Since the school's inception in 1979, students in the Graduate School of Biomedical Sciences (GSBS) have contributed hundreds of doctoral dissertations and masters theses to the field of biomedical sciences. The GSBS Dissertations and Theses collection makes this body of work accessible to our students, faculty, potential recruits, and the citizens of Massachusetts.

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Dissertations and Theses from 2015

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Rapid Access to Perinatal Psychiatric Care in Depression (RAPPID): A Master’s Thesis, Nancy Byatt

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Function and Regulation of the α6 Integrins in Mammary Epithelial Biology and Breast Cancer: A Dissertation, Cheng Chang

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A Tale of Two Projects: Basis for Centrosome Amplification after DNA Damage and Practical Assessment of Photodamage in Live-Cell Imaging: A Dissertation, Stephen Douthwright

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Language Proficiency, Citizenship, and Food Insecurity among Predominantly Immigrant Caribbean Latinos in Massachusetts: A Masters Thesis, Tariana V. Little

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Calcium Dependent Regulatory Mechanism in Wolfram Syndrome: A Dissertation, Simin Lu

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Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation, Allie Muthukumar

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IRF4 Does the Balancing Act: A Dissertation, Ribhu Nayar

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Advancements in the Synthesis and Application of Near-Infrared Imaging Reagents: A Dissertation, Steven M. Pauff

Dissertations and Theses from 2014

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rAAV-Mediated Gene Transfer For Study of Pathological Mechanisms and Therapeutic Intervention in Canavan's Disease: A Dissertation, Seemin Seher Ahmed

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Identification and Characteristics of Factors Regulating Hepatocellular Carcinoma Progression and Metastasis: A Dissertation, Leanne G. Ahronian

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Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation, Belinda Barbagallo

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Chromatin Regulators and DNA Repair: A Dissertation, Gwendolyn M. Bennett

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Regulation of Type II Responses in Lung Fibrosis and Systemic Autoimmunity: A Dissertation, Tia Bumpus Brodeur

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Heterologous Immunity and T Cell Stability During Viral Infections: A Dissertation, Jenny Wun-Yue Che

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From Neurodegeneration to Infertility and Back - Exploring Functions of Two Genes: ARMC4 and TARDBP: A Dissertation, Wei Cheng

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Neural Orchestration of the C. elegans Escape Response: A Dissertation, Christopher M. Clark

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A Feedback Loop Couples Musashi-1 Activity to Omega-9 Fatty Acid Biosynthesis: A PhD Dissertation, Carina C. Clingman

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Long-Term Survival and Prognostic Factors in Patients with Acute Decompensated Heart Failure According to Ejection Fraction Findings: A Population-Based Perspective: A Master Thesis, Andrew H. Coles

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Small RNAs and Argonautes Provide a Paternal Epigenetic Memory of Germline Gene Expression to Promote Thermotolerant Male Fertility: A Dissertation, Colin C. Conine

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ADHD-200 Patient Characterization and Classification using Resting State Networks: A Dissertation, Suzanne M. Czerniak

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Clinical and Financial Impact of Hospital Readmissions Following Colorectal Resection: Predictors, Outcomes, and Costs: A Thesis, Rachelle N. Damle

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Hypertensive Acute Decompensated Heart Failure Presentations: On the Decline? : A Master's Thesis, Chad E. Darling

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POS-1 Regulation of Endo-mesoderm Identity in C. elegans: A Dissertation, Ahmed M. Elewa

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Impact of COPD on the Mortality and Treatment of Patients Hospitalized with Acute Decompensated Heart Failure (The Worcester Heart Failure Study): A Masters Thesis, Kimberly A. Fisher

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Psychometric Evaluation of Joint-Specific Patient-Reported Outcome Measures Before and After Total Knee Replacement: A Dissertation, Barbara L. Gandek

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Characterization of Anti-Fungal Inflammasome Responses and the Role of Caspase-8 in Innate Immune Signaling: A Dissertation, Sandhya Ganesan

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Investigating Tumor Suppressors in the DNA Damage Response: Caretakers of the Genome and Biomarkers to Predict Therapeutic Response: A Dissertation, Shawna S. Guillemette

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Cognitive Status and Initiation of Lifestyle Changes Following Acute Coronary Heart Syndrome: A Dissertation, Alexandra M. Hajduk

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Characterization of the Visceral Endoderm Components in Early Post-Implantation Mouse Embryo Development: A Dissertation, Tingting Huang

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A Population-Based Perspective on Clinically Recognized Venous Thromboembolism: Contemporary Trends in Clinical Epidemiology and Risk Assessment of Recurrent Events: A Dissertation, Wei Huang

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Dissecting cis and trans Determinants of Nucleosome Positioning: A Dissertation, Amanda L. Hughes

