University of Massachusetts Medical School Faculty Publications


Intracranial hemorrhage with target specific oral anticoagulants in patients with atrial fibrillation: An updated meta-analysis of randomized controlled trials

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine

Publication Date


Document Type



Cardiology | Cardiovascular Diseases


Although individual trials with Target Specific Oral Anticoagulants (TSOACs) have shown decreased rates of intracranial hemorrhage (ICH), there is limited data regarding the absolute and relative benefit of TSOACs in prevention of ICH. We performed a meta analysis to evaluate the absolute risk of ICH with TSOACs in patients with atrial fibrillation (AF), using data from the most recent clinical trials.

Rights and Permissions

Citation: Int J Cardiol. 2016 Jan 15;203:1000-2. doi: 10.1016/j.ijcard.2015.11.097. Epub 2015 Nov 17. Link to article on publisher's site

Related Resources

Link to Article in PubMed


Apixaban, Atrial fibrillation, Dabigatran, Edoxaban, Intracranial hemorrhage, Rivaroxaban

Journal/Book/Conference Title

International journal of cardiology

PubMed ID