Shedding light on sperm pHertility
Department of Cell Biology
Medical Subject Headings
Animals; Humans; Hydrogen-Ion Concentration; Male; Membrane Potentials; Mice; *Sperm Capacitation; Spermatozoa
The acquisition of fertilization capacity by sperm is regulated by intracellular pH (pH(i)), but the transport pathways that regulate pH(i) are not well understood. Lishko et al. (2010) now report that Hv1, the voltage-sensitive proton channel, is present in human sperm and is an important regulator of the functional maturation of sperm.
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Citation: Cell. 2010 Feb 5;140(3):310-2. Link to article on publisher's site