The Department of Medicine's Division of Gastroenterology at the University of Massachusetts Medical School is dedicated to excellence in patient care, research and medical education. Our staff is committed to providing the highest quality of care to individuals as well as to the community. We strive to advance patient care through excellence in clinical, basic and translational research, and to educate future health care professionals. The high standards set by the division and the scope of services available ensure that patients will receive the best care possible for a wide variety of gastrointestinal and liver diseases. This collection showcases journal articles, book chapters, and other publications and presentations written by faculty and researchers in the Division of Gastroenterology.

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Publications from 2015

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Does Every Patient Need Colonoscopy Follow-up for Diverticulitis?, Rachel Ackerman, Justin Yamin, Anne Foley, Louise Maranda, and Benjamin Hyatt

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MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis, Timea Csak, Shashi Bala, Dora Lippai, Karen Kodys, Donna Catalano, Arvin Iracheta-Vellve, and Gyongyi Szabo

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The genetics of hepatitis C virus underlie its ability to escape humoral immunity, Jay K. Kolls and Gyongyi Szabo

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The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1, Laurent Roybon, Teresa L. Mastracci, Joyce Li, Simon R. W. Stott, Andrew B. Leiter, Lori Sussel, Patrik Brundin, and Jia-Yi Li

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Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes, Banishree Saha, Johanna C. Bruneau, Karen Kodys, and Gyongyi Szabo

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Gut-liver axis in alcoholic liver disease, Gyongyi Szabo

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Alcohol and HCV: implications for liver cancer, Gyongyi Szabo, Banishree Saha, and Terence N. Bukong

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MicroRNAs in alcoholic liver disease, Gyongyi Szabo and Abhishek Satishchandran

Publications from 2014

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Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury, Aditya Ambade, Donna Catalano, Arlene Lim, Andre Kopoyan, Scott A. Shaffer, and Pranoti Mandrekar

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Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals, Shashi Bala, Miguel Marcos, Arijeet Gattu, Donna Catalano, and Gyongyi Szabo

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Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells, Stefan Bohr, Suraj J. Patel, Radovan Vasko, Keyue Shen, Arvin Iracheta-Vellve, Jungwoo Lee, Shyam Sundhar Bale, Nilay Chakraborty, Michael Brines, Anthony Cerami, Francois Berthiaume, and Martin L. Yarmush

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A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection at the Level of Cell Entry, Terence N. Bukong, Karen Kodys, and Gyongyi Szabo

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Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90, Terence N. Bukong, Fatemeh Momen-Heravi, Karen Kodys, Shashi Bala, and Gyongyi Szabo

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microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis, Timea Csak, Shashi Bala, Dora Lippai, Abhishek Satishchandran, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis, Timea Csak, Arun Pillai, Michal Ganz, Dora Lippai, Jan Petrasek, Jin-Kyu Park, Karen Kodys, Angela Dolganiuc, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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High fat diet feeding results in gender specific steatohepatitis and inflammasome activation, Michal Ganz, Timea Csak, and Gyongyi Szabo

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Micro-RNA-155 Deficiency Prevents Alcohol-Induced Serum Endotoxin Increase and Small Bowel Inflammation in Mice, Dora Lippai, Shashi Bala, Donna Catalano, Karen Kodys, and Gyongyi Szabo

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Computerized 3-dimensional localization of a video capsule in the abdominal cavity: validation by digital radiography, Neil Marya, Andrew Karellas, Anne Foley, Abhijit Roychowdhury, and David R. Cave

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Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages, Fatemeh Momen-Heravi, Shashi Bala, Terence N. Bukong, and Gyongyi Szabo

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Innate immune cell networking in hepatitis C virus infection, Banishree Saha and Gyongyi Szabo

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Converging actions of alcohol on liver and brain immune signaling, Gyongyi Szabo and Dora Lippai

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Pancreatitis Quality of Life Instrument: Development of a New Instrument, Wahid Y. Wassef, Carol A. Bova, Bruce A. Barton, and Celia Hartigan

Publications from 2013

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Targeting Heat Shock Protein 90 Alters Epigenetic Genes in Alcoholic Liver Disease, Aditya Ambade and Pranoti Mandrekar

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Ethanol facilitates HCV replication via upregulation of GW182 and HSP90 in human hepatoma cells, Terence N. Bukong, Wei Hou, Karen Kodys, and Gyongyi Szabo

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Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection, Terence N. Bukong, Karen Kodys, and Gyongyi Szabo

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Another armed CD4(+) T cell ready to battle hepatocellular carcinoma, Roniel Cabrera and Gyongyi Szabo

