Impact of Plasmodium falciparum Coinfection on Longitudinal Epstein-Barr Virus Kinetics in Kenyan Children
Authors
Reynaldi, ArnoldSchlub, Timothy E.
Chelimo, Kiprotich
Sumba, Peter Odada
Piriou, Erwan
Ogolla, Sidney
Moormann, Ann M.
Rochford, Rosemary A.
Davenport, Miles P.
UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2016-03-15Keywords
Burkitt lymphomaEpstein-Barr virus
P. falciparum malaria
chronic infection
co-infection
infection dynamics
Immunology of Infectious Disease
Infectious Disease
Parasitic Diseases
Parasitology
Virology
Virus Diseases
Metadata
Show full item recordAbstract
Endemic Burkitt lymphoma is associated with Epstein-Barr virus (EBV) and Plasmodium falciparum coinfection, although how P. falciparum exposure affects the dynamics of EBV infection is unclear. We have used a modeling approach to study EBV infection kinetics in a longitudinal cohort of children living in regions of high and low malaria transmission in Kenya. Residence in an area of high malaria transmission was associated with a higher rate of EBV expansion during primary EBV infection in infants and during subsequent episodes of EBV DNA detection, as well as with longer episodes of EBV DNA detection and shorter intervals between subsequent episodes of EBV DNA detection. In addition, we found that concurrent P. falciparum parasitemia also increases the likelihood of the first and subsequent peaks of EBV in peripheral blood. This suggests that P. falciparum infection is associated with increased EBV growth and contributes to endemic Burkitt lymphoma pathogenesis.Source
J Infect Dis. 2016 Mar 15;213(6):985-91. doi: 10.1093/infdis/jiv525. Epub 2015 Nov 3. Link to article on publisher's siteDOI
10.1093/infdis/jiv525Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30590PubMed ID
26531246Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1093/infdis/jiv525