Clinical epidemiology of heart failure with preserved ejection fraction (HFpEF) in comparatively young hospitalized patients
Department of Medicine, Division of Cardiovascular Medicine; Department of Quantitative Health Sciences
Cardiology | Cardiovascular Diseases | Clinical Epidemiology
BACKGROUND: While heart failure with preserved ejection fraction (HFpEF) is primarily a disease of old age, risk factors that contribute to HFpEF are not limited to older patients. The objectives of this population-based observational study were to describe the clinical epidemiology of HFpEF in younger ( < 65years) as compared with older ( > /=65years) patients hospitalized with acute decompensated heart failure.
METHODS AND RESULTS: We reviewed the medical records of residents of central Massachusetts hospitalized with HFpEF at all 11 greater Worcester (MA) medical centers during the 5 study years of 1995, 2000, 2002, 2004, and 2006. Among the 2398 patients hospitalized with confirmed HFpEF, 357 (14.9%) were < 65years old. Younger patients were more likely to be male, non-Caucasian, obese, and to have a history of diabetes and chronic kidney disease than older patients with HFpEF. Younger patients hospitalized with HFpEF were less likely to have received commonly prescribed cardiac medications, had a longer hospital stay, and experienced significantly lower post-discharge death rates than older hospitalized patients.
CONCLUSION: While HFpEF is predominantly a disease of old age, data from longitudinal studies remain needed to identify risk factors in younger individuals that may predispose them to the development of HFpEF.
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Citation: Int J Cardiol. 2016 Jan 1;202:918-21. doi: 10.1016/j.ijcard.2015.09.114. Epub 2015 Oct 22. Link to article on publisher's site
Zacharias, Michael; Joffe, Samuel; Konadu, Elizabeth; Meyer, Theo E.; Kiernan, MIchael S.; Lessard, Darleen M.; and Goldberg, Robert J., "Clinical epidemiology of heart failure with preserved ejection fraction (HFpEF) in comparatively young hospitalized patients" (2016). University of Massachusetts Medical School Faculty Publications. 825.