University of Massachusetts Medical School Faculty Publications

Title

Mediators of inflammation and bone remodeling in rheumatic disease

UMMS Affiliation

Department of Medicine, Division of Rheumatology

Publication Date

1-2016

Document Type

Article

Disciplines

Cell Biology | Cellular and Molecular Physiology | Musculoskeletal Diseases | Rheumatology

Abstract

Remodeling of bone is a continuous process that occurs throughout life. Under normal physiologic conditions, bone-resorbing osteoclasts and bone-forming osteoblasts are tightly coupled and regulated to ensure proper balance, such that there is no net change in bone mass. However, inflammation perturbs normal bone homeostasis. The impact of inflammation on bone is dependent upon the anatomic site affected, cell types, factors and cytokines present in the local microenvironment, and local mechanical forces. Cytokines are central to the pathogenesis of inflammation-induced bone loss and contribute to the uncoupling of osteoclast-mediated bone resorption and osteoblast-mediated bone formation, thereby disrupting normal remodeling. In this review, we will discuss the effects of cytokines on bone in two settings, rheumatoid arthritis and spondyloarthritis, a disease category that includes ankylosing spondylitis, psoriatic arthritis, reactive arthritis, inflammatory bowel disease, and juvenile onset spondyloarthropathy. The outcome for bone in these disease settings is quite different, and an understanding of the pathogenic mechanisms leading to the net impact on bone has been essential in developing new therapeutic approaches to bone health in these diseases.

Keywords

Cytokines, Inflammation, Osteoblasts, Osteoclasts, Rheumatoid arthritis, Spondyloarthritis

Rights and Permissions

Citation: Semin Cell Dev Biol. 2016 Jan;49:2-10. doi: 10.1016/j.semcdb.2015.10.013. Epub 2015 Oct 19. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Seminars in cell and developmental biology

PubMed ID

26481971