PDF

Flipping Biological Switches: Solving for Optimal Control: A Dissertation, Joshua TsuKang Chang

PDF

Dissecting the Role of a lncRNA and Involvement of Plasmodium Infections in the Innate Immune Response: A Dissertation, Jennie Chan

PDF

Hospital Treatment Practices, 30-Day Hospital Readmissions, and Long-Term Prognosis in Patients Hospitalized with Acute Myocardial Infarction: A Dissertation, Han-Yang Chen

PDF

Systematic Dissection of Roles for Chromatin Regulators in Dynamics of Transcriptional Response to Stress in Yeast: A Dissertation, Hsiuyi V. Chen

PDF

A More Accessible Drosophila Genome to Study Fly CNS Development: A Dissertation, Hui-Min Chen

PDF

TAK1-Mediated Post-Translational Modifications Modulate Immune Response: A Dissertation, Li Chen

PDF

Function and Regulation of the Tip60-p400 Complex in Embryonic Stem Cells: A Dissertation, Poshen B. Chen

PDF

Characterization of Envelope-Specific Antibody Response Elicited by HIV-1 Vaccines: A Dissertation, Yuxin Chen

PDF

Gender Differences in Choice of Procedure and Case Fatality Rate for Elderly Patients with Acute Cholecystitis: A Masters Thesis, Courtney E. Collins

PDF

Attention Deficit/Hyperactivity Disorder, Screen Time, Physical Activity, and Diet Quality: A Dissertation, Carol Curtin

PDF

Role of Protein Kinase Map4k4 in Energy Metabolism: A Dissertation, Laura V. Danai

PDF

Systematic Analysis of Duplications and Deletions in the Malaria Parasite P. falciparum: A Dissertation, Derrick K. DeConti

PDF

Sentinel Lymph Node Biopsy in Elderly Patients with Intermediate Thickness Melanoma: A Masters Thesis, Kate H. Dinh

PDF

A Tale of Two Projects: Basis for Centrosome Amplification after DNA Damage and Practical Assessment of Photodamage in Live-Cell Imaging: A Dissertation, Stephen Douthwright

PDF

The Exocyst Subunit Sec6 Interacts with Assembled Exocytic Snare Complexes: A Dissertation, Michelle L. Dubuke

PDF

Exploring New Strategies to Overcome Resistance in Glioblastoma Multiforme: A Dissertation, Yulian P. Ellis

PDF

Predicting Other Cause Mortality Risk for Older Men with Localized Prostate Cancer: A Dissertation, Daniel M. Frendl

PDF

The Epithelial Transmembrane Protein PERP Is Required for Inflammatory Responses to S. typhimurium Infection: A Dissertation, Kelly N. Hallstrom

PDF

Using Experimental and Computational Strategies to Understand the Biogenesis of microRNAs and piRNAs: A Dissertation, Bo W. Han

PDF

Optimizing RNA Library Preparation to Redefine the Translational Status of 80S Monosomes: A Dissertation, Erin E. Heyer

PDF

Roles of Protein Arginine Methyltransferase 7 and Jumonji Domain-Containing Protein 6 in Adipocyte Differentiation: A Dissertation, Yu-Jie Hu

PDF

Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation, Sharanya Iyengar

PDF

Investigating the Effects of Mutant FUS on Stress Response in Amyotrophic Lateral Sclerosis: A Thesis, Laura J. Kaushansky

PDF

Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation, Daniel L. Keifenheim

PDF

Age-related Changes in the Neuronal Architecture of Caenorhabditis Elegans: A Dissertation, Anagha Khandekar

PDF

Exploring the Role of FUS Mutants from Stress Granule Incorporation to Nucleopathy in Amyotrophic Lateral Sclerosis: A Dissertation, Hae Kyung Ko

PDF

Language Proficiency, Citizenship, and Food Insecurity among Predominantly Immigrant Caribbean Latinos in Massachusetts: A Masters Thesis, Tariana V. Little

PDF

Calcium Dependent Regulatory Mechanism in Wolfram Syndrome: A Dissertation, Simin Lu

PDF

Molecular Pathways Mediating Glial Responses during Wallerian Degeneration: A Dissertation, Tsai-Yi Lu

PDF

ATP-Dependent Heterochromatin Remodeling: A Dissertation, Benjamin J. Manning

PDF

Endothelial Driven Inflammation in Metabolic Disease: A Dissertation, Anouch Matevossian

PDF

Yeast Upf1 Associates With RibosomesTranslating mRNA Coding Sequences Upstream of Normal Termination Codons: A Dissertation, Ei Ei Min

PDF

Pushing The Boundaries of Bioluminescence Using Synthetic Luciferins: A Dissertation, David M. Mofford

PDF

Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation, Allie Muthukumar

PDF

IRF4 Does the Balancing Act: A Dissertation, Ribhu Nayar

PDF

MicroRNA Regulation of Autophagy during Programmed Cell Death: A Dissertation, Charles J. Nelson

PDF

The Role of VTA Gabaergic Nicotinic Acetylcholine Receptors Containing the α4 Subunit in Nicotine Dependence: A Dissertation, Jennifer Ngolab

PDF

Small RNA Regulation of the Innate Immune Response: A Role for Dicer in the Control of Viral Production and Sensing of Nucleic Acids: A Dissertation, Ryan J. Nistler

PDF

Cathosis: Cathepsins in Particle-induced Inflammatory Cell Death: A Dissertation, Gregory M. Orlowski

PDF

The Role of Medial Habenula-Interpeduncular Nucleus Pathway in Anxiety: A Dissertation, Xueyan Pang

PDF

Advancements in the Synthesis and Application of Near-Infrared Imaging Reagents: A Dissertation, Steven M. Pauff

PDF

Use of Opioids for Pain Management in Nursing Homes: A Dissertation, Camilla B. Pimentel

PDF

Subtle Controllers: MicroRNAs Drive Pancreatic Tumorigenesis and Progression: A Dissertation, Brian J. Quattrochi

PDF

Jun Kinases in Hematopoiesis, and Vascular Development and Function: A Dissertation, Kasmir Ramo

PDF

RNA Exosome & Chromatin: The Yin & Yang of Transcription: A Dissertation, Mayuri Rege