The Program in Biochemistry & Molecular Pharmacology is an academic program of the Graduate School of Biomedical Sciences (GSBS) at the University of Massachusetts Medical School. The program offers graduate study and research focused in the areas of molecular, cellular and regulatory biochemistry; molecular biophysics; chemical biology; and structural biology. This collection showcases publications and presentations authored by students in this program.

Attention GSBS Biochemistry & Molecular Pharmacology students: To submit your publications, go to GSBS Student Publications and click on Submit Research in the left sidebar. You’ll need to log in or create a free account. If you have the article's PubMed ID, submission is very easy. Enter the PubMed ID and information from PubMed will be used to populate the submission form. Questions? Contact Lisa Palmer.

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Publications from 2000

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Snail/slug family of repressors: slowly going into the fast lane of development and cancer, Kirugaval Hemavathy, Shovon Imtiaz Ashraf, and Y. Tony Ip

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Expression screening of factors binding to the osteocalcin bone-specific promoter element OC box I: isolation of a novel osteoblast differentiation-specific factor, Heidi M. Hoffmann, Jack Green, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

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Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast, Ming-Chin Hou, Jeffrey Salek, and Dannel McCollum

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SWI-SNF-mediated nucleosome remodeling: role of histone octamer mobility in the persistence of the remodeled state, Mariela Jaskelioff, Igor M. Gavin, Craig L. Peterson, and Colin Logie

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Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription, Amjad Javed, Bo Guo, Scott W. Hiebert, Je-Yong Choi, Jack Green, Shan-Chuan Zhao, Mark A. Osborne, Stefano Stifani, Janet L. Stein, Jane B. Lian, Andre J. Van Wijnen, and Gary S. Stein

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Tolerance to acute ethanol inhibition of peptide hormone release in the isolated neurohypophysis, Thomas K. Knott, Govindan Dayanithi, Vincent Coccia, Edward E. Custer, Jose R. Lemos, and Steven N. Treistman

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A role for nuclear PTEN in neuronal differentiation, Mahesh B. Lachyankar, Nazneen Sultana, Christopher M. Schonhoff, Prasenjit Mitra, Wojciech Poluha, Stephen Lambert, Peter J. Quesenberry, N. Scott Litofsky, Lawrence D. Recht, Roya Nabi, Susan J. Miller, Shinji Ohta, Benjamin G. Neel, and Alonzo H. Ross

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Marrow transplantation and targeted gene therapy to the skeleton, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Andre J. Van Wijnen

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Transcriptional control of osteoblast differentiation, Jane B. Lian, Gary S. Stein, Janet L. Stein, and Andre J. Van Wijnen

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Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines, Christine Rauh-Adelmann, Kin-Mang Lau, Nari Sabeti, John P. Long, Samuel C. Mok, and Shuk-Mei Ho

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Sensitivity of bacteriophage RB69 DNA polymerase to N2-(p-n-butylphenyl)-2'-deoxyguanosine nucleotides, James Michael Walker Stattel and George E. Wright

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Interrelationships of transcriptional machinery with nuclear architecture, Gary S. Stein, Andre J. Van Wijnen, Janet L. Stein, and Jane B. Lian

Publications from 1999

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The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses, Mary-Alice Abbott, David G. Wells, and Justin R. Fallon

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AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation, Fauzia Aslam, Laura R. McCabe, Baruch Frenkel, Andre J. Van Wijnen, Gary S. Stein, Jane B. Lian, and Janet L. Stein

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The travels of mRNAs through all cells large and small, Gary J. Bassell, Yuri Oleynikov, and Robert H. Singer

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Overexpression of truncated Nmd3p inhibits protein synthesis in yeast, Jonathan Philip Belk, Feng He, and Allan Jacobson

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Hepatic iron concentration: noninvasive estimation by means of MR imaging techniques, Herbert L. Bonkovsky, Richard B. Rubin, Edward Earl Cable, Ashley Davidoff, Tammo H. Pels Rijcken, and David D. Stark