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Amphiphilic Degradable Polymer/Hydroxyapatite Composites as Smart Bone Tissue Engineering Scaffolds: A Dissertation, Artem B. Kutikov

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EspFU, an Enterohemorrhagic E. Coli Secreted Effector, Hijacks Mammalian Actin Assembly Proteins by Molecular Mimicry and Repetition: A Dissertation, YuShuan (Cindy) Lai

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Mechanistic Analysis of Differential Signal Transduction Mediated by the Insulin Receptor Substrate Proteins IRS-1 and IRS-2: A Dissertation, Justine M. Landis

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Outpatient Emergency Department Utilization: Measurement and Prediction: A Dissertation, Lisa M. Lines

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An Integrated Structural Mechanism for Relief of Autoinhibition and Membrane Targeting in Cytohesin Family Guanine Nucleotide Exchange Factors: A Dissertation, Andrew W. Malaby

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Identification of Molecular Determinants that Shift Co- and Post-Translational N-Glycosylation Kinetics in Type I Transmembrane Peptides: A Dissertation, Heidi L. H. Malaby

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MIRAGE DNA Transposon Silencing by C. elegans Condensin II Subunit HCP-6: A Masters Thesis, Anna Malinkevich

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Complex Roles of Macrophages in Lipid Metabolism and Metabolic Disease: A Dissertation, Kimberly A. Negrin

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Early Folding Biases in the Folding Free-Energy Surface of βα-Repeat Proteins: A Dissertation, Robert P. Nobrega

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Differences in Access to Care and Healthcare Utilization Among Sexual Minorities: A Master's Thesis, Tan Phu Pham

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GLI-IKBKE Requirement In KRAS-Induced Pancreatic Tumorigenesis: A Dissertation, Mihir S. Rajurkar

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Depression in Rheumatoid Arthritis and an Estimation of the Bi-directional Association of Depression and Disease Burden: A Dissertation, Alan M. Rathbun

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Role of Mycobacterium Tuberculosis-Induced Necrotic Cell Death of Macrophages in the Pathogenesis of Pulmonary Tuberculosis: A Dissertation, Teresa S. Repasy

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Analyses of All Possible Point Mutations within a Protein Reveals Relationships between Function and Experimental Fitness: A Dissertation, Benjamin P. Roscoe

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Putting the Pieces Together: Exons and piRNAs: A Dissertation, Christian K. Roy

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FUS/TLS in Stress Response - Implications for Amyotrophic Lateral Sclerosis: A Dissertation, Reddy Ranjith Kumar Sama

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Evolutionary Approaches to the Study of Small Noncoding Regulatory RNA Pathways: A Dissertation, Alfred T. Simkin

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The Three-Dimensional Structure of the Cystic Fibrosis Locus: A Dissertation, Emily M. Smith

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Comparative Effectiveness of Lithium and Valproate for Suicide Prevention and Associations With Nonsuicide Mortality: A Dissertation, Eric G. Smith

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Characterization of Innate Immune Pathways in DNA Vaccine-Induced, Antigen-Specific Immune Responses: A Dissertation, John J. Suschak III

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Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation, Ozge E. Tasdemir-Yilmaz

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Dissecting the Role of Cytosolic Nucleic Acid Sensors in the Type I Interferon Response to Herpes Simplex Virus-1 and other Ligands: A Dissertation, Mikayla R. Thompson

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CD8+ T Cell and NK Responses to a Novel Dengue Epitope: A Possible Role for KIR3DL1 in Dengue Pathogenesis: A Dissertation, Elizabeth Townsley

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Developing Three New Pathophysiologically Based Measures of Nicotine Dependence: A Dissertation, W. W. Sanouri A. Ursprung

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The Cellular Consequences of FUS/TLS Depletion: A Loss of Function Model for Amyotrophic Lateral Sclerosis: A Dissertation, Catherine L. Ward

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Caspase-8 and RIP Kinases Regulate Bacteria-Induced Innate Immune Responses and Cell Death: A Dissertation, Dan Weng

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Oncogene Function in Pre-Leukemia Stage of INV(16) Acute Myeloid Leukemia: A Dissertation, Liting Xue

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Molecular Landscape of Induced Reprogramming: A Dissertation, Chao-Shun Yang

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Studies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation, Liusong Yin

Dissertations and Theses from 2013

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Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A Dissertation, Shinya U. Amano

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Regulation of Higher Order Chromatin at GRIN2B and GAD1 Genetic Loci in Human and Mouse Brain: A Dissertation, Rahul Bharadwaj

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A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation, Alison R. Bright

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Disparate Activation of the Inflammasome by Chitin and Chitosan: A Dissertation, Chelsea L. Bueter

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Adjuvant-Specific Serum Cytokine Profiles in the Context of a DNA Prime-Protein Boost HIV-1 Vaccine: A Dissertation, Rachel Buglione-Corbett

