The Department of Medicine's Division of Gastroenterology at the University of Massachusetts Medical School is dedicated to excellence in patient care, research and medical education. Our staff is committed to providing the highest quality of care to individuals as well as to the community. We strive to advance patient care through excellence in clinical, basic and translational research, and to educate future health care professionals. The high standards set by the division and the scope of services available ensure that patients will receive the best care possible for a wide variety of gastrointestinal and liver diseases. This collection showcases journal articles, book chapters, and other publications and presentations written by faculty and researchers in the Division of Gastroenterology.

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Publications from 2010

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Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage, Gyongyi Szabo, Jack R. Wands, Ahment Eken, Natalia A. Osna, Steven A. Weinman, Keigo Machida, and Joe H. Wang

Publications from 2009

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Emerging role of microRNAs in liver diseases, Shashi Bala, Miguel Marcos, and Gyongyi Szabo

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MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice, Angela Dolganiuc, Jan Petrasek, Karen Kodys, Donna Catalano, Pranoti Mandrekar, Arumugam Velayudham, and Gyongyi Szabo

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In vitro and in vivo models of acute alcohol exposure, Angela Dolganiuc and Gyongyi Szabo

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The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes, Pranoti Mandrekar, Shashi Bala, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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Signalling pathways in alcohol-induced liver inflammation, Pranoti Mandrekar and Gyongyi Szabo

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Alcohol-induced modulation of signaling pathways in liver parenchymal and nonparenchymal cells: implications for immunity, Bharath D. Nath and Gyongyi Szabo

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Intracystic Papillary Carcinoma in a Male as a Rare Presentation of Breast Cancer: a Case Report and Literature Review, Laszlo Romics Jr., M. Emmet O'Brien, Norma Relihan, Fionnuala O'Connell, and Henry Paul Redmond

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T-bet knockout prevents Helicobacter felis-induced gastric cancer, Calin Stoicov, Xueli Fan, Jian Hua Liu, Glennice N. Bowen, Mark Whary, Evelyn A. Kurt-Jones, and JeanMarie Houghton

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How the study of Helicobacter infection can contribute to the understanding of carcinoma development, Calin Stoicov, Hanchen Li, Jan Cerny, and JeanMarie Houghton

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The "health" and future of the physician-scientist in hepatology, Gyongyi Szabo

Publications from 2008

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Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes, Angela Dolganiuc, Edward Paek, Karen Kodys, Joanne Thomas, and Gyongyi Szabo

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T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't, Angela Dolganiuc and Gyongyi Szabo

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The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88, Istvan Hritz, Pranoti Mandrekar, Arumugam Velayudham, Donna Catalano, Angela Dolganiuc, Karen Kodys, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Bone marrow-derived immune cells mediate sensitization to liver injury in a myeloid differentiation factor 88-dependent fashion, Istvan Hritz, Arumugam Velayudham, Angela Dolganiuc, Karen Kodys, Pranoti Mandrekar, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Antigen-presenting cells under the influence of alcohol, Audrey H. Lau, Gyongyi Szabo, and Angus W. Thomson

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Acute alcohol intake induces SOCS1 and SOCS3 and inhibits cytokine-induced STAT1 and STAT3 signaling in human monocytes, Oxana Norkina, Angela Dolganiuc, Donna Catalano, Karen Kodys, Pranoti Mandrekar, Amber Syed, Marian Efros, and Gyongyi Szabo

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Hepatitis C and innate immunity: recent advances, Gyongyi Szabo and Angela Dolganiuc

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The role of plasmacytoid dendritic cell-derived IFN alpha in antiviral immunity, Gyongyi Szabo and Angela Dolganiuc

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A recent perspective on alcohol, immunity, and host defense, Gyongyi Szabo and Pranoti Mandrekar

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Human monocytes, macrophages, and dendritic cells: alcohol treatment methods, Gyongyi Szabo and Pranoti Mandrekar

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VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice, Arumugam Velayudham, Angela Dolganiuc, Michael Ellis, Jan Petrasek, Karen Kodys, Pranoti Mandrekar, and Gyongyi Szabo

Publications from 2007

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Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins, Serena S. Chang, Angela Dolganiuc, and Gyongyi Szabo

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Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection, Angela Dolganiuc, Oxana Norkina, Karen Kodys, Donna Catalano, Gennadiy Bakis, Christopher Marshall, Pranoti Mandrekar, and Gyongyi Szabo

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Fas Ag-FasL coupling leads to ERK1/2-mediated proliferation of gastric mucosal cells, Hanchen Li, Xun Cai, Xueli Fan, Brian Moquin, Calin Stoicov, and JeanMarie Houghton