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Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment, Yin Ching I. Chen, Anna-Liisa Brownell, Wendy R. Galpern, Ole Isacson, Mikhail Bogdanov, M. Flint Beal, Eli Livni, Bruce R. Rosen, and Bruce G. Jenkins

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Alcohol modulation of calcium-activated potassium channels, Alejandro M. Dopico, Benson Chu, Jose R. Lemos, and Steven N. Treistman

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Effect of CpG methylation on isotype and magnitude of antibody responses to influenza hemagglutinin-expressing plasmid, David Marc Feltquate and Harriet L. Robinson

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Bystander target cell lysis and cytokine production by dengue virus-specific human CD4(+) cytotoxic T-lymphocyte clones, Susan J. Gagnon, Francis A. Ennis, and Alan L. Rothman

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Centrosome proteins: a major class of autoantigens in scleroderma, Irina Catrinel Gavanescu, Dolores Vazquez-Abad, J. McCauley, Jean-Luc Senecal, and Stephen J. Doxsey

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Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1), David G. Gourley, James Luba, Larry W. Hardy, Stephen M. Beverley, and William N. Hunter

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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse, Roger A. Greenberg, Lynda Chin, Andrea M. Femino, Kee-Ho Lee, Geoffrey J. Gottlieb, Robert H. Singer, Carol W. Greider, and Ronald A. DePinho

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Interaction and specificity of Rel-related proteins in regulating Drosophila immunity gene expression, Zhiqiang Han and Y. Tony Ip

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Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy, Zhen Hou, Que Nguyen, Baruch Frenkel, Susan K. Nilsson, Moira Milne, Andre J. Van Wijnen, Janet L. Stein, Peter J. Quesenberry, Jane B. Lian, and Gary S. Stein

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Diabetes prone BB rats are severely deficient in natural killer T cells, Neal N. Iwakoshi, Dale L. Greiner, Aldo A. Rossini, and John P. Mordes

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Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner, Neal N. Iwakoshi, John P. Mordes, Thomas G. Markees, Nancy E. Phillips, Aldo A. Rossini, and Dale L. Greiner

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Human CD8+ and CD4+ T lymphocyte memory to influenza A viruses of swine and avian species, Julie Marie Jameson, John Cruz, Masanori Terajima, and Francis A. Ennis

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Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D-responsive transcription and contribute to chromatin organization, Amjad Javed, Soraya E. Gutierrez, Martin Montecino, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

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Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC), Sridevi Kolluri, Kimberly K. Elbirt, and Herbert L. Bonkovsky

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Stop-flow analysis of cooperative interactions between GLUT1 sugar import and export sites, Lisa A. Sultzman and Anthony Carruthers

Publications from 1998

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Transcription sans TBP, Lynne Marie Apone and Michael R. Green

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Broad, but not universal, transcriptional requirement for yTAFII17, a histone H3-like TAFII present in TFIID and SAGA, Lynne M. Apone, Ching-man A. Virbasius, Frank C. P. Holstege, Jing Wang, Richard A. Young, and Michael R. Green

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Transcriptional control: repression by local chromatin modification, Shovon Imtiaz Ashraf and Y. Tony Ip

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HiNF-D (CDP-cut/CDC2/cyclin A/pRB-complex) influences the timing of IRF-2-dependent cell cycle activation of human histone H4 gene transcription at the G1/S phase transition, Farah Aziz, Andre J. Van Wijnen, Janet L. Stein, and Gary S. Stein

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The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled human histone H4 gene: mechanistic differences between distinct H4 genes, Farah Aziz, Andre J. Van Wijnen, Patricia S. Vaughan, Shujian Wu, A. Rauf Shakoori, Jane B. Lian, Kenneth J. Soprano, Janet L. Stein, and Gary S. Stein

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DNA polymerase III of Gram-positive eubacteria is a zinc metalloprotein conserving an essential finger-like domain, Marjorie H. Barnes, Christopher Leo, and Neal C. Brown

