The Department of Medicine's Division of Gastroenterology at the University of Massachusetts Medical School is dedicated to excellence in patient care, research and medical education. Our staff is committed to providing the highest quality of care to individuals as well as to the community. We strive to advance patient care through excellence in clinical, basic and translational research, and to educate future health care professionals. The high standards set by the division and the scope of services available ensure that patients will receive the best care possible for a wide variety of gastrointestinal and liver diseases. This collection showcases journal articles, book chapters, and other publications and presentations written by faculty and researchers in the Division of Gastroenterology.

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Publications from 2014

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Pancreatitis Quality of Life Instrument: Development of a New Instrument, Wahid Y. Wassef, Carol A. Bova, Bruce A. Barton, and Celia Hartigan

Publications from 2013

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Targeting Heat Shock Protein 90 Alters Epigenetic Genes in Alcoholic Liver Disease, Aditya Ambade and Pranoti Mandrekar

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Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells, Wei Hou, Terence N. Bukong, Karen Kodys, and Gyongyi Szabo

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Alcohol-induced IL-1beta in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation, Dora Lippai, Shashi Bala, Jan Petrasek, Timea Csak, Ivan Levin, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Evaluation of small bowel bleeding, Anupam Singh, Veronica Baptista, Calin Stoicov, and David R. Cave

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Timing of video capsule endoscopy relative to overt obscure GI bleeding: implications from a retrospective study, Anupam Singh, Christopher Marshall, Biswashree Chaudhuri, Chidimma Okoli, Anne Foley, Sharina D. Person, Kanishka Bhattacharya, and David R. Cave

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MicroRNAs in liver disease, Gyongyi Szabo and Shashi Bala

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IFN-gamma production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells, Shuye Zhang, Banishree Saha, Karen Kodys, and Gyongyi Szabo

Publications from 2012

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Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases, Shashi Bala, Jan Petrasek, Shiv Mundkur, Donna Catalano, Ivan Levin, Jeanine Ward, Hawau Alao, Karen Kodys, and Gyongyi Szabo

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Serum microRNA-122 and miR-155 as biomarkers of liver injury and inflammation in models of acute and chronic liver disease, Shashi Bala, Jan Petrasek, Shiv Mundkur, Donna Catalano, Jeanine Ward, Ivan Levin, Hawau Alao, Karen Kodys, and Gyongyi Szabo

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MicroRNA Signature in Alcoholic Liver Disease, Shashi Bala and Gyongyi Szabo

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Induction of Bcl-3 by acute binge alcohol results in Toll-like receptor 4/LPS tolerance, Shashi Bala, Alexander Tang, Donna Catalano, Jan Petrasek, Odette Taha, Karen Kodys, and Gyongyi Szabo

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Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection, Shashi Bala, Yaphet Tilahun, Odette Taha, Hawau Alao, Karen Kodys, Donna Catalano, and Gyongyi Szabo

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Ethanol facilitates HCV replication via upregulation of GW182 and HSP90 in human hepatoma cells, Terence N. Bukong, Wei Hou, Karen Kodys, and Gyongyi Szabo

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Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes, Terence N. Bukong, Tracie Lo, Gyongyi Szabo, and Angela Dolganiuc

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Increased oxidative capacity of circulating polymorphonuclear neutrophils (PMNs) in non-diabetic NASH patients, Timea Csak, Karen Kodys, Angela Dolganiuc, Dora Lippai, Michal Ganz, Christopher Marshall, and Gyongyi Szabo

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Type III Interferons, IL-28 and IL-29, Are Increased in Chronic HCV Infection and Induce Myeloid Dendritic Cell-Mediated FoxP3+ Regulatory T Cells, Angela Dolganiuc, Karen Kodys, Christopher Marshall, Banishree Saha, Shuye Zhang, Shashi Bala, and Gyongyi Szabo

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The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis, Ivan Levin, Jan Petrasek, and Gyongyi Szabo

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Cellular Signaling Pathways in Alcoholic Liver Disease, Pranoti Mandrekar and Aditya Ambade

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Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees, Trevor J. Morin, Teresa J. Broering, Brett A. Leav, Barbara M. Blair, Kirk J. Rowley, Elisabeth N. Boucher, Yang Wang, Peter S. Cheslock, Michael Knauber, David B. Olsen, Steve W. Ludmerer, Gyongyi Szabo, Robert W. Finberg, Robert H. Purcell, Robert E. Lanford, Donna M. Ambrosino, Deborah C. Molrine, and Gregory J. Babcock

