University of Massachusetts Medical School Faculty Publications

Title

Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts

UMMS Affiliation

Department of Medicine, Division of Rheumatology

Date

9-28-2015

Document Type

Article

Disciplines

Allergy and Immunology | Cell Biology | Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases

Abstract

Dysregulated bone remodeling occurs when there is an imbalance between bone resorption and bone formation. In rheumatic diseases, including rheumatoid arthritis (RA) and seronegative spondyloarthritis, systemic and local factors disrupt the process of physiologic bone remodeling. Depending upon the local microenvironment, cell types, and local mechanical forces, inflammation results in very different effects on bone, promoting bone loss in the joints and in periarticular and systemic bone in RA and driving bone formation at enthesial and periosteal sites in diseases such as ankylosing spondylitis (AS), included within the classification of axial spondyloarthritis. There has been a great deal of interest in the role of osteoclasts in these processes and much has been learned over the past decade about osteoclast differentiation and function. It is now appreciated that osteoblast-mediated bone formation is also inhibited in the RA joint, limiting the repair of erosions. In contrast, osteoblasts function to produce new bone in AS. The Wnt and BMP signaling pathways have emerged as critical in the regulation of osteoblast function and the outcome for bone in rheumatic diseases, and these pathways have been implicated in both bone loss in RA and bone formation in AS. These pathways provide potential novel approaches for therapeutic intervention in diseases in which inflammation impacts bone.

Rights and Permissions

Citation: Clin Rev Allergy Immunol. 2015 Sep 28. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Keywords

Ankylosing spondylitis, Bone erosions, Bone formation, Bone remodeling, DKK1, Entheses, IL-23, Inflammation, Osteoblast, Osteoclast, Rheumatoid arthritis, Sclerostin, Wnt, microRNAs

PubMed ID

26411424