Freeman Lab Publications

 

This collection showcases the journal articles and other publications authored by researchers in the Freeman Lab. The Freeman Lab at the University of Massachusetts Medical School was established in 2004, in the Department of Neurobiology.

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Publications from 2017

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Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling, Tsai-Yi Lu, Jennifer M. MacDonald, Lukas J. Neukomm, Amy E. Sheehan, Rachel Bradshaw, Mary A. Logan, and Marc R. Freeman

Publications from 2016

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Dendrites actively restrain axon outgrowth and regeneration, Michael M. Francis and Marc R. Freeman

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Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species, Jiang He, Ruobo Zhou, Zhuhao Wu, Monica A. Carrasco, Peri T. Kurshan, Jonathan E. Farley, David J. Simon, Guiping Wang, Boran Han, Junjie Hao, Evan Heller, Marc R. Freeman, Kang Shen, Tom Maniatis, Marc Tessier-Lavigne, and Xiaowei Zhuang

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Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1, Nils Henninger, James P. Bouley, Elif M. Sikoglu, Jiyan An, Constance M. Moore, Jean A. King, Robert Bowser, Marc R. Freeman, and Robert H. Brown Jr.

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Using Drosophila models of Huntington's disease as a translatable tool, Elizabeth A. Lewis and Gaynor A. Smith

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Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour, Zhiguo Ma, Tobias Stork, Dwight E. Bergles, and Marc R. Freeman

Publications from 2015

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Letting Go of JuNK by Disassembly of Adhesive Complexes, Jonathan E. Farley and Marc R. Freeman

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Drosophila Central Nervous System Glia, Marc R. Freeman

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Shank1 regulates excitatory synaptic transmission in mouse hippocampal parvalbumin-expressing inhibitory interneurons, Wenjie Mao, Takuya Watanabe, Sukhee Cho, Jeffrey L. Frost, Tina Truong, Xiaohu Zhao, and Kensuke Futai

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Astrocyte-Neuron Interactions Regulate Nervous System Assembly and Function: A Dissertation, Allie Muthukumar

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Genes Required for Wallerian Degeneration Also Govern Dendrite Degeneration: A Dissertation, Timothy M. Rooney

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Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2, Jemeen Sreedharan, Lukas J. Neukomm, Robert H. Brown Jr., and Marc R. Freeman

Publications from 2014

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Neuroscience. Astrocytes eyeball axonal mitochondria, Thomas C. Burdett and Marc R. Freeman

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PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury, Johnna E. Doherty, Amy E. Sheehan, Rachel Bradshaw, A. Nicole Fox, Tsai-yi Lu, and Marc R. Freeman

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Signaling mechanisms regulating Wallerian degeneration, Marc R. Freeman

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Glial wingless/Wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction, Kimberly S. Kerr, Yuly F. Fuentes Medel, Cassandra Brewer, Romina Barria, James A. Ashley, Katharine C. Abruzzi, Amy E. Sheehan, Ozge E. Tasdemir, Marc R. Freeman, and Vivian Budnik

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DRK/DOS/SOS Converge with Crk/Mbc/dCed-12 to Activate Rac1 during Glial Engulfment of Axonal Debris, Tsai-yi Lu, Johnna E. Doherty, and Marc R. Freeman

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Activity-dependent regulation of astrocyte GAT levels during synaptogenesis, Allie Muthukumar, Tobias Stork, and Marc R. Freeman

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Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila, Lukas J. Neukomm, Thomas C. Burdett, Michael A. Gonzalez, Stephan Zuchner, and Marc R. Freeman

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Diverse cellular and molecular modes of axon degeneration, Lukas J. Neukomm and Marc R. Freeman

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Drosophila models of neuronal injury, Timothy M. Rooney and Marc R. Freeman

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Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes, Tobias Stork, Amy E. Sheehan, Ozge E. Tasdemir-Yilmaz, and Marc R. Freeman

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Role of Astrocytes in Sculpting Neuronal Circuits in the Drosophila CNS: A Dissertation, Ozge E. Tasdemir-Yilmaz

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Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons, Ozge E. Tasdemir-Yilmaz and Marc R. Freeman

Publications from 2013

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Cell biology in neuroscience: Architects in neural circuit design: glia control neuron numbers and connectivity, Megan M. Corty and Marc R. Freeman

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Probing the enigma: unraveling glial cell biology in invertebrates, Jaeda Coutinho-Budd and Marc R. Freeman

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Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years, Marc R. Freeman and David H. Rowitch

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The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function, Jennifer M. MacDonald, Johnna E. Doherty, Rachel Hackett, and Marc R. Freeman

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Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo, Stefan Milde, A. Nicole Fox, Marc R. Freeman, and Michael P. Coleman

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dSarm/Sarm1 Governs a Conserved Axon Death Program: A Dissertation, Jeannette M. Osterloh