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Reduction in Hepatic Inflammation Is Associated With Less Fibrosis Progression and Fewer Clinical Outcomes in Advanced Hepatitis C, Chihiro Morishima, Mitchell L. Shiffman, Jules L. Dienstag, Karen L. Lindsay, Gyongyi Szabo, Gregory T. Everson, Anna S. F. Lok, Adrian M. Di Bisceglie, Marc G. Ghany, Deepa Naishadham, Timothy R. Morgan, Elizabeth C. Wright, and HALT-C Trial Group

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Hypoxia and hypoxia inducible factors: diverse roles in liver diseases, Bharath D. Nath and Gyongyi Szabo

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IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice, Jan Petrasek, Shashi Bala, Timea Csak, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, So-Yun Min, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Caspase-1-dependent, IL-1ß-mediated alcoholic steatohepatitis is ameliorated by IL-1 receptor antagonist treatment in mice, Jan Petrasek, Shashi Bala, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Inflammasomes in liver diseases, Gyongyi Szabo and Timea Csak

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Molecular hepatic carcinogenesis: impact of inflammation, Gyongyi Szabo and Dora Lippai

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MicroRNA silencing and the development of novel therapies for liver disease, Gyongyi Szabo, Peter Sarnow, and Shashi Bala

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Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study, Jeanine Ward, Shashi Bala, Jan Petrasek, and Gyongyi Szabo

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CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of HCV-infected cells and induction of IFNalpha, Shuye Zhang, Karen Kodys, Gregory J. Babcock, and Gyongyi Szabo

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CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of HCV-infected cells and induction of IFNα, Shuye Zhang, Karen Kodys, and Gyongyi Szabo

Publications from 2011

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Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease, Shashi Bala, Miguel Marcos, Karen Kodys, Timea Csak, Donna Catalano, Pranoti Mandrekar, and Gyongyi Szabo

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Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice, Timea Csak, Angela Dolganiuc, Karen Kodys, Bharath D. Nath, Jan Petrasek, Shashi Bala, Dora Lippai, and Gyongyi Szabo

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Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells, Timea Csak, Michal Ganz, Justin Pespisa, Karen Kodys, Angela Dolganiuc, and Gyongyi Szabo

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Deficiency in myeloid differentiation factor-2 and Toll-like receptor 4 expression attenuates non-alcoholic steatohepatitis and fibrosis in mice, Timea Csak, Arumugam Velayudham, Istvan Hritz, Jan Petrasek, Ivan Levin, Dora Lippai, Donna Catalano, Pranoti Mandrekar, Angela Dolganiuc, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C, Jules L. Dienstag, Marc G. Ghany, Timothy R. Morgan, Adrian M. Di Bisceglie, Herbert L. Bonkovsky, Hae-Young Kim, Leonard B. Seeff, Gyongyi Szabo, Elizabeth C. Wright, Richard K. Sterling, Gregory T. Everson, Karen L. Lindsay, William M. Lee, Anna S. F. Lok, Chihiro Morishima, Anne M. Stoddard, and James E. Everhart

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Dendritic cells in hepatitis C infection: can they (help) win the battle, Angela Dolganiuc and Gyongyi Szabo

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Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver, Michal Ganz, Timea Csak, Bharath D. Nath, and Gyongyi Szabo

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Innate immunity and alcoholic liver disease, Bin Gao, Ekihiro Seki, Jessica Cohen, Laura Nagy, Gyongyi Szabo, and Samir Zakhari

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Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity, Tse-Chun Kuo, Chun-Ting Chen, Desiree Baron, Tamer T. Onder, Sabine Loewer, Sandra Almeida, Cara M. Weismann, Ping Xu, JeanMarie Houghton, Fen-Biao Gao, George Q. Daley, and Stephen J. Doxsey

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An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice, Pranoti Mandrekar, Aditya Ambade, Arlene Lim, Gyongyi Szabo, and Donna Catalano

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Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice, Bharath D. Nath, Ivan Levin, Timea Csak, Jan Petrasek, Christian Mueller, Karen Kodys, Donna Catalano, Pranoti Mandrekar, and Gyongyi Szabo

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Pilot Testing a Novel Treatment for Inflammatory Bowel Disease, Barbara C. Olendzki, Gioia Persuitte, Taryn Silverstein, Katherine Baldwin, David Cave, John K. Zawacki, Kanishka Bhattacharya, and Yunsheng Ma

