Title

Aberrations in post-trauma monocyte (MO) subpopulation: role in septic shock syndrome

UMMS Affiliation

Department of Surgery; Department of Medicine, Division of Gastroenterology

Date

12-1-1990

Document Type

Article

Medical Subject Headings

Adult; Aged; Burns; Cell Separation; Humans; Immune Tolerance; Indomethacin; Middle Aged; Monocytes; Prostaglandins E; Rosette Formation; Shock, Septic; Tumor Necrosis Factor-alpha

Disciplines

Gastroenterology | Immunology and Infectious Disease

Abstract

Appearance of increased proportions of monocytes bearing the 72kd(FcRI) receptor for IgG correlated to aberrant monocyte (MO) functions, depressed immune functions, and poor clinical outcome. The trauma patients' FcRI+ MO subpopulation produced the majority of their elevated IL-6, TNF alpha, TGF beta, and PGE2. IgG stimulation of patients' MO through FcRI not only stimulated TNF alpha, IL-6, and PGE2 levels, but also greatly augmented the levels of these monokines produced after subsequent bacterial challenge. Post-trauma increased IL-6 levels can lead to polyclonal B-cell activation and high levels of circulating, nonspecific IgG as seen in trauma patients. This nonspecific IgG triggers the FcRI on the increased numbers of FcRI+ MO leading to ever-increasing monokine levels. IL-4 was found to downregulate patients' FcRI+ MO production of mediators. The cycle of altered cytokine levels, increased FcRI+ MO numbers, elevated IgG, and augmented triggering of FcRI+ MO may be broken by addition of IL-4.

Rights and Permissions

Citation: J Trauma. 1990 Dec;30(12 Suppl):S86-96.

Related Resources

Link to Article in PubMed

PubMed ID

2254998