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Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach, Jessica M. Donnelly, Ambreesh Chawla, JeanMarie Houghton, and Yana Zavros

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Immune and inflammatory pathways in NASH, Michal Ganz and Gyongyi Szabo

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Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells, Wei Hou, Terence N. Bukong, Karen Kodys, and Gyongyi Szabo

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Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice, Dora Lippai, Shashi Bala, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Alcohol-induced IL-1beta in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation, Dora Lippai, Shashi Bala, Jan Petrasek, Timea Csak, Ivan Levin, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation, Sujatha Muralidharan and Pranoti Mandrekar

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Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis, Jan Petrasek, Timea Csak, Michal Ganz, and Gyongyi Szabo

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Toll-like receptors in liver disease, Jan Petrasek, Timea Csak, and Gyongyi Szabo

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STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease, Jan Petrasek, Arvin Iracheta-Vellve, Timea Csak, Abhishek Satishchandran, Karen Kodys, Evelyn A. Kurt-Jones, Katherine A. Fitzgerald, and Gyongyi Szabo

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Expression of inhibitory markers is increased on effector memory T cells during hepatitis C virus/HIV coinfection as compared to hepatitis C virus or HIV monoinfection, Banishree Saha, Manish C. Choudhary, and Shiv K. Sarin

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Binge ethanol and liver: new molecular developments, Shivendra D. Shukla, Stephen B. Pruett, Gyongyi Szabo, and Gavin E. Arteel

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Evaluation of small bowel bleeding, Anupam Singh, Veronica Baptista, Calin Stoicov, and David R. Cave

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Timing of video capsule endoscopy relative to overt obscure GI bleeding: implications from a retrospective study, Anupam Singh, Christopher Marshall, Biswashree Chaudhuri, Chidimma Okoli, Anne Foley, Sharina D. Person, Kanishka Bhattacharya, and David R. Cave

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Timing of video capsule endoscopy relative to overt obscure GI bleeding: implications from a retrospective study, Anupam Singh, Christopher Marshall, Biswashree Chaudhuri, Chidimma Okoli, Anne Foley, Sharina D. Person, Kanishka Bhattacharya, and David R. Cave

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Mesenchymal stem cells utilize CXCR4-SDF-1 signaling for acute, but not chronic, trafficking to gastric mucosal inflammation, Calin Stoicov, Hanchen Li, Jian Hua Liu, and JeanMarie Houghton

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MicroRNAs in liver disease, Gyongyi Szabo and Shashi Bala

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CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of HCV-infected cells and induction of IFNalpha, Shuye Zhang, Karen Kodys, Gregory J. Babcock, and Gyongyi Szabo

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Human type 2 myeloid dendritic cells produce interferon-lambda and amplify interferon-alpha in response to hepatitis C virus infection, Shuye Zhang, Karen Kodys, Kui Li, and Gyongyi Szabo

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IFN-gamma production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells, Shuye Zhang, Banishree Saha, Karen Kodys, and Gyongyi Szabo

Publications from 2012

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Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice, Aditya Ambade, Donna Catalano, Arlene Lim, and Pranoti Mandrekar

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Oxidative stress and inflammation: essential partners in alcoholic liver disease, Aditya Ambade and Pranoti Mandrekar

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Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases, Shashi Bala, Jan Petrasek, Shiv Mundkur, Donna Catalano, Ivan Levin, Jeanine Ward, Hawau Alao, Karen Kodys, and Gyongyi Szabo

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Serum microRNA-122 and miR-155 as biomarkers of liver injury and inflammation in models of acute and chronic liver disease, Shashi Bala, Jan Petrasek, Shiv Mundkur, Donna Catalano, Jeanine Ward, Ivan Levin, Hawau Alao, Karen Kodys, and Gyongyi Szabo

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MicroRNA Signature in Alcoholic Liver Disease, Shashi Bala and Gyongyi Szabo

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Induction of Bcl-3 by acute binge alcohol results in Toll-like receptor 4/LPS tolerance, Shashi Bala, Alexander Tang, Donna Catalano, Jan Petrasek, Odette Taha, Karen Kodys, and Gyongyi Szabo

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Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection, Shashi Bala, Yaphet Tilahun, Odette Taha, Hawau Alao, Karen Kodys, Donna Catalano, and Gyongyi Szabo

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Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection, Shashi Bala, Yaphet Tilahun, Odette Taha, Hawau Alao, Karen Kodys, Donna Catalano, and Gyongyi Szabo

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Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes, Terence N. Bukong, Tracie Lo, Gyongyi Szabo, and Angela Dolganiuc

