Pattern recognition receptors: a contemporary view on liver diseases
Department of Medicine, Division of Gastroenterology; Department of Medicine, Rheumatology Division
Medical Subject Headings
Animals; Biological Markers; Humans; Liver Diseases; Receptors, Pattern Recognition
Gastroenterology | Hepatology | Rheumatology
Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell populations provide unique aspects to pathogen recognition and tissue damage in the liver. This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated.
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Citation: Hepatology. 2006 Aug;44(2):287-98. Link to article on publisher's site