The Department of Medicine's Division of Gastroenterology at the University of Massachusetts Medical School is dedicated to excellence in patient care, research and medical education. Our staff is committed to providing the highest quality of care to individuals as well as to the community. We strive to advance patient care through excellence in clinical, basic and translational research, and to educate future health care professionals. The high standards set by the division and the scope of services available ensure that patients will receive the best care possible for a wide variety of gastrointestinal and liver diseases. This collection showcases journal articles, book chapters, and other publications and presentations written by faculty and researchers in the Division of Gastroenterology.

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Publications from 2006

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Cytokines and alcohol, Fulton T. Crews, Rabih Bechara, Lou Ann Brown, David M. Guidot, Pranoti Mandrekar, Shilpa Oak, Liya Qin, Gyongyi Szabo, Michael Wheeler, and Jian Zou

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Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts, Angela Dolganiuc, Genadyi Bakis, Karen Kodys, Pranoti Mandrekar, and Gyongyi Szabo

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Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection, Angela Dolganiuc, Serena S. Chang, Karen Kodys, Pranoti Mandrekar, Gennadiy Bakis, Maureen Cormier, and Gyongyi Szabo

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Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection, Angela Dolganiuc, Catherine Garcia, Karen Kodys, and Gyongyi Szabo

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Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes, Yvonne Drechsler, Angela Dolganiuc, Oxana Norkina, Laszlo Romics, Weibo Li, Karen Kodys, Fritz H. Bach, Pranoti Mandrekar, and Gyongyi Szabo

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Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10, Pranoti Mandrekar, Donna Catalano, Bernadette M. White, and Gyongyi Szabo

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TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes, Shilpa A. Oak, Pranoti Mandrekar, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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The emerging role of toll-like receptor pathways in surgical diseases, Laszlo Romics, Gyongyi Szabo, John Calvin Coffey, Jiang Huai Wang, and Henry Paul Redmond

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Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics, Claudia Spies, Verena Eggers, Gyongyi Szabo, Alexandra Lau, Vera von Dossow, Helge Schoenfeld, Hilke Althoff, Katrin Hegenscheid, Birgit Bohm, Torsten Schroeder, Sebastian Pfeiffer, Sabine Ziemer, Christian Paschen, Martin Klein, Christian Marks, Peter Miller, Michael Sander, Klaus-D. Wernecke, Evelin Achterberg, Udo Kaisers, and Hans-Dieter Volk

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Hepatitis C virus NS5A protein--a master regulator, Gyongyi Szabo

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Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity, Gyongyi Szabo, Costica Aloman, Stephen J. Polyak, Steven A. Weinman, Jack Wands, and Samir Zakhari

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HCV immunopathogenesis: virus-induced strategies against host immunity, Gyongyi Szabo and Angela Dolganiuc

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Pattern recognition receptors: a contemporary view on liver diseases, Gyongyi Szabo, Angela Dolganiuc, and Pranoti Mandrekar

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Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury, Arumugam Velayudham, Istvan Hritz, Angela Dolganiuc, Pranoti Mandrekar, Evelyn A. Kurt-Jones, and Gyongyi Szabo

Publications from 2005

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RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damage, Pranoti Mandrekar, Stephen B. Pruett, Gavin Arteel, Geoffrey M. Thiele, and Gyongyi Szabo

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Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes, Laszlo Romics, Angela Dolganiuc, Arumugam Velayudham, Karen Kodys, Pranoti Mandrekar, Douglas Golenbock, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression, Laszlo Romics, Pranoti Mandrekar, Karen Kodys, Arumugam Velayudham, Yvonne Drechsler, Angela Dolganiuc, and Gyongyi Szabo

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Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection, Gyongyi Szabo and Angela Dolganiuc

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RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death, Gyongyi Szabo, Jan B. Hoek, Victor Darley-Usmar, Gyorgy Hajnoczky, Thomas Knudsen, Daria Mochly-Rosen, and Samir Zakhari

