The Program in Cancer Biology is an academic program of the Graduate School of Biomedical Sciences (GSBS) at the University of Massachusetts Medical School. Cancer biology is an academic discipline with a tangible end point: improving the prevention, diagnosis and treatment of human cancers. The Program in Cancer Biology provides students interested in pursuing a career in cancer biology with rigorous training in biochemistry, genetics, molecular and cell biology, as well as an understanding of the clinical aspects of cancer. This collection showcases publications and presentations authored by students in this program.

Attention GSBS Cancer Biology students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2014

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Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma, Sally E. Trabucco, Rachel M. Gerstein, Andrew M. Evens, James E. Brander, Leonard D. Shultz, Dale Greiner, and Hong Zhang

Publications from 2012

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Integrin beta4 regulates SPARC protein to promote invasion, Kristin D. Gerson, Jeffrey R. Shearstone, V.S.R. Krishna Maddula, Bruce E. Seligmann, and Arthur M. Mercurio

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Slow-cycling therapy-resistant cancer cells, Nathan F. Moore, JeanMarie Houghton, and Stephen Lyle

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Scd1 plays a tumor-suppressive role in survival of leukemia stem cells and the development of chronic myeloid leukemia, Haojian Zhang, Huawei Li, Ngoc Ho, Dongguang Li, and Shaoguang Li

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HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells, Haojian Zhang, Huawei Li, Hualin S. Xi, and Shaoguang Li

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The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells, Haojian Zhang, Cong Peng, Yiguo Hu, Huawei Li, Zhi Sheng, Yaoyu Chen, Con Sullivan, Jan Cerny, Lloyd Hutchinson, Anne Higgins, Patricia M. Miron, Xueqing Zhang, Michael A. Brehm, Dongguang Li, Michael R. Green, and Shaoguang Li

Publications from 2011

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Global DNA demethylation during mouse erythropoiesis in vivo, Jeffrey R. Shearstone, Ramona Pop, Christoph Bock, Patrick Boyle, Alexander Meissner, and Merav Socolovsky

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Functional ramifications for the loss of P-selectin expression on hematopoietic and leukemic stem cells, Con Sullivan, Yaoyu Chen, Yi Shan, Yiguo Hu, Cong Peng, Haojian Zhang, Linghong Kong, and Shaoguang Li

Publications from 2010

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Mutations in bone marrow-derived stromal stem cells unmask latent malignancy, JeanMarie Houghton, Hanchen Li, Xueli Fan, Yingwang Liu, Jian Hua Liu, Varada P. Rao, Theofilos Poutahidis, Christine L. Taylor, Erin A. Jackson, Christine Hewes, Stephen Lyle, Anna M. Cerny, Glennice N. Bowen, Jan Cerny, Nathan F. Moore, Evelyn A. Kurt-Jones, and Susan E. Erdman

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AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1, Shinsuke Ishigaki, Sonya G. Fonseca, Christine M. Oslowski, Agata Jurczyk, Jeffrey R. Shearstone, Lihua Julie Zhu, M. A. Permutt, Dale L. Greiner, Fumihiko Urano, and Rita Bortell

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miR-10b targets Tiam1: implications for Rac activation and carcinoma migration, Charlotte M. Harwood Moriarty, Bryan M. Pursell, and Arthur M. Mercurio

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A Key Commitment Step in Erythropoiesis Is Synchronized with the Cell Cycle Clock through Mutual Inhibition between PU.1 and S-Phase Progression, Ramona Pop, Jeffrey R. Shearstone, Qichang Shen, Ying Liu, Kelly N. Hallstrom, Miroslav Koulnis, Joost Gribnau, and Merav Socolovsky

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Therapeutic targeting of C-terminal binding protein in human cancer, Michael W. Straza, Seema Paliwal, Ramesh C. Kovi, Barur R. Rajeshkumar, Peter Trenh, Daniel Parker, Giles F. Whalen, Stephen Lyle, Celia A. Schiffer, and Steven R. Grossman

Publications from 2009

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Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia, Yaoyu Chen, Yiguo Hu, Haojian Zhang, Cong Peng, and Shaoguang Li

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Survivin as a global target of intrinsic tumor suppression networks, Minakshi Guha and Dario C. Altieri

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PTEN is a tumor suppressor in CML stem cells and BCR-ABL induced leukemias in mice., Cong Peng, Yaoyu Chen, Zhongfa Yang, Haojian Zhang, Lori Osterby, Alan G. Rosmarin, and Shaoguang Li

Publications from 2008

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A functional Notch-survivin gene signature in basal breast cancer, Connie Wing-Ching Lee, Karl Simin, Qin Liu, Janet Plescia, Minakshi Guha, Ashraf Khan, Chung-Cheng Hsieh, and Dario C. Altieri

Publications from 2007

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Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice, Hanchen Li, Xueli Fan, Ramesh C. Kovi, YunJu Jo, Brian Moquin, Richard Konz, Calin Stoicov, Evelyn A. Kurt-Jones, Steven R. Grossman, Stephen Lyle, Arlin B. Rogers, Marshall Montrose, and JeanMarie Houghton

Publications from 2006

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Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers, Hanchen Li, Calin Stoicov, Arlin B. Rogers, and JeanMarie Houghton

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Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc, Vishva Mitra Sharma, Jennifer Ann Calvo, Kyle M. Draheim, Leslie A. Cunningham, Nicole M. Hermance, Levi J. Beverly, Veena Krishnamoorthy, Manoj Bhasin, Anthony J. Capobianco, and Michelle A. Kelliher

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Bone marrow cells as the origin of stomach cancer, Calin Stoicov, Hanchen Li, Jane E. Carlson, and JeanMarie Houghton

Publications from 2005

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Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice, Xun Cai, Jane E. Carlson, Calin Stoicov, Hanchen Li, Timothy C. Wang, and JeanMarie Houghton

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Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission, Adam Scott Gromley, Charles Yeaman, Jack Rosa, Sambra D. Redick, Chun-Ting Chen, Stephanie Mirabelle, Minakshi Guha, James Sillibourne, and Stephen J. Doxsey

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Cortical actin turnover during cytokinesis requires myosin II, Minakshi Guha, Mian Zhou, and Yu-Li Wang

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Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation, Calin Stoicov, Xun Cai, Hanchen Li, Kristine Klucevsek, Jane E. Carlson, Reza Saffari, and JeanMarie Houghton

Publications from 2004

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Gastric cancer originating from bone marrow-derived cells, JeanMarie Houghton, Calin Stoicov, Sachiyo Nomura, Arlin B. Rogers, Jane E. Carlson, Hanchen Li, Xun Cai, James G. Fox, James R. Goldenring, and Timothy C. Wang

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Molecular biology of gastric cancer: Helicobacter infection and gastric adenocarcinoma: bacterial and host factors responsible for altered growth signaling, Calin Stoicov, Reza Saffari, Xun Cai, Chhaya Hasyagar, and JeanMarie Houghton

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Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections, Calin Stoicov, Mark T. Whary, Arlin B. Rogers, Frederick S. Lee, Kristine Klucevsek, Hanchen Li, Xun Cai, Reza Saffari, Zhongming Ge, Imtiaz A. Khan, Crescent L. Combe, Andrew D. Luster, James G. Fox, and JeanMarie Houghton

Publications from 2003

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Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility, Hanchen Li, Calin Stoicov, Xun Cai, Timothy C. Wang, and JeanMarie Houghton