Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis
Department of Medicine, Division of Gastroenterology; Graduate School of Biomedical Sciences
Digestive System Diseases | Gastroenterology | Hepatology | Immunity | Immunopathology
Upregulation of the inflammatory cascade is a major element both in the progression of steatohepatitis to severe alcoholic hepatitis as well as in the progression of NASH to advanced NASH with fibrosis. The mechanisms underpinning these changes are only partially understood. Activation of the inflammatory cascade requires multiple stimuli and in this report, we discuss the role of inflammasomes that activate IL-1beta as well as the sterile and pathogen-derived danger signals that results in inflammasome activation and inflammation in alcoholic and non-alcoholic steatohepatitis. The dynamics of inflammasome activation, the cell types involved and the trigger signals appear to be somewhat different between ASH and NASH. Further studies are needed to dissect the pathology-related differences between these two major forms of steatohepatitis. Clinical and therapeutic implications of inflammasome activation in steatohepatitis are also discussed.
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Citation: Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S18-23. doi: 10.1016/j.clinre.2015.06.012. Epub 2015 Jul 26. Link to article on publisher's site
Szabo, Gyongyi and Iracheta-Vellve, Arvin, "Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis" (2015). University of Massachusetts Medical School Faculty Publications. 937.