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Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4, Gyongyi Szabo, Arumugam Velayudham, Laszlo Romics, and Pranoti Mandrekar

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RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease, Gyongyi Szabo, Steven A. Weinman, Bin Gao, Stephen J. Polyak, Pranoti Mandrekar, and Geoffrey M. Thiele

Publications from 2004

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Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation, Angela Dolganiuc, Shilpa Oak, Karen Kodys, Douglas T. Golenbock, Robert W. Finberg, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production, Pranoti Mandrekar, Donna Catalano, Angela Dolganiuc, Karen Kodys, and Gyongyi Szabo

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Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice, Laszlo Romics, Angela Dolganiuc, Karen Kodys, Yvonne Drechsler, Shilpa Oak, Arumugam Velayudham, Pranoti Mandrekar, and Gyongyi Szabo

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Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver, Laszlo Romics, Karen Kodys, Angela Dolganiuc, Lucia Graham, Arumugam Velayudham, Pranoti Mandrekar, and Gyongyi Szabo

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Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells, Gyongyi Szabo, Donna Catalano, Bernadette White, and Pranoti Mandrekar

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Inhibition of antigen-presenting cell functions by alcohol: implications for hepatitis C virus infection, Gyongyi Szabo, Angela Dolganiuc, Pranoti Mandrekar, and Bernadette M. White

Publications from 2003

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Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation, Angela Dolganiuc, Karen Kodys, Andrea Kopasz, Christopher Marshall, Twan Do, Laszlo Romics, Pranoti Mandrekar, Maria L. Zapp, and Gyongyi Szabo

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Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction, Angela Dolganiuc, Karen Kodys, Andrea Kopasz, Christopher Marshall, Pranoti Mandrekar, and Gyongyi Szabo

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Pathogenic interactions between alcohol and hepatitis C, Gyongyi Szabo

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Liver in sepsis and systemic inflammatory response syndrome, Gyongyi Szabo, Laszlo Romics, and Gyorgy Frendl

Publications from 2002

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Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone, Herbert L. Bonkovsky, Riad Azar, Steven Bird, Gyongyi Szabo, and Barbara Banner

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FcgammaR cross-linking mediates NF-kappaB activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development, Yvonne Drechsler, Sangeeta S. Chavan, Donna Catalano, Pranoti Mandrekar, and Gyongyi Szabo

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Inhibition of NF-kappa B binding correlates with increased nuclear glucocorticoid receptor levels in acute alcohol-treated human monocytes, Pranoti Mandrekar, Gary Bellerose, and Gyongyi Szabo

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Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation, Pranoti Mandrekar, Angela Dolganiuc, Gary Bellerose, Karen Kodys, Laszlo Romics, Rabia Nizamani, and Gyongyi Szabo

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Ethanol-mediated regulation of transcription factors in immunocompetent cells, Gyongyi Szabo and Pranoti Mandrekar

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Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levels, Gyongyi Szabo, Pranoti Mandrekar, Angela Dolganiuc, Donna Catalano, and Karen Kodys

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Modulation of immunity and viral-host interactions by alcohol, Geoffrey M. Thiele, Gyongyi Szabo, Elizabeth J. Kovacs, Abraham P. Bautista, Laura Sosa, and Thomas R. Jerrells

Publications from 2001

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Interferon alpha and alcohol augment nuclear regulatory factor-kappaB activation in HepG2 cells, and interferon alpha increases pro-inflammatory cytokine production, Gyongyi Szabo, Donna Catalano, Gary Bellerose, and Pranoti Mandrekar

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Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cells, Gyongyi Szabo, C. Gavala, and Pranoti Mandrekar

Publications from 2000

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Acceptance of an ABO-incompatible mismatched (AB(+) to O(+)) liver allograft with the use of daclizumab and mycophenolate mofetil, W. Christopher Fang, John R. Saltzman, Sarah Rososhansky, Gyongyi Szabo, Stephen O. Heard, Barbara F. Banner, Ravi Chari, and Eliezer Katz

