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UMass Chan Affiliations
Department of Medicine, Division of GastroenterologyDocument Type
Book ChapterPublication Date
2013-03-07Keywords
AnimalsCytokines
Fatty Liver
Humans
Immunity, Innate
Liver Diseases
Liver Diseases, Alcoholic
Signal Transduction
Toll-Like Receptors
Digestive System Diseases
Gastroenterology
Hepatology
Immunopathology
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Show full item recordAbstract
Activation of inflammatory signaling pathways is of central importance in the pathogenesis of alcoholic liver disease (ALD) and nonalcoholic steatohepatitis (NASH). Recent studies demonstrated that Toll-like receptors, the sensors of microbial and endogenous danger signals, are expressed and activated in innate immune cells as well as in parenchymal cells in the liver and thereby contribute to ALD and NASH. In this review, we emphasize the importance of gut-derived endotoxin and its recognition by TLR4 in the liver. The significance of TLR-induced intracellular signaling pathways and cytokine production as well as the contribution of individual cell types to the inflammation is evaluated. The contribution of TLR signaling to the induction of liver fibrosis and to the progression of liver pathology mediated by viral pathogens is reviewed in the context of ALD and NASH.Source
Adv Clin Chem. 2013;59:155-201. DOI: 10.1016/B978-0-12-405211-6.00006-1DOI
10.1016/B978-0-12-405211-6.00006-1Permanent Link to this Item
http://hdl.handle.net/20.500.14038/31086PubMed ID
23461136Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/B978-0-12-405211-6.00006-1