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Sorting of beta-actin mRNA and protein to neurites and growth cones in culture, Gary J. Bassell, Honglai Zhang, Anne L. Byrd, Andrea M. Femino, Robert H. Singer, Krishan L. Taneja, Lawrence M. Lifshitz, Ira M. Herman, and Kenneth S. Kosik

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Immune mediated and inherited defences against flaviviruses, Margo A. Brinton, Ichiro Kurane, Anuja Mathew, Lingling Zeng, Pei Yong Shi, Alan L. Rothman, and Francis A. Ennis

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In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants, Anna-Liisa Brownell, Eli Livni, Wendy R. Galpern, and Ole Isacson

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Developmental association of the beta-galactoside-binding protein galectin-1 with the nuclear matrix of rat calvarial osteoblasts, Je-Yong Choi, Andre J. Van Wijnen, Fauzia Aslam, John D. Leszyk, Janet L. Stein, Gary S. Stein, Jane B. Lian, and Sheldon Penman

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Pericentrin and gamma-tubulin form a protein complex and are organized into a novel lattice at the centrosome, Jason B. Dictenburg, Wendy Cherie Zimmerman, Cynthia A. Sparks, Aaron Isadore Young, Charles A. Vidair, Yixian Zheng, Walter A. Carrington, Fredric S. Fay, and Stephen J. Doxsey

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Defective T cell differentiation in the absence of Jnk1, Chen Dong, Derek D. Yang, Mark Allen Wysk, Alan J. Whitmarsh, Roger J. Davis, and Richard A. Flavell

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Localization of motor-related proteins and associated complexes to active, but not inactive, centromeres, Nicole E. Faulkner, Baldev Vig, Christophe de Jesus Echeverri, Linda Wordeman, and Richard B. Vallee

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Visualization of single RNA transcripts in situ, Andrea M. Femino, Fredric S. Fay, Kevin E. Fogarty, and Robert H. Singer

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Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice, Teresa M. Foy, Melissa McIlraith, Sally R. Masters, Jonathan J. Dunn, Aldo A. Rossini, Leonard D. Shultz, RuthAnn M. Hesselton, Eric James Wagar, Peter E. Lipsky, Randolph J. Noelle, and Dale L. Greiner

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A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression, Zhiqiang Han, Herve Enslen, Xiaodi Hu, Xiangjun Meng, I-Huan Wu, Tamera Barrett, Roger J. Davis, and Y. Tony Ip

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Membrane-bound glyceraldehyde-3-phosphate dehydrogenase and multiphasic erythrocyte sugar transport, Karen Schray Heard, Melissa Diguette, Alex C. Heard, and Anthony Carruthers

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Increased expression of estrogen receptor beta in chemically transformed human breast epithelial cells, Y F. Hu, Kin-Mang Lau, S. M. Ho, and J. Russo

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High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats, Neal N. Iwakoshi, Irving Goldschneider, Frances Tausche, John P. Mordes, Aldo A. Rossini, and Dale L. Greiner

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Human cytotoxic T-lymphocyte repertoire to influenza A viruses, Julie Marie Jameson, John Cruz, and Francis A. Ennis

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Structural and physiologic determinants of human erythrocyte sugar transport regulation by adenosine triphosphate, Kara B. Levine, Erin K. Cloherty, Nancy J. Fidyk, and Anthony Carruthers

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Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the V1/2 and V3 regions, Shan Lu, Richard T. Wyatt, Joan F. L. Richmond, Farah Mustafa, Shixia Wang, Jiayu Weng, David C. Montefiori, Joseph Sodroski, and Harriet L. Robinson

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Synthesis and biochemical study of N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-(alpha,beta-imido)triphosphate (BuPdGMPNHPP): a non-substrate inhibitor of B family DNA polymerases, James Michael Walker Stattel, Ivan Yanachkov, and George E. Wright

Publications from 1997

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Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex, Chaitali Banerjee, Laura R. McCabe, Je-Yong Choi, Scott W. Hiebert, Janet L. Stein, Gary S. Stein, and Jane B. Lian

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mRNA and cytoskeletal filaments, Gary J. Bassell and Robert H. Singer