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Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice, Hanchen Li, Xueli Fan, Ramesh C. Kovi, YunJu Jo, Brian Moquin, Richard Konz, Calin Stoicov, Evelyn A. Kurt-Jones, Steven R. Grossman, Stephen Lyle, Arlin B. Rogers, Marshall Montrose, and JeanMarie Houghton

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Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytes, Pranoti Mandrekar, Valentina Jeliazkova, Donna Catalano, and Gyongyi Szabo

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Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes, Oxana Norkina, Angela Dolganiuc, Taryn Shapiro, Karen Kodys, Pranoti Mandrekar, and Gyongyi Szabo

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The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor, Seema Paliwal, Ramesh C. Kovi, Bharath D. Nath, Ya-Wen Chen, Brian C. Lewis, and Steven R. Grossman

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Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Leonard B. Seeff, Teresa M. Curto, Gyongyi Szabo, Gregory T. Everson, Herbert L. Bonkovsky, Jules L. Dienstag, Mitchell L. Shiffman, Karen L. Lindsay, Anna S. F. Lok, Adrian M. Di Bisceglie, William M. Lee, and Marc G. Ghany

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Moderate Drinking, Inflammation, and Liver Disease, Gyongyi Szabo

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Altered innate immunity in chronic hepatitis C infection: cause or effect, Gyongyi Szabo, Serena S. Chang, and Angela Dolganiuc

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Hepatitis C core protein - the "core" of immune deception, Gyongyi Szabo and Angela Dolganiuc

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TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effects, Gyongyi Szabo, Angela Dolganiuc, Qun Dai, and Stephen B. Pruett

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Innate immune response and hepatic inflammation, Gyongyi Szabo, Pranoti Mandrekar, and Angela Dolganiuc

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Effect of ethanol on inflammatory responses. Implications for pancreatitis, Gyongyi Szabo, Pranoti Mandrekar, Shilpa Oak, and Julia Mayerle

Publications from 2006

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Cytokines and alcohol, Fulton T. Crews, Rabih Bechara, Lou Ann Brown, David M. Guidot, Pranoti Mandrekar, Shilpa Oak, Liya Qin, Gyongyi Szabo, Michael Wheeler, and Jian Zou

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Gastrin-induced apoptosis contributes to carcinogenesis in the stomach, Guanglin Cui, Shigeo Takaishi, Wandong Ai, Kelly S. Betz, Jon R. Florholmen, Theodore J. Koh, JeanMarie Houghton, D. Mark Pritchard, and Timothy C. Wang

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Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts, Angela Dolganiuc, Genadyi Bakis, Karen Kodys, Pranoti Mandrekar, and Gyongyi Szabo

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Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection, Angela Dolganiuc, Serena S. Chang, Karen Kodys, Pranoti Mandrekar, Gennadiy Bakis, Maureen Cormier, and Gyongyi Szabo

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Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection, Angela Dolganiuc, Catherine Garcia, Karen Kodys, and Gyongyi Szabo

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Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes, Yvonne Drechsler, Angela Dolganiuc, Oxana Norkina, Laszlo Romics, Weibo Li, Karen Kodys, Fritz H. Bach, Pranoti Mandrekar, and Gyongyi Szabo

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Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers, Hanchen Li, Calin Stoicov, Arlin B. Rogers, and JeanMarie Houghton

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Moderate alcohol intake in humans attenuates monocyte inflammatory responses: inhibition of nuclear regulatory factor kappa B and induction of interleukin 10, Pranoti Mandrekar, Donna Catalano, Bernadette M. White, and Gyongyi Szabo

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Caerulein-induced Acute Pancreatitis in Mice that Constitutively Overexpress Reg/PAP Genes, Oxana Norkina, Rolf Graf, Philippe Appenzeller, and Robert C. De Lisle

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TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes, Shilpa A. Oak, Pranoti Mandrekar, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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The emerging role of toll-like receptor pathways in surgical diseases, Laszlo Romics, Gyongyi Szabo, John Calvin Coffey, Jiang Huai Wang, and Henry Paul Redmond

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Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics, Claudia Spies, Verena Eggers, Gyongyi Szabo, Alexandra Lau, Vera von Dossow, Helge Schoenfeld, Hilke Althoff, Katrin Hegenscheid, Birgit Bohm, Torsten Schroeder, Sebastian Pfeiffer, Sabine Ziemer, Christian Paschen, Martin Klein, Christian Marks, Peter Miller, Michael Sander, Klaus-D. Wernecke, Evelin Achterberg, Udo Kaisers, and Hans-Dieter Volk

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Bone marrow cells as the origin of stomach cancer, Calin Stoicov, Hanchen Li, Jane E. Carlson, and JeanMarie Houghton

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Hepatitis C virus NS5A protein--a master regulator, Gyongyi Szabo

