Department of Neurobiology; Freeman Lab
Medical Subject Headings
Animals; Drosophila; Humans; Neural Stem Cells; Neurogenesis; Neuroglia; Neurons; Synapses
Cell Biology | Molecular and Cellular Neuroscience
Glia serve many important functions in the mature nervous system. In addition, these diverse cells have emerged as essential participants in nearly all aspects of neural development. Improved techniques to study neurons in the absence of glia, and to visualize and manipulate glia in vivo, have greatly expanded our knowledge of glial biology and neuron-glia interactions during development. Exciting studies in the last decade have begun to identify the cellular and molecular mechanisms by which glia exert control over neuronal circuit formation. Recent findings illustrate the importance of glial cells in shaping the nervous system by controlling the number and connectivity of neurons.
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Citation: J Cell Biol. 2013 Nov 11;203(3):395-405. doi: 10.1083/jcb.201306099. Link to article on publisher's site
Corty, Megan M. and Freeman, Marc R., "Cell biology in neuroscience: Architects in neural circuit design: glia control neuron numbers and connectivity" (2013). University of Massachusetts Medical School Faculty Publications. 807.
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