Title

Antigen-presenting cells under the influence of alcohol

UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Date

12-9-2008

Document Type

Article

Medical Subject Headings

Animals; Antigen-Presenting Cells; Cell Movement; Cytokines; Ethanol; Humans; Liver; Signal Transduction

Disciplines

Gastroenterology | Immunology and Infectious Disease

Abstract

The negative influence of alcohol (ethanol) and its metabolites on innate and adaptive immunity is well-recognized. Much attention has recently been focused on the impact of acute and chronic alcohol exposure on antigen-presenting cells (APC). In particular, insights have been gained into how the properties of human blood monocytes and rodent macrophages are influenced by alcohol in vitro and in vivo. Here, we review the impact of alcohol on various aspects of APC function and the underlying mechanisms, including its effects on intracellular signaling events. We also discuss new information regarding the influence of alcohol on various APC populations in the liver, a primary site of alcohol metabolism.

Rights and Permissions

Citation: Trends Immunol. 2009 Jan;30(1):13-22. Epub 2008 Dec 6. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

19059005