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Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity, Gyongyi Szabo, Costica Aloman, Stephen J. Polyak, Steven A. Weinman, Jack Wands, and Samir Zakhari

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HCV immunopathogenesis: virus-induced strategies against host immunity, Gyongyi Szabo and Angela Dolganiuc

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Pattern recognition receptors: a contemporary view on liver diseases, Gyongyi Szabo, Angela Dolganiuc, and Pranoti Mandrekar

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Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury, Arumugam Velayudham, Istvan Hritz, Angela Dolganiuc, Pranoti Mandrekar, Evelyn A. Kurt-Jones, and Gyongyi Szabo

Publications from 2005

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Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice, Xun Cai, Jane E. Carlson, Calin Stoicov, Hanchen Li, Timothy C. Wang, and JeanMarie Houghton

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Overcoming Fas-mediated apoptosis accelerates Helicobacter-induced gastric cancer in mice, Xun Cai, Calin Stoicov, Hanchen Li, Jane E. Carlson, Mark T. Whary, James G. Fox, and JeanMarie Houghton

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RSA 2004: combined basic research satellite symposium - session two: toll-like receptors and organ damage, Pranoti Mandrekar, Stephen B. Pruett, Gavin Arteel, Geoffrey M. Thiele, and Gyongyi Szabo

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Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes, Laszlo Romics, Angela Dolganiuc, Arumugam Velayudham, Karen Kodys, Pranoti Mandrekar, Douglas Golenbock, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression, Laszlo Romics, Pranoti Mandrekar, Karen Kodys, Arumugam Velayudham, Yvonne Drechsler, Angela Dolganiuc, and Gyongyi Szabo

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Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation, Calin Stoicov, Xun Cai, Hanchen Li, Kristine Klucevsek, Jane E. Carlson, Reza Saffari, and JeanMarie Houghton

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Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection, Gyongyi Szabo and Angela Dolganiuc

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RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death, Gyongyi Szabo, Jan B. Hoek, Victor Darley-Usmar, Gyorgy Hajnoczky, Thomas Knudsen, Daria Mochly-Rosen, and Samir Zakhari

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Modulation of non-alcoholic steatohepatitis by pattern recognition receptors in mice: the role of toll-like receptors 2 and 4, Gyongyi Szabo, Arumugam Velayudham, Laszlo Romics, and Pranoti Mandrekar

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RSA 2004: combined basic research satellite symposium - session four: hepatitis virus and alcohol interactions in immunity and liver disease, Gyongyi Szabo, Steven A. Weinman, Bin Gao, Stephen J. Polyak, Pranoti Mandrekar, and Geoffrey M. Thiele

Publications from 2004

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Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation, Angela Dolganiuc, Shilpa Oak, Karen Kodys, Douglas T. Golenbock, Robert W. Finberg, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Gastric cancer originating from bone marrow-derived cells, JeanMarie Houghton, Calin Stoicov, Sachiyo Nomura, Arlin B. Rogers, Jane E. Carlson, Hanchen Li, Xun Cai, James G. Fox, James R. Goldenring, and Timothy C. Wang

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Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4, Leisa Mandell, Anthony P. Moran, Andrew Cocchiarella, JeanMarie Houghton, Nancy Taylor, James G. Fox, Timothy C. Wang, and Evelyn A. Kurt-Jones

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Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production, Pranoti Mandrekar, Donna Catalano, Angela Dolganiuc, Karen Kodys, and Gyongyi Szabo

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Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice, Laszlo Romics, Angela Dolganiuc, Karen Kodys, Yvonne Drechsler, Shilpa Oak, Arumugam Velayudham, Pranoti Mandrekar, and Gyongyi Szabo

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Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver, Laszlo Romics, Karen Kodys, Angela Dolganiuc, Lucia Graham, Arumugam Velayudham, Pranoti Mandrekar, and Gyongyi Szabo

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Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections, Calin Stoicov, Mark T. Whary, Arlin B. Rogers, Frederick S. Lee, Kristine Klucevsek, Hanchen Li, Xun Cai, Reza Saffari, Zhongming Ge, Imtiaz A. Khan, Crescent L. Combe, Andrew D. Luster, James G. Fox, and JeanMarie Houghton

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Acute alcohol consumption inhibits accessory cell function of monocytes and dendritic cells, Gyongyi Szabo, Donna Catalano, Bernadette White, and Pranoti Mandrekar

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Inhibition of antigen-presenting cell functions by alcohol: implications for hepatitis C virus infection, Gyongyi Szabo, Angela Dolganiuc, Pranoti Mandrekar, and Bernadette M. White

Publications from 2003

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Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation, Angela Dolganiuc, Karen Kodys, Andrea Kopasz, Christopher Marshall, Twan Do, Laszlo Romics, Pranoti Mandrekar, Maria L. Zapp, and Gyongyi Szabo

