The Program in Cell Biology is an academic program of the Graduate School of Biomedical Sciences (GSBS) at the University of Massachusetts Medical School. The program offers graduate study and research in molecular cell biology, leading to a PhD degree. Research interests of the graduate faculty and affiliates are focused on the use of cellular, genetic and molecular approaches to address structure-function relationships associated with cell growth and differentiation; development; stem cell biology; cell signaling; chromatin structure; transcriptional control of gene expression; DNA replication and repair; and cell motility. This collection showcases publications and presentations authored by students in this program.

Attention GSBS Cell Biology students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2014

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Senescence-associated β-galactosidase activity marks the visceral endoderm of mouse embryos but is not indicative of senescence, Tingting Huang and Jaime A. Rivera-Perez

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Smurf2 regulates hematopoietic stem cell self-renewal and aging, Charusheila Ramkumar, Yahui Kong, Sally E. Trabucco, Rachel M. Gerstein, and Hong Zhang

Publications from 2013

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Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1, Charusheila Ramkumar, Hang Cui, Yahui Kong, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang

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Serial Transplantation of Bone Marrow to Test Self-renewal Capacity of Hematopoietic Stem Cells In Vivo, Charusheila Ramkumar, Rachel M. Gerstein, and Hong Zhang

Publications from 2012

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Using Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis, Hugh S. Gannon and Stephen N. Jones

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Smurf2 regulates the senescence response and suppresses tumorigenesis in mice, Charusheila Ramkumar, Yahui Kong, Hang Cui, Suyang Hao, Stephen N. Jones, Rachel M. Gerstein, and Hong Zhang

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Conditional Aurora A deficiency differentially affects early mouse embryo patterning, Yeonsoo Yoon, Dale O. Cowley, Judith Gallant, Stephen N. Jones, Terry Van Dyke, and Jaime A. Rivera-Perez

Publications from 2011

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Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds, Tera M. Filion, Artem Kutikov, and Jie Song

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Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats, Tera M. Filion, Xinning Li, April Mason-Savas, Jaclynn M. Kreider, Steven A. Goldstein, David C. Ayers, and Jie Song

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Scalable Functional Bone Substitutes: Strategic Integration of Key Structural Elements of Bone in Synthetic Biomaterials, Tera M. Filion and Jie Song

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In vivo tissue responses to thermal-responsive shape memory polymer nanocomposites, Tera M. Filion, Jianwen Xu, Manju L. Prasad, and Jie Song

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Regulation of senescence in cancer and aging, Yahui Kong, Hang Cui, Charusheila Ramkumar, and Hong Zhang

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Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway, Melissa M. Matzelle, Maxime A. Gallant, Keith W. Condon, Nicole Walsh, Catherine A. Manning, Gary S. Stein, Jane B. Lian, David B. Burr, and Ellen M. Gravallese

Publications from 2010

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Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer, Gary S. Stein, Janet L. Stein, Andre J. Van Wijnen, Jane B. Lian, Martin A. Montecino, Carlo M. Croce, Je-Yong Choi, Syed A. Ali, Sandhya Pande, Mohammad Q. Hassan, Sayyed K. Zaidi, and Daniel W. Young

Publications from 2009

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Survival responses of human embryonic stem cells to DNA damage, Tera M. Filion, Meng Qiao, Prachi N. Ghule, Matthew Mandeville, Andre J. Van Wijnen, Janet L. Stein, Jane B. Lian, Dario C. Altieri, and Gary S. Stein

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Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications, Jie Song, Jianwen Xu, Tera M. Filion, Eduardo Saiz, Antoni P. Tomsia, Jane B. Lian, Gary S. Stein, David C. Ayers, and Carolyn R. Bertozzi

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Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer, Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande, and Mohammad Q. Hassan

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Transcription-factor-mediated epigenetic control of cell fate and lineage commitment, Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande, and Mohammad Q. Hassan

Publications from 2008

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The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes, Rachit Bakshi, Sayyed K. Zaidi, Sandhya Pande, Mohammad Q. Hassan, Daniel W. Young, Martin A. Montecino, Jane B. Lian, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein

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Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes, Sandhya Pande, Syed A. Ali, Christopher R. Dowdy, Sayyed K. Zaidi, Kosei Ito, Yoshiaki Ito, Martin A. Montecino, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein

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Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer, Gary S. Stein, Sayyed K. Zaidi, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, Martin A. Montecino, Daniel W. Young, Amjad Javed, Jitesh Pratap, Je-Yong Choi, Syed A. Ali, Sandhya Pande, and Mohammad Q. Hassan

Publications from 2007

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Practical aspects of adjusting digital cameras, Joshua J. Nordberg and Greenfield Sluder

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Myogenin and the SWI/SNF ATPase Brg1 maintain myogenic gene expression at different stages of skeletal myogenesis, Yasuyuki Ohkawa, Saori Yoshimura, Chiduru Higashi, Concetta G. A. Marfella, Caroline S. Dacwag, Taro Tachibana, and Anthony N. Imbalzano

