Elevated monocyte interleukin-6 (IL-6) production in immunosppressed trauma patients. II. Downregulation by IL-4
Department of Surgery; Department of Medicine, Division of Gastroenterology
Medical Subject Headings
Adult; Aged; Burns; Dinoprostone; Down-Regulation; Female; Humans; Immune Tolerance; Interleukin-4; Interleukin-6; Male; Middle Aged; Monocytes; RNA, Messenger; Tumor Necrosis Factor-alpha; Wounds and Injuries
Digestive System Diseases | Gastroenterology
Aberrant monocyte mediator production is pivotal in the development of posttrauma immunosuppression. We have previously shown that immunodepressed trauma patients' monocytes produce elevated interleukin-6, suggesting their in vivo preactivation. This study confirms that preactivated patients' Mo produce greater levels of IL-6 than normals' Mo to the same in the in vitro Fc gamma RI stimulation. We also demonstrate the capacity of interleukin-4 to downregulate the elevated interleukin-6 production of trauma patients' in vivo preactivated monocytes. Monocyte interleukin-6 downregulation by interleukin-4 is dose dependent and occurs whether Fc gamma RI cross-linking, muramyl dipeptide, indomethacin plus muramyl dipeptide, or interferon-gamma plus muramyl dipeptide is the interleukin-6 inducing stimulus. Furthermore, interleukin-4-dependent downregulation of monocyte interleukin-6 expression is confirmed at both the supernatant and the mRNA levels. Simultaneous downregulation of posttrauma elevated monokines implies a possible therapeutic benefit of interleukin-4 for trauma patients.
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Citation: J Clin Immunol. 1991 Nov;11(6):336-44.