Freeman Lab Student Publications

 

This collection showcases the journal articles and other publications authored by students in the Freeman Lab. The Freeman Lab at the University of Massachusetts Medical School was established in 2004, in the Department of Neurobiology. Student authors are Michelle A. Avery (PhD, Neuroscience Program, 2010), Johnna Doherty (PhD, Neuroscience Program, 2012), Jennifer S. Zeigenfuss (PhD, Neuroscience Program, 2012), Yuly Fuentes-Medel (PhD, Neuroscience Program (with Vivian Budnik), 2012), Kimberly S. Kerr (PhD, Neuroscience Program, 2012), Jeannette M. Osterloh (PhD, Neuroscience Program, 2013),Ozge Tasdemir-Yilmaz (PhD, Neuroscience Program, 2014), Jennifer MacDonald (MD/PhD 2014), Allie K. Muthukumar (PhD, Neuroscience Program, 2015), Elizabeth Lewis (MS, Neuroscience Program, 2016), Timothy M. Rooney (MD/PhD 2015), Thomas C. Burdett (Neuroscience Program), Sukhee Cho (Neuroscience Program), Jonathan Farley (Neuroscience Program), Tsai-yi Lu (PhD, Interdisciplinary Graduate Program, 2015), Margaret G. Beach (MS, Neuroscience Program, 2007) and Ermalinda Porpiglia (completed PhD elsewhere in UMMS).

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Publications from 2017

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Axon Death Pathways Converge on Axed to Promote Axon Disassembly, Thomas C. Burdett

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Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling, Tsai-Yi Lu, Jennifer M. MacDonald, Lukas J. Neukomm, Amy E. Sheehan, Rachel Bradshaw, Mary A. Logan, and Marc R. Freeman

Publications from 2016

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Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species, Jiang He, Ruobo Zhou, Zhuhao Wu, Monica A. Carrasco, Peri T. Kurshan, Jonathan E. Farley, David J. Simon, Guiping Wang, Boran Han, Junjie Hao, Evan Heller, Marc R. Freeman, Kang Shen, Tom Maniatis, Marc Tessier-Lavigne, and Xiaowei Zhuang

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Using Drosophila models of Huntington's disease as a translatable tool, Elizabeth A. Lewis and Gaynor A. Smith

Publications from 2015

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Letting Go of JuNK by Disassembly of Adhesive Complexes, Jonathan E. Farley and Marc R. Freeman

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Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons, Wenjie Mao, Takuya Watanabe, Sukhee Cho, Jeffrey L. Frost, Tina Truong, Xiaohu Zhao, and Kensuke Futai

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Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation, Allie Muthukumar

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Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation, Timothy M. Rooney

Publications from 2014

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Neuroscience. Astrocytes eyeball axonal mitochondria, Thomas C. Burdett and Marc R. Freeman

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PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury, Johnna E. Doherty, Amy E. Sheehan, Rachel Bradshaw, A. Nicole Fox, Tsai-yi Lu, and Marc R. Freeman

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Glial wingless/Wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction, Kimberly S. Kerr, Yuly F. Fuentes Medel, Cassandra Brewer, Romina Barria, James A. Ashley, Katharine C. Abruzzi, Amy E. Sheehan, Ozge E. Tasdemir, Marc R. Freeman, and Vivian Budnik

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DRK/DOS/SOS Converge with Crk/Mbc/dCed-12 to Activate Rac1 during Glial Engulfment of Axonal Debris, Tsai-yi Lu, Johnna E. Doherty, and Marc R. Freeman

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Activity-dependent regulation of astrocyte GAT levels during synaptogenesis, Allie Muthukumar, Tobias Stork, and Marc R. Freeman

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Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila, Lukas J. Neukomm, Thomas C. Burdett, Michael A. Gonzalez, Stephan Zuchner, and Marc R. Freeman

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Drosophila models of neuronal injury, Timothy M. Rooney and Marc R. Freeman

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Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes, Tobias Stork, Amy E. Sheehan, Ozge E. Tasdemir-Yilmaz, and Marc R. Freeman

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Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation, Ozge E. Tasdemir-Yilmaz

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Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons, Ozge E. Tasdemir-Yilmaz and Marc R. Freeman