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Consequences of alcohol consumption on host defence, Gyongyi Szabo

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New insights into the the molecular mechanisms of alcoholic hepatitis: a potential role for NF-kappaB activation, Gyongyi Szabo

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Management of recurrent hepatitis C after liver transplantation: a concise review, Gyongyi Szabo, Eliezer Katz, and Herbert L. Bonkovsky

Publications from 1999

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Inhibition of lipopolysaccharide-mediated NFkappaB activation by ethanol in human monocytes, Pranoti Mandrekar, Donna Catalano, and Gyongyi Szabo

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Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation, Gyongyi Szabo, Sangeeta Chavan, Pranoti Mandrekar, and Donna Catalano

Publications from 1998

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Regulation of monocyte interleukin-12 production by acute alcohol: a role for inhibition by interleukin-10, Linda Girouard, Pranoti Mandrekar, Donna Catalano, and Gyongyi Szabo

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Monocytes, alcohol use, and altered immunity, Gyongyi Szabo

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Regulation of monocyte IL-12 production: augmentation by lymphocyte contact and acute ethanol treatment, inhibition by elevated intracellular cAMP, Gyongyi Szabo, Linda Girouard, Pranoti Mandrekar, and Donna Catalano

Publications from 1997

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Alcohol-Induced Regulation of Nuclear Regulatory Factor-Kβ in Human Monocytes, Pranoti Mandrekar, Donna Catalano, and Gyongyi Szabo

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Alcohol's contribution to compromised immunity, Gyongyi Szabo

Publications from 1996

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Human monocyte IL-10 production is increased by acute ethanol treatment, Pranoti Mandrekar, Donna Catalano, Linda Girouard, and Gyongyi Szabo

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Acute ethanol treatment augments interleukin-12 production in activated human monocytes, Gyongyi Szabo, Linda Girouard, Pranoti Mandrekar, and Donna Catalano

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Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production, Gyongyi Szabo, Pranoti Mandrekar, Linda Girouard, and Donna Catalano

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NF-kB, a Prototypical Cytokine-Regulated Transcription Factor: Implications for Alcohol-Mediated Responses, Samir Zakhari and Gyongyi Szabo

Publications from 1995

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Inhibition of superantigen-induced T cell proliferation and monocyte IL-1 beta, TNF-alpha, and IL-6 production by acute ethanol treatment, Gyongyi Szabo, Pranoti Mandrekar, and Donna Catalano

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Modulation of Cytokine Production in Human Lymphoid and Myeloid Cells by Alcohol In Vitro, Gyongyi Szabo, Pranoti Mandrekar, Bikash K. Verma, and Donna Catalano

Publications from 1994

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Dibutyryl-cAMP modulation of receptor expression and antigen presentation capacity in monocyte subpopulations, Gyongyi Szabo, Karen Kodys, and Carol L. Miller-Graziano

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Acute ethanol consumption synergizes with trauma to increase monocyte tumor necrosis factor alpha production late postinjury, Gyongyi Szabo, Pranoti Mandrekar, Bikash K. Verma, Ann Isaac, and Donna Catalano

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Regulatory potential of ethanol and retinoic acid on human monocyte functions, Gyongyi Szabo, Maria Puppolo, Bikash K. Verma, and Donna Catalano

Publications from 1993

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Monocyte-Mediated Immunodepression after Acute Ethanol Exposure, Gyongyi Szabo

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Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure: the role of impaired monocyte antigen presentation capacity and mediator production, Gyongyi Szabo, Bikash K. Verma, and Donna Catalano

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Down-regulation of tumor necrosis factor alpha activity by acute ethanol treatment in human peripheral blood monocytes, Bikash K. Verma, Miklos C. Fogarasi, and Gyongyi Szabo

