Title
Inflammasomes in liver diseases
UMMS Affiliation
Department of Medicine, Division of Gastroenterology
Date
9-2012
Document Type
Article
Medical Subject Headings
Inflammasomes; Liver Diseases
Disciplines
Digestive System Diseases | Gastroenterology | Hepatology | Immunology and Infectious Disease
Abstract
Inflammation is a common element in the pathogenesis of most chronic liver diseases that lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune cells and production of pro-inflammatory cytokines IL-1alpha, IL-1beta, and TNFalpha. Inflammasomes are intracellular multiprotein complexes expressed in both parenchymal and non-parenchymal cells of the liver that in response to cellular danger signals activate caspase-1, and release IL-1beta and IL-18. The importance of inflammasome activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review. Elsevier B.V. All rights reserved.
Comments
Citation: J Hepatol. 2012 Sep;57(3):642-54. Epub 2012 May 23. Link to article on publisher's site