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Type I Interferons Protect From Toll-Like Receptor 9-Associated Liver Injury and Regulate IL-1 Receptor Antagonist in Mice, Jan Petrasek, Angela Dolganiuc, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells, Jan Petrasek, Angela Dolganiuc, Timea Csak, Bharath D. Nath, Istvan Hritz, Karen Kodys, Donna Catalano, Evelyn A. Kurt-Jones, Pranoti Mandrekar, and Gyongyi Szabo

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Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients, Gyongyi Szabo and Samir Zakhari

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Advanced molecular biologic techniques in toxicologic disease, Jeanine Ward, Gyongyi Szabo, David D. McManus, and Edward W. Boyer

Publications from 2010

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Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells, Serena S. Chang, Karen Kodys, and Gyongyi Szabo

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Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis C, Robert J. Fontana, Arun J. Sanyal, Marc G. Ghany, William M. Lee, Andrea E. Reid, Deepa Naishadham, Gregory T. Everson, Jeffrey A. Kahn, Adrian M. Di Bisceglie, Gyongyi Szabo, Timothy R. Morgan, and James E. Everhart

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Alcohol exposure as a risk factor for adverse outcomes in elective surgery, Bharath D. Nath, YouFu Li, James E. Carroll Jr., Gyongyi Szabo, Jennifer F. Tseng, and Shimul A. Shah

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The 40th anniversary of the National Institute on Alcoholism and Alcohol Abuse: the impact on liver disease, Gyongyi Szabo

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Alcoholic liver disease and the gut-liver axis, Gyongyi Szabo and Shashi Bala

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Toll-like Receptors, Gyongyi Szabo and Pranoti Mandrekar

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Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage, Gyongyi Szabo, Jack R. Wands, Ahment Eken, Natalia A. Osna, Steven A. Weinman, Keigo Machida, and Joe H. Wang

Publications from 2009

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Emerging role of microRNAs in liver diseases, Shashi Bala, Miguel Marcos, and Gyongyi Szabo

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MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice, Angela Dolganiuc, Jan Petrasek, Karen Kodys, Donna Catalano, Pranoti Mandrekar, Arumugam Velayudham, and Gyongyi Szabo

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In vitro and in vivo models of acute alcohol exposure, Angela Dolganiuc and Gyongyi Szabo

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The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes, Pranoti Mandrekar, Shashi Bala, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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Signalling pathways in alcohol-induced liver inflammation, Pranoti Mandrekar and Gyongyi Szabo

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Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity, Bharath D. Nath and Gyongyi Szabo

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The "health" and future of the physician-scientist in hepatology, Gyongyi Szabo

Publications from 2008

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Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes, Angela Dolganiuc, Edward Paek, Karen Kodys, Joanne Thomas, and Gyongyi Szabo

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T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't, Angela Dolganiuc and Gyongyi Szabo

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The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88, Istvan Hritz, Pranoti Mandrekar, Arumugam Velayudham, Donna Catalano, Angela Dolganiuc, Karen Kodys, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion, Istvan Hritz, Arumugam Velayudham, Angela Dolganiuc, Karen Kodys, Pranoti Mandrekar, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Antigen-presenting cells under the influence of alcohol, Audrey H. Lau, Gyongyi Szabo, and Angus W. Thomson

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Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes, Oxana Norkina, Angela Dolganiuc, Donna Catalano, Karen Kodys, Pranoti Mandrekar, Amber Syed, Marian Efros, and Gyongyi Szabo

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Hepatitis C and innate immunity: recent advances, Gyongyi Szabo and Angela Dolganiuc

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The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunity, Gyongyi Szabo and Angela Dolganiuc

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A recent perspective on alcohol, immunity, and host defense, Gyongyi Szabo and Pranoti Mandrekar

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Human monocytes, macrophages, and dendritic cells: alcohol treatment methods, Gyongyi Szabo and Pranoti Mandrekar

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VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice, Arumugam Velayudham, Angela Dolganiuc, Michael Ellis, Jan Petrasek, Karen Kodys, Pranoti Mandrekar, and Gyongyi Szabo

Publications from 2007

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Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins, Serena S. Chang, Angela Dolganiuc, and Gyongyi Szabo

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Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection, Angela Dolganiuc, Oxana Norkina, Karen Kodys, Donna Catalano, Gennadiy Bakis, Christopher Marshall, Pranoti Mandrekar, and Gyongyi Szabo

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Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice, Hanchen Li, Xueli Fan, Ramesh C. Kovi, YunJu Jo, Brian Moquin, Richard Konz, Calin Stoicov, Evelyn A. Kurt-Jones, Steven R. Grossman, Stephen Lyle, Arlin B. Rogers, Marshall Montrose, and JeanMarie Houghton