Publications from 2013

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The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function, Jennifer M. MacDonald, Johnna E. Doherty, Rachel Hackett, and Marc R. Freeman

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dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation, Jeannette M. Osterloh

Publications from 2012

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Wld(S) Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca(2+) Buffering, Michelle A. Avery, Timothy M. Rooney, Jignesh D. Pandya, Thomas M. Wishart, Thomas H. Gillingwater, James W. Geddes, Patrick G. Sullivan, and Marc R. Freeman

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Role of Glia in Sculpting Synaptic Connections at the Drosophila Neuromuscular Junction: A Dissertation, Yuly F. Fuentes Medel

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Integration of a retrograde signal during synapse formation by glia-secreted TGF-beta ligand, Yuly F. Fuentes-Medel, James A. Ashley, Romina Barria, Rachel Maloney, Marc R. Freeman, and Vivian Budnik

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Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens, Michael A. Gonzalez, Derek Van Booven, William Hulme, Rick H. Ulloa, Rafael F. Lebrigio Acosta, Jeannette M. Osterloh, Mary Logan, Marc R. Freeman, and Stephan Zuchner

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Glial Control of Synapse Assembly at the Drosophila Neuromuscular Junction: A Dissertation, Kimberly S. Kerr

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Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury, Mary A. Logan, Rachel Hackett, Johnna E. Doherty, Amy E. Sheehan, Sean D. Speese, and Marc R. Freeman

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A Role for c-Jun Kinase (JNK) Signaling in Glial Engulfment of Degenerating Axons: A Dissertation, Jennifer M. MacDonald

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dSarm/Sarm1 is required for activation of an injury-induced axon death pathway, Jeannette M. Osterloh, Jing Yang, Timothy M. Rooney, A. Nicole Fox, Robert Adalbert, Eric H. Powell, Amy E. Sheehan, Michelle A. Avery, Rachel Hackett, Mary A. Logan, Jennifer M. MacDonald, Jennifer S. Ziegenfuss, Stefan Milde, Ying-Ju Hou, Carl Nathan, Aihao Ding, Robert H. Brown Jr., Laura Comforti, Michael Coleman, Marc Tessier-Lavigne, Stephan Zuchner, and Marc R. Freeman

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Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo, Thomas M. Wishart, Timothy M. Rooney, Douglas J. Lamont, Ann K. Wright, A. Jennifer Morgon, Mandy Jackson, Marc R. Freeman, and Thomas H. Gillingwater

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Eaters of the Dead: How Glial Cells Respond to and Engulf Degenerating Axons in the CNS: A Dissertation, Jennifer S. Ziegenfuss

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Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy, Jennifer S. Ziegenfuss, Johnna E. Doherty, and Marc R. Freeman

Publications from 2011

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Cellular and Molecular Mechanisms Driving Glial Engulfment of Degenerating Axons: A Dissertation, Johnna E. Doherty

Publications from 2010

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Axon Death Prevented: Wlds and Other Neuroprotective Molecules: A Dissertation, Michelle A. Avery

Publications from 2009

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Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration, Michelle A. Avery, Amy E. Sheehan, Kimberly S. Kerr, Jing Wang, and Marc R. Freeman

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Ensheathing glia function as phagocytes in the adult Drosophila brain, Johnna E. Doherty, Mary A. Logan, Ozge E. Tasdemir, and Marc R. Freeman

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Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris, Yuly F. Fuentes Medel, Mary A. Logan, James A. Ashley, Bulent Ataman, Vivian Budnik, and Marc R. Freeman

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Neuronal death or dismemberment mediated by Sox14, Jeannette M. Osterloh and Marc R. Freeman

Publications from 2008

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Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling, Jennifer S. Ziegenfuss, Romi Biswas, Michelle A. Avery, Kyoungja Hong, Amy E. Sheehan, Yee-Guide Yeung, E. Richard Stanley, and Marc R. Freeman

Publications from 2006

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Glial cell biology in Drosophila and vertebrates, Marc R. Freeman and Johnna E. Doherty

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The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons, Jennifer MacDonald, Margaret Beach, Ermelinda Porpiglia, Amy E. Sheehan, Ryan J. Watts, and Marc R. Freeman