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Additive inhibition of dendritic cell allostimulatory capacity by alcohol and hepatitis C is not restored by DC maturation and involves abnormal IL-10 and IL-2 induction, Angela Dolganiuc, Karen Kodys, Andrea Kopasz, Christopher Marshall, Pranoti Mandrekar, and Gyongyi Szabo

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Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility, Hanchen Li, Calin Stoicov, Xun Cai, Timothy C. Wang, and JeanMarie Houghton

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Pathogenic interactions between alcohol and hepatitis C, Gyongyi Szabo

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Liver in sepsis and systemic inflammatory response syndrome, Gyongyi Szabo, Laszlo Romics, and Gyorgy Frendl

Publications from 2002

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Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone, Herbert L. Bonkovsky, Riad Azar, Steven Bird, Gyongyi Szabo, and Barbara Banner

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FcgammaR cross-linking mediates NF-kappaB activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development, Yvonne Drechsler, Sangeeta S. Chavan, Donna Catalano, Pranoti Mandrekar, and Gyongyi Szabo

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Inhibition of NF-kappa B binding correlates with increased nuclear glucocorticoid receptor levels in acute alcohol-treated human monocytes, Pranoti Mandrekar, Gary Bellerose, and Gyongyi Szabo

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Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation, Pranoti Mandrekar, Angela Dolganiuc, Gary Bellerose, Karen Kodys, Laszlo Romics, Rabia Nizamani, and Gyongyi Szabo

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Ethanol-mediated regulation of transcription factors in immunocompetent cells, Gyongyi Szabo and Pranoti Mandrekar

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Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levels, Gyongyi Szabo, Pranoti Mandrekar, Angela Dolganiuc, Donna Catalano, and Karen Kodys

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Modulation of immunity and viral-host interactions by alcohol, Geoffrey M. Thiele, Gyongyi Szabo, Elizabeth J. Kovacs, Abraham P. Bautista, Laura Sosa, and Thomas R. Jerrells

Publications from 2001

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Interferon alpha and alcohol augment nuclear regulatory factor-kappaB activation in HepG2 cells, and interferon alpha increases pro-inflammatory cytokine production, Gyongyi Szabo, Donna Catalano, Gary Bellerose, and Pranoti Mandrekar

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Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cells, Gyongyi Szabo, C. Gavala, and Pranoti Mandrekar

Publications from 2000

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Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock protein 27 (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus, Asit K. De, Karen Kodys, Berhan S. Yeh, and Carol L. Miller-Graziano

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Acceptance of an ABO-incompatible mismatched (AB(+) to O(+)) liver allograft with the use of daclizumab and mycophenolate mofetil, W. Christopher Fang, John R. Saltzman, Sarah Rososhansky, Gyongyi Szabo, Stephen O. Heard, Barbara F. Banner, Ravi Chari, and Eliezer Katz

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Consequences of alcohol consumption on host defence, Gyongyi Szabo

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New insights into the the molecular mechanisms of alcoholic hepatitis: a potential role for NF-kappaB activation, Gyongyi Szabo

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Management of recurrent hepatitis C after liver transplantation: a concise review, Gyongyi Szabo, Eliezer Katz, and Herbert L. Bonkovsky

Publications from 1999

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Inhibition of lipopolysaccharide-mediated NFkappaB activation by ethanol in human monocytes, Pranoti Mandrekar, Donna Catalano, and Gyongyi Szabo

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Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation, Gyongyi Szabo, Sangeeta Chavan, Pranoti Mandrekar, and Donna Catalano

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Partial agonist effect influences the CTL response to a heterologous dengue virus serotype, Jaroslav Zivny, Matthew DeFronzo, William Jarry, Julie Marie Jameson, John Cruz, Francis A. Ennis, and Alan L. Rothman

Publications from 1998

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Regulation of monocyte interleukin-12 production by acute alcohol: a role for inhibition by interleukin-10, Linda Girouard, Pranoti Mandrekar, Donna Catalano, and Gyongyi Szabo

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Monocytes, alcohol use, and altered immunity, Gyongyi Szabo

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Regulation of monocyte IL-12 production: augmentation by lymphocyte contact and acute ethanol treatment, inhibition by elevated intracellular cAMP, Gyongyi Szabo, Linda Girouard, Pranoti Mandrekar, and Donna Catalano

Publications from 1997

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Inflammatory markers in chronic hepatitis C, Barbara F. Banner, Carol Allan, Louis Savas, Stephen P. Baker, Graham F. Barnard, and Herbert L. Bonkovsky

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Increased monocyte TNF-alpha message stability contributes to trauma patients' increased TNF production, Robert K. Furse, Karen Kodys, Dan Zhu, and Carol L. Miller-Graziano