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Increased oxidative capacity of circulating polymorphonuclear neutrophils (PMNs) in non-diabetic NASH patients, Timea Csak, Karen Kodys, Angela Dolganiuc, Dora Lippai, Michal Ganz, Christopher Marshall, and Gyongyi Szabo

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Type III Interferons, IL-28 and IL-29, Are Increased in Chronic HCV Infection and Induce Myeloid Dendritic Cell-Mediated FoxP3+ Regulatory T Cells, Angela Dolganiuc, Karen Kodys, Christopher Marshall, Banishree Saha, Shuye Zhang, Shashi Bala, and Gyongyi Szabo

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The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis, Ivan Levin, Jan Petrasek, and Gyongyi Szabo

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Cellular Signaling Pathways in Alcoholic Liver Disease, Pranoti Mandrekar and Aditya Ambade

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Slow-cycling therapy-resistant cancer cells, Nathan F. Moore, JeanMarie Houghton, and Stephen Lyle

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Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees, Trevor J. Morin, Teresa J. Broering, Brett A. Leav, Barbara M. Blair, Kirk J. Rowley, Elisabeth N. Boucher, Yang Wang, Peter S. Cheslock, Michael Knauber, David B. Olsen, Steve W. Ludmerer, Gyongyi Szabo, Robert W. Finberg, Robert H. Purcell, Robert E. Lanford, Donna M. Ambrosino, Deborah C. Molrine, and Gregory J. Babcock

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Reduction in Hepatic Inflammation Is Associated With Less Fibrosis Progression and Fewer Clinical Outcomes in Advanced Hepatitis C, Chihiro Morishima, Mitchell L. Shiffman, Jules L. Dienstag, Karen L. Lindsay, Gyongyi Szabo, Gregory T. Everson, Anna S. F. Lok, Adrian M. Di Bisceglie, Marc G. Ghany, Deepa Naishadham, Timothy R. Morgan, Elizabeth C. Wright, and HALT-C Trial Group

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Hypoxia and hypoxia inducible factors: diverse roles in liver diseases, Bharath D. Nath and Gyongyi Szabo

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IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice, Jan Petrasek, Shashi Bala, Timea Csak, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, So-Yun Min, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Caspase-1-dependent, IL-1ß-mediated alcoholic steatohepatitis is ameliorated by IL-1 receptor antagonist treatment in mice, Jan Petrasek, Shashi Bala, Dora Lippai, Karen Kodys, Victoria Menashy, Matthew Barrieau, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Inflammasomes in liver diseases, Gyongyi Szabo and Timea Csak

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Molecular hepatic carcinogenesis: impact of inflammation, Gyongyi Szabo and Dora Lippai

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MicroRNA silencing and the development of novel therapies for liver disease, Gyongyi Szabo, Peter Sarnow, and Shashi Bala

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Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study, Jeanine Ward, Shashi Bala, Jan Petrasek, and Gyongyi Szabo

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CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of HCV-infected cells and induction of IFNα, Shuye Zhang, Karen Kodys, and Gyongyi Szabo

Publications from 2011

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Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease, Shashi Bala, Miguel Marcos, Karen Kodys, Timea Csak, Donna Catalano, Pranoti Mandrekar, and Gyongyi Szabo

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Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice, Timea Csak, Angela Dolganiuc, Karen Kodys, Bharath D. Nath, Jan Petrasek, Shashi Bala, Dora Lippai, and Gyongyi Szabo

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Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells, Timea Csak, Michal Ganz, Justin Pespisa, Karen Kodys, Angela Dolganiuc, and Gyongyi Szabo

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Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells, Timea Csak, Michal Ganz, Justin Pespisa, Karen Kodys, Angela Dolganiuc, and Gyongyi Szabo

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Deficiency in myeloid differentiation factor-2 and Toll-like receptor 4 expression attenuates non-alcoholic steatohepatitis and fibrosis in mice, Timea Csak, Arumugam Velayudham, Istvan Hritz, Jan Petrasek, Ivan Levin, Dora Lippai, Donna Catalano, Pranoti Mandrekar, Angela Dolganiuc, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C, Jules L. Dienstag, Marc G. Ghany, Timothy R. Morgan, Adrian M. Di Bisceglie, Herbert L. Bonkovsky, Hae-Young Kim, Leonard B. Seeff, Gyongyi Szabo, Elizabeth C. Wright, Richard K. Sterling, Gregory T. Everson, Karen L. Lindsay, William M. Lee, Anna S. F. Lok, Chihiro Morishima, Anne M. Stoddard, and James E. Everhart

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Dendritic cells in hepatitis C infection: can they (help) win the battle, Angela Dolganiuc and Gyongyi Szabo