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Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytes, Pranoti Mandrekar, Valentina Jeliazkova, Donna Catalano, and Gyongyi Szabo

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Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes, Oxana Norkina, Angela Dolganiuc, Taryn Shapiro, Karen Kodys, Pranoti Mandrekar, and Gyongyi Szabo

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Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Leonard B. Seeff, Teresa M. Curto, Gyongyi Szabo, Gregory T. Everson, Herbert L. Bonkovsky, Jules L. Dienstag, Mitchell L. Shiffman, Karen L. Lindsay, Anna S. F. Lok, Adrian M. Di Bisceglie, William M. Lee, and Marc G. Ghany

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Moderate Drinking, Inflammation, and Liver Disease, Gyongyi Szabo

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Altered innate immunity in chronic hepatitis C infection: cause or effect, Gyongyi Szabo, Serena S. Chang, and Angela Dolganiuc

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Hepatitis C core protein - the "core" of immune deception, Gyongyi Szabo and Angela Dolganiuc

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TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effects, Gyongyi Szabo, Angela Dolganiuc, Qun Dai, and Stephen B. Pruett

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Innate immune response and hepatic inflammation, Gyongyi Szabo, Pranoti Mandrekar, and Angela Dolganiuc

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Effect of ethanol on inflammatory responses. Implications for pancreatitis, Gyongyi Szabo, Pranoti Mandrekar, Shilpa Oak, and Julia Mayerle

Publications from 2006

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Cytokines and alcohol, Fulton T. Crews, Rabih Bechara, Lou Ann Brown, David M. Guidot, Pranoti Mandrekar, Shilpa Oak, Liya Qin, Gyongyi Szabo, Michael Wheeler, and Jian Zou

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Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts, Angela Dolganiuc, Genadyi Bakis, Karen Kodys, Pranoti Mandrekar, and Gyongyi Szabo

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Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection, Angela Dolganiuc, Serena S. Chang, Karen Kodys, Pranoti Mandrekar, Gennadiy Bakis, Maureen Cormier, and Gyongyi Szabo

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Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection, Angela Dolganiuc, Catherine Garcia, Karen Kodys, and Gyongyi Szabo

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Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes, Yvonne Drechsler, Angela Dolganiuc, Oxana Norkina, Laszlo Romics, Weibo Li, Karen Kodys, Fritz H. Bach, Pranoti Mandrekar, and Gyongyi Szabo

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Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10, Pranoti Mandrekar, Donna Catalano, Bernadette M. White, and Gyongyi Szabo

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TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes, Shilpa A. Oak, Pranoti Mandrekar, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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The emerging role of toll-like receptor pathways in surgical diseases, Laszlo Romics, Gyongyi Szabo, John Calvin Coffey, Jiang Huai Wang, and Henry Paul Redmond

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Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics, Claudia Spies, Verena Eggers, Gyongyi Szabo, Alexandra Lau, Vera von Dossow, Helge Schoenfeld, Hilke Althoff, Katrin Hegenscheid, Birgit Bohm, Torsten Schroeder, Sebastian Pfeiffer, Sabine Ziemer, Christian Paschen, Martin Klein, Christian Marks, Peter Miller, Michael Sander, Klaus-D. Wernecke, Evelin Achterberg, Udo Kaisers, and Hans-Dieter Volk

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Hepatitis C virus NS5A protein--a master regulator, Gyongyi Szabo

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Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity, Gyongyi Szabo, Costica Aloman, Stephen J. Polyak, Steven A. Weinman, Jack Wands, and Samir Zakhari

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HCV immunopathogenesis: virus-induced strategies against host immunity, Gyongyi Szabo and Angela Dolganiuc

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Pattern recognition receptors: a contemporary view on liver diseases, Gyongyi Szabo, Angela Dolganiuc, and Pranoti Mandrekar

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Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury, Arumugam Velayudham, Istvan Hritz, Angela Dolganiuc, Pranoti Mandrekar, Evelyn A. Kurt-Jones, and Gyongyi Szabo

Publications from 2005

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RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damage, Pranoti Mandrekar, Stephen B. Pruett, Gavin Arteel, Geoffrey M. Thiele, and Gyongyi Szabo

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Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes, Laszlo Romics, Angela Dolganiuc, Arumugam Velayudham, Karen Kodys, Pranoti Mandrekar, Douglas Golenbock, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression, Laszlo Romics, Pranoti Mandrekar, Karen Kodys, Arumugam Velayudham, Yvonne Drechsler, Angela Dolganiuc, and Gyongyi Szabo