UMass Chan Affiliations
Department of Medicine, Division of GastroenterologyDocument Type
Journal ArticlePublication Date
2014-07-07Keywords
Digestive System DiseasesGastroenterology
Hepatology
Immunology of Infectious Disease
Immunopathology
Metadata
Show full item recordAbstract
Persistent viral infection, such as HCV infection, is the result of the inability of the host immune system to mount a successful antiviral response, as well as the escape strategies devised by the virus. Although each individual component of the host immune system plays important roles in antiviral immunity, the interactive network of immune cells as a whole acts against the virus. The innate immune system forms the first line of host defense against viral infection, and thus, virus elimination or chronic HCV infection is linked to the direct outcome of the interactions between the various innate immune cells and HCV. By understanding how the distinct components of the innate immune system function both individually and collectively during HCV infection, potential therapeutic targets can be identified to overcome immune dysfunction and control chronic viral infection.Source
J Leukoc Biol. 2014 Jul 7. doi:10.1189/jlb.4MR0314-141R Link to article on publisher's siteDOI
10.1189/jlb.4MR0314-141RPermanent Link to this Item
http://hdl.handle.net/20.500.14038/31072PubMed ID
25001860Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1189/jlb.4MR0314-141R