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Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver, Michal Ganz, Timea Csak, Bharath D. Nath, and Gyongyi Szabo

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Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver, Michal Ganz, Timea Csak, Bharath D. Nath, and Gyongyi Szabo

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Innate immunity and alcoholic liver disease, Bin Gao, Ekihiro Seki, Jessica Cohen, Laura Nagy, Gyongyi Szabo, and Samir Zakhari

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Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity, Tse-Chun Kuo, Chun-Ting Chen, Desiree Baron, Tamer T. Onder, Sabine Loewer, Sandra Almeida, Cara M. Weismann, Ping Xu, JeanMarie Houghton, Fen-Biao Gao, George Q. Daley, and Stephen J. Doxsey

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Epigenetic regulation in alcoholic liver disease, Pranoti Mandrekar

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An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice, Pranoti Mandrekar, Aditya Ambade, Arlene Lim, Gyongyi Szabo, and Donna Catalano

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An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice, Pranoti Mandrekar, Aditya Ambade, Arlene Lim, Gyongyi Szabo, and Donna Catalano

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Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice, Bharath D. Nath, Ivan Levin, Timea Csak, Jan Petrasek, Christian Mueller, Karen Kodys, Donna Catalano, Pranoti Mandrekar, and Gyongyi Szabo

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Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice, Bharath D. Nath, Ivan Levin, Timea Csak, Jan Petrasek, Christian Mueller, Karen Kodys, Donna Catalano, Pranoti Mandrekar, and Gyongyi Szabo

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Pilot Testing a Novel Treatment for Inflammatory Bowel Disease, Barbara C. Olendzki, Gioia Persuitte, Taryn Silverstein, Katherine Baldwin, David Cave, John K. Zawacki, Kanishka Bhattacharya, and Yunsheng Ma

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Inhibition of TLR8- and TLR4-induced Type I IFN Induction by Alcohol is Different from its effects on inflammatory cytokine production in monocytes, Maoyin Pang, Shashi Bala, Karen Kodys, Donna Catalano, and Gyongyi Szabo

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Type I Interferons Protect From Toll-Like Receptor 9-Associated Liver Injury and Regulate IL-1 Receptor Antagonist in Mice, Jan Petrasek, Angela Dolganiuc, Timea Csak, Evelyn A. Kurt-Jones, and Gyongyi Szabo

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Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells, Jan Petrasek, Angela Dolganiuc, Timea Csak, Bharath D. Nath, Istvan Hritz, Karen Kodys, Donna Catalano, Evelyn A. Kurt-Jones, Pranoti Mandrekar, and Gyongyi Szabo

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Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients, Gyongyi Szabo and Samir Zakhari

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Advanced molecular biologic techniques in toxicologic disease, Jeanine Ward, Gyongyi Szabo, David D. McManus, and Edward W. Boyer

Publications from 2010

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Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells, Serena S. Chang, Karen Kodys, and Gyongyi Szabo

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Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis C, Robert J. Fontana, Arun J. Sanyal, Marc G. Ghany, William M. Lee, Andrea E. Reid, Deepa Naishadham, Gregory T. Everson, Jeffrey A. Kahn, Adrian M. Di Bisceglie, Gyongyi Szabo, Timothy R. Morgan, and James E. Everhart

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Mutations in bone marrow-derived stromal stem cells unmask latent malignancy, JeanMarie Houghton, Hanchen Li, Xueli Fan, Yingwang Liu, Jian Hua Liu, Varada P. Rao, Theofilos Poutahidis, Christine L. Taylor, Erin A. Jackson, Christine Hewes, Stephen Lyle, Anna M. Cerny, Glennice N. Bowen, Jan Cerny, Nathan F. Moore, Evelyn A. Kurt-Jones, and Susan E. Erdman

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Alcohol exposure as a risk factor for adverse outcomes in elective surgery, Bharath D. Nath, YouFu Li, James E. Carroll Jr., Gyongyi Szabo, Jennifer F. Tseng, and Shimul A. Shah

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Toll-like receptors in the pathogenesis of alcoholic liver disease, Jan Petrasek, Pranoti Mandrekar, and Gyongyi Szabo

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The 40th anniversary of the National Institute on Alcoholism and Alcohol Abuse: the impact on liver disease, Gyongyi Szabo

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Alcoholic liver disease and the gut-liver axis, Gyongyi Szabo and Shashi Bala

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Toll-like receptor signaling in liver diseases, Gyongyi Szabo, Timothy R. Billiar, Keigo Machida, Ian Nicholas Crispe, and Ekihiro Seki

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Toll-like Receptors, Gyongyi Szabo and Pranoti Mandrekar