Title

Inflammasomes in liver diseases

UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Date

9-2012

Document Type

Article

Medical Subject Headings

Inflammasomes; Liver Diseases

Disciplines

Digestive System Diseases | Gastroenterology | Hepatology | Immunology and Infectious Disease

Abstract

Inflammation is a common element in the pathogenesis of most chronic liver diseases that lead to fibrosis and cirrhosis. Inflammation is characterized by activation of innate immune cells and production of pro-inflammatory cytokines IL-1alpha, IL-1beta, and TNFalpha. Inflammasomes are intracellular multiprotein complexes expressed in both parenchymal and non-parenchymal cells of the liver that in response to cellular danger signals activate caspase-1, and release IL-1beta and IL-18. The importance of inflammasome activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review. Elsevier B.V. All rights reserved.

Comments

Citation: J Hepatol. 2012 Sep;57(3):642-54. Epub 2012 May 23. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

22634126