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Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity, Rita Bortell, Mark R. Rigby, Linda A. Stevens, Joel Moss, Toshihiro Kanaitsuka, John P. Mordes, Dale L. Greiner, and Aldo A. Rossini

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Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response, Edward Earl Cable, Otto S. Gildemeister, Joyce A. Pepe, Richard W. Lambrecht, and Herbert L. Bonkovsky

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Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data, Yin Ching I. Chen, Wendy R. Galpern, Anna-Liisa Brownell, Russell T. Matthews, Mikhail Bogdanov, Ole Isacson, John R. Keltner, M. Flint Beal, Bruce R. Rosen, and Bruce G. Jenkins

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Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice, Sherri W. Christianson, Dale L. Greiner, RuthAnn M. Hesselton, Jean H. Leif, Eric James Wagar, Isabelle B. Schweitzer, Thiruchandurai V. Rajan, Bruce Gott, Derry C. Roopenian, and Leonard D. Shultz

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Modulation of two cloned potassium channels by 1-alkanols demonstrates different cutoffs, Benson Chu and Steven N. Treistman

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A lipidated anti-Tat antibody enters living cells and blocks HIV-1 viral replication, William W. Cruikshank, Susan R. Doctrow, Melissa S. Falvo, Karl Huffman, Joseph Walter Maciaszek, Gregory A. Viglianti, Jay Raina, Hardy Kornfeld, and Bernard Malfroy

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A cytoplasmic inhibitor of the JNK signal transduction pathway, Martin Dickens, Jeffrey Scott Rogers, Julie Cavanagh, Art Raitano, Zhengui Xia, Jocelyn R. Halpern, Michael E. Greenberg, Charles L. Sawyers, and Roger J. Davis

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Kinetics of hairpin ribozyme cleavage in yeast, Christine Patricia Donahue and Martha J. Fedor

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U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction, Jan Fleckner, Meng Zhang, Juan Valcarcel, and Michael R. Green

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The T cell marker RT6 in a rat model of autoimmune diabetes, Dale L. Greiner, Samir Malkani, Toshihiro Kanaitsuka, Rita Bortell, John Doukas, Mark R. Rigby, Barbara J. Whalen, Linda A. Stevens, Joel Moss, John P. Mordes, and Aldo A. Rossini

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YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene, Bo Guo, Fauzia Aslam, Andre J. Van Wijnen, Stefan G. E. Roberts, Baruch Frenkel, Michael R. Green, Hector F. DeLuca, Jane B. Lian, Gary S. Stein, and Janet L. Stein

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ATF1 and CREB trans-activate a cell cycle regulated histone H4 gene at a distal nuclear matrix associated promoter element, Bo Guo, Janet L. Stein, Andre J. Van Wijnen, and Gary S. Stein

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The high resolution crystal structure of deoxyhemoglobin S, Daniel John Harrington, Kengo Adachi, and William E. Royer

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The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites, Akiko Iwasaki, Celia Aurora Tiglao Torres, Pamela S. Ohashi, Harriet L. Robinson, and Brian H. Barber

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Elimination of defective alpha-factor pheromone receptors, Duane D. Jenness, Yu Li, Christopher Tipper, and Phyllis Spatrick

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Allosteric regulation of RecA protein function is mediated by Gln194, Julie A. Kelley and Kendall L. Knight

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Embryonic precursor cells that express Trk receptors: induction of different cell fates by NGF, BDNF, NT-3, and CNTF, Mahesh B. Lachyankar, Peter J. Condon, Peter J. Quesenberry, N. Scott Litofsky, Lawrence D. Recht, and Alonzo H. Ross

Publications from 1996

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Yeast TAF(II)90 is required for cell-cycle progression through G2/M but not for general transcription activation, Lynne Marie Apone, Ching-man A. Virbasius, Joseph C. Reese, and Michael R. Green

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Analysis of low zone tolerance induction in normal and B cell-deficient mice, Allison Michelle Baird and David C. Parker

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An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene, Chaitali Banerjee, Scott W. Hiebert, Janet L. Stein, Jane B. Lian, and Gary S. Stein

