Inflammasomes in liver diseases
Department of Medicine, Division of Gastroenterology
Medical Subject Headings
Inflammasomes; Liver Diseases
Digestive System Diseases | Gastroenterology | Hepatology | Immunology and Infectious Disease
Inflammation is a common element in the pathogenesis of most chronic liver diseases that lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune cells and production of pro-inflammatory cytokines IL-1alpha, IL-1beta, and TNFalpha. Inflammasomes are intracellular multiprotein complexes expressed in both parenchymal and non-parenchymal cells of the liver that in response to cellular danger signals activate caspase-1, and release IL-1beta and IL-18. The importance of inflammasome activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review. Elsevier B.V. All rights reserved.
Szabo, Gyongyi and Csak, Timea, "Inflammasomes in liver diseases" (2012). Gastroenterology Publications and Presentations. 102.