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Layered Reward Signalling Through Octopamine and Dopamine in Drosophila: A Dissertation, Christopher J. Burke

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A Novel Autophagy Regulatory Mechanism that Functions During Programmed Cell Death: A Dissertation, Tsun-Kai Chang

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Expanding the Known DNA-binding Specificity of Homeodomains for Utility in Customizable Sequence-specific Nucleases: A Dissertation, Stephanie W. Chu

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On Identifying Signatures of Positive Selection in Human Populations: A Dissertation, Jessica L. Crisci

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Nuclear Organization in Breast Cancer: A Dissertation, Jason R. Dobson

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Itk is a Dual Action Regulator of Immunoreceptor Signaling in the Innate and Adaptive Immune System: A Dissertation, John W. Evans III

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Dynamic Regulation at the Neuronal Plasma Membrane: Novel Endocytic Mechanisms Control Anesthetic-Activated Potassium Channels and Amphetamine-Sensitive Dopamine Transporters: A Dissertation, Luke R. Gabriel

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Genetic Deficiency of CD40 in Mice Exacerbates Metabolic Manifestations of Diet-induced Obesity: A Dissertation, Chang-An Guo

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Understanding Regulation of the Cytoskeleton during Cell Cycle Transitions through Examination of Crosstalk between Homologous Fission Yeast Pathways, Septation Initiation Network and Morphogenesis ORB6 Network: A Dissertation, Sneha Gupta

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Modulating Influenza and Heparin Binding Viruses’ Pathogenesis with Extrinsic Receptor Decoy Liposomes: A Dissertation, Gabriel L. Hendricks

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Experimental Illumination of Comprehensive Fitness Landscapes: A Dissertation, Ryan T. Hietpas

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Structure-based Targeting of Transcriptional Regulatory Complexes Implicated in Human Disease: A Dissertation, Brendan J. Hilbert

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Suppressive Oligodeoxynucleotides Inhibit Cytosolic DNA Sensing Pathways: A Dissertation, John J. Kaminski III

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Tissue-dependent T Cell Apoptosis and Transcriptional Regulation of Memory CD8+T Cell Differentiation During Viral Infections: A Dissertation, Varun N. Kapoor

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Modulators of the Acute Inflammatory Response: A Dissertation, Dipti Karmarkar

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The Role of Heterologous Immunity in Viral Co-Infections and Neonatal Immunity: A Dissertation, Laurie L. Kenney

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Role of Inflammation in Diet-Induced Obesity: A Dissertation, Sophia Kogan

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Role of Autophagy in Post-Mitotic Midbody Fate and Function: A Dissertation, Tse-Chun Kuo

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Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation, Alexander N. Lagadinos

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Runx Expression in Normal and Osteoarthritic Cartilage: Possible Functions of Runx Proteins in Chondrocytes: A Dissertation, Kimberly T. LeBlanc

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Understanding Neural Networks in Awake Rat by Resting-State Functional MRI: A Dissertation, Zhifeng Liang

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Transcriptional and Translational Mechanisms Controlling Circadian Rhythms in Drosophila: A Dissertation, Jinli Ling

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The Effects of Family and Social Engagement on the Screen Time of Youth with Developmental Disabilities: A Dissertation, Charmaine B. Lo

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The Role and Regulation of Etv2 in Zebrafish Vascular Development: A Dissertation, John C. Moore

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Elucidating the Molecular Mechanism of CYLD-Mediated Necrosis: A Dissertation, David M. Moquin

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Role of the Cytoplasmic Polyadenylation Element Binding Proteins in Neuron: A Dissertation, Aparna Oruganty

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dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation, Jeannette M. Osterloh

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Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation, Aysegul Ozen

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The Role of Ion Channels in Coordinating Neural Circuit Activity in Caenorhabditis elegans: A Dissertation, Jennifer K. Pirri

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Investigation of Multiple Concerted Mechanisms Underlying Stimulus-induced G1 Arrest in Yeast: A Dissertation, Patricia A. Pope

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The Role of Inducible T Cell Kinase (Itk) in the Development of Innate T Cells and in the Formation of Protective Memory Responses: A Dissertation, Amanda L. Prince

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HIV-1 and the Nucleolus: A Role for Nucleophosmin/NPM1 in Viral Replication: A Dissertation, Tracy E. Schmidt

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Investigating Cancer Molecular Genetics using Genome-wide RNA Interference Screens: A Dissertation, Ryan W. Serra

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Application of a Naïve Bayes Classifier to Assign Polyadenylation Sites from 3' End Deep Sequencing Data: A Dissertation, Sarah E. Sheppard

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A Role for Neuronal Nicotinic Acetylcholine Receptors in Dopamine-Mediated Behaviors and the Hypnotic Response to Anesthetics: A Dissertation, Lindsey G. Soll