Binge ethanol and liver: new molecular developments
Department of Medicine, Division of Gastroenterology
Medical Subject Headings
Animals; Binge Drinking; Ethanol; Humans; Inflammation Mediators; Liver; Liver Diseases, Alcoholic
Digestive System Diseases | Gastroenterology | Hepatology | Substance Abuse and Addiction
Binge consumption of alcohol is an alarming global health problem. Binge (acute) ethanol (EtOH) is implicated in the pathophysiology of alcoholic liver disease (ALD). New studies from experimental animals and from humans indicate that binge EtOH has profound effects on immunological, signaling, and epigenetic parameters of the liver. This is in addition to the known metabolic effects of acute EtOH. Binge EtOH alters the levels of several cellular components and dramatically amplifies liver injury in chronically EtOH exposed liver. These studies highlight the importance of molecular investigations into binge effects of EtOH for a better understanding of ALD and also to develop therapeutic strategies to control it. This review summarizes these recent developments.
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Citation: Alcohol Clin Exp Res. 2013 Apr;37(4):550-7. doi: 10.1111/acer.12011. Epub 2013 Jan 24. Link to article on publisher's site
Shukla, Shivendra D.; Pruett, Stephen B.; Szabo, Gyongyi; and Arteel, Gavin E., "Binge ethanol and liver: new molecular developments" (2013). Gastroenterology Publications and Presentations. 139.