Publications from 2012

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Wld(S) Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca(2+) Buffering, Michelle A. Avery, Timothy M. Rooney, Jignesh D. Pandya, Thomas M. Wishart, Thomas H. Gillingwater, James W. Geddes, Patrick G. Sullivan, and Marc R. Freeman

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Role of Glia in Sculpting Synaptic Connections at the Drosophila Neuromuscular Junction: A Dissertation, Yuly F. Fuentes Medel

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Integration of a retrograde signal during synapse formation by glia-secreted TGF-beta ligand, Yuly F. Fuentes-Medel, James A. Ashley, Romina Barria, Rachel Maloney, Marc R. Freeman, and Vivian Budnik

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Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens, Michael A. Gonzalez, Derek Van Booven, William Hulme, Rick H. Ulloa, Rafael F. Lebrigio Acosta, Jeannette M. Osterloh, Mary Logan, Marc R. Freeman, and Stephan Zuchner

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Glial Control of Synapse Assembly at the Drosophila Neuromuscular Junction: A Dissertation, Kimberly S. Kerr

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Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury, Mary A. Logan, Rachel Hackett, Johnna E. Doherty, Amy E. Sheehan, Sean D. Speese, and Marc R. Freeman

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A Role for c-Jun Kinase (JNK) Signaling in Glial Engulfment of Degenerating Axons: A Dissertation, Jennifer M. MacDonald

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dSarm/Sarm1 is required for activation of an injury-induced axon death pathway, Jeannette M. Osterloh, Jing Yang, Timothy M. Rooney, A. Nicole Fox, Robert Adalbert, Eric H. Powell, Amy E. Sheehan, Michelle A. Avery, Rachel Hackett, Mary A. Logan, Jennifer M. MacDonald, Jennifer S. Ziegenfuss, Stefan Milde, Ying-Ju Hou, Carl Nathan, Aihao Ding, Robert H. Brown Jr., Laura Comforti, Michael Coleman, Marc Tessier-Lavigne, Stephan Zuchner, and Marc R. Freeman

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Analysis of glial cell development and function in Drosophila, Tobias Stork, Rebecca Bernardos, and Marc R. Freeman

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Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo, Thomas M. Wishart, Timothy M. Rooney, Douglas J. Lamont, Ann K. Wright, A. Jennifer Morgon, Mandy Jackson, Marc R. Freeman, and Thomas H. Gillingwater

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Eaters of the Dead: How Glial Cells Respond to and Engulf Degenerating Axons in the CNS: A Dissertation, Jennifer S. Ziegenfuss

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Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy, Jennifer S. Ziegenfuss, Johnna E. Doherty, and Marc R. Freeman

Publications from 2011

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Cellular and Molecular Mechanisms Driving Glial Engulfment of Degenerating Axons: A Dissertation, Johnna E. Doherty

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Invertebrate glia. Introduction, David Featherstone and Marc R. Freeman

Publications from 2010

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Axon Death Prevented: Wlds and Other Neuroprotective Molecules: A Dissertation, Michelle A. Avery

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Wallerian degeneration, wld(s), and nmnat, Michael P. Coleman and Marc R. Freeman

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Specification and morphogenesis of astrocytes, Marc R. Freeman

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Activation of autophagy during cell death requires the engulfment receptor Draper, Christina K. McPhee, Mary A. Logan, Marc R. Freeman, and Eric H. Baehrecke

Publications from 2009

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Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration, Michelle A. Avery, Amy E. Sheehan, Kimberly S. Kerr, Jing Wang, and Marc R. Freeman

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Ensheathing glia function as phagocytes in the adult Drosophila brain, Johnna E. Doherty, Mary A. Logan, Ozge E. Tasdemir, and Marc R. Freeman

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Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris, Yuly F. Fuentes Medel, Mary A. Logan, James A. Ashley, Bulent Ataman, Vivian Budnik, and Marc R. Freeman

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Neuronal death or dismemberment mediated by Sox14, Jeannette M. Osterloh and Marc R. Freeman

Publications from 2008

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Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling, Jennifer S. Ziegenfuss, Romi Biswas, Michelle A. Avery, Kyoungja Hong, Amy E. Sheehan, Yee-Guide Yeung, E. Richard Stanley, and Marc R. Freeman

Publications from 2007

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Glia got rhythm, Patrick Emery and Marc R. Freeman

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A look inside, Marc R. Freeman

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The scoop on the fly brain: glial engulfment functions in Drosophila, Mary A. Logan and Marc R. Freeman

Publications from 2006

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Sculpting the nervous system: glial control of neuronal development, Marc R. Freeman

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Glial cell biology in Drosophila and vertebrates, Marc R. Freeman and Johnna E. Doherty

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The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons, Jennifer MacDonald, Margaret Beach, Ermelinda Porpiglia, Amy E. Sheehan, Ryan J. Watts, and Marc R. Freeman

Publications from 2005

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Glial (and neuronal) cells missing, Marc R. Freeman

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Glial control of synaptogenesis, Marc R. Freeman