Publications from 1992

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Induction of transforming growth factor-beta and prostaglandin E2 production by ethanol in human monocytes, Gyongyi Szabo, Bikash K. Verma, Miklos C. Fogarasi, and Donna Catalano

Publications from 1991

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Role of elevated monocyte transforming growth factor beta (TGF beta) production in posttrauma immunosuppression, Carol L. Miller-Graziano, Gyongyi Szabo, Katherine Griffey, Bela Mehta, Karen Kodys, and Donna Catalano

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Elevated monocyte interleukin-6 (IL-6) production in immunosppressed trauma patients. II. Downregulation by IL-4, Gyongyi Szabo, Karen Kodys, and Carol L. Miller-Graziano

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Elevated monocyte interleukin-6 (IL-6) production in immunosuppressed trauma patients. I. Role of Fc gamma RI cross-linking stimulation, Gyongyi Szabo, Karen Kodys, and Carol L. Miller-Graziano

Publications from 1990

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Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome, Carol L. Miller-Graziano, Gyongyi Szabo, Karen Kodys, and Katherine Griffey

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Induction and regulation of monocyte procoagulant activity, Gyongyi Szabo and Carol L. Miller-Graziano

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Antigen presentation by the CD4 positive monocyte subset, Gyongyi Szabo, Carol L. Miller-Graziano, and Karen Kodys

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Differential tumor necrosis factor production by human monocyte subsets, Gyongyi Szabo, Carol L. Miller-Graziano, Jia-Yan Wu, Thomas K. Takayama, and Karen Kodys

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Elevated tumor necrosis factor alpha production concomitant to elevated prostaglandin E2 production by trauma patients' monocytes, Thomas K. Takayama, Carol L. Miller-Graziano, and Gyongyi Szabo

Publications from 1989

Polymorphonuclear functions in patients with mixed connective tissue disease, E. Bodolay, Katalin Lukacs, G. Frendl, Gyongyi Szabo, G. Arato, and Gyula Szegedi

Monocyte functions in patients with mixed connective tissue disease, E. Bodolay, Katalin Lukacs, Gyongyi Szabo, G. Frendl, T. Ben, and Gyula Szegedi

Publications from 1988

Selective induction of mononuclear phagocytes to produce neopterin by interferons, Gabriele Bitterlich, Gyongyi Szabo, Ernst R. Werner, C. Larcher, Dietmar Fuchs, Arno Hausen, Gilbert Reibnegger, T.F. Schulz, J. Troppmair, and Helmut Wachter

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Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients, Carol L. Miller-Graziano, Mitchell P. Fink, Jia-Yan Wu, Gyongyi Szabo, and Karen Kodys

Publications from 1987

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Human macrophages degrade tryptophan upon induction by interferon-gamma, Ernst R. Werner, Gabriele Bitterlich, Dietmar Fuchs, Arno Hausen, Gilbert Reibnegger, Gyongyi Szabo, Manfred P. Dierich, and Helmut Wachter

Publications from 1985

Inhibitory effect of monocyte reactive antibodies on monocyte chemotaxis in systemic lupus erythematosus, Gyula Szegedi, Katalin Lukacs, E. Bodolay, L. Gulacsi, Ildiko Sonkoly, Gyongyi Szabo, and J. Szollosi

Publications from 1984

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Effects of immune complexes from SLE patients on human monocyte locomotion and Fc receptor function, Katalin Lukacs, Maria Kavai, Aniko Banyai, Ildiko Sonkoly, Eva Vegh, Gyongyi Szabo, and Gyula Szegedi

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Stimulating effect of tuftsin and its analogues on the defective monocyte chemotaxis in systemic lupus erythematosus, Katalin Lukacs, Gyongyi Szabo, Ildiko Sonkoly, Eva Vegh, Janos Gacs, Maria Szekerke, and Gyula Szegedi