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Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site, Chaitali Banerjee, Janet L. Stein, Andre J. Van Wijnen, Baruch Frenkel, Jane B. Lian, and Gary S. Stein

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Role of different lymphoid tissues in the initiation and maintenance of DNA-raised antibody responses to the influenza virus H1 glycoprotein, Christine Margaret Boyle, Merribeth J. Morin, Robert G. Webster, and Harriet L. Robinson

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Agonist-specific conformational changes in the yeast alpha-factor pheromone receptor, Gul Bukusoglu and Duane D. Jenness

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Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins, Edward Earl Cable, Otto S. Gildemeister, Joyce A. Pepe, Susan E. Donohue, Richard W. Lambrecht, and Herbert L. Bonkovsky

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Regulation of GLUT1-mediated sugar transport by an antiport/uniport switch mechanism, Erin K. Cloherty, Deborah L. Diamond, Karen Schray Heard, and Anthony Carruthers

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Human erythrocyte sugar transport is incompatible with available carrier models, Erin K. Cloherty, Karen Schray Heard, and Anthony Carruthers

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Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation, Jonathan H. Dinsmore, Judson Ratliff, Terrence W. Deacon, Peyman Pakzaban, Douglas Jacoby, Wendy R. Galpern, and Ole Isacson

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Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis, Christophe de Jesus Echeverri, Bryce Mark Paschal, Kevin T. Vaughan, and Richard B. Vallee

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Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: requirement of upstream sequences for control by the proximal regulatory domain, Baruch Frenkel, Martin A. Montecino, Jack Green, Fauzia Aslam, R. Desai, Chaitali Banerjee, Janet L. Stein, Jane B. Lian, and Gary S. Stein

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Identification of two epitopes on the dengue 4 virus capsid protein recognized by a serotype-specific and a panel of serotype-cross-reactive human CD4+ cytotoxic T-lymphocyte clones, Susan J. Gagnon, Weilan Zeng, Ichiro Kurane, and Francis A. Ennis

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Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: functional recovery and graft morphology, Wendy R. Galpern, Lindsay H. Burns, Terrence W. Deacon, Jonathan H. Dinsmore, and Ole Isacson

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Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration, Wendy R. Galpern, David M. Frim, Stephen B. Tatter, C. Anthony Altar, M. Flint Beal, and Ole Isacson

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NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease, Wendy R. Galpern, Russell T. Matthews, M. Flint Beal, and Ole Isacson

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Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism, David Alan Hartley and Silvia Corvera

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Bone tissue-specific transcription of the osteocalcin gene: role of an activator osteoblast-specific complex and suppressor hox proteins that bind the OC box, Heidi M. Hoffmann, T. L. Beumer, Shamim Rahman, Laura R. McCabe, Chaitali Banerjee, Fauzia Aslam, J. A. Tiro, Andre J. Van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

Control of cell cycle regulated histone genes during proliferation and differentiation, Janet L. Stein, Andre J. Van Wijnen, Jane B. Lian, and Gary S. Stein

Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE, Cherie A. Taglienti, Mark Allen Wysk, and Roger J. Davis

Publications from 1995

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Contributions of distal and proximal promoter elements to glucocorticoid regulation of osteocalcin gene transcription, Fauzia Aslam, Victoria Shalhoub, Andre J. Van Wijnen, Chaitali Banerjee, Rita Bortell, A. Rauf Shakoori, Gerald Litwack, Janet L. Stein, Gary S. Stein, and Jane B. Lian

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Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy, Ann L. Barton, Barbara F. Banner, Edward Earl Cable, and Herbert L. Bonkovsky

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Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells, Randy R. Brutkiewicz and Raymond M. Welsh

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Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators, Benson Chu, Vellareddy Anantharam, and Steven N. Treistman

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The contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat, Matthew J. Cielinski, M. Jolie, Gary E. Wise, and Sandy C. Marks

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Bone metabolism in the osteopetrotic rat mutation microphthalmia blanc, Matthew J. Cielinski and Sandy C. Marks