University of Massachusetts Medical School Faculty Publications

Title

Perspective: The RNA exosome, cytokine gene regulation and links to autoimmunity

UMMS Affiliation

Program in Innate Immunity; Department of Medicine, Division of Infectious Diseases and Immunology

Date

8-1-2015

Document Type

Article

Medical Subject Headings

Animals; Autoimmune Diseases; Cytokines; Exosome Multienzyme Ribonuclease Complex; Gene Expression Regulation; Humans; RNA Processing, Post-Transcriptional; *Self Tolerance

Disciplines

Immunity

Abstract

The RNA exosome is a highly conserved exoribonuclease complex that is involved in RNA processing, quality control and turnover regulation. The exosome plays pleiotropic functions by recruiting different cofactors that regulate its target specificity. Recently, the exosome has been implicated in the regulation of immune processes including cytokine production and negative regulation of innate sensing of nucleic acids. Careful regulation of such mechanisms is critical to avoid a breakdown of self-tolerance and the pathogenesis of autoimmune disorders. This perspective briefly introduces the exosome, its its normal function in RNA biology and summarizes regulatory roles of the RNA exosome in immunity. Finally we discuss how dysregulation of exosome function can lead to autoimmune disease.

Rights and Permissions

Citation: Cytokine. 2015 Aug;74(2):175-80. doi: 10.1016/j.cyto.2015.03.005. Epub 2015 Mar 30. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Keywords

Autoimmune disease, Cytokines, Exosome, Innate immunity, RNA sensors

PubMed ID

25835609