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Microscope basics, Greenfield Sluder and Joshua J. Nordberg

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Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells, Yumi Uetake, Jadranka Loncarek, Joshua J. Nordberg, Christopher N. English, Sabrina La Terra, Alexey Khodjakov, and Greenfield Sluder

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Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential, Sayyed K. Zaidi, Sandhya Pande, Jitesh Pratap, Tripti Gaur, Simina R. Grigoriu, Syed A. Ali, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein

Publications from 2006

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Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation, Tripti Gaur, Lillian Rich, Christopher J. Lengner, Sadiq Hussain, Brune Trevant, David C. Ayers, Janet L. Stein, Peter V. N. Bodine, Barry S. Komm, Gary S. Stein, and Jane B. Lian

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Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1, Yasuyuki Ohkawa, Concetta G. A. Marfella, and Anthony N. Imbalzano

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Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis, Seema Paliwal, Sandhya Pande, Ramesh C. Kovi, Norman E. Sharpless, Nabeel Bardeesy, and Steven R. Grossman

Publications from 2005

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Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression, Tripti Gaur, Christopher J. Lengner, Hayk Hovhannisyan, Ramesh A. Bhat, Peter V. N. Bodine, Barry S. Komm, Amjad Javed, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

Publications from 2004

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Transcriptional compensation for loss of an allele of the Ini1 tumor suppressor, Cynthia J. Guidi, Timothy M. Veal, Stephen N. Jones, and Anthony N. Imbalzano

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Microscope basics, Greenfield Sluder and Joshua J. Nordberg

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The good, the bad and the ugly: the practical consequences of centrosome amplification, Greenfield Sluder and Joshua J. Nordberg

Publications from 2001

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Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice, Cynthia J. Guidi, Arthur T. Sands, Brian P. Zambrowicz, Tod K. Turner, Delia A. Demers, William Webster, Thomas W. Smith, Anthony N. Imbalzano, and Stephen N. Jones

Publications from 2000

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Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene, Ivana L. de la Serna, Kerri A. Carlson, David A. Hill, Cynthia J. Guidi, Ryan O. Stephenson, Said Sif, Robert E. Kingston, and Anthony N. Imbalzano

Publications from 1999

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The mesoderm determinant snail collaborates with related zinc-finger proteins to control Drosophila neurogenesis, Shovon Imtiaz Ashraf, Xiaodi Hu, John Roote, and Y. Tony Ip

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The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor, Sandra Marie McNeil, Congmei Zeng, Kimberly Stacy Harrington, Scott W. Hiebert, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein

Publications from 1998

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Nuclear matrix associated DNA-binding proteins of ocular lens epithelial cells, Mihir Bagchi, Shamim A. Ansari, Danielle M. Lindenmuth, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, and Gary S. Stein

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Stabilization and localization of Xist RNA are controlled by separate mechanisms and are not sufficient for X inactivation, Christine Moulton Clemson, Jennifer C. Chow, Carolyn J. Brown, and Jeanne B. Lawrence

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Osteocalcin gene promoter: unlocking the secrets for regulation of osteoblast growth and differentiation, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Andre J. Van Wijnen

Publications from 1996

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Product of the oncogene-activating gene Tpr is a phosphorylated protein of the nuclear pore complex, Peter Lawrence Bangs, Cynthia A. Sparks, Paul R. Odgren, and Edward G. Fey

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X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse, Laura Carrel, Christine Moulton Clemson, John M. Dunn, Andrew P. Miller, Patricia A. Hunt, Jeanne B. Lawrence, and Huntington F. Willard

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Multifunctional compartments in the nucleus: insights from DNA and RNA localization, Christine Moulton Clemson and Jeanne B. Lawrence

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XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure, Christine Moulton Clemson, John A. McNeil, Huntington F. Willard, and Jeanne B. Lawrence

Publications from 1995

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Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3, Mark J. Birnbaum, Andre J. Van Wijnen, Paul R. Odgren, Thomas J. Last, Guntram Suske, Gary S. Stein, and Janet L. Stein

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The nuclear matrix protein NMP-1 is the transcription factor YY1, Bo Guo, Paul R. Odgren, Andre J. Van Wijnen, Thomas J. Last, Jeffrey A. Nickerson, Sheldon Penman, Jane B. Lian, Janet L. Stein, and Gary S. Stein

Publications from 1993

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Synapsin I gene expression in the adult rat brain with comparative analysis of mRNA and protein in the hippocampus, Richard H. Melloni, Liza M. Hemmendinger, James E. Hamos, and Louis J. DeGennaro

Publications from 1992

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Downregulation of histone H4 gene transcription during postnatal development in transgenic mice and at the onset of differentiation in transgenically derived calvarial osteoblast cultures, Stephan P. Gerbaulet, Andre J. Van Wijnen, Neil Aronin, Melissa S. Tassinari, Jane B. Lian, Janet L. Stein, and Gary S. Stein